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Saliency-guided meta-hallucinator for few-shot learning

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Science China(Information Sciences) 2024年第10期67卷 189-210页

作者： Hongguang ZHANG Chun LIU Jiandong WANG Linru MA Piotr KONIUSZ Philip H.S.TORR Lin YANG Systems Engineering Institute Academy of Military Sciences data61 Commonwealth Scientific and Industrial Research Organisation Australian National University Oxford University

Learning novel object concepts from limited samples remains a considerable challenge in deep learning. The main directions for improving the few-shot learning models include(i) designing a stronger backbone,(ii) designing a powerful(dynamic) meta-classifier, and(iii) using a larger pre-training set obtained by generating or hallucinating additional samples from the small scale dataset. In this paper, we focus on item(iii) and present a novel meta-hallucination strategy. Presently, most image generators are based on a generative network(i.e., GAN) that generates new samples from the captured distribution of images. However, such networks require numerous annotated samples for training. In contrast, we propose a novel saliency-based end-to-end meta-hallucinator, where a saliency detector produces foregrounds and backgrounds of support images. Such images are fed into a two-stream network to hallucinate feature samples directly in the feature space by mixing foreground and background feature samples. Then, we propose several novel mixing strategies that improve the quality and diversity of hallucinated feature ***, as not all saliency maps are meaningful or high quality, we further introduce a meta-hallucination controller that decides which foreground feature samples should participate in mixing with backgrounds. To our knowledge, we are the first to leverage saliency detection for few-shot learning. Our proposed network achieves state-of-the-art results on publicly available few-shot image classification and anomaly detection benchmarks, and outperforms competing sample mixing strategies such as the so-called Manifold Mixup.

关键词： few-shot learning saliency detection object recognition anomaly detection computer vision

Advancements in nanotechnology for the delivery of phytochemicals

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Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan K.Yadav Nazneen Sultana Arun Agarwal Saurabh Verma Manish K.Chourasia Jiaur R.Gayen division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

Stability Analysis and Performance Evaluation of Additive Mixed-Precision Runge-Kutta Methods

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Communications on Applied Mathematics and Computation 2024年第1期6卷 705-738页

作者： Ben Burnett Sigal Gottlieb Zachary J.Grant Center for scientific Computing and data Science Research UMass DartmouthNorth DartmouthMassachusettsUSA CSME Michigan State UniversityEast LansingMichiganUSA

Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and *** specially designed methods use reduced precision for the implicit computations and full precision for the explicit *** this work,we analyze the stability properties of these methods and their sensitivity to the low-precision rounding errors,and demonstrate their performance in terms of accuracy and *** develop codes in FORTRAN and Julia to solve nonlinear systems of ODEs and PDEs using the mixed-precision additive Runge-Kutta(MP-ARK)*** convergence,accuracy,and runtime of these methods are *** show that for a given level of accuracy,suitably chosen MP-ARK methods may provide significant reductions in runtime.

关键词： Mixed precision Runge-Kutta methods Additive methods Accuracy

Linear OPF-based Robust Dynamic Operating Envelopes with Uncertainties in Unbalanced Distribution Networks

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1320-1326页

作者： Bin Liu Julio H.Braslavsky Nariman Mahdavi Energy Centre Commonwealth Scientific and Industrial Research Organisation(CSIRO)Newcastle 2300Australia the Network Planning division TransgridSydney 2000Australia the Energy Systems Program Energy CentreCommonwealth Scientific and Industrial Research Organisation(CSIRO)Newcastle 2300Australia

Dynamic operating envelopes(DOEs),as key enablers to facilitate distributed energy resource(DER)integration,have attracted increasing attention in the past ***,uncertainties,which may come from load forecasting errors or inaccurate network parameters,have been rarely discussed in DOE calculation,leading to compromised quality of the hosting capacity allocation *** letter studies how to calculate DOEs that are immune to such uncertainties based on a linearised unbalanced three-phase optimal power flow(UTOPF)*** uncertain parameters constrained by norm balls,formulations for calculating robust DOEs(RDOEs)are presented along with discussions on their *** cases,including a 2-bus illustrative network and a representative Australian network,are tested to demonstrate the effectiveness and efficiency of the proposed approach.

关键词： Distributed energy resource(DER) dynamic operating envelope(DOE) feasible region robust optimisation uncertainty modelling unbalanced optimal power flow

Flexible bronchoscopy for foreign body aspiration in children:A single-centre experience

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World Journal of Clinical Pediatrics 2024年第2期13卷 127-134页

作者： Aleh Sautin Kirjl Marakhouski Aleh Pataleta Kirill Sanfirau Diagnostic division Republican Scientific and Practical Centre of Paediatric SurgeryMinsk 220013Belarus

BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic ***,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body *** To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature *** This was a single-centre retrospective ***-four patients were enrolled between January 2017 and January *** records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel *** were analysed using MedCalc Statistical *** Patient ages varied from 9 months to 11 *** median age was 23.5 months,95%confidence interval(CI)*** observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 *** expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all *** to a rigid bronchoscope was not required in any of the *** major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were *** Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.

