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Science China Materials 2022年第12期65卷 3504-3512页

作者： Xingcheng Ma Feng Wang Dongxu Jiao Dantong Zhang Xiao Zhao David JSingh Jingxiang Zhao Xiaoqiang Cui Weitao Zheng State Key Laboratory of Automotive Simulation and Control School of Materials Science and EngineeringKey Laboratory of Automobile Materials of MOEJilin UniversityChangchun 130012China Key Laboratory of Photonic and Electronic Bandgap Materials Ministry of Educationand College of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025China Department of Physics and Astronomy and Department of chemistry University of MissouriColumbiaMissouri 65211United States Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

Nanoporous metals show promising performances in electrochemical *** this paper,we report a self-supporting bimetallic porous heterogeneous indium/copper structure synthesized with a eutectic gallium-indium(EGaIn)material on a copper *** nanoporous copper-indium heterostructure catalyst exhibits excellent performance in the reduction of carbon dioxide to *** ratio of H_(2)/CO is tunable from 0.47 to 2.0 by changing working *** catalyst is highly stable,showing 96%maintenance of the current density after a 70-h continuous *** functional theory calculations reveal that the indium/copper interface induces charge redistribution within the copper surface,leading to the formation of two distinct active sites,namely,Cu^(δ)and Cu0,and enabling a high-performance generation of CO and H_(2).This work provides a new strategy for obtaining self-supporting nanoporous metal electrode catalysts.

关键词： syngas liquid metal EGaIn heterostructure nanoporous metal

The Gene Expression Patterns Indicate Tissue Development and Functions

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The Gene Expression Patterns Indicate Tissue Development and...

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者：潘建波 Shi-Chang Hu Xian-Ying Cheng Mei-Chun Cai Quan Zou Zhi-Liang Ji Department of chemical Biology College of Chemistry and Chemical EngineeringThe Key Laboratory for Chemical Biology of Fujian Province school of Information Science and Technology Xiamen University State Key Laboratory of Stress Cell Biology School of Life Sciences

Background:Spatiotemporal variation of gene expression can happen extensively. Thanks to current applications of high throughput technologies,***,SAGE and next generation sequencing,gene differential expressions could be motored simultaneously in large scale. Methods:Here,we developed a method to identify housekeeping genes,tissue-specific/ selective genes and tissue-repressed genes using three novel statistical parameters:Specificity Measure(SPM),Contribution Measure(CTM) and Dispersion Measure(DPM).Accordingly, a number of pattern genes were thus identified from several microarray *** these pattern genes,a systematic and genome-wide exploration of these pattern genes were demonstrated in various aspects of chromosomal locus,sub-cellular distribution,physiological function,and association with tissue functions. Results:It is observed that many housekeeping genes are non-evenly expressed across tissues in normal physiological state or under experimental *** tend to lie in intracellular organelles,especially in nucleus and ribosome,and their products function in aspects of nucleic acid binding,nucleic acid metabolic process,transcription and translation. To the contrast,products of tissue-specific genes are normally extracellular,*** plasma membrane or in plasma,in the form of secreted proteins or *** often play roles in receptor binding,homeostasis,organ development and signal ***,tissueselective genes may serve as a bridge between *** even provide clues of tissue development. Conclusions:In summary,our study provides an easier,more sensitive and robust way in quantitative detection of gene expression patterns and further better understanding of tissue function and development.

关键词： Specific/Selective Genes Housekeeping Genes Tissue Function

“On Water”Effect for Green Click Reaction:Spontaneous Polymerization of Activated Alkyne with“Inert”Aromatic Amine in Aqueous Media

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CCS chemistry 2023年第2期5卷 385-396页

作者： Xinyue Liu Chen Zhang Lianrui Hu Jinghan Wang Kai Li Hai-Tao Feng Jacky WYLam Benzhao He Ben Zhong Tang Department of chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 HKUST-Shenzhen Research Institute Shenzhen 518057 Department of Biomedical engineering SUSTech Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518055 AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013 Center for Advanced Materials Research Beijing Normal University at ZhuhaiZhuhai 519085 school of Science and engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen 518172

Organic reactions in water have attracted great attention due to their advantages such as unique reaction performance and environmental *** reactions as well as polymerizations in aqueous media have been extensively investigated,and so far,there has been a massive amount of reporting about polymerizations in ***,reports about click polymerization in water have been ***,click polymerization of activated alkyne and aromatic amine in aqueous media is ***“on water”effect facilitates polymerization in aqueous media better than in organic solvents,and its mechanism is deciphered through experimental data and theoretical *** participates in the reaction and reduces the energy barrier to some ***,polymerization makes it possible for aromatic amine with low reactivity to be *** using this strategy,polymers with high molecular weights can be obtained in high yields(up to 95.4%).They show good thermal stability and high *** can be *** polymers with tetraphenylethylene moieties show aggregation-induced emission and can be used as materials for generating photopatterns and visualizing agents for specific staining of lysosome in living cells.

