在HIV感染的患者中使用可生物降解的物质改善面部皮下脂肪萎缩(法国)
Correction of facial lipoatrophy with a biodegradable material in HIV-infected patients (Fren)作者机构：Service de Dermatologie Hopital Edouard Herriot 69437 Lyon France
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第10期
页 面：15-16页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：皮下脂肪萎缩 HIV感染 生物降解 三联疗法 埋植剂 超声波检测法 生活质量 永久地
摘 要：Introduction. Facial lipoatrophy in HIV-infected patients undertri-therapy occurs frequently and alters their quality of life. No systemic treatment is capable of curing this problem. Patients and methods. Eighty-one patients were included in an open, prospective, compassionate study. A strict intradermal injection of a biodegradable, polyacrylamide cationic copolymer was administered in several sessions. Results. In all the patients, the correction of the facial lipoatrophy was considered satisfactory and stable over a period of 6 months using comparative photographic cliches. The thickness of the dermal skin, assessed by sonography, was doubled. No local or systemic side effect was reported. Conclusion. Our study shows that is it possible to durably correct the facial lipoatrophy of HIV-infected patients under tri-therapy by using a biodegradable implant.
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