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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Variability in permeability and integrity of cell membrane and depletion of food reserves in neem(Azadirachta indica) seeds from trees of different age classes

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Journal of Forestry Research 2014年第1期25卷 147-153页

作者： evendra Kumar Dhruv Kumar Mishra seed Testing Laboratory Silviculture DivisionArid Forest Research Institute

We quantified cell membrane permeability （electrical conduc-tivity-EC, water soluble sugar-WSS, and amino acids-AA） and integrity （phospholipids,α-tocopherol and lipid peroxidation） along with food reserve deterioration （total proteins, total sugar, and total starch） of neem seeds collected from various mother tree age classes and stored for 65 days in airtight plastic containers at ambient room temperature （35±5°C）. Results show that the activities were higher in fresh seeds （EC 267.56-2950.01 μS/g, WSS 19.96-19.48 mg/g and AA 5.40-5.35 mg/g） and declined with increasing duration of storage period （EC 153.37-195.17 μS/g, WSS 3.13-4.17 mg/g and AA 4.29-4.49 mg/g after 35 days and EC 144.02-161.56 μS/g, WSS 2.06-2.40 mg/g and AA 3.98-4.27 mg/g after 65 days of storage）. Phospholipids andα-tocopherol were higher in fresh seed （0.073-0.093 OD at 710 nm and 0.080-0.105 OD, respectively） and declined as storage duration in-creased （0.033-0.042 OD at 710 nm and 00.0010-0.0020 OD, respec-tively）. Dead seeds showed reduced amounts of phospholipids and minimum activity ofα- tocopherol （antioxidants）. The level of MDA was lower in fresh seeds （0.0066-0.0087 OD at 600-535 nm） and increased as storage duration increased （0.0248-0.0268 OD after 65 days of stor-age）. The higher amount of MDA indicated that seeds died due to rancid-ity of the oil inside the seed. Neem seed cake was assessed for deteriora-tion of food reserves （total proteins, total sugar, and total starch）, concen-trations of which were higher in fresh seed and declined as storage dura-tion increased. Germination was higher in fresh seeds and after 65 days, no germination was received perhaps due to deterioration of biochemi-cals in seeds. Patterns of seed deterioration were similar across all seed lots.

关键词： phospholipids α-Tocopherol Lipid peroxidation Azadirachta indica

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Variability in cone,seed and seedling characteristics of Pinus kesiya Royle ***

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Journal of Forestry Research 2015年第2期26卷 331-337页

作者： Ombir Singh Satyam Bordoloi N.Mahanta Forest Tree seed Laboratory Silviculture DivisionForest Research Institute Biotechnology and Genetics division Rain Forest Research Institute

Investigations were made to determine the nature and extent of variations present for 10 morphological characters of cone,seed and seedlings of 17 plus trees（PTs）of Pinus kesiya growing in eastern Himalayas（Meghalaya state） of *** significant variations has been observed in cone weight,cone length,cone diameter,seed length,seed diameter,seed weight,number of seeds per cone,seed germination,seedling height and seedling collar diameter among different PTs of the *** positive correlation（p ／ 0.01） between seed weight,cone length and cone diameter showed that seed weight in *** depend more on the cone *** germination is found positively correlated（p ／ 0.01） with seed weight,seed diameter,cone size and number of seeds per cone in the *** geographical factors,latitude and altitude are found positively correlated（p ／ 0.05） with cone weight and seed diameter,*** genetic parameters for seed,cone and seedlings of PTs of *** also showed a wide range of variability in terms of variance,coefficient of variability,broad sense heritability,genetic advance and genetic *** weight,seeds per cone and seedling diameter showed high heritability values（[75） coupled with maximum genetic *** with such values indicate the presence of good amount of heritable additive components and are under strong genetic *** findings of the study revealed that PTs expressed both phenotypic and genotypic differences in the seed,cone and seedling characters,which may be attributed to the differences in genetic makeup of various PTs and environmental factors *** and environmental *** presence of high variability in *** PTs for different characters provide further opportunities to improve the population in subsequent generations so as to establish this species as an important timber tree to be grown on less fertile and degraded soils in its distributional ranges.