关键词： “on water”effect click polymerization aromatic amine photodegradation specific lysosome-staining

Preparation of CB8-Cd Column by Sol-gel Technology for Capillary Gas Chromatography

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Preparation of CB8-Cd Column by Sol-gel Technology for Capil...

河南省化学会2016年学术年会

作者： Tao Sun Meiling Qi college of chemistry and chemical engineering and Henan Key laboratory of Function-Oriented Porous Materials Luoyang Normal University Key Laboratory of Cluster Science Ministry of Education of China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials and School of Chemistry Beijing Institute of Technology

A new sol-gel capillary column consisting of the complex cucurbituril[8] with cadmium(II)(CB8-Cd)was prepared for capillary gas chromatographic(CGC) separation. The average polarity of the as-prepared columns evaluated by Mc Reynolds constants was 88, suggesting its nonpolar *** column efficiencies were 1400 theoretical plates/m for the CB8-Cd column. The retention behaviors and separation efficiencies were demonstrated by separating the n-alkanes, bromoalkanes,halogeno benzenes and BTEX. In conclusion, the present study demonstrates that CB8-Cd stationary phases exhibit satisfactory selectivity and have good prospect for complexation chromatography.

关键词： Sol-gel Capillary gas chromatography Cucurbiturils Stationary phases

Cell Imaging Using Two-Photon Excited CdS Fluorescent Quantum DotsWorking within the Biological Window

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Cell Imaging Using Two-Photon Excited CdS Fluorescent Quantu...

第十一届全国化学生物学学术会议

作者： Nannan Zhang Xiao Liu Zhongchao Wei Haiying Liu Jie Peng Liya Zhou Hongmei Li Haihua Fan Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal University Department of Electronic engineering College of Information Science and Technology/College of Cyber SecurityJinan University school of chemistry and chemical engineering Guangxi University school of Life Sciences Sun Yat-Sen UniversityState Key Lab for Biocontrol

In recent years,two-photon excited semiconductor quantum dots（QDs） have been the subject of intense investigation due to their long excitation wavelength which helps to achieve deeper penetration and higher image resolution in optical *** this paper,water-soluble CdS QDs were synthesized using a hydrothermal method and applied to human liver hepatocellular carcinoma（HepG2） *** first-principles calculation suggested that the S-rich defected structure contributes to a narrower band gap compared to the pristine *** resulting fluorescence wavelength was significantly red shifted,which was attributed to the deep defect states *** large Stokes shifts（＞200 nm） of the QDs can eliminate the possible cross-talk between the excitation light and the emission ***-photon induced red fluorescence emission can avoid overlapping with the autofluorescence emission of biological *** uptake and cell viability measurements of the HepG2 cells showed a good biocompatibility and a low toxicity of CdS ***-photon excited scanning microscopy images revealed that the HepG2 cells incubated with CdS QDs emitted bright red upconversion fluorescence and the fluorescence brightness was 38.2 times of that of the control *** results support CdS QDs as a good candidate for application in cellular imaging.

关键词： CdS quantum dots deep defect states two-photon absorption HePG2 cells biological imaging

Preparation of Dithienyl Benzothiadiazole Derivatives as Stationary Phase for Capillary Gas Chromatography Through A Polymerization Reaction

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Preparation of Dithienyl Benzothiadiazole Derivatives as Sta...

河南省化学会2016年学术年会

In this study, 4,7-di(5-allyl-2-thienyl)-benzothiadiazole(DTBT-R1) was used to prepare cross-linked DTBT- R1 column for capillary gas chromatography(CGC). The prepared capillary column of DTBTR1 achieved column efficiency of 1939 plates/m, and showed medium polarity based on the measured Mc Reynolds constants. Additionally, the DTBT-R1 columns showed good separation performance for a variety of analytes such as n-alkanes, alcohols, esters, aldehydes, aromatic hydrocarbons and Grob mixtures. In conclusion, this work demonstrates the excellent chromatographic performance of DTBT derivatives as a new type of GC stationary phases and their potential in separation science.

关键词： Dithienyl benzothiadiazole Capillary gas chromatography Stationary phases

Strain-Assisted Single Pt Sites on High-Curvature MoS_(2)Surface for Ultrasensitive H_(2)S Sensing

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CCS chemistry 2022年第12期4卷 3842-3851页

