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Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

Cancer Biology & medicine 2022年第2期19卷 175-186页

作者： Yufei Jiang Huiyun Yuan Zhuoying Li Xiaowei Ji Qiuming Shen Jiayi Tuo Jinghao Bi Honglan Li Yongbing Xiang State Key Laboratory of Oncogene and Related Genes&Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032China Renji Hospital Shanghai Jiao Tong University School of MedicineShanghai 200127China school of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China

This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer *** performed a systematic search of China National Knowledge Infrastructure(CNKI),Wanfang Data,PubMed,Web of Science,EMBASE,and SEER and collected all population-based survival studies of colorectal cancer(up to June 2020).Estimates of observed and relative survival rates of colorectal cancer by sex,period,and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st ***,5-year observed survival rates were higher in Seoul,Republic of Korea(1993–1997;56.8%and 54.3%for colon and rectum cancers,respectively),Zhejiang province(2005–2010;52.9%for colon cancer),Tianjin(1991–1999;52.5%for colon cancer),shanghai(2002–2006;50.0%for rectum cancer)of China,and in Japan(1993–1996,59.6%for colorectal cancer).Five-year relative survival rates of colorectal cancer in the Republic of Korea(2010–2014),Queensland,Australia(2005–2012),and the USA(2005–2009)ranked at relatively higher positions compared to other *** general,colorectal cancer survival rates are improving over time *** disparities in survival rates were also observed in the colon,rectum,and colorectal cancers in most countries or *** poorest age-specific 5-year relative survival rate was observed in patients>75 years of *** conclusion,over the past 3 decades,colorectal cancer survival has gradually *** variations,sex differences,and age gradients were also observed globally in colorectal cancer *** studies are therefore warranted to investigate the prognostic factors of colorectal cancer.

关键词： Colorectal cancer survival rate prognosis population-based study cancer registration

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Comparative analysis of indentation and magnetic resonance elastography for measuring viscoelastic properties

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Acta Mechanica Sinica 2021年第3期37卷 527-536,I0004页

作者： Yu Chen Suhao Qiu Zhao He Fuhua Yan Ruokun Li Yuan Feng Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Measurement the viscoelastic properties is important for studying the developmental and pathological behavior of soft biological *** resonance elastography(MRE)is a non-invasive method for in vivo measurement of tissue *** a flexible method capable of testing small samples,indentation has been widely used for characterizing soft *** 2nd-order Prony series and dimensional analysis,we analyzed and compared the model parameters estimated from both indentation and *** of the model parameters estimated from the two methods were *** found that the indention test is better at capturing the dynamic response of tissues at a frequency less than 10 Hz,while MRE is better for describing the frequency responses at a relatively higher *** results provided helpful information for testing soft tissues using indentation and *** models analyzed are also helpful for quantifying the frequency response of viscoelastic tissues.

关键词： Viscoelastic properties Indentation Magnetic resonance elastography Dimensional analysis Frequency response

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Proportion of viable myocardium is more reliable than semi-quantitative score in predicting functional recovery: a pilot studyof PET myocardial viability imaging

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Nuclear Science and Techniques 2008年第1期19卷 32-38页

作者： ZHANG Jiayin KONG Ye ZHOU Jian ZHANG Jianfeng ZHANG Liying WANG Chao ZHU Chengmo LI Biao Department of Nuclear medicine Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Cardiac / Thoracic Surgery Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

PET myocardial viability imaging is the "gold standard" for the non-invasive assessment of myocardial viability. The research aims to find out the best methods of imaging interpretation in predicting the postoperative functional recovery. Twenty-one CAD patients with multi-vessel involvement were recruited. All patients underwent gated myocardial perfusion imaging(G-MPI) and FDG PET myocardial imaging within 2 weeks before coronary artery bypass grafting. The postoperative G-MPI was performed in all patients 3 months after the surgery. Out of the total 420 segments, 164 segments of ischemic myocardium were detected by preoperative G-MPI. Among them, 93 ischemic segments were identified as non-viable(difference score≥0) and the rest 71 segments were identified as viable(difference score<0). The proportion of viable segments (the ratio of viable segments versus ischemic segments) and summed difference score of metabolism to perfusion were calculated. The patients were further divided into 2 groups according to the proportion of viable myocardium: groupⅠ(the proportion≥50%, 12 cases) and groupⅡ(the proportion<50%, 9 cases) while another division was made according to SDS: group A (SDS≥0), group B (-5≤SDS<0) and group C (SDS<-5). The diagnostic accuracy of proportion of viable segments and SDS in predicting the post-revascularization improvement in the left ventricular ejection fraction by at least 5 or more ejection fraction units was 88.89% (8/9) and 55.56% (5/9) respectively. It is concluded that both approaches allow accurate evaluation of myocardial viability. Furthermore, the proportion of viable myocardium is more reliable in predicting the postoperative functional recovery.

