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Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Color-kinematics duality and dual conformal symmetry for a four-loop form factor in N=4 SYM

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 64-71页

作者： Guanda Lin Gang Yang Siyuan Zhang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China school of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China school of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing/Hangzhou 310024China

We obtain the integrand of full-color four-loop three-point form factor of the stress-tensor supermultiplet in N=4 SYM,based on the color-kinematics(CK)duality and generalized unitarity *** result not only manifests all dual Jacobi relations via CK duality but also contains 133 free *** suggests the constructibility of the form factor at even higher loops via CK *** also find that the planar form factor has a hidden dual conformal symmetry in the lightlike limit of the operator momentum,which is checked up to four loops.

关键词： S-matrix supersymmetric model perturbative calculations

General formalism for dirty extreme-mass-ratio inspirals

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 22-29页

作者： Ye Jiang Wen-Biao Han Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China school of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China school of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Frontiers Science Center for Gravitational Wave Detection Shanghai 200240China

Detecting the environment around the supermassive black holes and tests of general relativity are important applications of extreme-mass-ratio inspirals(EMRIs).There is still a challenge to efficiently describe various“dirty”impacts on the inspirals,such as dark matter,gas,dipole radiation,and electromagnetic *** this study,we find the inherent linearity of the asymptotic solution of the inhomogeneous Teukolsky *** the basis of this property,we completely decouple the factors of the perturber and the background spacetime in the energy fluxes and *** the new decoupling form,the waveforms of EMRIs with non-geodesic motion in Kerr spacetime can be conveniently *** will help to resolve the environment(including gas,field,dark matter,electromagnetic interaction)around supermassive black holes and test general relativity.

关键词： gravitational wave Teukolsky equation extreme-mass-ratio inspirals

DNA of neutrophil extracellular traps promote NF-κBdependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3040-3055页

作者： Jun Chen Tao Wang Xiaoou Li Lijuan Gao Ke Wang Mengxin Cheng Zijian Zeng Lei Chen Yongchun Shen Fuqiang Wen Department of Respiratory and Critical Care medicine West China HospitalWest China School of Medicineand Division of Pulmonary DiseasesState Key Laboratory of BiotherapySichuan UniversityChengduSichuan 610041China

Chronic obstructive pulmonary disease(COPD)is characterised by persistent airway inflammation even after cigarette smoking *** extracellular traps(NETs)have been implicated in COPD severity and acute airway inflammation induced by short-term cigarette smoke(CS).However,whether and how NETs contribute to sustained airway inflammation in COPD remain *** study aimed to elucidate the immunoregulatory mechanism of NETs in COPD,employing human neutrophils,airway epithelial cells(AECs),dendritic cells(DCs),and a long-term CS-induced COPD mouse model,alongside cyclic guanosine monophosphate-adenosine monophosphate synthase and toll-like receptor 9 knockout mice(cGAS-^(−/−)TLR9^(−/−));Additionally,bronchoalveolar lavage fluid(BALF)of COPD patients was *** from COPD patients released greater cigarette smoke extract(CSE)-induced NETs(CSE-NETs)due to mitochondrial respiratory chain *** CSE-NETs,containing oxidatively-damaged DNA(NETs-DNA),promoted AECs proliferation,nuclear factor kappa B(NF-κB)activation,NF-κB-dependent cytokines and type-I interferons production,and DC maturation,which were ameliorated/reversed by silencing/inhibition of cGAS/*** the COPD mouse model,blocking NETs-DNA-sensing via cGAS^(−/−)and TLR9^(−/−)mice,inhibiting NETosis using mitoTEMPO,and degrading NETs-DNA with DNase-I,respectively,reduced NETs infiltrations,airway inflammation,NF-κB activation and NF-κBdependent cytokines,but not type-I interferons due to IFN-α/βreceptor *** NETs components(myeloperoxidase and neutrophil elastase activity)in BALF of COPD smokers correlated with disease severity and NF-κB-dependent cytokine levels,but not type-I interferon *** conclusion,NETs-DNA promotes NF-κB-dependent autoimmunity via cGAS/TLR9 in long-term CS exposure-induced ***,targeting NETs-DNA and cGAS/TLR9 emerges as a potential strategy to alleviate persistent airway inflammation in COPD.

关键词： inflammation TLR9 neutrophil

A bird's-eye overview of molecular mechanisms regulating feed intake in chickens—with mammalian comparisons

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Animal Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia R.Volyanskaya Ilya R.Akberdin Mikhail A.Kulyashov Ivan S.Yevshin Michael N.Romanov Elena I.Shagimardanova Oleg A.Gusev Fedor A.Kolpakov Department of Natural Sciences Novosibirsk State University Biosoft.Ru Ltd. Sirius University of Science and Technology school of Biosciences University of Kent L.K.Ernst Federal Research Centre for Animal Husbandry Regulatory Genomics Research Center Institute of Fundamental Medicine and BiologyKazan Federal University Life Improvement By Future Technologies (LIFT) Center Intractable Disease Research Center Juntendo University

In recent decades, a lot of research has been conducted to explore poultry feeding behavior. However, up to now, the processes behind poultry feeding behavior remain poorly understood. The review generalizes modern expertise about the hormonal regulation of feeding behavior in chickens, focusing on signaling pathways mediated by insulin, leptin, and ghrelin and regulatory pathways with a cross-reference to mammals. This overview also summarizes state-of-the-art research devoted to hypothalamic neuropeptides that control feed intake and are prime candidates for predictors of feeding *** analysis of the signaling pathways that mediate the feed intake regulation allowed us to conclude that there are major differences in the processes by which hormones influence specific neuropeptides and their contrasting roles in feed intake control between two vertebrate clades.