作者： Zhenggang Xue Chun Wang Yujing Tong Muyu Yan Jiangwei Zhang Xiao Han Xun Hong Yafei Li Yuen Wu NEST Laboratory Department of PhysicsDepartment of ChemistryCollege of ScienceShanghai UniversityShanghai 200444 Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)School of Chemistry and Materials ScienceNational Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026 Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023 Dalian National Laboratory for Clean Energy State Key Laboratory of CatalysisDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 Dalian National Laboratory for Clean Energy Dalian 116023

engineering the local three-dimensional structure of metal sites has an important effect of maximizing the activity and selectivity of single-atom site ***,we engineered a strain-assisted single Pt sites structure on a highly curved MoS_(2)surface to enhance its H_(2)S sensor *** introducing N-methyl-2-pyrrolidone(NMP)as guiding molecules,a multilayer MoS_(2)structure with bending base planes was *** bending behavior could inject not only uniform in-plane strain into the original inert MoS_(2)basal plane but also introduce sufficient accessible sites to anchor Pt *** experimental and theoretical results showed that the highcurvature MoS_(2)surface endowed 0.8%stretch strain onto the low-coordinated single Pt sites with a unique“tip”effect,which led to more accumulation of electrons around the Pt species,thereby accelerating the electric transfer process between H_(2)S and *** final catalyst delivered pronouncedly enhanced H_(2)S sensing response and response speed at room *** proposed strain-assisted strategy might create a new path to design highly active single-atom site catalysts for gas sensors.

关键词： strain-assisted strategy high-curvature Mo_(S)2 surface single-atom site catalysts H_(2)S sensors

Trends in particulate matter and its chemical compositions in China from 2013–2017

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Science China Earth Sciences 2019年第12期62卷 1857-1871页

作者： Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG State Key Laboratory of Atmospheric Boundary Lacer Physics and Atmospheric chemistry(LAPC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China China National Environmental Monitoring Centre Beijing 100012China Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China school of Environment Tsinghua UniversityBeijing 100084China college of Environmental Sciences and engineering Peking UniversityBeijing 100871China University of Chinese Academy of Sciences Beijing 100049China college of Atmospheric Science Lanzhou UniversityLanzhou 730000China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control *** on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from *** results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased *** mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,*** mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,*** mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,*** mean c

关键词： PM2.5 Action Plan for Prevention and Control of Air Pollution,Key regions chemical composition Particle size distribution Variation characteristics

Antibacterial mechanism and activity of cerium oxide nanoparticles

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Science China Materials 2019年第11期62卷 1727-1739页

作者： Mengzhen Zhang Chao Zhang Xinyun Zhai Feng Luo Yaping Du Chunhua Yan Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsSchool of Materials Science and Engineering&National Institute for Advanced MaterialsNankai UniversityTianjin 300350China IMDEA Nanoscience Faraday 9Ciudad Universitaria de CantoblancoMadrid 28049Spain Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China college of chemistry and chemical engineering Lanzhou UniversityLanzhou 730000China

Nanomaterials have been applied as antibacterial agents by virtue of their unique functioning mechanism different from that of conventional *** oxide nanoparticles(CeO2 NPs)are important antibacterial agents due to their relatively low toxicity to normal cells and their distinct antibacterial mechanism based on the reversible conversion between two valence states of Ce(III)/Ce(IV).Some studies have been conducted to explore their antibacterial activities;however,systematic research reviews on the related mechanisms and influencing factors are still quite *** this review,we discuss the plausible mechanisms of the antibacterial activity of CeO2 NPs,analyze different influencing factors,and summarize various research reports on antibacterial effects on *** and *** also propose the potential applications and prospects,and hope to provide an in-depth understanding on the antibacterial mechanism and a better guidance to the design and applications of this promising antibacterial material in the future.

关键词： cerium oxide nanoparticles antibacterial mechanism electrostatic interaction

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第1期7卷 228-242页

作者： Jin-Lan Zhang Yu-Huan Li Lu-Lu Wang Hong-Qi Liu Shuai-Yao Lu Yong Liu Ke Li Bin Liu Su-Yun Li Feng-Min Shao Kun Wang Ning Sheng Rui Li Jin-Jin Cui Pei-Chun Sun Chun-Xia Ma Bo Zhu Zhe Wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang Wang Chen Wang Qiangqian Zhang Li-Min Zhao Xiao-Zhong Peng Zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medical Biology Chinese Academy of Medical Science and Peking Union Medical CollegeKunming 650031 YunnanChina Genuine Biotech.Inc. Pingdingshan 467000 HenanChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerWuhan 430071 HubeiChina The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000 HenanChina Department of Internal Medicine Henan Provincial Peoples HospitalZhengzhou 450003 HenanChina Henan Key Laboratory of Organic Functional Molecule and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007 HenanChina National Clinical Research Center for Respiratory Diseases Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China school of chemistry Zhengzhou UniversityZhengzhou 450001 HenanChina

Azvudine(FNC)is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-19 *** monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC_(50) between 1.2 and 4.3 μM,depending on viruses or cells,and selective index(SI)in 15-83 *** administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest *** gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31)showed that oral FNC(5 mg,qd)cured all COVID-19 patients,with 100%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1-9 days)and 100%hospital discharge rate in 9.00±4.93 days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 16.12%(5/31)***,FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity.

关键词： patients inhibited concentrated