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Genes & Diseases 2023年第4期10卷 1161-1164页

作者： Yichun Yu Jiamin Zhong Connie Chen Yannian Gou Guozhi Zhao Piao Zhao Yonghui Wang Wei Zeng Annie Wang William D.Wagstaff Jr Rex C.Haydon Tong-Chuan He Russell R.Reid Michael J.Lee Hue H.Luu Jiaming Fan Emergency Department Beijing Hospitaland The National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100051China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the School of Laboratory Diagnostic MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Neurology The Second Affiliated Hospital of Jianghan UniversityWuhanHubei 430050China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

While progenitor cell-based cardiomyocyte regeneration holds great promise of repairing an injured heart,primary cardiomyogenic progenitors(CPs)have a limited life span in culture,hampering the use of CPs for in vitro and in vivo *** previously isolated primary CPs from mouse E15.5 fetal heart,and reversibly immortalized them with SV40 large T antigen(SV40 LTA),resulting in immortalized CPs(iCPs),which maintain long-term proliferation and ex-press cardiomyogenic markers and retain differentiation potential under appropriate differentiation conditions.

关键词： progenitor cardio potential

Principles of Nasal Reconstruction 2

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Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases

2011年

作者： Shan R. Baker

ISBN: (数字)9780387890289

ISBN: (纸本)9780387890272;9781493939039

Principles of Nasal Reconstruction, Second Edition, is a comprehensive, in-depth resource written by one of the world’s foremost practitioners of nasal reconstruction. This thoroughly revised and updated textbook discusses a wide range of basic and advanced nasal reconstructive procedures in patients presenting with a variety of partial and full thickness defects of the nose. Part One discusses the fundamentals of nasal reconstruction. It provides algorithms to assist the surgeon in selecting the preferred method of restoring internal lining, structural support, and external cover, all of which are governed by the extent of the nasal defect and availability of resources that can be used for the repair. Part Two represents the “how to” section of the book. It provides detailed step-by step discussions of techniques used to design, dissect, transfer and refine flaps and grafts used in nasal reconstruction. It also reviews the prevention and management of complications. In Part Three, each chapter discusses a representative case or cases that demonstrate typical complications and limitations confronting all surgeons when reconstructing the nose. Designed so practitioners can add to their surgical repertoire with a thorough reading, or quickly consult the text aided by detailed labeling and hundreds of photographs, Principles of Nasal Reconstruction is an invaluable resource for otolaryngologists, head-and-neck surgeons, and plastic and reconstructive facial surgeons.About the AuthorShan R. Baker, M.D., is Professor and Chief of the section of Facial plastic and Reconstructive Surgery and Director of the Center for Facial Cosmetic Surgery in the Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System. He has more than 30 years of surgical experience in reconstructing the nose.

关键词： plastic Surgery Otorhinolaryngology Dermatology General Surgery

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Genes & Diseases 2023年第4期10卷 1351-1366页

作者： Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang Departments of Orthopedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Research Center Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA The Medical Scientist Training Program The University of Chicago Pritzker School of MedicineChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene *** one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and ***,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or ***,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic *** discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of ***,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions.

关键词： Cancer Epigenetic regulation H19 LncRNA Long-noncoding RNA Metabolic diseases Stem cell differentiation

Adaptive heating the powder bed for SLS system

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Journal of Harbin Institute of Technology(New Series) 2007年第3期14卷 404-410页

作者：蔡道生史玉升钟建伟黄树槐 State Key Laboratory of plastic Forming Simulation and Die & Mould Technology School of Material Science and EngineeringHuazhong University of Science and Technology

The temperature of powder bed is very important for selective laser sintering system(SLS),because it directly affects the quality of ***,the temperature of powder bed should alter according to the slicing section contour of model in order to ensure that the integration is successful and ***,the temperature of powder bed should change with shape of CAD model at different *** paper illuminates how to distinguish the slicing contour loops from adjacent *** this way,the temperature can be adaptively adjusted with altering of the sectional contours.