关键词：心肌活力射线诊断冠状动脉疾病定量检测

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Functionalized magnetic nanoparticles for drug delivery in tumor therapy

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Chinese Physics B 2021年第1期30卷 87-93页

作者： Ruo-Nan Li Xian-Hong Da Xiang Li Yun-Shu Lu Fen-Fen Gu Yan Liu school of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pharmacy Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

The side effects of chemotherapy are mainly the poor control of drug release. Magnetic nanoparticles(MNPs) have super-paramagnetic behaviors which are preferred for biomedical applications such as in targeted drug delivery, besides, in magnetic recording, catalysis, and others. MNPs, due to high magnetization response, can be manipulated by the external magnetic fields to penetrate directly into the tumor, thus they can act as ideal drug carriers. MNPs also play a crucial role in drug delivery system because of their high surface-to-volume ratio and porosity. The drug delivery in tumor therapy is related to the sizes, shapes, and surface coatings of MNPs as carriers. Therefore, in this review, we first summarize the effects of the sizes, shapes, and surface coatings of MNPs on drug delivery, then discuss three types of drug release systems, i.e., p H-controlled, temperature-controlled, and magnetic-controlled drug release systems, and finally compare the principle of passive drug release with that of active drug release in tumor therapy.

关键词： magnetic nanoparticles tumor drug carriers targeted therapy

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Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness

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Research 2022年第3期2022卷 45-59页

作者： Yilin Cai Shiyi Huang Zhinan Zhang Jiazheng Zhang Xingyue Zhu Xiaoxiang Chen Xianting Ding State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Oncogenes and Related Genes Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Department of Rheumatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Microneedle permits transdermal biosensing and drug delivery with minor ***,accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomogeneous skin topology and discontinuous force applied to the ***,we introduce bioinspired rotation microneedles for in vivo accurate microneedle positioning as inspired by honeybees’*** demonstrate the benefits of rotation microneedles in alleviating skin resistance through finite element analysis,full-thickness porcine validations,and mathematical derivations of microneedleskin interaction stress *** max penetration force was mitigated by up to 45.7%and the force attenuation rate increased to 2.73 times in the holding stage after penetration.A decrease in max skin deflection and a faster deformation recovery introduced by rotation microneedles implied a more precise penetration ***,we applied the rotation microneedles in psoriasis mice,a monogenic disorder animal model,for minimally invasive biological sample extraction and proinflammatory cytokine *** ultrasensitive detection method is realized by using only one microneedle to achieve cytokine mRNA level determination compared to commonly required biopsies or blood ***,rotation microneedles permit a simple,rapid,and ultraminimal-invasive method for subcutaneous trace biological sample acquisition and subsequent point-of-care diagnostics with minimal damage to both microneedles and skins.

关键词： rotation precise faster

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Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice

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Neural Regeneration Research 2022年第9期17卷 2058-2063页

作者： Li-Dong Deng Lin Qi Qian Suo Sheng-Ju Wu Muyassar Mamtilahun Ru-Bing Shi Ze Liu Jun-Feng Sun Yao-Hui Tang Zhi-Jun Zhang Guo-Yuan Yang Ji-Xian Wang Department of Rehabilitation medicine Ruijin HospitalSchool of Medicineand Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Blood-brain barrier(BBB)disruption underlies the vasogenic edema and neuronal cell death induced by acute ischemic *** this disruption has therapeutic *** focused ultrasound stimulation has shown neuromodulatory and neuroprotective effects in various brain diseases including ischemic *** stimulation can reduce inflammation and promote angiogenesis and neural circuit ***,its effect on the BBB in the acute phase of ischemic stroke is *** this study of mice subjected to middle cerebral artery occlusion for 90 minutes,low-intensity low-frequency(0.5 MHz)transcranial focused ultrasound stimulation was applied 2,4,and 8 hours after *** stimulation reduced edema volume,improved neurobehavioral outcomes,improved BBB integrity(enhanced tight junction protein ZO-1 expression and reduced IgG leakage),and reduced secretion of the inflammatory factors tumor necrosis factor-αand activation of matrix metalloproteinase-9 in the ischemic *** results show that low-intensity ultrasound stimulation attenuated BBB disruption and edema formation,which suggests it may have therapeutic use in ischemic brain disease as a protector of BBB integrity.

