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immunovirological Discordance and Associated Factors among People Living with HiV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea

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Open Journal of Medical Microbiology 2024年第2期14卷 93-104页

作者： Mariama Sadjo Diallo Djiba Kaba Charles Tchibinda delicat issiaga Diallo Boh Fanta Diane Doufin Traore Ousmane Niabaly Oumar Mouctar Diallo Ouo-Ouo Yaramon Kolie Aly Patrice Kamano Pascal Koivogui Ahmed Sékou Keita Mohamed Macire Soumah Thierno Mamadou Tounkara Mohamed Cisse Facult des Sciences et Techniques de la Sant Universit Gamal Abdel Nasser de Conakry Conakry Guine Laboratoire de Biologie Molculaire Nestor Bangoura/Helene Labrousse Hpital de Jour Donka CHU Donka Conakry Guine Centre dexcellence Africain Pour la Prvention et le Contrle des Maladies Transmissibles Conakry Guine service de dermatologie-Vnrologie CHU Donka Conakry Guine

The antiretroviral treatment (ART) has significantly reduced the number of new HiV/AiDS infections and related deaths. However, cases of immunovirological discordance (iVD) are found in various locations. The objective of this study was to determine the profile of People living with HiV (PLHiV) with iVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHiV under ART for at least 6 months, followed at Hpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4 T-cell count. Prevalence of iVD was 34.57%, with 23.87% for immunological discordance (iD) and 10.7% for virological discordance (VD). Females were predominant (66.26%), and male gender influenced iVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 11.30 years. PLHiV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 - 12]. The mean initial CD4 T-cell count was 272.84 cells/mm3 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 - 31,675,000]. The initial CD4 T-cell count 3 was associated with iVD with a statistically significant difference (p = 0.0009) and correlated with iD (p = 0.000). Prurigo was associated with iVD with a statistically significant difference (p = 0.003). Cerebral toxoplasmosis was not associated with iVD but was associated with iD (p = 0.04). This study allowed us to describe the profile of PLHiV with iVD. The main associated factors were male gender, initial CD4 T-cell count 3, toxoplasmosis, prurigo, and herpes zoster.

关键词： HiV Antiretroviral Treatment (ART) immunovirological Discordance Donka Guinea

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Profile of Autoantibodies and Clinical Symptoms in Guinean Patients with Connective Tissue Diseases

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Open Journal of immunology 2024年第1期14卷 1-10页

作者： Mariama Sadjo Diallo Doufin Traore Adame Diouf Djiba Kaba issiaga Diallo Doudou Georges Massar Niang Alimou Camara Oumar Mouctar Diallo Boh Fanta Diane Abdoulaye Barry Ouo-Ouo Yaramon Kolie Moustapha Mbow Aly Badra Kamissoko Djibril Sylla Babacar Mbengue Mohamed Cisse Faculté des Sciences et Techniques de la Santé Université Gamal Abdel Nasser de Conakry Conakry Guinée Laboratoire de Biologie Moléculaire Nestor BANGOURA/Helene LABROUSSE H&#244pital de jour Donka CHU Donka Conakry Guinée Centre d’Excellence Africain Pour la Prévention et le Contrô le des Maladies Transmissibles Conakry Guinée Laboratoire d’immunologie Université Cheikh Anta Diop Dakar Sénégal service de dermatologie-Vénérologie CHU Donka Conakry Guinée service de Rhumatologie H&#244pital National Ignace Deen Conakry Guinée service de Médecine interne CHU Donka Conakry Guinée

Connective tissue diseases (CTDs) are Autoimmune diseases (AiDs) characterized by the appearance of autoantibodies, which are diagnostic markers. investigations of these autoantibodies play a major role in the management of several autoimmune diseases. The objective of this study was to describe the profile of anti-ENA antibodies according to the clinical symptoms of mixed CTDs in Conakry teaching Hospital. We performed a cross-sectional study during six months. A total of 20 patients was recruited and we measured antibodies using the ELiSA technique. The mean age of our patients was 36.5 years, with a predominance of females. Cutaneous and rheumatological signs were the main clinical manifestations. SLP was the most frequent CTDs;the threshold of ENA antibodies positivity was higher in scleroderma with and SLP. Anti-ENA identification reveals the frequency of anti-SSA (83.33%), anti-U1RNP (66.66%) and anti-histone (50%) antibodies. Antinuclear antibodies (ANA) react with various components of the cell nucleus. Their detection is of major interest in the diagnosis of CTDs. Our results highlight the importance of determining the specificity of these antibodies to guide differential diagnosis.

