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Cyclopeptidic Constituents from Arenaria oreophila J.D,Hooker(Caryophyllaceae)

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Journal of Integrative Plant Biology 2006年第6期48卷 740-744页

作者： Ai-Qun Jia Ning-Hua Tan Jun Zhou State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 Yunnan China

To further investigate the cyclopeptldes of the Caryophyllaceae family, two new cyclopeptldes, named Arenarlphilin E （compound 1） and Arenariphilin F （compound 2）, were obtained from Arenaria oreophUe J. D. Hooker using some Isolation methods, e. g. normal and reverse silica gel. By detailed spectroscopic analysis, such as FAB^＋-MS, 1 D NMR, 2D NMR, the structures of Arenariphilin E （compound 1） and Arenariphilln F （compound 2） were determined as cyclo（lle^1-Gly-Val^1-Ala-Leu-lle^3-lle^2-Val^2-Pro） and cyclo（Pro^2-Pro^1-Gly^2-lle-Val-Leu-Gly^1-AiaThr- Gly^3）, respectively.

关键词： Arenaria oreophila Arenariphilin E Arenariphilin F Caryophyllaceae Cyclopeptide.

A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

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Chinese Journal of Chemistry 2003年第12期21卷 1665-1668页

作者：曹建新来国防王易芬杨刘兵罗士德 State key laboratory of phytochemistry and Plant Resouces in West China Kunming Institute of BotanyChinese Academy of Sciences Kunming University of Science and Technology

A new triterpenoid saponin with novel sugar moiety (1),a new trisaccharide derivative (2),as well as a known monosaccharide derivative (3),were isolated from the dried stem of Epigynum aurilum. The structures of compo... 详细信息

关键词： Epigynum aurilum Apocynaceae triterpenoid saponin saccharide derivative

Enantioselective recognition based on aggregation-induced emission

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Chinese Chemical Letters 2023年第6期34卷 70-80页

作者： Pu Chen Panpan Lv Chang-Sheng Guo Rui-Peng Wang Xiaolong Su Hai-Tao Feng Ben Zhong Tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China

Chirality is one of the most important features of the *** recognition of enantiomers plays significant roles in the field of life science,pharmaceutical analysis and food *** various recognition methods,fluorescence spectrometry has attracted much attention of researchers thanks to its high sensitivity and easy *** with traditional fluorescent probes,chiral molecules with aggregation-induced emission(AIE)have drawn increasing interests due to their huge potential in high-efficiency chemo/biosensors and solid *** AIE luminogens(AIEgens)can not only discriminate two enantiomers with excellent enantioselectivity,but also show general applicability for many chiral analytes,such as chiral acids,amino acids,amines,*** this review,we mainly summarized the recent development of chiral probes with AIE properties,including chiral tetraphenylethylene(TPE)derivatives,α-cyanostilbene derivatives,Schiff base derivatives and other *** synthetic routes,recognition capabilities and possible working mechanisms were well *** is envisioned that the present review can give some significant guidance for design and synthesis of chiral AIEgens with good enantioselectivity and inspire more readers to join the research of chiral AIE.

关键词： Aggregation-induced emission Enantioselective recognition Fluorescent probe Host-guest interaction Tetraphenylethylene derivatives α-Cyanostilbene derivatives Schiff base derivatives

6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity

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Chinese Chemical Letters 2014年第4期25卷 541-544页

作者： Hua-Yi Jiang Wei-Guang Wang Min Zhou Hai-Yan Wu Rui Zhan Xue Du Jian-Xin Pu Han-Dong Sun State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences University of Chinese Academy of Sciences

One new 6,7-seco-ent-kaurane diterpenoid, sculponin T （1）, was isolated from the aerial parts of lsodon sculponeatus, along with four known analogs, sculponeatin J （2）, sculponeatin K （3）, sculponeatin C （4）, and sculponeatin Q （5）. Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 μmol/L.

关键词： lsodon sculponeatus 6 7-seco-ent-Kaurane diterpenoid Cytotoxicity Anti-inflammatory activity

Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

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Chinese Journal of Natural Medicines 2017年第12期15卷 950-954页

作者： LI Shi-Fei LI Shun-Lin Institute of Molecular Science Shanxi University State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C(1) and its glucoside, cycloccidentaliside VI(2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC_(50) value of 1.44 μmol·L^(-1) and TI(Therapeutic Index) value of 15.59.

