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Deciphering the role of FSCN family genes in cancer:a pan-cancer bioinformatics study

Medical Data Mining 2024年第4期7卷 10-18页

作者： Wen-Shuai Zhang Dan-Yang Ren Xin Li Department of Pathology Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical research center for cancer Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell ***1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility,invasion,and ***,their specific contributions across different cancer types remain ***:We conducted a pan-cancer bioinformatics analysis of FSCN genes using data from The cancer Genome *** included differential expression patterns,copy number variations(CNVs),mutations,methylation status,and correlations with tumor mutational burden,microsatellite instability,and immune checkpoint molecule *** expression was analyzed using DESeq2,while CNV and mutation analyses utilized GISTIC2.0 and *** data were assessed using the Illumina Human Methylation 450K ***:FSCN1 and FSCN2 showed significant differential expression in multiple cancers,often correlating with poor ***3 exhibited less variability but a protective role in certain *** analysis indicated frequent gene gains in FSCN genes,correlating with increased ***3 had a higher mutation rate,suggesting genetic *** analysis showed hypomethylation of FSCN1 and FSCN2 in tumors compared to normal tissues,whereas FSCN3 had minor *** associations were found between FSCN gene expression and tumor mutational burden,microsatellite instability,and immune checkpoint molecules,suggesting their involvement in tumor immunogenicity and the immune ***:This pan-cancer analysis highlights the multifaceted roles of FSCN genes in cancer biology,emphasizing their potential as biomarkers and therapeutic ***1 and FSCN2 are associated with poor prognosis and aggressive phenotypes,while FSCN3 shows protective roles in specific *** findings offer new avenues for cancer diagnosis and treatment,particularly in personalized *** studie

关键词： Fascin family pan-cancer analysis gene expression copy number variation tumor mutational burden

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New developments in the treatment of castration resistant prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 555-560页

作者： Roxanne Wadia Daniel P Petrylak Department of Medicine Smilow Cancer Center Yale University School of Medicine Yale Comprehensive Cancer Center New Haven Connecticut USA

In the past 5 years, the treatment and understanding of metastatic castrate resistant prostate cancer （CRPC） have improved dramatically. Our understanding of the mechanisms of castration resistance has allowed for the development of new drugs to target prostate cancer, and our understanding of genetic mutations may give us new tools with which to more accurately diagnose and be able to predict the course of this heterogeneous disease. This article summarizes the recent advances in the understanding of the development of CRPC, as well as the new drugs and targets, which have evolved from this basic research.

关键词： castration resistant prostate cancer abiraterone enzalutamide chemotherapy docetaxel cabazitaxel PSMA antibody

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cancer Precision Medicine in China

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Genomics, Proteomics & Bioinformatics 2016年第5期14卷 325-328页

作者： Hui Li National Clinical research center for cancer(Tianjin) Tianjin 300060China Department of Gastrointestinal cancer Biology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China

Background cancer, as a global health issue, has been attracting increasing attention from scientists, medical professionals, as well as the general population. During the past several decades, many therapeutic approaches, including surgery, chemotherapy, radiotherapy and immunotherapy, have come into play for cancer treatment. Nonetheless, many of these treatments are not personalized according to the specific situation or genetic context of a particular patient. Nowadays, precision medicine,

关键词： cancer Precision Medicine in China

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Metabolic reprogramming in tumors:Contributions of the tumor microenvironment

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Genes & Diseases 2020年第2期7卷 185-198页

作者： Andrew N.Lane Richard M.Higashi Teresa W-M.Fan center for Environmental and Systems Biochemistry Markey Cancer CenterDepartment of Toxicology and Cancer BiologyUniversity of KentuckyUSA

The genetic alterations associated with cell transformation are in large measure expressed in the metabolic phenotype as cancer cells proliferate and change their local environment,and prepare for ***,the fundamental biochemistry of cancer cells is generally the same as in the untransformed cells,but the cancer cells produce a local environment,the TME,that is hostile to the stromal cells,and compete for *** order to proliferate,cells need sufficient nutrients,either those that cannot be made by the cells themselves,or must be made from simpler ***,in solid tumors,the nutrient supply is often limiting given the potential for rapid proliferation,and the poor quality of the ***,cancer cells may employ a variety of strategies to obtain nutrients for survival,growth and *** much has been learned using established cell lines in standard culture conditions,it is becoming clear from in vivo metabolic studies that this can also be misleading,and which nutrients are used for energy production versus building blocks for synthesis of macromolecules can vary greatly from tumor to tumor,and even within the same *** we review the operation of metabolic networks,and how recent understanding of nutrient supply in the TME and utilization are being revealed using stable isotope tracers in vivo as well as in vitro.

