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Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized ***126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR126-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

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Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering management 2024年第1期11卷 79-91页

作者： Lebing WANG Jian Gang JIN Lijun SUN Der-Horng LEE school of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

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Neighborhood garden's age shapes phyllosphere microbiota associated with respiratory diseases in cold seasons

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Environmental Science and Ecotechnology 2024年第2期18卷 114-123页

作者： Chang Zhao Xinxin Liu Haoxin Tan Shan Yin Lantian Su Baoming Du Muhammad Khalid Aki Sinkkonen Nan Hui school of Agriculture and Biology Shanghai Jiao Tong University800 Dongchuan Rd.200240ShanghaiChina shanghai Yangtze River Delta Eco-Environmental Change and management Observation and Research Station Ministry of Science and TechnologyMinistry of Education800 Dongchuan Rd.200240ShanghaiChina shanghai Urban Forest Ecosystem Research Station National Forestry and Grassland Administration800 Dongchuan Rd.200240ShanghaiChina Department of Biology College of Science and TechnologyWenzhou-Kean UniversityWenzhouChina Department of Garden Technologies Horticulture TechnologiesNatural Resources Institute FinlandHelsinkiFinland Ecosystems and Environment Research Programme Faculty of Biological and Environmental SciencesUniversity of HelsinkiLahtiFinland

Neighborhood gardens serve as sensitive sites for human microbial encounters,with phyllosphere microbes directly impacting our respiratory ***,our understanding remains limited on how factors like season,garden age,and land use shape the risk of respiratory diseases(RDs)tied to these garden *** we examined the microbial communities within the phyllosphere of 72 neighborhood gardens across shanghai,spanning different seasons(warm and cold),garden ages(old and young),and locales(urban and rural).We found a reduced microbial diversity during the cold season,except for Gammaproteobacteria which exhibited an inverse *** land use influenced the microbial composition,urban and rural gardens had strikingly similar microbial ***,young gardens in the cold season hosted a substantial proportion of RDs-associated species,pointing towards increased respiratory inflammation *** essence,while newer gardens during colder periods show a decline in microbial diversity,they have an increased presence of RDs-associated microbes,potentially escalating respiratory disease *** underscores the pivotal role the garden age plays in enhancing both urban microbial diversity and respiratory health.

关键词： Neighborhood gardens Phyllosphere microbial communities Seasonal variation Garden age Respiratory diseases

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Association of Human Whole-blood NAD+Levels with Nabothian Cyst

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Biomedical and Environmental Sciences 2024年第5期37卷 471-478页

作者： XU Ling WANG Yue Xuan WANG Wei FAN Xue CHEN Xue Yu ZHOU Tian Yun LIU Yu He YU Ye YANG Fan JU Zhen Yu ZHOU Yong WANG Deng Liang Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drugs and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China Department of Applied Statistics Johannes Kepler University LinzLinz 4040Austria Hematology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Biostatistics School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Clinical Medicine School of Basic MedicineShanghai Medical College Fudan UniversityShanghai 200032China Department of Biochemistry and Molecular Biology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanChina Administrative Office Total Quality Management OfficeTotal Quality Management InstituteShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First Affiliated Hospital of Jinan university Institute of Aging and Regenerative MedicineJinan UniversityJinan 510632GuangzhouChina Department of Scientific Research The First Affiliated Hospital of Huzhou UniversityHuzhou 313000ZhejiangChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian *** study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese *** Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian *** The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/*** cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,*** total nabothian cyst prevalence gradually decreased from37.4%to 21.6%from Q1 to Q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)*** compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)Q1 was 1.89(1.14–3.14)for total nabothian *** risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 28.0 to35.0μmol/***:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关键词： Nicotinamide adenine dinucleotide Nabothian cyst Female Risk factor

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Facilitating and hindering factors of community nurses'emergency and critical care treatment abilities:A qualitative study

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World Journal of Clinical Cases 2024年第18期12卷 3453-3460页

