Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

作     者：Liem Minh Phan Sai-Ching Jim Yeung Mong-Hong Lee 

作者机构：Department of Molecular and Cellular Oncology Department of General Internal Medicine Ambulatory Treatment and Emergency Care Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer Center 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2014年第11卷第1期

页      面：1-19页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Institutes of Health through The University of Texas MD Anderson Cancer Center’s Support Grant CA016672 National Cancer Institute grant RO1CA 089266 (MHL) Directed Medical Research Programs Department of Defense Synergistic Idea Development Award BC062166 (SCY, MHL) the Susan G.Komen Breast Cancer Research Foundation Promise Grant KG081048 (SCY, MHL) Vietnam Education Foundation, Rosalie B.Hite Foundation Department of Defense Breast Cancer Research Program (Award # W81XWH-10-0171) 

主　　题：物质代谢 癌症患者 重编程 抗肿瘤治疗 疗法 抗癌 瞄准 肿瘤细胞 

摘      要：Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.