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Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?

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World Journal of Gastroenterology 2016年第11期22卷 3202-3211页

作者： Alfredo Di Leo Gabriella Nesi Mariabeatrice Principi Domenico Piscitelli Bruna Girardi Maria Pricci Giuseppe Losurdo Andrea Iannone Enzo Ierardi Francesco Tonelli Gastroenterology section Department of Emergency and Organ TransplantationUniversity of Bari Pathology section Department of Surgery and Translational MedicineUniversity of Florence Pathology section Department of Emergency and Organ TransplantationUniversity of Bari General surgery section Department of Surgery and Translational MedicineUniversity of Florence

AIM: To investigate estrogen receptors expression in duodenal familial adenomatous polyposis (FAP) and any relationship with epithelial proliferation/apoptosis ***: Twenty-two patients affected by FAP undergoing duodenal resection for malignancies were recruited. Controls were 15 healthy subjects undergoing endoscopy for dyspeptic symptoms. ER-α, ER-α, Ki-67, TUNEL and caspase 3 expression (labeling index: percentage of positive cells) were evaluated by immunohistochemistry or immunofluorescence and examined by light or confocal microscopy. Samples were assigned to four groups: normal tissue, low (LGD) and high-grade dysplasia (HGD), adenocarcinoma (AC). One-way analysis of variance, corrected by Bonferroni’s test, and Pearson’s correlation test were applied for statistical ***: ER-beta showed a progressive decline: normal tissue (23.5 ± 4.9), LGD (21.1 ± 4.8), HGD (9.3 ± 3.5), AC (7.1 ± 3.1). The normal tissue of FAP subjects expressed ER-beta like the controls (23.9 ± 6.2). Conversely, ER-α showed a progressive increase from normal tissue (24.8 ± 5.6) to AC (52.0 ± 8.2); the expression in normal tissue was similar to controls (22.5 ± 5.3). Ki67 demonstrated a statistically significant progressive increase at each disease stage up to AC. TUNEL did not reveal differences between controls and normal tissue of FAP subjects, but progressive decreases were observed in LGD, through HGD to AC. Pearson’s correlation test showed a direct relationship between ER-β and TUNEL LI (r = 0.8088, P < 0.0001). Conversely, ER-α was inversely correlated with TUNEL LI (r = - 0.7257, P < 0.0001). The co-expression of ER-β and caspase 3 declined progressively from normal to neoplastic ***: This study confirmed that ER-β is strongly decreased in duodenal FAP carcinomas, declining in a multiple

关键词： Familial adenomatous polyposis Duodenal cancer Estrogen receptors Immunohistochemistry Confocal microscopy Dysplasia

Current state of laparoscopic parastomal hernia repair:A meta-analysis

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World Journal of Gastroenterology 2015年第28期21卷 8670-8677页

作者： Francis J DeAsis Brittany Lapin Matthew E Gitelis Michael B Ujiki section of Minimally Invasive surgery Department of Surgery North Shore University Health System

AIM:To evaluate the efficacy and safety of the laparoscopic approaches for parastomal hernia repair reported in the ***:A systematic review of PubMed and MEDLINE databases was conducted using various combination of the following keywords:stoma repair,laparoscopic,parastomal,and *** reports,studies with less than 5 patients,and articles not written in English were *** studies were further scrutinized with the 2011 levels of evidence from the Oxford Centre for Evidence-Based *** authors reviewed and analyzed each *** there was any discrepancy between scores,the study in question was referred to another author.A meta-analysis was performed using both random and fixed-effect *** bias was evaluated using Begg's funnel plot and Egger's regression *** primary outcome analyzed was recurrence of parastomal *** outcomes were mesh infection,surgical site infection,obstruction requiring reoperation,death,and other *** were grouped by operative technique where *** for recurrence,most postoperative morbidities were reported for the overall cohort and not by approach so they were analyzed across ***:Fifteen articles with a total of 469 patients were deemed eligible for *** postoperative morbidities were reported for the overall cohort,and not by *** overall postoperative morbidity rate was 1.8%(95%CI:0.8-3.2),and there was no difference between *** most common postoperative complication was surgical site infection,which was seen in 3.8%(95%CI:2.3-5.7).Infected mesh was observed in 1.7%(95%CI:0.7-3.1),and obstruction requiring reoperation also occurred in 1.7%(95%CI:0.7-3.0).Other complications such as ileus,pneumonia,or urinary tract infection were noted in16.6%(95%CI:11.9-22.1).Eighty-one recurrences were reported overall for a recurrence rate of 17.4%(95%CI:9.5-26.9).The recurrence rate was 10.2%(95%CI:3.9-19.0) for the modif

关键词： Parastomal Hernia Laparoscopic Repair Treatment Sugarbaker Keyhole Sandwich Ileostomy Colostomy

Adhesive small bowel obstruction: How long can patients tolerate conservative treatment?