关键词： Cycloartane triterpenoid Cassia occidentalis Cycloccidentalic acid C Cycloccidentaliside Ⅵ

A Novel Dimeric Coumarin from Clausena lenis

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Chinese Chemical Letters 2003年第11期14卷 1150-1153页

作者： Hong Ping HE Shun Ting CHEN Yue Mao SHEN Chang Xiang CHEN Yi Bin ZHAO Xiao Jiang HAO The State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 The key laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002

A novel dimeric coumarin (1), a dimeric of seselin named diseselin A, was isolated from the aerial part of Clausena lenis. The structure was elucidated based on the MS, 1D and 2D NMR data.

关键词： Clausena lenis coumarin diseselin A seselin dimer.

New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1648-1666页

作者： Lihua Su Xintian Zhang Yunbao Ma Changan Geng Xiaoyan Huang Jing Hu Tianze Li Shuang Tang Cheng Shen Zhen Gao Xuemei Zhang Ji-Jun Chen State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesYunnan Key Laboratory of Natural Medicinal ChemistryKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A-R and lavandiolides A,B,C,H,and *** compounds(1,4,10,12,13,and 19-21) were unambiguously confirmed by the single-crystal X-ray diffraction analyses,and the others were elucidated based on IR,UV,HRESIMS,1 D and 2 D NMR experiments,and comparison of the experimental and calculated ECD ***,all of them were [4+2] Diels-Alder adducts of two monomeric *** isolates were evaluated for their cytotoxicity against three human hepatoma cell lines,and 19 compounds demonstrated cytotoxicity against HepG2,SMMC-7721,and Huh7 cell ***,compounds 1,12,14,and 15 exhibited cytotoxicity with IC50 values of 4.4,3.8,7.6,and 6.7 μmol/L(HepG2),9.6,4.6,6.6,and 6.0 μmol/L(SMMC-7721),and 7.6,4.5,6.9,and 5.6 μmol/L(Huh7),***,compound 12 showed the most promising activity against three human hepatoma cell lines and dose-dependently inhibited cell migration and invasion,induced G2/M cell cycle arrest and cell apoptosis in HepG2 cells,down-regulated the expression of BCL-2 and PARP-1,and activated PARP-1 to up-regulate the expression of cleaved-PARP-1.

关键词： Guaianolide dimers Artematrolides Ae R Artemisia atrovirens Cytotoxicity Cell cycle Apoptosis

Dictamformal, a new tetranortriterpenoidal limonoid from Dictamnus dasycarpus

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Dictamformal, a new tetranortriterpenoidal limonoid from Dic...

Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis

中国化学会第十届全国天然有机化学学术会议

作者： Xiao-Ling Wang Jian Xiao Ming-Jin Fan Lin Ma shaanxi key laboratory of phytochemistry Baoji University of Arts and Sciences

＜正＞The medicinal plant Dictamnus dasycarpus is widely distributed in Asia,the root bark of this plant has been used for treatment of various ailments such as skin inflammation,eczema,rubella,scabies,acute heumatoid arthritis,jaundice and *** investigation on *** revealed the existence of all kinds of compounds including limonoids,furoquinoline alkaloids,

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来源： cnki会议评论

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Science China(Life Sciences) 2023年第8期66卷 1800-1817页

作者： Xiaoyu Yang Yonghong Chen Longlong Zhang Jiangbo He Qunfu Wu Shuhong Li Donglou Wang Jianghui Gou Zhuang Wu Keqin Zhang Shenghong Li Xuemei Niu State key laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Key Laboratory for Southwest Microbial Diversity of the Ministry of EducationYunnan UniversityKunming 650032China State key laboratory of phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Kunming key laboratory of Respiratory Disease Kunming UniversityKunming 650214China

The discovery of biological activities of natural products plays a vital part in drug *** mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic.A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid *** in 1 caused melanin loss and accumulated extra lipid mass,unexpectedly leading to seriously damaged mitochondria diagnostic for *** analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid *** also found that melanin in mice lowered lipid level but enhanced animal resistance to cold *** with melanin precursors significantly increased mouse cell survival rate under cold *** results unveiled a metabolite-lipid-ferroptosis-cold relationship,which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold *** findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents.

关键词： melanin precursor lipid ferroptosis temperature change anti-cold