New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
作者机构：College of Life Sciences and BioengineeringSchool of Physical Science and EngineeringBeijing Jiaotong University3 ShangyuanCunHaidian District100044 BeijingP.R.China Cancer Research CenterBeijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Institute101149 BeijingChina Laboratory of Cancer InnovationCenter for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21702USA.
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2023年第20卷第7期
页 面：739-776页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：the National Natural Science Foundation of China(NSFC Grant No.81872021,32200462) Beijing Jiaotong University undergraduate innovation and entrepreneurship training project(No.220171097,220171072,220171037,220171088,220171104) R&D Program of Beijing Municipal Education Commission(Grant No.KM202110025004) Beijing Hospitals Authority Youth Programme(grant No.QML20231602) JH,KC and JMW were also funded in part by Federal funds from the National Cancer Institute,National Institutes of Health(under Contract No.HHSN261200800001E) the Intramural Research Programs of the NCI,CCR,and NIH
主 题：Chemokine Chemokine receptor Migration Homeostasis Genetics Epigenetics
摘 要：Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly *** interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to *** and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional *** and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important *** integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and *** of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.
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