The Gene Expression Patterns Indicate Tissue Development and Functions
作者单位：Department of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe Key Laboratory for Chemical Biology of Fujian Province School of Information Science and TechnologyXiamen University State Key Laboratory of Stress Cell BiologySchool of Life Sciences
会议名称：《第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学》
会议日期：2012年
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
关 键 词：Specific/Selective Genes Housekeeping Genes Tissue Function
摘 要：Background:Spatiotemporal variation of gene expression can happen extensively. Thanks to current applications of high throughput technologies,***,SAGE and next generation sequencing,gene differential expressions could be motored simultaneously in large scale. Methods:Here,we developed a method to identify housekeeping genes,tissue-specific/ selective genes and tissue-repressed genes using three novel statistical parameters:Specificity Measure(SPM),Contribution Measure(CTM) and Dispersion Measure(DPM).Accordingly, a number of pattern genes were thus identified from several microarray *** these pattern genes,a systematic and genome-wide exploration of these pattern genes were demonstrated in various aspects of chromosomal locus,sub-cellular distribution,physiological function,and association with tissue functions. Results:It is observed that many housekeeping genes are non-evenly expressed across tissues in normal physiological state or under experimental *** tend to lie in intracellular organelles,especially in nucleus and ribosome,and their products function in aspects of nucleic acid binding,nucleic acid metabolic process,transcription and translation. To the contrast,products of tissue-specific genes are normally extracellular,*** plasma membrane or in plasma,in the form of secreted proteins or *** often play roles in receptor binding,homeostasis,organ development and signal ***,tissueselective genes may serve as a bridge between *** even provide clues of tissue development. Conclusions:In summary,our study provides an easier,more sensitive and robust way in quantitative detection of gene expression patterns and further better understanding of tissue function and development.