关键词： Chicken Feed intake Hypothalamus Neuropeptide Signaling pathway Hormone

Pressure-triggered stacking dependence of interlayer coupling in bilayer WS_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 177-186页

作者： Zejuan Zhang Chenyin Jiao Shenghai Pei Xilong Zhou Jiaze Qin Wanli Zhang Yu Zhou Zenghui Wang Juan Xia school of Integrated Sciences and Engineering(Exemplary school of Microelectronics) University of Electronic Science and Technology of ChinaChengdu 610054China Institute of fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China school of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China

Tungsten disulfide(WS_(2))has been reported to show negligible stacking dependence under ambient conditions,impeding its further explorations on physical properties and potential ***,we realize efficient modulation of interlayer coupling in bilayer WS_(2)with 3R and 2H stackings by high pressure,and find that the pressure-triggered interlayer coupling and pressure-induced resonant-to-nonresonant transition exhibit prominent stacking dependence,which are experimentally observed for the first time in *** work may unleash the stacking degree of freedom in designing WS_(2)devices with tailored properties correlated to interlayer coupling.

关键词： tungsten disulfide pressure engineering stacking order interlayer coupling

Prescribed Performance Evolution Control for Quadrotor Autonomous Shipboard Landing

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1151-1162页

作者： Yang Yuan Haibin Duan Zhigang Zeng State Key Laboratory of Virtual Reality Technology and Systems the School of Automation Science and Electrical EngineeringBeihang UniversityBeijing 100083China State Key Laboratory of Virtual Reality Technology and Systems the School of Automation Science and Electrical EngineeringBeihang UniversityBeijing 100083 Virtual Reality fundamental Research Laboratory Department of Mathematics and TheoriesPeng Cheng LaboratoryShenzhen 518000China school of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China

The shipboard landing problem for a quadrotor is addressed in this paper,where the ship trajectory tracking control issue is transformed into a stabilization control issue by building a relative position *** guarantee both transient performance and steady-state landing error,a prescribed performance evolution control(PPEC)method is developed for the relative position *** addition,a novel compensation system is proposed to expand the performance boundaries when the input saturation occurs and the error exceeds the predefined *** the wind and wave on the relative position model,an adaptive sliding mode observer(ASMO)is designed for the disturbance with unknown upper *** on the dynamic surface control framework,a shipboard landing controller integrating PPEC and ASMO is established for the quadrotor,and the relative position control error is guaranteed to be uniformly ultimately *** results have verified the feasibility and effectiveness of the proposed shipboard landing control scheme.

关键词： error integrating stabilization

Clinical applications of stem cell-derived exosomes

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Signal Transduction and Targeted Therapy 2024年第2期9卷 621-651页

作者： Fei Tan Xuran Li Zhao Wang Jiaojiao Li Khawar Shahzad Jialin Zheng Department of ORL-HNS Shanghai Fourth People’s Hospitaland School of MedicineTongji UniversityShanghaiChina Plasma medicine and Surgical Implants Center Tongji UniversityShanghaiChina The Royal College of Surgeons in Ireland DublinIreland The Royal College of Surgeons of England LondonUK Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Nanocatalytic medicine Tongji UniversityShanghaiChina

Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery,it nevertheless comes with inescapable drawbacks that might limit its clinical *** to stem cells,stem cell-derived exosomes possess numerous advantages,such as non-immunogenicity,non-infusion toxicity,easy access,effortless preservation,and freedom from tumorigenic potential and ethical *** can inherit similar therapeutic effects from their parental cells such as embryonic stem cells and adult stem cells through vertical delivery of their pluripotency or *** a thorough search and meticulous dissection of relevant literature from the last five years,we present this comprehensive,up-to-date,specialty-specific and disease-oriented review to highlight the surgical application and potential of stem cell-derived *** derived from stem cells(e.g.,embryonic,induced pluripotent,hematopoietic,mesenchymal,neural,and endothelial stem cells)are capable of treating numerous diseases encountered in orthopedic surgery,neurosurgery,plastic surgery,general surgery,cardiothoracic surgery,urology,head and neck surgery,ophthalmology,and obstetrics and *** diverse therapeutic effects of stem cells-derived exosomes are a hierarchical translation through tissue-specific responses,and cell-specific molecular signaling *** this review,we highlight stem cell-derived exosomes as a viable and potent alternative to stem cell-based therapy in managing various surgical *** recommend that future research combines wisdoms from surgeons,nanomedicine practitioners,and stem cell researchers in this relevant and intriguing research area.

关键词： viable stem capable

Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： Xiao-Min Li Junchao Jia Danting Yang Jiali Jin Junkuo Gao school of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport *** strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton ***,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced ***,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism