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Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang Ting Fei Xiong-Hua Xiang Quan Wang En-Cheng Zhou Department of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina ambulatory Surgery center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach combined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatment of inguinal *** A total of 152 SIL-TPP surgeries were performed at the First Affiliated Hospital of Ningbo University from February 2019 to November 2022.A single-port,named Iconport,and standard laparoscopic instruments were used during the *** data,intraoperative parameters and short-term postoperative outcomes were collected and retrospectively *** The demographic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from 21 to 81 years).The average body mass index was 27.7 kg/m^(2)(range from 17.7 kg/m^(2) to 35.6 kg/m^(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdominal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** mean operative time was 64.5 minutes(range:36.0-110.0 minutes)for unilateral direct and femoral hernias and 81.6 minutes for indirect hernias(range:40.0-150.0 minutes).The mean postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdominal wall ***,doctors should be encouraged to actively apply the TPP approach combined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

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Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin Wang Min Yang Wei Xiong Quan Wang Bobo Zheng Yang Bai Kaiyong Zou Jibin Li Jiansong Ren Wanqing Chen Jingbo Zhai Jiang Li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China ambulatory Surgery center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of Clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health ***-screening services that can reduce cancer mortality are strongly ***,the specific role of COVID-19 in cancer screening is not fully *** study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next *** searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,*** studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were *** methodological quality of the included studies was assessed using the Newcastle-Ottawa *** in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this *** screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,p<0.01),cervical cancer(Pooled IRR=0.56,95%CI:0.47 to 0.67,p<0.01),breast cancer(Pooled IRR=0.57,95%CI:0.49 to 0.66,p<0.01)and prostate cancer(Pooled IRR=0.71,95%CI:0.56 to 0.90,p<0.01)during the COVID-19 pandemic were significantly lower than those before the COVID-19 *** screening rates of lung cancer(Pooled IRR=0.77,95%CI:0.58 to 1.03,p=0.08)and colorectal cancer using noninvasive screening methods(Pooled IRR=0.74,95%CI:0.50 to 1.09,p=0.13)were reduced with no statistical *** subgroup analyses revealed that the reduction in cancer-screening rates varied across *** results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer *** innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare fo

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

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Trends in oxycodone and oxycodone-containing analgesics administration for back pain in emergency departments in the USA(2007–2018)

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World Journal of Emergency Medicine 2024年第3期15卷 169-174页

作者： Jonathan Chabon Jemer Garrido Deanna Schreiber-Gregory Jefferson Drapkin Sergey Motov Department of Emergency Medicine Maimonides Medical CenterBrooklyn 11219USA

BACKGROUND:To describe trends in oxycodone and oxycodone-containing analgesic prescribing for the treatment of back pain among adults in emergency departments(EDs) in the USA from 2007 to ***:Data were gathered from the National Hospital ambulatory Medical care Survey(NHAMCS) from 2007 to *** study population included individuals of all ages presenting to USA *** NHAMCS reasons for visit and oxycodone drug ID codes were used to isolate patients with back *** main outcome was the proportion of oxycodone and oxycodone-containing analgesics prescribed for back pain in the EDs over the specified time ***:There was a relative decrease in the overall administration of oxycodone for back pain in the EDs by 62.3% from 2007(244,000 visits) to 2018(92,000 visits).The proportion of ED patients prescribed with oxycodone-containing analgesics for back pain increased among patients aged 45 years and older(from 43.8% to 57.6%),female patients(from 54.5% to 62.0%),black patients(from 22.5% to 30.4%),and Hispanic/Latino patients(from 9.4% to 19.6%).Oxycodone/acetaminophen was most prescribed and accounted for 90.2% of all oxycodone-containing analgesics in 2007,with a decrease to 68.5% in *** oxycodone was the second most prescribed medication,accounting for 6.1% in 2007 and 31.5% in ***:The overall number of oxycodone-containing analgesics decreased significantly from 2007 to ***,that number trended upward in 45-year-old and older,female,black,or Hispanic/Latino patients from 2007 to *** total amount of pure oxycodone increased significantly from 2007 to 2008.

关键词： Oxycodone Back pain Emergency department

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Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

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Cancer Biology & Medicine 2014年第1期11卷 1-19页

作者： Liem Minh Phan Sai-Ching Jim Yeung Mong-Hong Lee Department of Molecular and Cellular Oncology Department of General Internal Medicine Ambulatory Treatment and Emergency Care Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer Center

Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warhurg＇s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.

关键词： Cell cycle energy metabolism glycolysis glutaminolysis mitochondria biogenesis

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A 3-dimensional transoesophageal echocardiography perspective of mitral valve abscess

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Journal of Geriatric Cardiology 2020年第2期17卷 124-124页

作者： Pujan Patel Shreya Ghetiya Emil Missov Srinivasan Sattiraju Division of Cardiology Department of Internal MedicineUniversity of FloridaAmbulatory Care Center

An 85-year-old female with history of dementia presented with concern for severe sepsis and was found to have methicillin sensitive staphylococcus aureus bacteremia complicated by atrial *** further workup,a transoesophageal echocardiography(TOE)was *** study revealed a large echogenic density with multiple echolucent areas within the *** was evidence of blood flow in these echolucent areas based on color flow *** mass was intermittently protruding into the left ventricle causing a function mitral *** collective findings on echocardiography,in context of bacteremia,were highly suggestive of mitral valve abscess(Figure 1).

