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Liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality

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World Journal of Gastroenterology 2014年第39期20卷 14455-14462页

作者： Alban Zarzavadjian Le Bian Renato Costi mohamed Said Sbai-Idrissi Claude Smadja service de Chirurgie digestive H?pital Antoine BéclèreClamart Assistance Publique-H?pitaux de ParisUniversité Paris Sud-XI 91400 Orsay France Laboratoire d’Ethique médicale et de médecine Légale Université Paris Descartes-V 75006 Paris France service de Chirurgie digestive H?pital Simone Veil95600 Eaubonne France dipartimento di Scienze Chirurgiche Università degli Studi di Parma 43100 Parma Italy

AIm: To investigate the mechanism leading to perioperative mortality in patients undergoing major liver resection and presenting with metabolic disorders.

关键词： metabolic syndrome major hepatectomy Liver resection Postoperative mortality Hepatorenal syndrome

Enhanced Trust Based Access Control for multi-Cloud Environment

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Computers, materials & Continua 2021年第12期69卷 3079-3093页

作者： N.R.Rejin Paul d.Paul Raj Technology PuduvoyalGummidipoondi601206India R m d Engineering College KavaraipettaiGummidipoondi601206India

Security is an essential part of the cloud *** ensuring the security of the data being communicated to and from the cloud server,a significant parameter called trust was ***-based security played a vital role in ensuring that the communication between cloud users and service providers remained unadulterated and *** most cloud-based data distribution environments,emphasis is placed on accepting trusted client users’requests,but the cloud servers’integrity is seldom *** paper designs a trust-based access control model based on user and server characteristics in a multi-cloud environment to address this *** proposed methodology consists of data encryption using Cyclic Shift Transposition Algorithm and trust-based access control *** this trust-based access control mechanism framework,trust values are assigned to cloud users using direct trust *** direct trust degree is estimated based on the following metrics:success and failure rate of interactions,service satisfaction index,and dishonesty *** addition to this,trust values are assigned to cloud servers based on the metrics:server load,service rejection rate,and service access *** role-Based Access control policy of each user is modified based on his trust *** the server fails to meet the minimum trust level,then another suitable server will be *** proposed system is found to outperform other existing systems in a multi-cloud environment.

关键词： Cloud computing trust access control cloud service provider cloud data user CSTA

Energetic Argument for Bimodal Black Hole Accretion discs

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Chinese Physics Letters 2002年第10期19卷 1562-1564页

作者： Lin Yi-Qing Lu Ju-Fu Gu Wei-min department of Physics Xiamen University Xiamen 361005 service d'Astrophysique CEA/DSM/DAPNIA CE-Saclay 91191 Gif-sur-Yvette France

Based on simple energetic considerations, we show that two crucial ingredients of bimodal black hole accretion discs, namely the sonic point and the transition radius, can be determined from the disc constant paramete... 详细信息

关键词： Gravitation

Colorectal cancer and immunity:what we know and perspectives

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World Journal of Gastroenterology 2014年第14期20卷 3738-3750页

作者： Simon Pernot magali Terme Thibault Voron Orianne Colussi Elie marcheteau Eric Tartour Julien Taieb service d’Hépatogastro-entérologie et d’oncologie digestive H?pital Européen Georges-PompidouUniversité Paris DescartesSorbonne Paris Cité INSERm U970 Paris Cardiovascular Research CenterUniversité Paris-Descartes service d’Immunologie biologique H?pital Européen Georges-PompidouUniversité Paris Descartes

Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer. In particular, the density of T Cd8+ and Cd45+ lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor. Other immune subsets, as macrophages, natural killer cells or unconventionnal lymphocytes, seem to play an important role. Induction of regulatory T cells (Tregs) or immunosuppressive molecules such as Pd-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response. The development of these mechanisms is a major obstacle to the establishment of an effective immune response, but also to the use of immunotherapy. Although immunotherapy is not yet routinely used in colorectal cancer, we now know that most treatments used (chemotherapy and biotherapy) have immunomodulatory effects, such as induction of immunogenic cell death by chemotherapy, inhibition of immunosuppression by antiangiogenic agents, and antibody-dependent cytotoxicity induced by cetuximab. Finally, many immunotherapy strategies are being developed and tested in phase I to III clinical trials. The most promising strategies are boosting the immune system with cytokines, inhibition of immunoregulatory checkpoints, vaccination with vectorized antigens, and adoptive cell therapy. Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future.

