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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 392-395页

作者： Laurent Coubeau Samuele Iesari Paulina Henry Philippe D’Abadie Aude Vanbuggenhout Raymond Reding aTransplantation Abdominale Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Pole de Chirurgie Experimentale et Transplantation Institut de Recherche Experimentale et CliniqueUniversite catholique de LouvainBrusselsBelgium department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly service d’anatomo-pathologie Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium service de medecine nucleaire Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium

To the Editor:While organ shortage commonly dooms patients on waiting list,alternative options as living-donor liver transplantation(LDLT)are assiduously *** principles of liver surgery rule LDLT:there must be suffici... 详细信息

关键词： donor liver surgery

Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

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World Journal of Gastroenterology 2009年第3期15卷 300-309页

作者： Frédérique Caillot Céline derambure Paulette Bioulac-Sage Arnaud Franois Michel Scotte Odile Goria Martine Hiron Maryvonne Daveau Jean-Philippe Salier Inserm Unité 905 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides Faculté de Médecine-Pharmacie76183 RouenFrance service d'Anatomie Pathologique Centre Hospitalier Universitaireand Inserm U88933000 BordeauxFrance Département pathologie Centre Hospitalier Universitaire76183 RouenFrance service de Chirurgie Générale et digestive Centre Hospitalier Universitaire76183 RouenFrance service d'Hépato-gastro-entérologie Centre Hospitalier Universitaire76183 RouenFrance

AIM:To search for transcription dysregulation that could(1) differentiate hepatocellular carcinoma(HCC)-free from HCC-related cirrhosis(2) differentiate HCC-free cirrhosis related to HCV from that related to alcohol ***:Using microarray analysis,we compared transcript levels in HCC-free cirrhosis(alcoholism:7;hepatitis C:7),HCC-associated cirrhosis(alcoholism:10;hepatitis C:10) and eight control *** identified transcripts were validated by qRT-PCR in an independent cohort of 45 samples(20 HCC-free cirrhosis;15 HCC-associated cirrhosis and 10 control livers).We also confirmed our results by *** which differentiated between alcoholic-related cirrhosis,HCV-related cirrhosis and control *** mainly corresponded to *** of Signal Transduction and Activator of Transcription-3(STAT-3) was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free *** contrast,in HCC,such transcription dysregulations were not ***:We report that transcriptional dysregulations exist in HCC-free cirrhosis,are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition.

关键词：肝疾病病理学酒精中毒肝炎病毒基因表达

Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer,liver metastasis of colorectal cancer and hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第23期12卷 3782-3783页

作者： Muriel Mathonnet Bernard descottes denis Valleix Francois Labrousse Véronique Truffinet Yves denizot service de Chirurgie digestive Endocrinienne et GénéraleCHU Dupuytren2 avenue Luther KingLimoges 87045France service de Chirurgie Viscérale et Transplantation CHU Dupuytren2 avenue Luther King87045 LimogesFrance service d'Anatomo-pathologie CHU Dupuytren2 avenue Luther King87045 LimogesFrance UMR CNRS 6101 Faculté de Médecine2 rue Docteur Marcland87025 LimogesFrance

TO THE EDITOR Angiogenesis consists of the sprouting of capillaries from pre-existing vessels . It is well-known that tumor growth is angiogenesis-dependent. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulated vascular endothelial cell proliferation and are involved in the neoplastic angiogenesis of several types of tumors including those of the intestinal *** usually investigated VEGF and bFGF protein expressions using immunohistochemistry or Western blotting and VEGF and bFGF transcripts using reverse transcriptase polymerase chain reaction (RT-PCR). We recently reported in a previous issue of the World Journal of Gastroenterology that cirrhotic liver tissue levels of these two

关键词：血管内皮生长因子定量分析结直肠癌肝细胞癌

Effectiveness and safety of therapeutic plasma exchange to modify the functionality of heparin-induced thrombocytopenia antibodies and correct profound thrombocytopenia:A case report and literature review

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Journal of Intensive Medicine 2023年第4期3卷 373-375页

作者： Audrey Graser Anne Bauters Jean-Luc Auffray Caroline Vayne François Provot Merce Jourdain Laurent Robriquet department of Intensive Care Medicine CHU LilleLille F-59000France service d'Hémostase-Transfusion Institut d'HématologieCentre de Biologie Pathologie GénétiqueBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France service de Cardiologie Institut Coeur PoumonBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France service d'Hématologie-Hémostase Centre Hospitalier Universitaire de ToursUniversitéde ToursTours EA4245 T2IFrance Pôle de Néphrologie Hôpital Albert CalmetteBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France department of Intensive Care Medicine Univ LilleInsermCHU LilleLille F-59000France

Introduction Heparin-induced thrombocytopenia(HIT)is a rare but life-threatening complication of heparin *** IgG antibodies recognize heparin-modified platelet factor 4(PF4/H IgG)and activate the platelets,increasing ... 详细信息

关键词： heparin antibodies thrombocytopenia

Neurodevelopment from 0 to 24 months in normocephalic children,in utero exposed to Zika virus in 2016:A cohort study

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Infectious Medicine 2022年第3期1卷 224-226页

作者： A.Mallard L.Kovacic B.Tressieres E.Couchy R.Grant B.Hoen A.Cabié service de Pédiatrie médico-chirurgicale.Centre Hospitalier Universitaire de Guadeloupe Pointe-à-PitreFrance Centre d’Investigation Clinique 97159 Pointe-à-PitreFrance Emerging Disease Epidemiology Unit Institut PasteurParisFrance Sorbonne UniversitéParisFrance department of Medical Research Institut PasteurParisFrance service de pathologie Infectieuse et tropicale Fort-de FranceCentre Hospitalier Universitaire de Martinique

Zika virus(ZIKV)is a neurotropic arbovirus almost exclusively transmitted by the bite of Aedes species mosquitoes[1].An outbreak of ZIKV infection was first confirmed in Northeast of Brazil,early *** prevalence of micro-cephaly in 15 states of Brazil with laboratory-confirmed ZIKV transmission significantly exceeded that in four states without confirmed ZIKV transmission[2].

关键词： Northeast prevalence infection

VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues

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World Journal of Gastroenterology 2006年第5期12卷 830-831页

作者： Muriel Mathonnet Bernard descottes denis Valleix Francois Labrousse Yves denizot service de Chimrgie DigestiveEndocrinienne et GénéraleCHU DupuytrenLimogesFrance service de Chirurgie Viscérale et TransplantationCHU DupuytrenLimogesFrance service d'Anatomo-pathologie CHU DupuytrenLimogesFrance UMR CNRS 6101Faculté de MédecineLimogesFrance

TO THE EDITORWe read with a great interest the recent work of deli andcolleagues. in the World Journal of Gastroenterology reportingvascular endothelial growth factor (VEGF) expressionin hepatocellular carcinoma (HCC) and cirrhotic livertissues. This well-documented work shows that VEGFwas significantly higher in surrounding cirrhotic livertissues than in HCC. Authors assessed VEGF expressionusing ***

关键词：肝细胞癌肝硬化血管内皮生长因子病理机制

Acute liver failure is frequent during heat stroke

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World Journal of Gastroenterology 2008年第1期14卷 158-159页

作者： JM Garcin JA Bronstein S Cremades P Courbin F Cointet Clinique médicale hpital d'instruction des armées Bégin F 94163 Saint Mandé France service de pathologie digestive hpital d'instruction des armées Clermont Tonnerre F 29200 Brest France

Acute liver failure (ALF) is relatively frequent during heat stroke (HS). This risk must be emphasized, because its incidence is higher than is usually thought. In a recent study by Weigand et al , two cases were reported in which liver failure was the leading symptom. We have confirmed their conclusion in a study of 25 cases of HS with ALF, compared with 25 other cases without ALF. Moreover, we observed that hypophosphatemia on admission could predict occurrence of ALF during HS. As for clinical and other biological parameters, phosphatemia should be monitored for at least 3 d in all cases of HS, even when it is thought to be mild.

关键词：中暑血磷酸盐过少急性肝功能衰竭肝脏疾病

Giant Myositis Ossificans Circumscribed Post Traumatic of Gluteus and Adductor Muscles: Case Report

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Open Journal of Orthopedics 2015年第6期5卷 157-162页

作者： Koné Samba Touré Stanislas Bana Abdoulaye Dogba Eric Doukouré Brahima Ngandeu Nawé Astrid Koffi Gérard Vangah Marius Mègné Estelle Allou Sylvain service de Chirurgie Orthopédique et Traumatologique C.H.U de Cocody Abidjan Ivory Coast service d’Anatomie pathologie du C.H.U de Cocody Abidjan Ivory Coast service de Rhumatologie C.H.U de Cocody Abidjan Ivory Coast service de Chirurgie Orthopédique et Traumatologique C.H.U de Bouake Bouake Ivory Coast

Myositis ossificans circumscribed is a bone and cartilage heterotopic non neoplastic proliferation inside the soft tissues. It is a benign focal heterotopic ossification process of soft tissues, and a rare disorder that occurs spontaneously or after local trauma. Clinical and radiographic appearances are quite hustler. A careful histological examination of biopsy straightens diagnosis is necessary. There is no consensus in support (surgical or/and medical). From Benign prognosis, evolution of this pathology is usually favorable. The authors report a case of giant myositis ossificans circumscribed post-traumatic localized on gluteus and adductor muscles of the right hip on a 26-year-old man. Through a review of literature the mechanism, the diagnostic methods and therapeutic will be discussed.