关键词：温度选择性激光烧结系统适应性加热原型速成机械制造

Establishment of Optimal Blade Clearance of Stainless Steel Rolling-Cut Shear and Test of Shearing Force Parameters

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Journal of Iron and Steel Research(International) 2012年第9期19卷 52-61页

作者： MA Li-feng 1 , 2 , HUANG Qing-xue 1 , HUANG Zhi-quan 1 , CHU Zhi-bing 1 , TIAN Ya-qin 1 ( 1.College of Material Science and Engineering , Taiyuan University of Science and Technology , Taiyuan 030024 , Shanxi , China 2.Superplastic and plastic Research Institute , Jilin University , Changchun 130025 , Jilin , China ) College of Material Science and Engineering Taiyuan University of Science and Technology Taiyuan Shanxi China Superplastic and plastic Research Institute Jilin University Changchun Jilin China

The purpose aims to improve the plate shearing section quality and metal yield by means of optimal blade clearance adjustment model of rolling-cut shear and accurate calculation of the maximum shearing force , as well as for the system optimization design , structure optimization design to provide important basis.A 3 500mm rolling shear of a large stainless steel factory was taken as the test object , and the blade clearance under different influence factors of the clearance value and the shearing section were *** optimized production accumulated data regression analysis and the rolling shear process of stainless steel shear *** test results show that the optimal blade clearance adjustment module is a comprehensive function , which include steel plate thickness , material , temperature and shear plate *** shear stress at starting stage with the relative penetration depth increases affected by the above factors , and the fracture peak decreases rapidly after being cut into the roll phase constant.

关键词： stainless steel rolling-cut shear blade clearance shearing force industrial test

Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis

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Burns & Trauma 2021年第1期9卷 488-506页

作者： Peng Hu Anna Chiarini Jun Wu Giuliano Freddi Kaiyu Nie Ubaldo Armato Ilaria Dal Prà Human Histology&Embryology section Department of SurgeryDentistryPaediatrics&GynaecologyUniversity of Verona Medical SchoolStrada Le Grazie 8I-37134VeronaVenetiaItaly Department of Burns&plastic Surgery The Affiliated Hospital of ZunYi Medical University149 Dalian RoadZunYi City563003 Guizhou ProvinceChina Department of Burns and plastic Surgery Second People’s HospitalUniversity of Shenzhen3002 Sungang West RoadFutian DistrictShenzhen518000Guangdong ProvinceChina Silk Biomaterials S.r.l. Via Cavour 2I-22074LomazzoLombardyItaly

Background:Bombyx mori silk fibroin is a biomacromolecule that allows the assembly of scaffolds for tissue engineering and regeneration purposes due to its cellular adhesiveness,high biocompatibility and low *** work showed that two types of 3D silk fibroin nonwovens(3D-SFnws)implanted into mouse subcutaneous tissue were promptly vascularized via undefined molecular *** present study used nontumorigenic adult human dermal fibroblasts(HDFs)adhering to a third type of 3D-SFnws to assess whether HDFs release exosomes whose contents promote ***:Electron microscopy imaging and physical tests defined the features of the novel carded/hydroentangled *** were cultured on 3D-SFnws and polystyrene plates in an exosome-depleted *** amounts and D-glucose consumption revealed the growth and metabolic activities of HDFs on ***9-expressing total exosome fractions were from conditioned media of 3D-SFnws and 2D polystyrene plates HDF *** growth factors(AGFs)in equal amounts of the two groups of exosomal proteins were analysed via doubleantibody arrays.A tube formation assay using human dermal microvascular endothelial cells(HDMVECs)was used to evaluate the exosomes’angiogenic ***:The novel features of the 3D-SFnws met the biomechanical requirements typical of human soft *** experimental day 15,3D-SFnws-adhering HDFs had increased 4.5-fold in numbers and metabolized 5.4-fold more D-glucose than at day 3 in *** to polystyrene-stuck HDFs,exosomes from 3D-SFnws-adhering HDFs carried significantly higher amounts of AGFs,such as interleukin(IL)-1α,IL-4 and IL-8;angiopoietin-1 and angiopoietin-2;angiopoietin-1 receptor(or Tie-2);growth-regulated oncogene(GRO)-α,GRO-βand GRO-γ;matrix metalloproteinase-1;tissue inhibitor metalloproteinase-1;and urokinase-type plasminogen activator surface receptor,but lesser amounts of anti-angiogenic tissue inhibitor metalloproteinase-2 and

关键词： Silk fibroin Nonwovens Dermis Fibroblast Human endothelial cell Exosome Cytokine Chemokine Angiogenesis Regeneration Tissue engineering

Adipose derived stem cells and nerve regeneration

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Neural Regeneration Research 2014年第14期9卷 1341-1346页

作者： Alessandro Faroni Richard JP Smith Adam J Reid Blond McIndoe Laboratories Institute of Inflammation and RepairUniversity of ManchesterManchesterUK Department of plastic Surgery & Burns University Hospital of South Manchester ManchesterUK

Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts.