关键词： Plus trees seed traits Heritability Genetic gain Improvement

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Variability and divergence in horsegram (Dolichos uniflorus)

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Journal of Arid Land 2012年第1期4卷 71-76页

作者： Kanaka K DURGA seed Research & technology Centre RajendranagarHyderabadAPIndia

Horsegram is an important and unexploited tropic and sub-tropic legume crop grown mostly in dry land agriculture. The study involving 23 cultivars of horsegram （Dolichos uniflorus） was conducted at the seed Research ＆ technology Centre in Rajendranagar, Hyderabad, India during the early spring seasons of 2008 and 2009 to assess the nature and magnitude of variability in the existing species and also to identify diverse parents for use in further breeding programmes. The results indicated significant differences among the 23 cultivars for all characters studied, indicating the presence of sufficient genetic variation. High variability and heritability coupled with high genetic advance were reported for seed yield per plant and pod hulm per plant, indicating additive gene action and a possible scope for the improvement of these characters. Mahalanobis D2 statistics grouped all the 23 cultivars of horsegram into six ,clusters. The maximum inter cluster distance （62.39） was noticed between cluster IV （HG 50） and cluster V （HG 11）. The maximum Jntra cluster distance ranged from 0 （clusters III, IV, V and VI） to 15.17 （cluster I）, indicating that the genotypes in these clusters were relatively more diverse than the genotypes within other clusters. seed yield per plant contributed the maximum （33.20%） to the genetic divergence.

关键词： horsegram Dolichos uniflorus variability divergence genotype yield components seed quality parameters

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Screening and characterization of extracelluar L-asparaginase producing Bacillus subtilis strain hswx88,isolated from Taptapani hotspring of odisha,India

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Asian Pacific Journal of Tropical Biomedicine 2013年第12期3卷 936-941页

作者： Biswaprakash Pradhan Sashi K Dash Sabuj Sahoo Pharmaceutical Biotechnology division University Department of Pharmaceutical SciencesUtkal University Department of seed technology Orissa University of Agriculture and Technology

Objective:To screen and isolate an eco-friendly,u thermophilic and potent L-asparaginase producing bacterium,with novel immunological properties that may obviates hypersensitivity ***:In the present study baclerial strain isolated for extracellular L-asparaginase production from hotspring,identified by morphological,biochemical and physiological tests followed by t6S rDNA technology and the L-asparaginase production ability was tested by both semi quantitative and quantitative enzymatic ***:The bacterial strain was identified as Bacillus sublilis strain hswx88(GenBank Accession Number JQ237656.1).The extracellular enzyme yielding capacity isolate Bacillus subtilis strain hswx88(23.8 IU/mL)was found to be 1.7 and 14.5 limes higher than the reference organism Pectobacterium carotovorum MTCC 1428(14.2 IU/mL)and Bacillus *** 034(1.64 IU/mL).Conclusion:The isolate is eco-friendly and useful to produce bulk quantity of extracellular,thermophilic L-asparaginase for the treatment of various tumor cases and for preparation of acrylamide free fry food preparation.

关键词： L-asparaginase Thermophilic bacteria Bacillus subtilis strain hswx88 16S rDNA

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Variability in seed traits and genetic divergence in a clonal seed orchard of Dalbergia sissoo Roxb.

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Journal of Forestry Research 2012年第1期23卷 109-114页

作者： Ombir singh Altaf Hussain Sofi Forest Tree seed Laboratory Silviculture DivisionForest Research InstituteDehradun-248006India

The variations in seed and pod traits, genetic superiority and genetic divergence were evaluated for a Clonal seed Orchard （CSO） of Dalbergia sissoo Roxb. at Bithmera, India consisting of 20 clones from different agro-climatic conditions of four northern states （Uttar Pradesh, Uttarakhand, Haryana and Rajasthan）. The seeds and pods of various clones in the orchard exhibited significant variability in size, weight and other characters. Significant positive correlations were observed between seed length and seed width （p〈0.05）, seed length and sccd thickness （p〈0.01）, seed length and seed weight （p〈0.01）, seed thickness and seed weight （p〈0.01）, seed length and germination value （p〈0.05）. The ge- netic parameters for seed and pod traits also showed a wide range of variations in the orchard. Heritability values were found to be over 50 percent for most of ~e seed and pod traits. seed weight, seed length and seed thickness showed high heritability values coupled with maximum genetic gain for these characters. Ward＇s minimum variance dendrogram of clones of D. sissoo showed three distinct clusters; cluster I was the largest with 12 better clones whereas cluster 2 and 3 consisting of seven moderate clones and one poor clone, respectively. Mean cluster values showed sufficient variation among the clusters for seed weight, germina- tion value and seed length. The possible hybridization between best clones of cluster I to the disease resistant clone of cluster 2 （resistant against deadly Gandoderma lucidum root rot disease of D. sissoo） is also suggested for further breeding programmes of the species. The deploy- ment of clone 194 （better performed and disease resistant） is also rec- ommended in future plantation programmes of D. sissoo in northern India.

关键词： clones Dalbergia sissoo divergence seed traits variability

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