关键词： Autoantibodies Extractible Nuclear Antigen (ENA) Connective Tissue Diseases ELiSA

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转移性恶性黑素瘤患者对达卡巴嗪发生超敏反应(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 27-28页

作者： Levy A. Guitera P. Kerob D. N.Basset-Seguin 潘敏 service de dermatologie i H■pital Saint-Louis1avenue Claude Vellefaux75010 Paris

***(DTiC)is the first-line chemotherapy for metastatic malignant melanoma without cerebral *** clinical and hematological safety is usually *** in hepatic failure patients is the most serious side effect *** and *** was a retrospective study of the prevalence of hypersensitivity in patients treated with DTiC for metastatic melanoma between 11/01/2002 and 10/31/*** was diagnosed in the event of fever,hypereosinophilia(>500/mm3)with or without liver dysfunction(> twice pre-therapeutic values).Clinical data,DTiC administration modalities,number of courses and clinical and laboratory safety data were *** patients were included,11 women and 9 men of median age 58.6 years(22-82 years)with multiple metastases in all *** was the first-line treatment for 19 patients,being administered for 4 days to 10 patients and for 1 day to the other 10 patients,depending on their overall health *** hypersensitivity-like manifestations were observed,all in the 4-day treatment *** 3 patients,fever and hypereosinophilia were seen without liver dysfunction at D3 of the second course of *** 2 patients,treatment was stopped after the second course because of disease *** the third patient,4 courses were given with recurrence of symptoms,although the latter were controlled during the fifth course with corticosteroids and antihistamines given 15 minutes before the start of *** patients experienced severe forms of hypersensitivity with fever,hypereosinophilia,liver dysfunction(cytolysis and cholestasis)and delayed medullar aplasia,after the first and second course *** one patient,bone marrow examination showed a block at the promyelocytic stage consistent with a toxic *** with DTiC was stopped,and all signs regressed with symptomatic *** with DTiC seems to be frequent,being observ

关键词：恶性黑素瘤达卡巴嗪超敏反应嗜酸细胞增多症血液学毒性一线化疗骨髓形态学前髓细胞肝功能障

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伊维菌素成功治疗1例HiV感染患者的螨皮炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 25-26页

作者： Clyti E. Sayavong K. Chanthavisouk K. 崔荣 service de dermatologie Institut Guyanais de Dermatologie Tropicale Centre Hospitalier de Cayenne BP 6006 97306 Cayenne France

introduction. demodex is a saprophyte parasite in mammals. in Man, it is associated with differing clinical profiles (rosacealike dermatitis, folliculitis and blepharitis). We report a case of demodecidosis in an HiV-infected patient that was successfully treated with ivermectin. Case report. A man from Laos, infected by HiV and treated for glandular tuberculosis, presented with a prurigenous eruption on the face and the pre-sternal and interscapular areas. Direct examination of scraped product and histopathological examinations confirmed the diagnosis of demodecidosis. Clinical cure was obtained after 2 single cures of ivermectin a one month’s distance. Discussion. The features of demodecidosis are often similar to those of rosacea. in immunodeficient patients, the semiology remains the same but the eruption is more abundant. During HiV-infection, demodecidosis occurs at the AiDS stage or with a CD4 count lower than 200/mm3. Many anti-dust mite molecules are used to treat the disease but frequently lead to irritation. Administration of a single cure of ivermectin, repeated if necessary, appears to be an interesting alternative to contact anti-dust mite agents.

关键词：螨皮炎 HiV感染患者伊维菌素蠕形螨感染肩胛间区眼睑炎细胞计数痒疹直接镜检免疫缺陷患者

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An Atypical Ovarian and Peritoneal Pelvic Tuberculosis Complicated by Toxidermia

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Case Reports in Clinical Medicine 2023年第8期12卷 261-269页

作者： Ndeye Amy Sarr Daouda Thioub Agbogbenkou Tevi Déla Lawson Khalifa Ababacar Mansour Fall Haby Dione Kane Sylvie Audrey Diop service des Maladies infectieuses et tropicales de l’h&ocirc pital Abdoul Aziz Sy Dabakh de Tivaouane Tivaouane Sénégal service gynécologie et obstétrique de l’h&ocirc pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal service dermatologie de l’h&ocirc pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal

Background: Ovarian tuberculosis is a rare form of tuberculosis. its clinical presentation mimics an ovarian tumor, leading to misdiagnosis. Proper treatment with anti-tuberculosis drugs can lead to a cure for the disease but can sometimes cause adverse effects that compromise therapeutic management. Observation: We report a 71-year-old female Senegalese patient who presented with a chronic abdominopelvic mass with an elevated Cancer Antigen 125 (CA125) level, raising the suspicion of an ovarian tumor. She underwent an exploratory laparotomy and the anatomopathological study confirmed the diagnosis of ovarian and peritoneal tuberculosis. After starting treatment with anti-tuberculosis drugs, she developed toxidermia in the form of generalized urticaria. Discontinuation of the four-drug therapy and separate reintroduction of anti-tuberculosis drugs led to the incrimination of rifampicin. Progress was then favorable on isoniazid (H) pyrazinamide (Z) and Ethambutol (E). Conclusion: Ovarian tuberculosis should be suspected in the presence of an abdominopelvic mass in a woman living in an endemic area. The occurrence of adverse reactions to anti-tuberculosis treatment is not uncommon, hence the importance of regular monitoring.

关键词： Ovarian Peritoneal Tuberculosis Toxidermia Senegalese

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女性阴部巨大皮脂腺异常增生(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 39-40页

作者： Masmoudi A. Bouassida S. Ayadi L. 李晓莉 service de dermatologie EPS Hedi Chaker 3029 Sfax Tunisia

Background. Sebaceous gland hyperplasia is an epithelial tumour with sebaceous differentiation. Genital involvement is rare. in this paper, we report a new case of sebaceous gland hyperplasia of the vulva. Case report. A 27 year-old woman presentedmultiple polypoid lesions of the lower third of left labium majus. The lesions were soft to the touch, measured 5 cm in length and were painless. The cutaneous biopsy confirmed the diagnosis of sebaceous gland hyperplasia of the vulva. Surgical excision was performed in two separate procedures and was successful. Discussion. This case was unusual in terms of the site, the clinical appearance and the weeping seen due to the high concentration of hyperplasic sebaceous glands.

关键词：异常增生大阴唇上皮性肿瘤息肉状生殖器部位损害部位女阴

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PHACE(S)综合征的不完全表达:与颈内动脉缺失相关的面部血管瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 24-25页

作者： Monnier D. Pelletier F. Aubin F. P. Humbert 崔荣 service de dermatologie i CHU Saint-Jacques 2 place Saint-Jacques 25030 Besanc.on Cedex France

introduction. Hemangiomas are the most common benign tumors in childhood. in rare cases, they can be associated with dysmorphic malformations. The acronym, the PHACE (S) syndrome, was recently described by Frieden et al. in 1996 as a large facial or cervical Hemangioma, associated with one or more of the following systemic abnormalities including:Posterior fossa malformation, Arterial abnormalities, Coarctation of the aorta and/or cardiac defects, Eye abnormalities and Sternal clefts. Case report. A 2 year-old girl presented with a large left hemifacial hemangioma. The rest of the clinical examination was normal. initially, simple clinical surveillance was scheduled. The outcome was good with almost complete regression of the hemangioma by the age of 8. However, there were remains to the left of the upper lip and plastic surgery was scheduled. Pre-operative conventional arteriography revealed the complete, asymptomatic, absence of the ipsilateral internal carotid artery. Cerebral MRi and cardiac ultrasonography were normal. in the absence of somatic manifestations, regular clinical surveillance was decided on. Discussion. Large facial or cervical hemagiomas can be associated with one or more systemic abnormalities described by the PHACE (S) acronym. its prevalence is unknown, but is shows marked female preponderance. Among the systemic abnormalities, neurological and cardiac malformations predominate. Hence the PHACE (S) syndrome must be recognized. Moreover, in patients presenting with large facial or cervical hemangioma, the following examinations should be performed:neurological examination and cerebral MRi to rule out abnormality of the posterior fossa,completed by a sequence of angio-MRi in the search for cerebral artery malformations;cardiovascular exploration,completed by echocardiography in the case of doubt and examination of the eyes and sternum. Lastly, the enhanced risk of laryngeal sub-glottis hemangioma should be kept in mind.