关键词： blood-brain barrier brain edema cerebral blood flow ischemia matrix metalloproteinase-9 neurobehavioral outcomes tight junction transcranial ultrasound

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Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 631-637页

作者： Li-jin PU Ying SHEN Rui-yan ZHANG Qi ZHANG Lin LU Feng-hua DING Jian HU Zheng-kun YANG Wei-feng SHEN Department of Cardiology Ruijin Hospital Shanghai Jiao Tong Uniwzrsity School of MedicineShanghai 200025China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention.

关键词： Renal artery stenosis Transradial coronary angiography Resistant hypertension

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MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression

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World Journal of Gastroenterology 2017年第6期23卷 976-985页

作者： Zhan-Jun Lu Jian-Jiong Wu Wei-Liang Jiang Jun-Hua Xiao Kai-Zhong Tao Lei Ma Ping Zheng Rong Wan Xing-Peng Wang Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Department of Gastroenterology Shanghai East HospitalSchool of MedicineTong Ji University

AIM To explore the mechanism by which microRNA-155 (miR-155) regulates the pathogenesis of experimental colitis. METHODS A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3'-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established and then utilized in gain-and loss-of-function studies performed in raw264.7 cells and primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium (DSS)-induced colitis mouse model with or without antagomiR-155 treatment was established, and the levels of miR-155 and SHIP-1, as well as the pro-inflammatory capabilities, were measured by western blot, quantitative polymerase chain reaction, and immunohistochemistry. RESULTS MiR-155 directly bound to the 3'-UTR of SHIP-1 mRNA and induced a significant decrease in SHIP-1 expression in both raw264.7 cells and primary BMDMs. MiR-155 markedly promoted cell proliferation and proinflammatory secretions including IL-6, TNF-alpha, IL-1 beta, and IFN-gamma, whereas these effects could be reversed by the restoration of SHIP-1 expression. In vivo studies showed that antagomiR-155 administration could alleviate DSS-induced intestinal inflammation in Balb/c mice. Moreover, significantly increased SHIP-1 expression, as well as decreased Akt activation and in-flammatory response, were observed in the antagomiR-155-treated mice. CONCLUSION MiR-155 promotes experimental colitis by repressing SHIP-1 expression. Thus, the inhibition of miR-155 might be a promising strategy for therapy.

关键词： Experimental colitis Inflammatory bowel disease MicroRNA-155 SHIP-1

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Cell-Type Identification in the Autonomic Nervous System

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Neuroscience Bulletin 2019年第1期35卷 145-155页

作者： Di-Shi Liu Tian-Le Xu Department of Anatomy and Physiology Shanghai Jiao Tong University School of Medicine

The autonomic nervous system controls various internal organs and executes crucial functions through sophisticated neural connectivity and circuits. Its dysfunction causes an imbalance of homeostasis and numerous human disorders. In the past decades, great efforts have been made to study the structure and functions of this system, but so far, our understanding of the classification of autonomic neuronal subpopulations remains limited and a precise map of their connectivity has not been *** of the major challenges that hinder rapid progress in these areas is the complexity and heterogeneity of autonomic neurons. To facilitate the identification of neuronal subgroups in the autonomic nervous system, here we review the well-established and cutting-edge technologies that are frequently used in peripheral neuronal tracing and profiling, and discuss their operating mechanisms, advantages, and targeted applications.

关键词： Autonomic nervous system Neuronal tracing Genetic marker Molecular profiling Cell-type diversity

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Coronavirus disease 2019(COVID-19):a clinical update

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Frontiers of medicine 2020年第2期14卷 126-135页

作者： Min Zhou Xinxin Zhang Jieming Qu National Research Center for Translational medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Respiratory and Critical Care medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Research Laboratory of Clinical Virology Ruijin Hospital and Ruijin Hospital North Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has posed a significant threat to global *** caused a total of 80868 confirmed cases and 3101 deaths in Chinese mainland until March 8,*** novel virus spread mainly through respiratory droplets and close *** disease progressed,a series of complications tend to develop,especially in critically ill *** findings showed representative features of acute respiratory distress syndrome and involvement of multiple *** from supportive care,no specific treatment has been established for *** efficacy of some promising antivirals,convalescent plasma transfusion,and tocilizumab needs to be investigated by ongoing clinical trials.

关键词： coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment

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