关键词： Endocarditis Three dimensional transoesophageal echocardiography Valvular abscess

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Incidence and Factors Associated with the Switch to the Second Line Antiretroviral Treatment at the ambulatory Treatment center (CTA) in Dakar

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Health 2016年第14期8卷 1566-1575页

作者： Ndeye Fatou Ngom-Gueye Gilbert Batista Abdoul Aziz Ndiaye Assane Diouf KA. Daye Alioune Badara Tall Awa Diouf Kine Ndiaye Makhtar Ndiaga Diop Mountaga Dia Cheikh Tacko Diop Awa Gaye Cheikh Tidiane Ndour Moussa Seydi Lamine Gueye Bernard Marcel Diop Papa Salif Sow ambulatory Treatment center Fann University Teaching Hospital Dakar Senegal Department of Community Health Alioune Diop University Bambey Senegal Department of Infectious Diseases Fann University Teaching Hospital Dakar Senegal

Introduction: Over the past years, efforts have been made to expand access to antiretroviral combinations (cART) in low-income countries. However, major concerns are noted with drug resistance emergence, as treatment failure result and need to introduce a second line treatment, more expensive and difficult to implement. The objective was to study the incidence of switch to second line, reasons for switch and risk factors using a cohort of people living with HIV in an ambulatory Treatment center in Dakar. Methodology: This was a cohort study of people living with HIV under cART from January 2004 to December 2013. Naive patients monitored for at least six months, regardless of their profile and regimen with baseline CD4 counts Results: The median age of the 827 patients included was 44 [IQR = 18 - 78]. The switch to second-line treatment was observed in 72 patients (8.7%) after an average of 38.5 months of follow-up. The overall incidence rate of switch to second line of antiretroviral treatment was 1.59 per 100 persons-years. Most of changes in first-line treatment were motivated by virological failures (n = 60, 83.3%) under treatment with AZT/3TC/NVP (n = 25, 34.7%) or AZT/3TC/EFV21 (29.2%). 9.7% of switch occurred after immunological failure, 1.4% after clinical failure, 4.2% after severe toxicity and 1.4% was not documented. Predictive factors identifying failures at the end of the multivariate analysis were age Conclusions: In total, CTA identified a low incidence rate of treatment failure of the first line of treatment. Associated risk factors were age 3 and high viral load at treatment initiation.

关键词： Incidence Associated Factors Switch to 2nd Line cART CTA Dakar

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Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the ambulatory Treatment center (CTA) of Fann National University Hospital in Dakar

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Health 2017年第4期9卷 727-737页

作者： Ndeye Fatou Ngom Gueye Daye Ka Alioune Badara Tall Kine Ndiaye Abdoul Aziz Ndiaye Viviane Marie Pierre Cisse Aissata Guindo Ndeye Méry Dia Badiane Sylvie Audrey Diop Noel Magloire Manga Cheikh Tidiane Ndour Moussa Seydi ambulatory Treatment center Fann University Teaching Hospital Dakar Senegal Department of Infectious Diseases Fann University Teaching Hospital Dakar Senegal Department of Community Health Alioune Diop University Bambey Senegal

Introduction: The efficacy of antiretroviral therapy in people living with HIV (PLHIV) has been associated with an important increase in metabolic disorders, such as hypertension (HTA). This work allowed us to estimate the prevalence of hypertension in PLHIV and to describe associated factors. Methods: A retrospective, descriptive and analytical study was carried out based on the records of people living with HIV followed at the ambulatory Treatment center (CTA), from January 1st 1998 to 31st, December 2014. The WHO criteria were used to diagnose hypertension. Data entry was performed using ESOPE software and data analysis was done using Epi Info software version 3.5.3. A multiple logistic regression was used to identify the risk factors associated with hypertension. Results: During the study period, 3624 patients followed at CTA were included of which 1184 patients (32.7%) had hypertension. The average age was 47. 3 years ±10.5 years, with a sex ratio of 0.7. The most common opportunistic infections at diagnosis were tuberculosis (14.9%) and oral candidiasis (15.3%). The HIV infection was advanced (stage 3 or 4 of WHO classification) for 39% of cases. Overweight and obesity was found in 19.1%. Only 17.6% were treated by protease inhibitors. Higher average age (OR:1,05;IC [1.04 - 1.05], p = 0.000001), higher average BMI (OR:5,3;IC [3.3 - 8.5], p = 0.00001), WHO clinical stage I-II (OR:1,4;IC [1.2 - 1.6], p = 0.00003), and ARV treatment (OR:2,5;IC [1.7 - 3.7], p = 0.000001) are associated with the occurrence of hypertension. Conclusion: The prevalence of hypertension was high among PLHIV and associated factors were: advanced age, high BMI, WHO clinical stages I and II and antiretroviral therapy. Hence, the interest of a systematic screening of hypertension and others cardiovascular risk factors particularly in patients under ARV antiretroviral therapy.

