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Associations between Geriatric Nutrition Risk Index,bone mineral density and body composition in type 2 diabetes patients

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World Journal of Diabetes 2024年第3期15卷 403-417页

作者： Xiao-Xiao Zhu Kai-Feng Yao Hai-Yan huang Li-Hua Wang Department of Pediatrics The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Nursing The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM),a fast-growing issue in public health,is one of the most common chronic metabolic disorders in older *** and sarcopenia are highly prevalent in T2DM patients and may result in fractures and *** people with T2DM,the association between nutrition,sarcopenia,and osteoporosis has rarely been *** To evaluate the connections among nutrition,bone mineral density(BMD)and body composition in patients with *** We enrolled 689 patients with T2DM for this cross-sectional *** patients underwent dual energy X-ray absorptiometry(DXA)examination and were categorized according to baseline Geriatric Nutritional Risk Index(GNRI)values calculated from serum albumin levels and body *** GNRI was used to evaluate nutritional status,and DXA was used to investigate BMD and body *** forward linear regression analysis was used to identify the factors associated with BMD and skeletal muscle mass *** Of the total patients,394 were men and 295 were *** with patients in tertile 1,those in tertile 3 who had a high GNRI tended to be younger and had lower HbA1c,higher BMD at all bone sites,and higher appendicular skeletal muscle index(AsMI).These important trends persisted even when the patients were divided into younger and older *** GNRI was positively related to AsMI(men:r=0.644,Psites,lumbar spine(L1-L4)BMD(men:r=0.110,P=0.029;women:r=0.256,Pstment for other clinical parameters,the GNRI was still significantly associated with BMD at the lumbar spine and femoral ***,a low lean mass index and higherβ-collagen special sequence were associated with low BMD at all bone *** was negatively correlated with

关键词： Geriatric Nutrition Risk Index Bone mineral density skeletal muscle mass Type 2 diabetes

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subclinical impairment of left ventricular myocardium function in type 2 diabetes mellitus patients with or without hypertension

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World Journal of Diabetes 2024年第6期15卷 1272-1279页

作者： Zeng-Guang Chen Guang-An Li Jun huang Li Fan Department of Cardiology The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Department of Echocardiography The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last *** To determine whether layer-specific global longitudinal strain(GLs)combined with peak strain dispersion(PsD)can be used to assess left ventricle(LV)myocardium systolic dysfunction in T2DM patients or without hypertension(HP).METHODs We enrolled 97 T2DM patients,70 T2DM+HP patients and 101 healthy ***-specific GLs and PsD were calculated by EchoPAC software in apical three-,four-and two-chamber *** of the epimyocardial,middle-layer and endomyocardial(GLsepi,GLsmid,and GLsendo)were measured and *** operating characteristic analysis was performed to detect LV myocardium systolic dysfunction in T2DM *** There were significant differences in GLsepi,GLsmid,GLsendo,and PsD between healthy subjects,T2DM patients and T2DM patients with HP(Psts yielded the ranking of healthy subjects>T2DM patients>T2DM with HP patients in the absolute values of GLsepi,GLsmid and GLsendo(PsD was ranked healthy subjectsspecific GLs and PsD had high diagnostic efficiency for detecting LV myocardium systolic dysfunction in T2DM patients,however,the area under the curve(AUC)for layer-specific GLs and PsD combined was significantly higher than the AUCs for the individual indices(PsION Layer-specific GLs and PsD were associated with LV myocardium systolic dysfunction in T2DM patients,T2DM patients with HP.T2DM patients with HP have more severe LV myocardium systolic dysfunction than T2DM patients without HP and normal control *** combination of layer-specific GLs and PsD may provide additional prognostic information for T2DM patients with or without HP.

关键词： Type 2 diabetes mellitus Hypertension speckle tracking echocardiography Global longitudinal strain Peak strain dispersion

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In situ Deposition of Drug and Gene Nanoparticles on a Patterned supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating Qin Zhongming huang Yifan Wu Long sun Cong Wang Wei Wang Gang Feng Yiying Qi Department of Orthopaedic surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GsK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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Nonalcoholic Fatty Liver Disease:Changes in Gut Microbiota and Blood Lipids

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 333-345页

作者： Keen Yang Jieying Zeng Huaiyu Wu Huiyu Liu Zhimin Ding Weiyu Liang Linghu Wu Ziwei Lin Wenhui huang Jinfeng Xu Fajin Dong Department of Ultrasound Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdongChina

Background and Aims:The global prevalence of nonalcoholic fatty liver disease(NAFLD)is 25%.This study aimed to explore differences in the gut microbial community and blood lipids between normal livers and those affected by NAFLD using 16s ribosomal deoxyribonucleic acid ***:Gut microbiome profiles of 40 NAFLD and 20 non-NAFLD controls were *** about four blood lipids and 13 other clinical features was *** were divided into three groups by ultrasound and Fibroscan,those with a normal liver,mild FL(FL1),and moderate-to-severe FL(FL2).FL1 and FL2 patients were divided into two groups,those with either hyperlipidemia or non-hyperlipidemia based on their blood *** keystone species within the groups were identified using univariate analysis and a specificity–occupancy *** difference in biochemical parameters ion NAFLD patients and healthy individuals were identified by detrended correspondence analysis and canonical correspondence ***:Decreased gut bacterial diversity was found in patients with ***/Bacteroidetes decreased as NAFLD *** and Ruminococcus 2 were the most representative fatty-related *** pyruvic transaminase,aspartate aminotransferase,and white blood cell count were selected as the most significant biochemical *** of areas under the curve identified two microbiomes combined with the three biochemical indexes that identified normal liver and FL2 very well but performed poorly in diagnosing ***:Faecalibacterium and Ruminococcus 2,combined with glutamate pyruvic transaminase,aspartate aminotransferase,and white blood cell count distinguished *** speculate that regulating the health of gut microbiota may release NAFLD,in addition to providing new targets for clinicians to treat NAFLD.

