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Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis

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food Science and Human Wellness 2024年第2期13卷 736-747页

作者： Yilin Lin Ruifei Wang Xiaoqing Li Keren Agyekumwaa Addo Meimei Fang Yehui Zhang Yigang Yu School of food sciences and Engineering South China University of TechnologyGuangzhou 510640China sericulture&agri-food research institute guangdong academy of agricultural sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China research Center of food Safety and Detection College of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in *** previous found that a combination of kojic acid and tea polyphenols exhibited better activity against *** O157:H7 than using either *** study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene *** functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against *** O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic ***,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid *** results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against *** O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.

关键词： Kojic acid Tea polyphenols Antibacterial mechanism Escherichia coli O157:H7 RNA-seq

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Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties

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Journal of Integrative agriculture 2024年第2期23卷 494-510页

作者： Wenqing Tan Xinbo Guo Zhangying Wang Rong Zhang Chaochen Tang Bingzhi Jiang Ruixue Jia Yuanyuan Deng Shaohai Yang Jingyi Chen Crops research institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Crop Genetic Improvement of Guangdong ProvinceGuangzhou 510640China School of food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural&agri-food research institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional FoodsMinistry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China

Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their *** this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato *** varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were *** addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological *** comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with ***,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf *** findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value.

关键词： sweet potato leaf tips phenotypic traits metabolic profile differentially expressed metabolites polyphenols

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The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients

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food Science and Human Wellness 2024年第2期13卷 1079-1092页

作者： Qingqing Xu Weifei Wang Dongxiao Sun-Waterhouse Qian Zou Menglei Yan Xuan Liu Dongming Lan Yonghua Wang School of food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural and agri-food research institute Guangdong Academy of Agricultural SciencesGuangzhou 510610China School of Chemical sciences The University of AucklandPrivate Bag 92019New Zealand guangdong Youmei institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these *** oil-based DAG(LD)and linseed oil(LT)were ***-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously *** conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid ***-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients.

关键词： Diacylglycerol In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency

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Synergistic effects of the entomopathogenic fungus Isaria javanica and low doses of dinotefuran on the efficient control of the rice pest Sogatella furcifera

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Journal of Integrative agriculture 2024年第2期23卷 621-638页

作者： Tingting Zhou Qian Zhao Chengzhou Li Lu Ye Yanfang Li Nemat OKeyhani Zhen Huang Department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510642China Department of Microbiology and Cell Science Institute of Food and Agricultural SciencesUniversity of FloridaFL 32611USA

The rice planthopper,Sogatella furcifera,is a piercing-sucking insect pest of rice,Oryza *** is responsible for significant crop yield losses,and has developed moderate to high resistance to several commonly used chemical *** investigated the effects of the insect fungal pathogen Isaria javanica,alone and in combination with the chemical insecticide dinotefuran,on *** under both laboratory and field *** results show that *** displays high infection efficiency and mortality for different stages of ***,reducing adult survival,female oviposition and ovary *** bioassays showed that the combined use of *** with a low dose(4-16 mg L^(-1))of dinotefuran resulted in higher mortality in *** than the use of *** or dinotefuran *** combined treatment also had more significant effects on several host enzymes,including superoxide dismutase,catalase,peroxidase,and prophenol oxidase *** field trials,*** effectively suppressed populations of rice planthoppers to low levels(22-64%of the level in untreated plots).Additional field experiments showed synergistic effects,i.e.,enhanced efficiency,for the control of *** populations using the combination of a low dose of ***(1×10^(4) conidia mL^(-1))and a low dose of dinotefuran(~4.8-19.2%of normal field use levels),with control effects of>90%and a population level under 50 insects per 100 hills at 3-14 days *** findings indicate that the entomogenous fungus *** offers an attractive biological control addition as part of the integrated pest management(IPM)practices for the control of rice plant pests.

关键词： Isaria javanica Sogatella furcifera entomopathogenic fungus white planthopper rice synergistic effect on pest control

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Structural elucidation of mulberry leaf oligosaccharide and its selective promotion of gut microbiota to alleviate type 2 diabetes mellitus

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food Science and Human Wellness 2024年第4期13卷 2161-2173页

作者： Tenggen Hu Yuanshan Yu Jijun Wu Yujuan Xu Gengsheng Xiao Kejing An Erna Li Sentai Liao Yuxiao Zou Sericultural&agri-food research institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional FoodsMinistry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China Huagongliya(Foshan)Technology Industry Co. Ltd.Foshan 528313China Heyuan Branch Guangdong Laboratory for Lingnan Modern AgricultureHeyuan 517001China Zhongkai University of agriculture and Engineering Guangzhou 510225China