关键词： peripheral nerve injury adipose derived stem cells nerve guidance tubes bioengineerednerve graft axonal regeneration Schwann cell cell therapy nerve repair

Inferior Pedicle Breast Reduction for the Management of Gestational Gigantomastia: Literature Review and a Case Presentation

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Modern plastic Surgery 2017年第4期7卷 39-49页

作者： P. Agbenorku W.B. Rockwell M. Obeng J. Akpaloo O. Owusu-Danso P.E. Hoyte-Williams B. Farhat E. Turkson E. Tano Z. Schumacher P.K.S. Fiifi-Yankson Division of plastic & Reconstructive Surgery Department of Surgery School of Medical Sciences Komfo Anokye Teaching Hospital Kwame Nkrumah University of Science & Technology Kumasi Ghana plastic Surgery Division University of Utah Health Sciences Center Salt Lake City UT USA section of plastic Surgery St. Elizabeth Boardman Health Center University of Pittsburgh School of Medicine Boardman OH USA

Background: The actual cause of Gestational gigantomastia (Gg) remains a dilemma. Its treatment has ideally been surgical, employing most commonly the different pedicle techniques in the last decade. Aim: This paper reviews the literature on the management of Gg using the inferior pedicle technique (IPT) and supports it with a successful case presentation using the IPT. Method: Using the PubMed search engine and Google scholar, literature search was done for Gg treated with the inferior pedicle reduction method. Published literature from other sources was also included. Data obtained was cleaned and analysed. The inferior pedicle breast reduction technique was employed without any modification in the normal procedure for the case presented. Results: Thirty-one literature addressing Gg and IPT were identified. Most surgeons use this technique with very good outcomes. Our patient confirmed reduced breast mould, firm and adolescent looking breast with no back, shoulder, neck and rib pains. She also experienced with time increased nipple areolar sensation, ability to undertake all tasks with ease and a new sense of confidence. Conclusion: The inferior pedicle breast reduction technique can be the standard treatment for gestational gigantomastia with the length from suprasternal notch to the nipple ≤ 50 cm that present without any anatomical complications.

关键词： Gestational Gigantomastia Hormones Surgical Inferior Pedicle Medical Treatment

The analysis of the bending stiffness and intensity of cylindrical tubes

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Science China(Technological Sciences) 2007年第3期50卷 268-278页

作者： SONG YuQuan GUAN ZhiPing NIE YuQin GUAN XiaoFang Superplastic and plastic Research Institute Jilin UniversityChangchun 130025China Department of Engineering Mechanics Institute of Mechanical Science and EngineeringJilin UniversityChangchun 130025China

Based on the mechanics of material,the bending stiffness and intensity of cylin-drical bar and tube are analyzed. By comparing the cylindrical tube whose ratio of outside diameter to internal diameter is 0.7 with the cylindrical bar,it is concluded that when both of them have the same mass,the section stiffness of the cylindrical tube is three times that of the cylindrical bar;when both of them have the same external diameter,the mass of the cylindrical tube is only 1/2 that of the cylindrical bar,but the section stiffness of the cylindrical tube is 3/4 that of the cylindrical bar. By virtue of the elemental elastic-plastic theory,the yield stress of the liquid-filled cylindrical tube is investigated. Due to the incompressibility of liquid and the strain hardening effect of material,the yield stress of the liquid-filled tube is enlarged compared with the hollow tube,thus raising its bending intensity. Under the dy-namic load,compared with the hollow tube,the impact resistance of the liquid-filled tube is also raised due to elastic recovery. Because the hydraulic pressures per-pendicular to the inner surface are identical everywhere,the local stress concen-tration resulting from the ovalisation of the tube would be decreased,and the re-sistance to buckling would be improved.

关键词： bending of cylindrical tube liquid filled stiffness intensity

Comparison of Intraarterial VS with Intravenous Heparin Delivery in Maintaining Microvascular Patency

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中国医科大学学报 1990年第S1期19卷 66-71页

作者：王玉新 Department of plastic and Maxilofacial Surgery The Affiliated Stomatological Hosp China Medical University Shenyang China

Utilizing a reliable, reproducible arterial inversiongraft thrombosis model, comparison of intraarterial VSwith intravenous heparin delivery in maintaining micro-vascular patency has been finished, concentrated on thestudy of the effective mechanism of heparin. Vesselpatency, complication rate and representative electromi-croscopy section of the AIG were studied. Patency inthe intraarterial group is 90% (26/29) as compared to50% (12/26) in the intravenous delivery group(P<0.05).Scanning electromicroscopy showed a significant absenceof dense fibrin deposition and decrease in the numberof aggregated platelets in the intra-arterial perfusedAIG. The results of the present study indicate that thesmall dose of heparin through the artery is still effectivein maintaining the vessel pateney. Furthermore, in alarge, carefully controlled series, the complication ratewas low.

关键词： microvascular thrombosis heparin