关键词：面部血管瘤 PHACE 颈内动脉超声波检查大脑动脉无症状性神经学左侧面部全身系统性眼部异常

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在HiV感染的患者中使用可生物降解的物质改善面部皮下脂肪萎缩(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 15-16页

作者： Carbonnel E Claudy A 刘安 service de dermatologie Hopital Edouard Herriot 69437 Lyon France

introduction. Facial lipoatrophy in HiV-infected patients undertri-therapy occurs frequently and alters their quality of life. No systemic treatment is capable of curing this problem. Patients and methods. Eighty-one patients were included in an open, prospective, compassionate study. A strict intradermal injection of a biodegradable, polyacrylamide cationic copolymer was administered in several sessions. Results. in all the patients, the correction of the facial lipoatrophy was considered satisfactory and stable over a period of 6 months using comparative photographic cliches. The thickness of the dermal skin, assessed by sonography, was doubled. No local or systemic side effect was reported. Conclusion. Our study shows that is it possible to durably correct the facial lipoatrophy of HiV-infected patients under tri-therapy by using a biodegradable implant.

关键词：皮下脂肪萎缩 HiV感染生物降解三联疗法埋植剂超声波检测法生活质量永久地

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铈诱导的肉芽肿性皮炎(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 33-34页

作者： Boye T. Terrier J.-P. Coillot C. F. Carsuzaa 焦婷 service de dermatologie HIA Sainte-Anne 83800 Toulon Naval

Background. The presence of inorganic foreign bodies in granulomatous cutaneous lesions is not infrequent. in this paper, we describe the first case of cerium-induced cutaneous granulomatous dermatitis. Case report. A 57-year-old woman seriously burned four years ago presented with papulonodular lesions affecting only the burned areas treated with topical cerium nitrate-silver sulfadiazine cream (Flammacé rium ). Biopsies revealed sarcoidal granuloma associated with exogenous particles. Electron probe X-ray microanalysis demonstrated a high cerium content. Screening for systemic sarcoidosis was negative. The patient was treated with hydroxychloroquine. After four months of follow-up, clinical and histological evidence of decreased infiltrate was noted. Discussion. Cerium nitratesilver sulfadiazine cream (Flammacé rium ) is widely used for the topical treatment of burns. The main effect of cerium is to create superficial calcification, which decreases wound colonization and prevents the formation of granulation tissue (no hypertrophic scar formation) in bur-ns. Prior to our case, no cutaneous side-effects of cerium had been encountered. inoculation of foreign matter may or may not induce granuloma formation or sarcoidosis in different subjects, according to their immunologic status. The favorable outcome in this case could in fact be due to a change in the pattern of cytokinin production (TH1→ TH2) rather than the effects of hydroxychloroquine therapy.

关键词：肉芽肿性系统性结节病硝酸铈浅表性钙化烧伤部位严重烧伤磺胺嘧啶银乳膏丘疹结节硫酸羟氯喹

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原发于皮肤的骨外Ewing肉瘤(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 27-28页

作者： Kourda M. Chatti S. Sfia M. 李晓莉 service de dermatologie Hopital de Nabeul avenue Habib Thameur Nabeul 8000Tunisia

Background. Cutaneous extraskeletal Ewing s sarcoma is rare, being seen principally in children. We report a case of cutaneous sarcoma in the sole of the foot in a child. Case report. A 9-yearold child with no medical history of note was presenting a skin tumor for 3months on the heel of the right foot. This tumor was burgeoning and painful and measured 3.5cm in diameter; it was ulcerative at the surface and covered with a crust. Histological and immunohistochemical examinations confirmed the diagnosis of Ewing s sarcoma. Staging examinations proved negative and the patient underwent polychemotherapy, resulting in complete regression of the tumor. Comments. Until 1998, 37 cases of cutaneous and subcutaneous Ewing s sarcoma were reported, being seen in 21 girls and 16 boys. Mean age at diagnosis was 15 years and mean tumor size was 3 cm (range: 1 to 12 cm). The tumors were observed throughout the body, being seen in the sole of the foot in 2 cases. Confirmation of the diagnosis was made by histological examination (malignant proliferation of small round cells in the dermis), immunohistochemical examination (CD99+ ) and cytogenetic analysis (translocation between chromosomes 22 and 11). The prognosis for cutaneous Ewing s sarcoma appears more favorable than that of Ewing s sarcoma in bone. Of the 37 patients treated, 7 had metastases and 2 presented relapse. Treatment for cutaneous Ewing s sarcoma, though not codified, consists of polychemotherapy associated with surgery and/or radiotherapy.

关键词： Ewing 骨外肿瘤平均直径联合化疗免疫组化检查足后跟组织学检查小圆细胞特殊病史组织

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