关键词： Liver Gut microbiota Blood lipids Nonalcoholic fatty liver disease Hyperlipidemia

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Evaluation of left ventricular systolic function in type 2 diabetes mellitus patients with and without peripheral vascular disease

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World Journal of Diabetes 2024年第6期15卷 1280-1290页

作者： Guang-An Li Jun huang Li Fan Department of Echocardiography The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic *** To evaluate left ventricular(LV)systolic function by layer-specific global longitudinal strain(GLs)and peak strain dispersion(PsD)in T2DM patients with and without *** sixty-five T2DM patients without PVD,57 T2DM patients with PVD and 63 normal controls were enrolled in the ***-specific GLs[GLs of the epimyocardium(GLsepi),GLs of the middle myocardium(GLsmid)and GLs of the endocardium(GLsendo)]and PsD were *** operating characteristic(ROC)analysis was performed to calculate the sensitivity and specificity of LV systolic dysfunction in T2DM patients with *** calculated Pearson’s correlation coefficients between biochemical data,echocardiographic characteristics,and layer-specific GLs and *** There were significant differences in GLsepi,GLsmid and GLsendo between normal controls,T2DM patients without PVD and T2DM patients with PVD(Psts revealed a ranking of normal controls>T2DM patients without PVD>T2DM patients with PVD in the absolute value of GLs(PsD differed significantly between the three groups,and the trend ranking was as follows:normal controlss without PVDs with PVD(Psis revealed that the combination of layer-specific GLs and PsD had high diagnostic efficiency for detecting LV systolic dysfunction in T2DM patients with *** lipoprotein cholesterol was positively correlated with GLsepi,GLsmid and PsD(Ps negatively correlated with GLsepi,GLsmid and GLsendo in T2DM patients with PVD(PsION PVD may aggravate the deterioration of LV systolic dysfunction in T2DM ***-specific GLs and PsD can be used to detect LV systolic dysfunction accurately and conveniently in T2DM patients with or without PVD.

关键词： Type 2 diabetes mellitus Peripheral vascular disease speckle tracking echocardiography Global longitudinal strain Peak strain dispersion

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Alcoholic Liver Disease in China:A Disease Influenced by Complex social Factors That should Not Be Neglected

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 677-684页

作者： Xiaofeng Feng Nafei huang Yuqin Wu Fei Gao Xiaomei Chen Chenyi Zhang Bing Zhang Tao sun The second Clinical Medical College of Zhejiang Chinese Medical University HangzhouZhejiangChina The second Affiliated hospital.of Zhejiang Chinese Medical University HangzhouZhejiangChina Hangzhou First people’s hospital HangzhouZhejiangChina

Alcoholic liver disease(ALD)encompasses liver damage caused by chronic,excessive alcohol *** manifests initially as marked hepatocellular steatosis and can progress to steatohepatitis,liver fibrosis,and *** China’s rapid economic growth,coupled with a complex social background and the influence of a deleterious wine culture,the number of patients with ALD in China has increased significantly;the disease has become a social and health problem that cannot be *** this review,we briefly described the social factors affecting ALD in China and elaborated on differences between alcoholic and other liver diseases in terms of complications(e.g.,cirrhosis,upper gastrointestinal bleeding,hepatic encephalopathy,hepatocellular carcinoma,addiction,and other extrahepatic diseases).We also emphasized that ALD was more dangerous and difficult to treat than other liver diseases due to its complications,and that precise and effective treatment measures were *** addition,we considered new ideas and treatment methods that may be generated in the future.

关键词： Alcoholic liver disease Wine culture Complication Epidemiology Treatment strategies Comparison

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Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-Yi Zhu Xiu-Hong huang Hui-Qing Jiang Li Liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients with ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new prognostic model for patients with ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the second hospital.of Hebei Medical University in *** The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all Psistency between actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score was excellent and superior to that of existing *** net benefit of MIMIC ACLF was greater than that achieved using existing scores within the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external *** We developed and validated a new prognostic model with satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model scores

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan Yang shan-shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate school Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General surgery Department of Chengdu second people's hospital.from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia Jin Yu-hui huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye Lu-hang Jin Jian Wu Chang-zheng Yuan Feng Gao Lu-sha Tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina school of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(css)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of css and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(css-CMB−,css-CMB+,css+CMB−,css+CMB+)according to css and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had css and 468(69.5%)had *** with css+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** css−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of css+.Conclusions Patients with different combinations of css and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

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Analysis and monitoring of drug therapy in a patient with peptic ulcer complicated by infection:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1530-1535页

作者： Yan-Ping Gou Yue huang Li Chen Wei Zheng Yun-Hua Zheng The second people’s hospital.of Meishan City&Renshou County people’s hospital Meishan 620500Sichuan ProvinceChina Quality Evaluation and Medical Record Management The Affiliated Hospital of Southwest Jiaotong University&The Third People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Patriotic Health Campaign Qionglai City Health BureauChengdu 610000Sichuan ProvinceChina

BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug *** sUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal *** rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of *** temperature,routine blood examination,and adverse drug reactions were strictly *** treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the ***,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin *** is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary *** A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.

关键词： Ampicillin-sulbactam Famotidine Lansoprazole Kangfuxin Liquid Chinese pharmacist Case report

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