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World Journal of Gastroenterology 2003年第3期9卷 603-605页

作者： Shou-Chuan Shih Kuo-Shyang Jeng Shee-Chan Lin Chin-Roa Kao Sun-Yen Chou Horng-Yuan Wang Wen-Hsiung Chang Cheng-Hsin Chu Tsang-En Wang General surgery section Department of SurgeryMackay Memorial HospitalTaipeiTaiwan China Mackay Junior School of NursingTaipeiTaiwanChina General surgery section Department of SurgeryMackay Memorial HospitalTaipeiTaiwan China Gastroenterology section Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwan

AIM: To evaluate how long patients with small bowel obstruction caused by postoperative adhesions can tolerate conservative ***: The records of patients with small bowel obstruction due to postoperative adhesions were retrospectively reviewed. Data collected included the number of admissions, type of management for each admission,duration of conservative treatment, number of repeat laparotomies, and operative ***: One hundred fifty-five patients with this condition from January 1999 to December 2001, for a total of 293 admissions were enrolled in this study. Medical treatment alone was given in 220 admissions, and repeat laparotomy was performed in 73 admissions. The period of observation in patients managed medically ranged from 2 to 12 days (average: 6.9 days), while for those who underwent surgery,the range was 1 to 14 days (average 5.4 days). At surgery,adhesions were the only finding in 46 cases, while there were intestinal complications in 27, or 9.2 % of all 293admissions. Fever and leukocytosis greater than 15 000/mm3were prediction of intestinal ***: With closely monitoring, most patients with small bowel obstruction due to postoperative adhesions could tolerate supportive treatment and recover well averagely within 1 week, although some patients require more than 10 days of observation.

关键词：粘连性小肠梗阻保守疗法耐受性术后并发症临床研究

Extraordinary sneeze:Spontaneous transmaxillarytransnasal discharge of a migrated dental implant

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World Journal of Clinical Cases 2016年第8期4卷 229-232页

作者： Pasquale Procacci Daniele De Santis Dario Bertossi Massimo Albanese Cristina Plotegher Giovanni Zanette Alessia Pardo Pier Francesco Nocini section of Oral and Maxillofacial surgery Department of Surgery University of Verona

This case report describes an extraordinary case of the spontaneous transmaxillary-transnasal discharge of a dental implant, which occurred during a sneeze. The patient was complained of symptoms of acute sinusitis. She underwent a computed tomography scan that revealed a dental implant dislocated in the maxillary sinus. Medical treatment based on antibiotics and mucolytics was administered to the patient in order to prepare her for endoscopic endonasal surgery. The implant was spontaneously discharged two days after during a sneeze. Mucociliary clearance in combination with a local osteolytic inflammatory process and mucolytics therapy are the likely causes of this unusual discharge.

关键词： Complications Dental implant Acute sinusitis Implant surgery

Definitive palliation for neoplastic colonic obstruction using enteral stents:Personal case-series with literature review

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World Journal of Gastroenterology 2004年第5期10卷 758-764页

作者： Giuseppe Piccinni Anna Angrisano Mario Testini G.Martino Bonomo section of General surgery Vascular Surgery and Clinical OncologyDepartment of Applications in Surgery of Innovative TechnologiesUniversity of Bari-School of Medicine-BariItaly

Acute colonic obstruction due to malignancies is an emergency that requires surgical *** patients or inoperable tumors require intestinal decompression that is a simple colostomy in almost all ***“manoeuvre” leads the patient to a percentage of moRality/morbidity and to a bad quality of life due to acceptance of *** introduction of enteral metal stent inserted endoscopically has,in our opinion,provided a new way to obtaining the definitive palliation of inoperable colo-rectal cancer with a simple *** reported our case-series and we analyzed the current literature and costs of treatments.

关键词： Stents Aged Aged, 80 and over Colonic Neoplasms Endoscopy Female Humans Intestinal Obstruction Male Palliative Care

Telomeres,telomerase and colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 1940-1950页

作者： Roberta Bertorelle Enrica Rampazzo Salvatore Pucciarelli Donato Nitti Anita De Rossi Department of surgery Oncology and GastroenterologySection of Oncology and ImmunologyUniversity of PadovaIOV-IRCCS35128 PadovaItaly Department of surgery Oncology and GastroenterologySection of SurgeryUniversity of Padova35128 PadovaItaly

Colorectal cancer(CRC)is the third most common cancer worldwide and,despite improved treatments,is still an important cause of cancer-related *** encompasses a complex of diseases arising from a multistep process of genetic and epigenetic *** heterogeneity in the molecular and biological features of CRC,chromosomal instability is a hallmark of cancer and cancer cells may also circumvent replicative senescence and acquire the ability to sustain unlimited ***/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential,and its dysfunction plays a key role in the oncogenetic *** erosion of telomeres,mainly because of cell proliferation,may be accelerated by specific alterations in the genes involved in CRC,such as APC and *** there is general agreement that the shortening of telomeres plays a role in the early steps of CRC carcinogenesis by promoting chromosomal instability,the prognostic role of telomere length in CRC is still under *** activation of telomerase reverse transcriptase(TERT),the catalytic component of the telomerase complex,allows cancer cells to grow indefinitely by maintaining the length of the telomeres,thus favouring tumour formation/*** studies indicate that TERT increases with disease progression,and most studies suggest that telomerase is a useful prognostic *** TERT mRNA may also be a promising marker for the minimally invasive monitoring of disease progression and response to therapy.

关键词： Telomere Telomerase Telomerase reverse transcriptase Colorectal cancer Prognostic marker

Cytokines,synaptic plasticity and network dynamics:a matter of balance

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Neural Regeneration Research 2023年第12期18卷 2569-2572页

作者： Laura Bellingacci Jacopo Canonichesi Andrea Mancini Lucilla Parnetti Massimiliano Di Filippo section of Neurology Department of Medicine and SurgeryUniversity of PerugiaPerugiaItaly

The modern view of the immune system as a sensitizing and modulating machinery of the central nervous system is now well ***,the specific mechanisms underlying this fine crosstalk have yet to be fully *** control cognitive function and behavior,the two systems are engaged in a subtle interacting *** this scenario,a dual action of pro-inflammatory cytokines in the modulation of brain network connections is ***-inflammatory cytokines are indeed required to express physiological plasticity in the hippocampal network while being detrimental when over-expressed during uncontrolled inflammatory *** this dynamic equilibrium,synaptic functioning and the performance of neural networks are ensured by maintaining an appropriate balance between pro-and anti-inflammatory molecules in the central nervous system microenvironment.

关键词： brain networks cognition cytokines hippocampus memory neuroimmunology neuroinflammation synaptic plasticity

Notes for developing a molecular test for the full characterization of circulating tumor cells

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Chinese Journal of Cancer Research 2015年第5期27卷 471-478页

作者： Elisabetta Rossi Antonella Facchinetti Rita Zamarchi Department of surgery Oncology and GastroenterologyOncology SectionUniversity of Padova IOV-IRCCS

The proved association between the circulating tumor cell （CTC） levels and the patients＇ survival parameters has been growing interest to investigate the molecular profile of these neoplastic cells among which hide out precursors capable of initiating a new distant metastatic lesion. The full characterization of the tumor cells in peripheral blood of cancer patients is expected to be of help for understanding and （prospectively） for counteracting the metastatic process. The major hitch that is hampering the successful gaining of this result is the lack of a consensus onto standard operating procedures （SOPs） for performing what we generally define as the ＂liquid biopsy＂. Here we review the more recent acquisitions in the analysis of CTCs and tumor related nucleic acids, looking to the main open questions that are hampering their definitive employ in the routine clinical practice.

关键词： Circulating tumor cells (CTCs) single-cell analysis liquid biopsy

Rectal biopsy for Hirschsprung's disease:a review of techniques,pathology,and complications

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World Journal of Pediatrics 2016年第2期12卷 135-141页

作者： Eleanor Dorothy Muise Robert Anthony Cowles section of Pediatric surgery Department of SurgeryYale University School of MedicineNew HavenCTUSA

Background:Hirschsprung's disease(HD)is one of the most common congenital anomalies of colorectal function,affecting approximately 1 in 5000 live births,with a 4:1 male *** is characterized by aganglionosis that is most often limited to the rectosigmoid,but can extend proximally along the colon and,in rare instances,reach into the small intestine.A clinical history of delayed passage of meconium beyond 48 hours after birth,physical exam findings of abdominal distention and vomiting,and a contrast enema demonstrating a transition zone are highly suggestive of *** sources:We searched databases including PubMed,Google Scholar,and Scopus for the following key words:Hirschsprung's disease,rectal biopsy,pathology,ganglion cell,nerve trunk hypertrophy,pediatric constipation,and selected publications written in English that were relevant to the scope of this ***:Based on the data presented in the literature,we reviewed 1)biopsy techniques for the diagnosis of Hirschsprung's disease,addressed inadequate biopsies,and complications from rectal biopsy,and 2)pathologic and histologic interpretation of biopsy specimens for the diagnosis of Hirschsprung's ***:A well-executed rectal biopsy with expert pathologic evaluation of the specimen remains the gold standard for the diagnosis of Hirschsprung's disease and is the subject of this review.

关键词： ganglion cell Hirschsprung's disease nerve trunk hypertrophy pediatric constipation rectal biopsy