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The efficacy and safety of NeuroWell antidepressant dietary supplement,Deanxit,and their combination in the treatment of mild-to-moderate depression:A randomized clinical trial

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Genes & Diseases 2024年第6期11卷 36-39页

作者： Honglei Yin Zhuxin Sui Yutong Wang Dechen Liu Qinglu Wang Yanchao Wang Lei Sun Jinfeng Li Zhen Li Yue Liu Shang Guo Wenwen Wang Hongtao Yin Ping Liu Kezhong Zhang Huaibo Zhang Yajun Liu Yanqiu Liu Qiqi Zhou Dianfang Wei Hui Zhang Shanshan Wang Yaochao Ning Shuang Geng Xuejun Wen Youping Deng Hongwei Wang Yunliang Wang Neurology Department ZiBo 148 HospitalChina RongTong Medical Healthcare Group Co.Ltd.ZiboShandong 255300China Department of Histology and Embryology Teaching Department of Basic MedicineQiluMedical UniversityZiboShandong 255300China School of Public Health and Laboratory Qilu Medical UniversityZiboShandong 255300China School of Medicine The Henan University of Chinese MedicineZhengzhouHenan 450046China College of Sport and Health Shandong Sport UniversityJinanShandong 250102China Institute of Oncology The Fifth Medical CentreChinese PLA General HospitalBeijing 100071China School of Nursing Qilu Medical UniversityZiboShandong 255300China Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200023China Office of Infection Prevention and Control The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital)ZhengzhouHenan 450002China Department of Neurology Zibo Central HospitalZiboShandong 255036China Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Research Assistant Professor center for Alcohol Research in Epigenetics Department of PsychiatryUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Pharmacology School of PharmacyQilu Medical UniversityZiboShandong 255300China Department of Rehabilitation Medicine Zibo First HospitalZiboShandong 255200China XREGEN Research Institute HangzhouZhejiang 310056China School of Life Sciences Zhengzhou UniversityZhengzhouHenan 450001China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopedic Department of Tongji HospitalSchool of Life Science and TechnologyTongji UniversityShanghai 200065China international Institute for Biomedical Biomaterials(I2BM) ZhengzhouHenan 450018China Department of Chemical and Life Science Engineering School of EngineeringVirginia Commonwealth Uni

Depression is the leading global cause of,disability,affecting about 300 milion people worldwide.1;2 Depending on the number and severity of symptoms,depressive episodes can be classified as mild,moderate,and *** studies have typically focused on the treatment of severe refractory depression,while there have been few studies on the treatment of mild-to-moderate depression.

关键词： treatment clinical typically

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Chinese Clinical Practice Guidelines for the Prevention and Treatment of Mother-to-child Transmission of Hepatitis B Virus(Version 2024)

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Journal of Clinical and Translational Hepatology 2024年第11期12卷 975-983页

作者： Jinfeng Liu Qinglei Zeng Fanpu Ji Hong Ren Wenhong Zhang Lanjuan Li Yingren Zhao Infectious Diseases Physicians Branch,Chinese Medical Doctor Association Chinese Society of Infectious Diseases,Chinese Medical Association The First Affiliated Hospital of Xi’an Jiaotong University Xi’anShaanxiChina Shaanxi Clinical Medical Research center of Infectious Diseases Xi’anShaanxiChina The First Affiliated Hospital of Zhengzhou University ZhengzhouHenanChina The Second Affiliated Hospital of Xi’an Jiaotong University Xi’anShaanxiChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina Huashan Hospital Fudan UniversityShanghaiChina The First Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiangChina 不详

The Chinese Clinical Practice Guidelines for the Prevention and Treatment of Mother-to-child Transmission of Hepatitis B Virus,developed by the Chinese Society of Infectious Diseases of the Chinese Medical Association in 2019,serves as a valuable reference for standardizing the prevention of mother-to-child transmission in *** new evidence continues to emerge,it is essential to update these guidelines regularly to optimize clinical practice and *** this end,the Infectious Disease Physician Branch of the Chinese Medical Doctor Association and the Chinese Society of Infectious Diseases of the Chinese Medical Association,in collaboration with multidisciplinary experts,have updated the guidelines based on the latest domestic and international research advancements and clinical practices,providing upto-date guidance for clinicians and maternal and child healthcare workers.