关键词： Hypertension (HTA) HIV Infection Senegal

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Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded,multicenter study

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World Journal of Pediatrics 2017年第1期13卷 27-33页

作者： Herman Avner Cohen Moshe Hoshen Shmuel Gur Arie Bahir Yoseph Laks Hannah Blau Pediatric ambulatory Community Clinic Petah—TikvaIsrael Sackler Faculty of Medicine Tel.Aviv UniversityTel—AvivIsrael Clalit Research Institute Chief Physician's OfficeClalit Health ServicesTel AvivIsrael Pediatric ambulatory Community Clinic Kefar SabaIsrael Pediatric ambulatory Community Clinic Bat YamIsrael Pediatric ambulatory Community Clinic Ramat Aviv.Israel Pulmonary Institute Schneider Children Medical Center ofIsrael.Petah Tikva.Israel.

Background:Available pediatric treatments for acute cough are limited by lack of demonstrated *** objective of this trial is to compare the effects of a poIysaccharide—resin-honey based cough syrup,and carbocysteine ... 详细信息

关键词： cough children upper respiratory tract infection

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Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice

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BIOCELL 2023年第2期47卷 393-400页

作者： YAO LU QIUYUE WANG CAIHUI ZHANG Department of Anesthesiology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China ambulatory Surgery center The First Affiliated Hospital of Anhui Medical UniversityHefei230022China

Myocardial fibrosis is an important manifestation of diabetic *** study investigated the potential mechanism of diabetic myocardial *** C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic(DB)and control *** 20 weeks,the mouse heart was harvested and subjected to hematoxylin-eosin staining(HE)and Masson staining to investigate the degree of *** expressions of transforming growth factor-beta 1(TGF-β1),collagen-III,B-cell lymphoma-2(Bcl2),Bcl2-associated X protein(Bax),cleaved gasdermin D(GSDMD),cysteinyl aspartate specific proteinase-1(caspase-1),apoptosis-associated speck-like protein containing a CARD(ASC),and nucleotide-binding oligomerization domain(NOD)-like receptor 3(NLRP3)were measured by western *** and TdT-mediated dUTP nick end labeling(TUNEL)staining were performed to analyze the development of apoptosis and pyroptosis.A significant increase in body weight and blood glucose in the DB group was *** pathological injury,fibrosis,apoptosis,and pyroptosis were more obvious and serious in the DB *** expression of anti-apoptotic Bcl2 significantly decreased,while the expression levels of pro-apoptotic Bax,caspase-3,and pyroptosis-related proteins,such as cleaved GSDMD,and caspase-1 in the DB group were significantly *** and apoptosis were probably the main mechanisms that caused myocardial fibrosis in mice with diabetes.

关键词： Pyroptosis Apoptosis Fibrosis Diabetes Diabetic cardiomyopathy

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Better renal replacement therapy to improve sexual function in female patients with end-stage renal disease:A cross-sectional study

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Current Urology 2024年第3期18卷 232-236页

作者： Tjahjodjati Tjahjodjati Steven Steven Urology Department Hasan Sadikin Academic Medical CenterUniversitas PadjadjaranBandungIndonesia

Background Sexual dysfunction is commonly observed in patients with end-stage renal disease(ESRD).Sexual dysfunction in correlation with ESRD is associated with physiological and psychological problems resulting in low sexual desire,arousal,difficulties in achieving orgasm,and pain during *** on female sexual dysfunction(FSD)in correlation with renal replacement therapy are limited,and previous studies reporting contradictive results have indicated that the best modality for providing better outcomes(especially on FSD)remains ***,this study aimed to compare the sexual function between female patients with ESRD who were on continuous ambulatory peritoneal dialysis(CAPD)and those on hemodialysis(HD).Materials and methods This study enrolled female patients who were randomly selected from the urology and renal division of the Internal Medicine Outpatient Clinic of our hospital from January 2020 to August 2021 and divided into the following groups:predialysis,HD,CAPD,and control *** participants were asked to fill out the Female Sexual Function Index(FSFI)questionnaires,and their data were recorded and analyzed using GraphPad Prism *** Of the 280 patients,200 female patients were included in this *** rate of FSD(cutoff:26.55)was 42%in the control group,72%in the predialysis group,62%in the CAPD group,and 66%the in HD *** control group had a higher mean score in all parameters(p0.05)between the patients on HD and those on CAPD;the mean of each point was almost identical except for satisfaction,which was higher among patients on CAPD(p<0.05).Significant differences in the components of desire,arousal,orgasm,and satisfaction were observed between the *** Patients on CAPD had better FSFI scores than the female patients with ESRD who were on HD,and the scores of both groups of patients were better than those of the predialysis group.

关键词： Female sexual dysfunction Chronic kidney disease Continuous ambulatory peritoneal dialysis Hemodialysis

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