Two oligosaccharide fractions(MLO 2-1 and 2-2)were purified from enzymatic hydrolysate of mulberry leaf *** results of simulated digestion showed that MLO 2-2 was a digestible oligosaccharide,which could be degraded by human digestive juice;while MLO 2-1 possessed the non-digestible property in the upper gastrointestinal tract and performed the function by regulating the gut ***,MLO 2-1 was selected for the further *** structure of MLO 2-1 was elucidated as follow:α-T-Glcp-(1→3)-β-Glcp-(1→5)-α-Araf-(1→5)-α-Araf-1→5)-α-Araf-(1→3)-α-(2-OAc)-*** in vitro fecal fermentation results showed that MLO 2-1 could modulate the composition of gut ***,MLO 2-1 was effectively metabolized by fecal bacteria to produce lactate and short chain fatty acids,especially acetate and *** specific metabolic pathways of MLO 2-1 by gut microbiota were further *** microbiota analysis revealed that MLO 2-1 selectively promoted the growth of Ligilactobacillus murinus,a commensal bacterium presented a reduced level in T2DM *** experiments indicated that MLO 2-1 and *** exhibited hypoglycemic *** results demonstrated that MLO 2-1 might alleviate T2DM by selectively accelerating the proliferation of ***.

关键词： Mulberry leaf oligosaccharide Characterization Gut microbiota Lactobacillus murinus Hypoglycemic activity

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Haplotype-resolved chromosome-level genome of hexaploid Jerusalem artichoke provides insights into its origin,evolution,and inulin metabolism

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Plant Communications 2024年第3期5卷 77-92页

作者： Sen Wang Anqi Wang Rong Chen Dong Xu Hengchao Wang Fan Jiang Hangwei Liu Wanqiang Qian Wei Fan guangdong Laboratory for Lingnan Modern agriculture(Shenzhen Branch) Genome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-Biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China

Jerusalem artichoke(Helianthus tuberosus)is a global multifunctional *** has wide applications in the food,health,feed,and biofuel industries and in ecological protection;it also serves as a germplasm pool for breeding of the global oil crop common sunflower(Helianthus annuus).However,biological studies of Je-rusalem artichoke have been hindered by a lack of genome sequences,and its high polyploidy and large genome size have posed challenges to genome ***,we report a 21-Gb chromosome-level as-sembly of the hexaploid Jerusalem artichoke genome,which comprises 17 homologous groups,each with 6 *** found multiple large-scale chromosome rearrangements between Jerusalem artichoke and common sunflower,and our results show that the hexaploid genome of Jerusalem artichoke was formed by a hybridization event between a tetraploid and a diploid Helianthus species,followed by chromosome doubling of the hybrid,which occurred approximately 2 million years ***,we iden-tied more copies of actively expressed genes involved in inulin metabolism and showed that these genes may still be undergoing loss of function or sub-or *** genomic resources will pro-mote further biological studies,breeding improvement,and industrial utilization of Helianthus crops.

关键词： Helianthus tuberosus hexaploid genome hybridization origin chromosome rearrangement inulin metabolism genes

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Fluorescence analysis of antibiotics and antibiotic-resistance genes in the environment: A mini review

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Chinese Chemical Letters 2024年第10期35卷 82-91页

作者： Yuxin Li Chengbin Liu Qiuju Li Shun Mao College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai 200092China institute for agri-food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

Antibiotics,as widely used antibacterial drug,exist in various environmental *** residues can affect biological metabolism and lead to bacterial resistance and the formation of antibiotic-resistance genes,posing a threat to human health and ecological *** efficient detection methods for antibiotics and antibiotic-resistance genes has great environmental *** detection methods,due to their fast response,high sensitivity and specificity,and low-cost,are widely used in chemical and biological *** review first summarizes the pre-treatment methods for different types of environmental samples,and then focuses on the recent advances of fluorescence methods for the detection of antibiotics and antibiotic-resistance ***,main challenges and future research directions of fluorescence methods for antibiotic and antibiotic-resistance genes detection are *** review highlights the promising prospect of fluorescence methods in-situ detection and monitoring of antibiotics and antibiotic-resistance genes,and provides guidance for the construction of overall risk assessment system of environmental media.