关键词： Guidelines Hepatitis B virus Mother-to-child transmission Prevention Treatment Update

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Mechanically and Conductively Robust Eutectogel Fiber Produced by Continuous Wet Spinning Enables Epidermal and Implantable Electrophysiological Monitoring

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Advanced Fiber Materials 2024年第6期6卷 1980-1991页

作者： Shufeng Hu Jingya Song Qiong Tian Chen Zeng Yuchen Jiang Qihua Li Jun Xu Wei Yan Jun Li Zhiyuan Liu Weiqing Kong Meifang Zhu State Key Laboratory of Pulp and Paper Engineering Plant Fiber Materials Science Research CenterSouth China University of TechnologyGuangzhou 510006China State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligent-Systems Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Standard Robots Co. LtdRoom 405Building DHuafeng International Robot Fusen Industrial ParkHangcheng AvenueGuxing CommunityXixiang StreetBaoan DistrictShenzhen 518000China Research center for Neural Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

In recent years,the collection and monitoring of human physiological signals have garnered increasing attention due to their wide-ranging applications in healthcare,human-machine interaction,sports,and other ***,the continuous fabrication of flexible gel fiber electrodes with high mechanical performance,high conductivity,and durability for extreme environments using a simple,efficient,and universal strategy remains challenging for physiological signal ***,we have employed a strategy of solvent replacement and multi-level hydrogen bond enhancement to construct eutectogel fibers with continuous solid-liquid structure,achieving continuous production of fibers with high strength,high conductivity,and low-temperature *** the fiber,PVA serves as the solid-state elastic phase,DES as the liquid ionic conductive phase,and CNF as the reinforcement *** resulting eutectogel fibers exhibit excellent tensile strength(37.3 MPa),good elongation(>700%),high electrical conductivity(0.543 S/m),and resistance to extreme dry and-60°C low-tem-perature ***,these eutectogel fibers demonstrate high sensitivity for monitoring joint movements and effectively detecting in vitro and in vivo signals,show casing their potential for wearable strain sensors and monitoring physiological signals.

关键词： Eutectogel fibers Wet spinning Hydrogen-bond networks Sensing

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Chinese Clinical Practice Guidelines for the Prevention and Treatment of Mother-to-Child Transmission of Hepatitis B Virus(Version 2024)

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Infectious Microbes & Diseases 2024年第3期6卷 108-116页

作者： Jinfeng Liu Qinglei Zeng Fanpu Ji Hong Ren Wenhong Zhang Lanjuan Li Yingren Zhao Infectious Diseases Physicians Branch of Chinese Medical Doctor Association Chinese Society of Infectious Diseases of Chinese Medical Association The First Affiliated Hospital of Xi’an Jiaotong University Xi’anChina Shaanxi Clinical Medical Research center of Infectious Diseases Xi’anChina The First Affiliated Hospital of Zhengzhou University ZhengzhouChina The Second Affiliated Hospital of Xi’an Jiaotong University Xi’anChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina Huashan Hospital Fudan UniversityShanghaiChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina 不详

The Chinese Clinical Practice Guidelines for the prevention and treatment ofmother-to-child transmission of hepatitis B virus,developed by the Chinese Society of Infectious Diseases of the Chinese Medical Association in 2019,serves as a valuable reference for standardizing the process of preventing mother-to-child transmission in *** new evidence emerges,it is crucial that timely and regular updates are made to the clinical practice guidelines so as to optimize guidance for clinical practice and *** this end,the Infectious Disease Physician Branch of Chinese Medical Doctor Association and the Chinese Society of Infectious Diseases of Chinese Medical Association,in collaboration with multidisciplinary experts,have updated the guidelines based on the latest domestic and international research advancements and clinical practice,in order to provide guidance and reference for clinicians andmaternal and child healthcare workers.

