Telomeres,telomerase and colorectal cancer

作     者：Roberta Bertorelle Enrica Rampazzo Salvatore Pucciarelli Donato Nitti Anita De Rossi 

作者机构：Department of SurgeryOncology and GastroenterologySection of Oncology and ImmunologyUniversity of PadovaIOV-IRCCS35128 PadovaItaly Department of SurgeryOncology and GastroenterologySection of SurgeryUniversity of Padova35128 PadovaItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第8期

页      面：1940-1950页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by A grant from Cariparo Project"Tumour mi-croenvironment and tumour spread in gastrointestinal cancers" 2013/2014 No.6421 to Rampazzo E 

主　　题：Telomere Telomerase Telomerase reverse transcriptase Colorectal cancer Prognostic marker 

摘      要：Colorectal cancer(CRC)is the third most common cancer worldwide and,despite improved treatments,is still an important cause of cancer-related *** encompasses a complex of diseases arising from a multistep process of genetic and epigenetic *** heterogeneity in the molecular and biological features of CRC,chromosomal instability is a hallmark of cancer and cancer cells may also circumvent replicative senescence and acquire the ability to sustain unlimited ***/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential,and its dysfunction plays a key role in the oncogenetic *** erosion of telomeres,mainly because of cell proliferation,may be accelerated by specific alterations in the genes involved in CRC,such as APC and *** there is general agreement that the shortening of telomeres plays a role in the early steps of CRC carcinogenesis by promoting chromosomal instability,the prognostic role of telomere length in CRC is still under *** activation of telomerase reverse transcriptase(TERT),the catalytic component of the telomerase complex,allows cancer cells to grow indefinitely by maintaining the length of the telomeres,thus favouring tumour formation/*** studies indicate that TERT increases with disease progression,and most studies suggest that telomerase is a useful prognostic *** TERT mRNA may also be a promising marker for the minimally invasive monitoring of disease progression and response to therapy.