关键词： Giant Myositis Ossifying Gluteus and Adductor Muscles Biopsy

The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 588-603页

作者： Faten Merhi Ruoping Tang Ollivier Legrand Florence Nguyen-Khac Santos A.Susin Brigitte Bauvois Centre de Recherche des Cordeliers INSERMSorbonne UniversitéUSPCUniversitéParis DescartesUniversitéParis DiderotParis F-75006France department of Life&Earth Sciences Faculty of Sciences(I)Lebanese UniversityBeirutLebanon Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Saint-AntoineService d’Hématologie CliniqueParis F-75012France service Génétique des Tumeurs Département de Biologie et de Pathologie MédicaleGustave Roussy Cancer CamusVillejuif F-94805France Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Pitié-SalpêtrièreService d’Hématologie BiologiqueParis F-75013France.

Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to *** regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers of disease status in *** natural phloroglucinol hyperforin(HF)displays antitumoral properties of potential pharmacological ***,we investigated the effects of HF on MMP-2/9 and VEGF-A expression and survival of primary AML ***:Blood and bone marrow samples were collected in 45 patients with distinct subtypes defined by French American British classification,i.e.,M0,M1,M2,M3,M4,and *** of MMPs and VEGF-A in leukemic blood cells and culture supernatants were determined by RT-PCR,ELISA,and gelatin zymography(MMPs).The balance between cell death and survival was assessed by flow cytometry with analysis of phosphatidylserine externalization and caspase-3 ***:The administration of HF promoted a caspase-associated apoptosis in primary AML blasts(from blood and bone marrow),but not normal blood cells and *** addition,HF inhibited the levels of secreted proMMP-2,proMMP-9,and VEGF-A without altering *** induction of apoptosis by HF significantly paralleled the inhibition of MMP-2/9 and VEGF-A release by *** differences were seen in response to the deleterious effects of HF between AML cells of distinct ***:Our results suggest that HF,through its proapoptotic and potential antiangiogenic properties(by inhibiting MMP-2/9 and VEGF-A)on primary AML cells,might be a useful experimental agent,in combination with existing drugs,for new therapeutic approaches in the treatment of this incurable disease.

关键词： Acute myeloid leukemia apoptosis hyperforin matrix metalloproteinase VEGF secretion

SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging

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World Journal of Gastroenterology 2017年第2期23卷 216-223页

作者： Rachel Marion-Letellier Pierre Bohn Romain Modzelewski Pierre Vera Moutaz Aziz Charlène Guérin Guillaume Savoye Céline Savoye-Collet INSERM Unit UMR1073 Rouen University and Rouen University Hospital QUANTIF LITIS EA 4108 Rouen University and Rouen University Hospital service d’Anatomo-pathologie Rouen University Hospital Gastroenterology department Rouen University Hospital Radiology department Rouen University Hospital

AIM To assess the feasibility of SPECT-computed tomography(CT) in rats with trinitrobenzene sulfonic acid(TNBS)-induced acute colitis and confront it with model inflammatory *** Colitis was induced in Sprague-Dawley rats by intrarectal injection of TNBS(n = 10) while controls received vehicle(n = 10). SPECT-CT with intravenous injection of 10 MBq of 67Ga-Citrate was performed at day 2. SPECT-CT criteria were colon wall thickness andmaximal wall signal intensity. Laboratory parameters were assessed: colon weight:length ratio, colon cyclooxygenase-2 expression by western blot and histological inflammatory *** Colon weight/length ratio, colon COX-2 expression and histological inflammatory score were significantly higher in the TNBS group than in the control group(P = 0.0296, P < 0.0001, P = 0.0007 respectively). Pixel max tend to be higher in the TNBS group than in the control group but did not reach statistical significance(P = 0.0662). Maximal thickness is significantly increased in the TNBS group compared to the control group(P = 0.0016) while colon diameter is not(P = 0.1904). Maximal thickness and colon diameter were correlated to colon COX-2 expression(P = 0.0093, P = 0.009 respectively) while pixel max was not(P = 0.22). Maximal thickness was significantly increased when inflammation was histologically observed(P = 0.0043) while pixel max and colon diameter did not(P = 0.2452, P = 0.3541, respectively).CONCLUSION SPECT-CT is feasible and easily distinguished control from colitic rats.

关键词： Crohn’ s 疾病大肠炎大肠炎成像 Cyclooxygenase-2 计算 SPECT 的断层摄影术