关键词： cancer metabolism Nutrient supply Stable isotope resolved metabolomics Tumor microenvironment Metabolic flux

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New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

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Cellular & Molecular Immunology 2023年第7期20卷 739-776页

作者： Hanli Xu Shuye Lin Ziyun Zhou Duoduo Li Xiting Zhang Muhan Yu Ruoyi Zhao Yiheng Wang Junru Qian Xinyi Li Bohan Li Chuhan Wei Keqiang Chen Teizo Yoshimura Ji Ming Wang Jiaqiang Huang College of Life Sciences and Bioengineering School of Physical Science and EngineeringBeijing Jiaotong University3 ShangyuanCunHaidian District100044 BeijingP.R.China cancer research center Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Institute101149 BeijingChina Laboratory of cancer Innovation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21702USA.

Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly *** interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to *** and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional *** and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important *** integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and *** of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.

关键词： Chemokine Chemokine receptor Migration Homeostasis genetics Epigenetics

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In Loving Memory of Professor Shiping Wang

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Molecular Plant 2019年第9期12卷 1171-1172页

作者： Meng Yuan National Key Laboratory of Crop genetic Improvement National Center of Plant Gene Research(Wuhan)Huazhong Agricultural UniversityWuhan 430070China

We are deeply saddened that our respected colleague *** Wang passed away on May 14,2019,at the age of 64 after a hard-fought battle with cancer for four years and seven *** was a professor of plant pathology at Huazho... 详细信息

关键词： Loving mother passed

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Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： Qiu-Xiao Yu Ping-Ying Fu Chi Zhang Li Li Wen-Ting Huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality ***-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor *** amplification has been reported in CRC,but data are very *** pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical *** To determine the pathological significance of MET amplification in CRC and to propose a feasible screening *** A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen cancer Hospital of Chinese Academy of Medical Sciences were *** patients were without RAS/RAF mutation or microsatellite *** amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),*** between MET aberration and pathological features were detected using the chi-squared *** free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank *** results of MET FISH and IHC were com pared using one-way *** Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not ***-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was dete

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

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Fabrication of ultrathin Zn（OH）2 nanosheets as drug carriers

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Nano research 2016年第8期9卷 2520-2530页

作者： Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Shands Cancer Center UF Genetics Institute McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA Molecular Sciences and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering and College of Biology Collaborative Innovation Center for Molecular Engineering and Theranostics Hunan University Changsha 410082 China School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore

Ultrathin two-dimensional （2D） porous Zn（OH）2 nanosheets （PNs） were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4-10 nm. To form ＂smart＂ porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, effident cellular uptaker and promising pH-stimulated drug release.

关键词： aptamer porous Zn(OH)2 nanosheets cancer cell cell-targeted delivery

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Esophageal cancer:Epidemiology,risk factors and screening

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Chinese Journal of cancer research 2021年第5期33卷 535-547页

作者： Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He Office for cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chinese Academy of Medical Sciences Key Laboratory for National cancer Big Data Analysis and Implement Beijing 100021China Evidence-Based Medicine center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou UniversityLanzhou 730000China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence *** half of the world’s EC was diagnosed in China and a majority of which belong to ***,the overall incidence rate of EC is *** some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet *** some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and *** risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also *** incidence and mortality of advanced EC can be reduced through early diagnosis and *** light endoscopy is still the gold standard in the current screening *** article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC.

关键词： Esophageal cancer esophageal squamous cell carcinoma epidemiology risk factors screening

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Structural insight into mechanisms for dynamic regulation of PKM2

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Protein & Cell 2015年第4期6卷 275-287页

作者： Ping Wang Chang Sun Tingting Zhu Yanhui Xu1 Fudan University Shanghai cancer center and Institute of Biomedical Sciences Shanghai Medical College of Fudano University Shanghai 200032 China State Key Laboratory of genetic Engineering School of Life Sciences Fudan University Shanghai 200433 China

Pyruvate kinase isoform M2 （PKM2） converts phospho- enolpyruvate （PEP） to pyruvate and plays an important role in cancer metabolism. Here, we show that post- translational modifications and a patient-derived muta- tion regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer. We determined crystal structures of human PKM2 mutants and proposed a ＂seesaw＂ model to illustrate confor- mational changes between an inactive T-state and an active R-state tetramers of PKM2. Biochemical and structural analyses demonstrate that PKM2^Y105E （phos- phorylation mimic of Y105） decreases pyruvate kinase activity by inhibiting FBP （fructose 1,6-bisphosphate）- induced R-state formation, and PKM2K^3305Q （acetylation mimic of K305） abolishes the activity by hindering tet- ramer formation. K422R, a patient-derived mutation of PKM2, favors a stable, inactive T-state tetramer because of strong intermolecular interactions. Our study reveals the mechanism for dynamic regulation of PKM2 by post- translational modifications and a patient-derived muta- tion and provides a structural basis for further investi- gation of other modifications and mutations of PKM2 yet to be discovered.

关键词： pyruvate kinase M2 crystal structureallosteric regulation Warburg effect post-translational modifications

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