作者： Wen-Lin Cheng Rui Li Yan Song Fei-Hu Qian Si-Yuan Sha Shuang-Yuan Song school of Nursing Beihua UniversityJilin 132013Jilin ProvinceChina Department of Nursing Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study adopts a descriptive phenomenological approach to investigate the facilitators and barriers of community nurses'abilities in managing critical and emergency *** the transition of healthcare systems to the community,the evolution of nursing practices,and the attention from policies and practices,community nurses play a crucial role in the management of critical and emergency ***,there is still a lack of comprehensive understanding regarding the factors that promote or hinder their capabilities in this *** To understand the facilitators and barriers of community nurses in managing critical and emergency conditions,exploring the fundamental reasons and driving forces influencing their treatment *** This study utilized the destination sampling method between May 2023 and July *** employed a descriptive phenomenological approach within qualitative research *** objective sampling,17 community nurses from 7 communities in Changning District,shanghai,were selected as the study ***-structured interviews were conducted to gather data,which were subsequently organized and analyzed using Colaizzi's seven-step analysis method,leading to the extraction of final *** The barrier factors identified from the interviews encompassed three topics:resource allocation,professional factors,and personal *** facilitators comprised three themes:professionalism,management attention,and training and continuing *** identified that the root causes of the barriers included the lack of practical treatment experience among community nurses,insufficient awareness of self-directed learning,and limited knowledge and technical *** professional quality of community nurses and management attention serve as motivation for them to enhance their treatment *** To enhance the capability of community nurses in treating acute and critical patients,it is

关键词： Community nurse Acute and critical illness Promoting factors Obstacle factors Qualitative study

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Clinical pathological characteristics of“crawling-type”gastric adenocarcinoma cancer:A case report

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1660-1667页

作者： Yong-Wei Xu Yan Song Jun Tian Ba-Cui Zhang Yu-Sheng Yang Jing Wang Department of Gastroenterology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China Department of Pathology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China

BACKGROUND Gastric cancer(GC)is a significant health problem worldwide,and early detection and accurate diagnosis are crucial for improving patient ***-type gastric adenocarcinoma is a rare subtype of GC that has unique histopathological and clinical characteristics,and its diagnosis and management can be *** pathological type of GC is also *** SUMMARY Here,we report the case of a patient who underwent ordinary endoscopy,na-rrow-band imaging,and endoscopic ultrasonography intending to determine the extent of tumor invasion and upper abdominal enhanced computed tomography and whether there was tumor ***,endoscopic submucosal dissection was *** pathological and immunohistochemical examination,the pathological diagnosis was crawling-type gastric *** is a very rare and special pathological type of *** case highlights the importance of using advanced endoscopic techniques and pathological examination in diagnosing and managing gastric crawling-type ***,the findings underscore the need for continued research and clinical experience in this rare subtype of GC to improve patient *** The“crawling-type”GC is a rare and specific tumor *** is difficult to identify and diagnose gliomas via *** tumor is ill-defined,with a flat appearance and indistinct borders due to the lack of contrast against the background *** revealed that the tumor cells were hand-like,so the patient has diagnosed with“crawling-type”gastric adenocarcinoma.

关键词： Clinicopathological Crawling-type gastric Pathology Gastric cancer Gastric adenocarcinoma cancer Case report

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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

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Comparative Analysis of ARIMA and LSTM Model-Based Anomaly Detection for Unannotated Structural Health Monitoring Data in an Immersed Tunnel

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1797-1827页

作者： Qing Ai Hao Tian Hui Wang Qing Lang Xingchun Huang Xinghong Jiang Qiang Jing school of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Key Laboratory of Road and Bridge Detection and Maintenance Technology of Zhejiang Province Hangzhou311305China Zhejiang Scientific Research Institute of Transport Hangzhou310023China State Key Laboratory of Coal Mine Dynamics and Control Chongqing UniversityChongqing400044China Hong Kong-Zhuhai-Macao Bridge Authority Zhuhai519060China