关键词： Colorectal cancer Immunotherapy Immunity Immunoregulation Vaccination

Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation

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Cellular & molecular Immunology 2020年第4期17卷 426-429页

作者： Caroline Galeotti Anupama Karnam Jordan d.dimitrov Alain Chevailler Srini V.Kaveri Jagadeesh Bayry Institut National de la Santéet de la Recherche médicale/Centre de Recherche des Cordeliers Equipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéParis F-75006France service de Rhumatologie Pédiatrique Centre de Référence des Maladies Auto-Inflammatoires Rares et des AmylosesCHU de Bicêtrele Kremlin Bicêtre F-94270France UniversitéParis descartes Sorbonne Paris CitéParis F-75006France Laboratoire d’Immunologie et d’Allergologie/CHU d’Angers Universitéd’Angers/INSERM Unité1232/LabEx IGO“Immuno-Graft-Onco”Angers F-49933France

Basophils are rare *** representing only~0.5%of all leukocytes,basophils have several important physiological functions.1,2 Although basophils lack the classic features of professional antigen-presenting cells,3–7 through the secretion of cytokines,they orient the immune response by polarizing Th2 differentiation and supporting B-cell differentiation and class *** are also critical for mediating protection against helminth infection.1,2,8,9 Basophils receive activation signals from diverse *** is well recognized that cytokines such as IL-3,granulocyte–macrophage colony-stimulating factor(Gm-CSF),thymic stromal lymphopoietin(TSLP)and IL-33;various toll-like receptor ligands;allergen-bound IgE provide activation signals to basophils and induce the release of inflammatory mediators.10–15 In addition,several reports have also demonstrated the existence of anti-IgE autoantibodies that possess the capacity to induce basophil activation in patients with chronic spontaneous urticaria(CSU),atopic or non-atopic asthma or autoimmune disease.16–21 However,isolation and functional exploration of such anti-IgE IgG autoantibodies from either healthy donors or patients have not been attempted *** using a pooled normal IgG preparation from healthy donors,specifically intravenous immunoglobulin G(IVIG)22 that represents the complete IgG repertoire of a normal individual,we attempted to address this outstanding question in the field.

关键词： activation attempted IgE

Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging

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World Journal of Clinical Oncology 2016年第3期7卷 293-301页

作者： Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet denis Pezet Nicolas Barnich Elisabeth miot-Noirault mathilde Bonnet UmR1071 Inserm/Université d’Auvergne and INRA USC2018 Clermont Université service de Chirurgie digestive Centre Hospitalier Universitaire UmR990 Inserm/Université d’Auvergne Clermont Université service de médecine Nucléaire Centre Jean Perrin

AIm: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical ***: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(mPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and mPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 dSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting mPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P med that mPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/dSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided

关键词： Colorectal carcinoma Escherichia coli Colibactin myeloperoxidase In vivo optical imaging

Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 1-12页

作者： Jean marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus mohamed Lakehal Veronique desfourneaux Aude merdrignac Elodie Gaignard Alexandre Thobie damien Bergeat Bernard meunier michel Rayar CHU Rennes Service de Chirurgie Hépatobiliaire et DigestiveRennesFrance UniversitéRennes 1 Facultéde MédecineRennesFrance CHU Rennes Service des Maladies du FoieRennesFrance INSERm CIC 1414RennesFrance CHU Rennes Service de Maladies Infectieuses et Réanimation MédicaleRennesFrance

Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not ***:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to ***:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were *** groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as *** median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,Pdysfunction(EAd)(P=0.07)or arterial complications(P=0.26)was not statistically *** of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POd)was significantly improved in the SA *** difference was observed regarding graft(P=0.18)and patient(P=0.16)***:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.

关键词： Liver transplantation(LT) hepatic artery(HA) arterial anastomosis splenic artery(SA)

CAUSES OF 425 dEATHS dURING THE LAST FIVE YEARS ON THE SURGICAL service OF THE FIRST HOSPITAL OF THE REd CROSS SOCIETY OF CHINA, SHANGHAI

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中华医学杂志(英文版) 1935年第7期 652-657页

作者： K. C. WEN J. R. B. BRANCH m.d. First Hospital of the Red Cross Society of China Shanghai

Of the 5,628 patients admitted to the surgical service between 1929-1933 inclusive, 425 died. Of these, 2042 were operated upon. One hundred and sixty-four died within 24 hours after admission. One hundred and five deaths were due to the Sino-Japanese war in *** are given showing age, incidence, most frequent causes of death, complications, etc. Critical study is made of the possible cases of avoidable death with suggestions as to a reduction of mortahty. The gross mortality averages about 7 per cent which is also the operative mortality rate.

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World Journal of Gastroenterology 2016年第2期22卷 490-500页

作者： Hussein Akil Aurélie Perraud marie-Odile Jauberteau muriel mathonnet Laboratoire Homéostasie Cellulaire et Pathologies(LHCP-EA3842) Facultéde Médecine et de PharmacieFédération de Recherche GEIST87025 LimogesFrance service de Chirurgie digestive Générale et EndocrinienneCHU de Limoges87042 LimogesFrance service d’Immunologie CHU de Limoges87042 LimogesFrance

Colorectal cancer(CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor(EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B(Trk B), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of Trk B and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating Trk B-expressing CRC tumors.

关键词： Colorectal cancer Tyrosine kinase receptor B Brain-derived neurotrophic factor Therapeutic targets Cell survival