关键词： Antibiotics Antibiotic-resistancegenes Fluorescence detection Environmental samples In-situdetection

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Aβ-Carotene Ketolase Gene NfcrtO from Subaerial Cyanobacteria Confers Drought Tolerance in Rice

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Rice science 2024年第1期31卷 62-76页

作者： GAO Ningning YE Shuifeng ZHANG Yu ZHOU Liguo MA Xiaosong YU Hanxi LI Tianfei HAN Jing LIU Zaochang LUO Lijun College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Shanghai Agrobiological Gene Center Shanghai 201106China College of Life sciences Shangrao Normal UniversityShangrao 334001China institute for agri-food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

Nostoc flagelliforme is a terrestrial cyanobacterium that can resist many types of stressors,including drought,ultraviolet radiation,and extreme *** this study,we identified the drought tolerance gene NfcrtO,which encodes aβ-carotene ketolase,through screening the transcriptome of *** under water loss *** expression of NfcrtO under 0.6 mol/L sorbitol or under 0.3 mol/L NaCl stress significantly increased the growth rate of Escherichia *** NfcrtO was heterologously expressed in rice,the seedling height and root length of NfcrtO-overexpressing rice plants were significantly higher than those of the wild type(WT)plants grown on½Murashige and Skoog solid medium with 120 mmol/L mannitol at the seedling *** analysis revealed that NfcrtO was involved in osmotic stress,antioxidant,and other stress-related ***,the survival rate of the NfcrtO-overexpression lines was significantly higher than that of the WT line under both hydroponic stress(24%PEG and 100 mmol/L H_(2)O_(2))and soil drought treatment at the seedling *** traits,including the activity levels of superoxide dismutase,peroxidase,catalase,total antioxidant capacity,and the contents of proline,trehalose,and soluble sugar,were significantly improved in the NfcrtO-overexpression lines relative to those in the WT line under 20%PEG ***,when water was withheld at the booting stage,the grain yield per plant of NfcrtO-overexpression lines was significantly higher than that of the WT *** two-hybrid analysis identified interactions between NfcrtO and Dna J protein,E3 ubiquitin-protein ligase,and pyrophosphate-energized vacuolar membrane proton ***,heterologous expression of NfcrtO in rice could significantly improve the tolerance of rice to osmotic stress,potentially facilitating the development of new rice varieties.

关键词： antioxidant enzyme β-carotene ketolase drought resistance Nostoc flagelliforme osmotic stress rice transcriptome analysis

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Partially substituting alfalfa hay with hemp forage in the diet of goats improved feed efficiency, ruminal fermentation pattern and microbial profiles

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Animal Nutrition 2024年第2期17卷 49-60页

作者： Tao Ran Zhipeng Xu Wenzhu Yang Dalin Liu Duanqin Wu College of Pastoral agriculture Science and Technology Lanzhou University State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems Changshu Center for Animal Disease Prevention and Control Lethbridge research and Development Centre Agriculture and Agri-Food Canada College of Animal Science and Technology Yangzhou University institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences

The use of hemp as a forage source in livestock diets has been less studied because bioactive residues in animal tissues may pose a risk to consumers. This study investigated the effects of partial substitution of alfalfa hay(AH) with hemp forage(HF) in growing goat diets on growth performance, carcass traits, ruminal fermentation characteristics, rumen microbial communities, blood biochemistry, and antioxidant *** Xiangdong black goats with body weight(BW) 7.82 ± 0.57 kg(mean ± SD) were grouped by BW and randomly assigned into one of the four treatment diets(n = 10/treatment) in a completely randomized design. The goats were fed ad libitum total mixed rations containing 60% forage and 40% concentrate(DM basis). The diets included control(CON; 60% AH and 40% concentrate), 55% AH and 5% HF(HF5), 50% AH and10% HF(HF10), and 40% AH and 20% HF(HF20). Increasing the substitution of HF for AH linearly decreased(P = 0.004) DM intake and improved feed conversion efficiency. However, final BW, average daily gain,carcass traits, meat quality, and most blood biochemistry indices did not differ among treatments. The ruminal NH3-N concentration(P = 0.003) and blood urine nitrogen(P = 0.050) linearly increased(P < 0.01)with increasing substitution rate of HF, whereas the total volatile fatty acids concentration quadratically changed(P = 0.007). Substitution of AH with HF had no effect on the diversity and richness of ruminal microbes, though it linearly decreased(P = 0.040) Prevotella＿1 and linearly increased(P = 0.017) Rikenellaceae＿RC9＿gut＿group. The cannabinoids and/or their metabolites were detected in both ruminal filtrates(8) and plasma(4), however, no detectable cannabinoid-related residues were observed in *** results indicate that the HF could be used to partially substitute AH in goat diets, whereas the effects vary between substitution rates of HF for AH. Although no cannabinoid-related residues were detected in meat, the presence of cannabinoids resid

关键词： Alfalfa hay Hemp forage Growth performance Ruminal microbiota Cannabinoid metabolism Goat

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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan Ling Na Wang John Shi Wei-Chun Pan Qi-Zhen Du Jun-Feng Yin Tea research institute Chinese academy of agricultural sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of agriculture College of food and Health sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph food research Center， agriculture and agri-food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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