Structural Health Monitoring(SHM)systems have become a crucial tool for the operational management of long *** immersed tunnels exposed to both traffic loads and the effects of the marine environment,efficiently identifying abnormal conditions from the extensive unannotated SHM data presents a significant *** study proposed amodel-based approach for anomaly detection and conducted validation and comparative analysis of two distinct temporal predictive models using SHM data from a real immersed ***,a dynamic predictive model-based anomaly detectionmethod is proposed,which utilizes a rolling time window for modeling to achieve dynamic *** the assumption of temporal data similarity,an interval prediction value deviation was employed to determine the abnormality of the ***,dynamic predictive models were constructed based on the Autoregressive Integrated Moving Average(ARIMA)and Long Short-Term Memory(LSTM)*** hyperparameters of these models were optimized and selected using monitoring data from the immersed tunnel,yielding viable static and dynamic predictive ***,the models were applied within the same segment of SHM data,to validate the effectiveness of the anomaly detection approach based on dynamic predictive modeling.A detailed comparative analysis discusses the discrepancies in temporal anomaly detection between the ARIMA-and LSTM-based *** results demonstrated that the dynamic predictive modelbased anomaly detection approach was effective for dealing with unannotated SHM *** a comparison between ARIMA and LSTM,it was found that ARIMA demonstrated higher modeling efficiency,rendering it suitable for short-term *** contrast,the LSTM model exhibited greater capacity to capture long-term performance trends and enhanced early warning capabilities,thereby resulting in superior overall performance.

关键词： Anomaly detection dynamic predictive model structural health monitoring immersed tunnel LSTM ARIMA

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Recovery of Flavor Perception and Umami Taste Sensitivity in Young Chinese Adults Following SARS-CoV-2 Omicron Infection: A Case-Control Series

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Food Science and Human Wellness 2024年

作者： Yiwen Zhu Xiaoxiao Feng Yuxia Fan Yin Zhang Ye Liu Yuan Liu Department of Food Science & Technology， school of Agriculture & Biology， shanghai jiao tong university Key Laboratory of Meat Processing of Sichuan， Chengdu university Beijing Engineering and Technology Research Center of Food Additives， school of Food and Health， Beijing Technology and Business university school of Food and Health， Beijing Technology and Business university

SARS-CoV-2， particularly the Omicron variant， often leads to flavor perception dysfunction in infected individuals， making a comprehensive understanding of its duration and recovery patterns a critical part of disease management. This study surveyed a cohort of 199 mildly-to-moderately affected SARS-CoV-2 Omicron-infected patients， focusing on the alterations in their olfaction， taste， and chemesthesis perception. Further， a subset of 36 participants (18 healthy and 18 infected) underwent sensory evaluations to check the variation of umami taste sensitivity. The results demonstrated that most of the infected cohort experienced chemosensory disorders， with the recovery period varying between one week and over a month. Intriguingly， the severity of flavor perception changes during infection significantly correlated with the length of the recovery period. Furthermore， this study explored the specific manifestations of flavor perception dysfunction， potential contributing factors， and potential mechanistic explanations for chemosensory disorders. These include local damage， inflammatory responses， and virus-induced neural damage. However， this study revealed no significant change (P > 0.05) in umami taste sensitivity among infected patients 55 days post-infection. While this research faces limitations related to its self-reported， cross-sectional design， and regional focus， it offers valuable insights into the multifaceted impact of COVID-19， particularly the Omicron variant， on chemosensory perception.

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Initial clinical evaluation of chest digital tomosynthesis in adult patients with COVID-19 pneumonia

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中华医学杂志(英文版) 2024年第18期137卷 2024 Aug 14页

作者： Li Zhanxia Wu Xiuhua Zhang Guobin Wu Dianliang Zhang Yunjiao Wang Chengji Zou Lumin Gu Xiaohua Ren Tao Department of Pulmonary and Critical Care Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Radiology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China school of Mechanical Engineering Shanghai Jiao Tong University Shanghai China shanghai Laboratory Animal Research Center Shanghai China E-COM Technology Limited Beijing China

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