关键词： guidelines hepatitis B virus mother-to-child transmission prevention treatment update

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CACA guidelines for holistic integrative management of esophageal carcinoma

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Holistic Integrative Oncology 2023年第1期2卷 330-372页

作者： Lei Gong Ming Bai Liang Dai Xufeng Guo Xuefeng Leng Zhigang Li Zhihao Lu Teng Mao Qingsong Pang Lin Shen Yifeng Sun Hong Yang Jun Yin Hongdian Zhang Wencheng Zhang Gang Zhao Bin Zheng Yueyang Yang Yi Ba Chun Chen Haiquan Chen Longqi Chen Ting Deng Qingxia Fan Wentao Fang Xiangning Fu Jing Huang Xiaofei Li Yin Li Shuoyan Liu Yongyu Liu Jianqun Ma Weimin Mao Jingli Ren Lijie Tan Peng Tang Lvhua Wang Qun Wang Wenqiang Wei Qi Xue Renquan Zhang Keneng Chen Jianhua Fu Junfeng Liu Yongtao Han Jie He Zhentao Yu Yousheng Mao Department of Esophageal Cancer Tianjin Medical University Cancer Institute and HospitalTianjinChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalTianjinChina The First Department of Thoracic Surgery Peking University Cancer Hospital and InstitutePeking University School of OncologyBeijingChina Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina Division of Thoracic Surgery Sichuan Cancer Hospital&Research InstituteSchool of MedicineUniversity of Electronic Science and Technology of China(UESTC)ChengduChina Section of Oesophageal Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina Department of Gastrointestinal Oncology Peking University Cancer Hospital and InstituteBeijingChina Department of Radiation Oncology Tianjin Medical University Cancer Institute and HospitalTianjinChina Department of Thoracic Oncology Sun Yat-Sen University Cancer CenterGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhouFujianChina Department of Thoracic Surgery Fudan University Shanghai Cancer CenterShanghaiChina Department of Thoracic Surgery West China HospitalSichuan UniversityChengduChina Department of Oncology The First Affiliated Hospital of ZhengzhouZhengzhouChina Department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Thoracic Surgery the Second Hospital(Tang Du Hospital)Air Force Military Medical UniversityXianChina Department of Thoracic Surgery National Cancer Center/National Clinica

Esophageal carcinoma(EC)is a common malignant tumor of the upper digestive tract *** analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of deaths due to EC in China in 2015 were 266,000 and 188,000,respectively,ranking sixth(6.3%)and fourth(8.0%)among all malignant *** early diagnosis and treatment of EC and standardized diagnosis and treatment are important tasks for EC healthcare professionals in various centers across the *** present,the 8th edition of the EC staging system jointly released by Union for international Cancer Control(UICC)and American Joint Committee on Cancer(AJCC)is the most recent,authoritative and widely used EC staging *** EC professional committee of the Chinese Anti-Cancer Association also organizes the"EC Standardization Campaign in China"every year to promote the development of EC diagnostic and treatment norms throughout the *** 2011,the EC Committee of the Chinese Anti-Cancer Association has published the Guidelines for Standardized Diagnosis and Treatment of *** the increasing number of EC clinical studies and the continuous progress in diagnostic and treatment technologies in recent years,the updated Guidelines will include the latest progress in the diagnosis and treatment of EC,with a goal of promoting the forward development of EC diagnosis and treatment in clinical practice.

关键词： Esophageal cancer Clinical guideline Holistic integrative medicine

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Evaluating spatial accessibility to healthcare services from the lens of emergency hospital visits based on floating car data

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international Journal of Digital Earth 2022年第1期15卷 108-133页

作者： Wei Jiao Wei Huang Hongchao Fan School of Remote Sensing and Information Engineering Wuhan UniversityWuhanPeople’s Republic of China College of Surveying and Geo-Informatics Tongji UniversityShanghaiPeople’s Republic of China Department of Civil Engineering Ryerson UniversityTorontoCanada Department of Civil and Environmental Engineering Norwegian University of Science and TechnologyTrondheimNorway

Public medical facilities that are closely related to the health of residents have been recognised as one of the most crucial elements in sustainable urban *** the sake of social equality of medical services(especially for emergency medical conditions),the spatial distributions of medical resources need to be accurately measured and continuously *** study presents an effective method to examine night emergency hospital visit and analyse its spatiotemporal characteristics using float car data(FCD).By extracting the hospital service areas,the two-step floating catchment area(2SFCA)methodology was improved to calculate hospital ***,the balance between hospital accessibility and population density was *** addition,we investigated the relationship between individual hospital choice preferences and hospital level and analysed several factors that affect individual *** results help us understand the special requirements and need of emergency hospital travel in cities and identify areas where medical resources are *** can be used as guidance for urban hospital planning and *** the approach of hospital access behaviour investigation and the improved 2SFCA method can also provide insights for other activity-based travel behaviour research.

关键词： Floating car data hospital emergency travels hospital service areas hospital accessibility

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Nursing ethics for prevention and control of major infectious disease outbreaks:Chinese expert consensus

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international Journal of Nursing Sciences 2022年第1期9卷 5-10,I0001页

作者： Yaling Wang Yuchen Li Biyu Shen Huiling Li Hongyu Sun Changrong Yuan Hongzhen Xie Xiaomei Li Yinglan Li Jian Guan Qi'ai Jia Xinqing Zhang School of Nursing Soochow UniversitySuzhouChina Department of Nursing Shanghai Children’s Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina School of Nursing Fudan UniversityShanghaiChina Department of Nursing People’s Liberation Army General Hospital of Southern Theatre CommandGuangzhouChina Xi’an Jiaotong University Health Science Centre Xi’anChina Xiangya School of Nursing Central South UniversityChangshaChina Peking Union Medical College Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Jiangsu Nursing Vocational College Huai’anChina School of Humanities and Social Sciences Peking Union Medical CollegeBeijingChina

Background Major infectious disease has become a serious threat to people’s health *** the world’s largest healthcare workforce and the core forces fighting against the epidemic,nurses are on the frontline of this battle.A number of ethical issues have given rise to numerous concerns that have largely affected nurses in different ways as they respond to the *** addition,excessive expectations from people can exert undue pressure,which can easily lead to burnout in *** In this consensus,the expert panel method was used to develop and reach a *** members involved in the formation of the consensus included an expert discussion panel and a consensus writing expert group,a methodologist,and four *** 16 rounds of online expert consultation and two rounds of expert panel meetings,the writing team analyzed and reviewed the 78 amendments suggested by the experts to develop a consensus on nursing ethics for prevention and control of major infectious disease outbreaks based on the ethical vision of life *** This expert consensus focuses on five essential domains:the responsibilities and rights of nurses,the nurse-patient relationship,the doctor-nurse relationship,and the relationship between society and nurses throughout the *** We hope this consensus can help nurses better understand and respond to the ethical issues and challenges in public health emergencies,and raise reasonable public expectations of the roles and responsibilities of nurses in these situations.

关键词： Consensus Disease outbreaks Nurses Nursing ethics Public health

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Re-emergence of Ebola virus disease in Uganda:Should Southeast Asia countries be worried?

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Journal of Safety Science and Resilience 2023年第3期4卷 262-264页

作者： Haruna Muhammad Daiyab Farouq Muhammad Dayyab Department of Medicine Murtala Mohammed Specialist HospitalKanoNigeria Cardiac Intensive Care Unit Mohammed Bin KhalifaBin Salman Al Khalifa Cardiac CenterAwaliBahrain

An outbreak of Ebola virus disease(EVD)(Sudan virus)was first reported in the Republic of Uganda on September 20,*** of November 17,2022,151 confirmed cases have been reported,including 55 deaths(with a case fatality rate among confirmed cases of 39%).During the EVD outbreak in 2013–2016,international travel played a significant role in the spread of the disease across national *** that time,several tasks requiring improvement were identified in the World Health Organization(WHO)Southeast Asia Region(SEAR),including inadequate risk communication and risk assessment,data management gaps for surveillance purposes,inadequate capacity in molecular diagnostic techniques,lack of adequate planning for a surge of cases,and inadequate isolation *** is therefore recommended that all countries of the WHO SEAR revisit their level of Ebola preparedness and address existing *** emergence and rapid global spread of coronavirus disease 2019(COVID-19)have reiterated that the world has become a global *** was confirmed by the spread of the monkeypox virus with cases reported in the WHO ***,given the weak health infrastructure in the region,complacency could wreak havoc on the healthcare system if another epidemic emerges without an adequate level of preparedness.

关键词： Ebola Uganda Southeast Asia Outbreak

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Endovascular therapy in acute anterior circulation large vessel occlusive patients with a large infarct core(ANGEL-ASPECT):protocol of a multicentre randomised trial

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Stroke & Vascular Neurology 2023年第2期8卷 169-174页

作者： Xiaochuan Huo Gaoting Ma Xuelei Zhang Yuesong Pan Xu Tong Dapeng Sun Liping Liu Yilong Wang David S Liebeskind Yongjun Wang Vitor Mendes Pereira Zeguang Ren Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Department of Neurology Beijing Tiantan HospitalBeijingChina Clinical Research center Capital Medical UniversityInstitute of Brain DisordersBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Neurology University of CaliforniaLos AngelesCaliforniaUSA Division of Neurosurgery Department of SurgerySt Michael's HospitalUniversity of TorontoTorontoOntarioCanada Department of Neurosurgery The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina

Background The benefit of stroke thrombectomy for large infarct core still lacks robust randomised controlled *** To demonstrate the design of a clinical trial on endovascular therapy for acute anterior circulation large vessel occlusion(LVO)patients with large infarct core *** ANGEL-ASPECT is a multicentre,prospective,randomised,open-label,blinded End-point trial to evaluate whether best medical management(BMM)combined with endovascular therapy improves neurological functional outcomes as compared with BMM alone in acute LVO patients with Alberta Stroke Program Early CT Score(ASPECTS)of 3-5 on non-contrast CT or infarct core volume range of 70-100 mL(defined as rCBF<30%on CT perfusion or ADC<620 on MRI)up to 24 hours from symptom onset or last seen *** outcomes The primary efficacy outcome is 90(±7)days modified Rankin *** intracranial haemorrhage within 48 hours from randomisation is the primary safety *** The ANGEL-ASPECT trial will screen patients with large infarct core(ASPECTS 3-5 or 70-100 mL)through image evaluation criteria within 24 hours and explore the efficacy and safety of endovascular therapy compared with BMM.

关键词： patients infarct acute

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Epidemiology and Clinical Characteristics of the First 500 Positive Cases of COVID-19. A Multicenter Retrospective Study across the Najran Region of the Kingdom of Saudi Arabia (KSA)

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Open Journal of Epidemiology 2021年第3期11卷 222-236页

作者： Hadi J. Al Sulayyim Mohammed Ch Al-Noaemi Mohammed M. Alyami Shoab Ahmad Mohammad H. Alyami Hamad S. Alyami Ali D. Al-Swedan Ibraheem S. Banihameem Musallam A. Sedran Ali M. Al-Zubaidi Obaid M. Al Abbas General Directorate of Health Affairs Najran Ministry of Health Najran KSA Al-Ghad international College of Applied Medical Sciences Najran KSA Batterjee Medical College Jeddah KSA Najran University Najran KSA

Introduction: Coronavirus Disease 2019 (COVID-19) is a viral infection that was first reported in Wuhan, China on 31 December 2019. This study aimed to clarify the epidemiology and clinical characteristics of 500 first COVID-19 in the Najran region, Saudi Arabia. Material and Methods: A multi-center retrospective study design was employed to study the first 500 confirmed COVID-19 positive cases in Najran province, Kingdom of Saudi Arabia (KSA). Data were collected from 1 March 2020 until 1 July 2020 and provided by the Infection Prevention and Control (IPC) department from the hospitals. Included cases were confirmed using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Demographic, vital signs, symptoms, incubation period, travel or exposure history medical history, and comorbidities were collected. Logistic regression analysis was used to explore the association between potential risk factors associated with symptoms occurrence of COVID-19. Results: The median age of 500 COVID-19 patients was 31 years;333 (66.6%) males. A total of 34 (6.8%) were healthcare Workers (HCWs). Out of the 500 patients, 180 (36%) had at least one comorbid disease. The most common symptoms on admission were fever 281 (56.2%), cough 266 (53.2%), shortness of breath 166 (33.2%), and malaise 113 (22.6%). Most of the patients presented with mild disease severity 310 (62%). Nationality, age, and Diabetes Miletus (DM) were independently and significantly associated with being symptomatic (P β = 2.968, CI = 2.002 - 4.400, P = 0.0010). For every 1 year increase in age, the risk of being symptomatic increased by 5.8% (β = 1.045, CI = 1.033 - 1.058, P = 0.001). Compared with non-DM patients, DM patients had a 4.05 times higher risk (β = 4.05, CI = 2.188 - 7.507, P = 0.0

关键词： Epidemiology Characteristics COVID-19 Najran KSA

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