Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

作     者：LI Shi-Fei LI Shun-Lin 

作者机构：Institute of Molecular Science Shanxi University State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2017年第15卷第12期

页      面：950-954页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.31270404 31470427) 

主　　题：Cycloartane triterpenoid Cassia occidentalis Cycloccidentalic acid C Cycloccidentaliside Ⅵ 

摘      要：In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C(1) and its glucoside, cycloccidentaliside VI(2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC_(50) value of 1.44 μmol·L^(-1) and TI(Therapeutic Index) value of 15.59.