关键词： Foreign body aspiration Tracheobronchial foreign body Paediatric bronchoscopy Flexible bronchoscopy Rigid bronchoscopy

The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli Matteo Iannacone division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

Construction of Optimal Mixed-Level Uniform Designs

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Journal of Systems Science & Complexity 2024年第2期37卷 841-862页

作者： CHATTERJEE Kashinath LIU Min-Qian QIN Hong YANG Liuqing Department of Population Health Sciences Division of Biostatistics and Data ScienceAugusta UniversityGA 30912USA NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China

The theory of uniform design has received increasing interest because of its wide application in the field of computer *** generalized discrete discrepancy is proposed to evaluate the uniformity of the mixed-level factorial *** this paper,the authors give a lower bound of the generalized discrete discrepancy and provide some construction methods of optimal mixed-level uniform designs which can achieve this lower *** methods are all deterministic construction methods which can avoid the complexity of stochastic *** saturated mixed-level uniform designs and supersaturated mixed-level uniform designs can be obtained with these ***,the resulting designs are also χ^(2)-optimal and minimum moment aberration designs.

关键词： Generalized discrete discrepancy Hadamard matrix mixed-level design orthogonal array supersaturated design

Performance assessment of prefabricated vertical drains in mitigating soil reliquefaction subjected to repeated seismic events using shaking table experiments

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 411-427页

作者： Gowtham PADMANABHAN Ganesh Kumar SHANMUGAM Department of Earthquake Engineering Indian Institute of Technology RoorkeeUttarakhand 247667India Geotechnical Engineering division CSIR-Central Building Research Institute Academy of Scientific and Innovative Research(AcSIR)Uttarakhand 247667India

The use of prefabricated vertical drains(PVD)in liquefiable deposits is gaining attention due to enhanced ***,investigations on PVD in mitigating re-liquefaction during repeated shaking events are not *** study performed a series of shaking table experiments on untreated and PVD-treated specimens prepared with 40%and 60%relative *** sinusoidal loading was applied with an incremental peak acceleration of 0.1g,0.2g,0.3g,and 0.4g,at 5 Hz shaking frequency with 40 s *** performance of treated ground was evaluated based on the generation and dissipation of excess pore water pressure(EPWP),induced sand densification,subsidence,and cyclic stress *** addition,the strain accumulated in fresh and exhumed PVD was investigated using geotextile tensile testing apparatus aided with digital image *** evidence of pore pressure was reported up to 0.2g peak acceleration for 40%and 60%relative density *** continuous occurrence of soil densification and drainage medium restrained and delayed the generation of EPWP and expedited the dissipation *** study demonstrates PVD can mitigate re-liquefaction,without suffering from deterioration,when subjected to medium to high intense repeated shaking events.

关键词： prefabricated vertical drains drainage re-liquefaction shaking table digital image correlation

Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

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World Journal of Gastroenterology 2024年第34期30卷 3850-3855页

作者： Swati Katoch Vikram Patial division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

In this editorial,we comment on the article by Zhou et *** study reveals the connection between ferroptosis and pyroptosis and the effect of silent information regulator sirtuin 1(SIRT1)activation in acute liver failure(ALF).ALF is characterized by a sudden and severe liver injury resulting in significant hepatocyte damage,often posing a high risk of *** predominant form of hepatic cell death in ALF involves apoptosis,ferroptosis,autophagy,pyroptosis,and *** peroxidase 4(GPX4)inhibition sensitizes the cell to ferroptosis and triggers cell death,while Gasdermin D(GSDMD)is a mediator of *** study showed that ferroptosis and pyroptosis in ALF are regulated by blocking the p53/GPX4/GSDMD pathway,bridging the gap between the two *** inhibition of p53 elevates the levels of GPX4,reducing the levels of inflammatory and liver injury markers,ferroptotic events,and GSDMDN protein *** p53 expression and increased GPX4 on deletion of GSDMD indicated ferroptosis and pyroptosis ***1 is a NAD-dependent deacetylase,and its activation attenuates liver injury and inflammation,accompanied by reduced ferroptosis and pyroptosis-related proteins in ***1 activation also inhibits the p53/GPX4/GSDMD axis by inducing p53 acetylation,attenuating LPS/D-GalN-induced ALF.

关键词： Acute liver failure Ferroptosis Gasdermin D Pyroptosis p53 Silent information regulator sirtuin 1