检索结果-南通市图书馆

Chinese Journal of Chemical engineering 2024年第5期69卷 212-219页

作者： Guangxia Jin Yuxue Wu Feng Wei school of biological and Chemical engineering NingboTech UniversityNingbo 315100China

The isolation of minor components from complex natural product matrices presents a significant challenge in the field of purification science due to their low concentrations and the presence of structurally similar *** study introduces an optimized twin-column recycling chromatography method for the efficient and simultaneous purification of these elusive *** introducing water at a small flowing rate between the twin columns,a step solvent gradient is created,by which the leading edge of concentration band would migrate at a slower rate than the trailing edge as it flowing from the upstream to downstream ***,the band broadening is counterbalanced,resulting in an enrichment effect for those minor components in separation ***,two target substances,which showed similar peak position in high performance liquid chromatography(HPLC)and did not exceed 1.8%in crude paclitaxel were selected as target compounds for *** using the twin-column recycling chromatography with a step solvent gradient,a successful purification was achieved in getting the two with the purity almost 100%.We suggest this method is suitable for the separation of most components in natural produces,which shows higher precision and recovery rate compared with the common lab-operated separation ways for natural products(thin-layer chromatography and prep-HPLC).

关键词： Solvent gradient Twin-column recycling chromatography Purification Minor component Natural products

An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 512-522页

作者： Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang Department of Pharmaceutical&biological engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent ***,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants ***,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing *** this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was ***,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE *** decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping ***,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid ***,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers.

关键词： Perfluoropolyether lubricants Catalyzed decomposition Fluorine-containing gas Immobilized conversion Fluoride

Stability and transepithelial transport of oligopeptide(KRQKYD)with hepatocyte-protective activity from Jinhua ham in human intestinal Caco-2 monolayer cells

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1503-1512页

作者： Wen Nie Feiran Xu Kai Zhou Jieying Deng Ying Wang Baocai Xu engineering Research Center of Bio-process Ministry of EducationSchool of Food and Biological EngineeringHefei University of TechnologyHefei 230601China school of biological and Food engineering Chuzhou UniversityChuzhou 239001China

The study evaluated the stability of an oligopeptide(Lys-Arg-Gln-Lys-Tyr-Asp,KRQKYD)and its transport mechanism by simulating gastrointestinal digestion and a model of human intestinal Caco-2 monolayer cells in *** this study,the effects of environmental factors(temperature,pH and NaCl concentration)and simulated gastrointestinal digestion on the stability of KRQKYD were evaluated by indicators of the levels of alanine transaminase(ALT),aspartate transaminase(AST)and malondialdehyde(MDA)in an alcoholinduced hepatocyte injury *** results showed that KRQKYD still maintained satisfactory hepatocyteprotective activity after treatment with different temperatures(20-80℃),pH(3.0-9.0),NaCl concentration(1%-7%)and simulated gastrointestinal digestion,which indicated that KRQKYD showed good stability to environmental factors and simulated gastrointestinal ***,the intact KRQKYD could be absorbed in a model of Caco-2 monolayer cells with a P_(app)value of(9.70±0.53)×10^(-7)cm/*** with an energy inhibitor(sodium azide),a competitive peptide transporter inhibitor(Gly-Pro)and a transcytosis inhibitor wortmannin did not decrease the level of transepithelial KRQKYD transport,indicating that the transport mechanism of KRQKYD was not associated with energy dependent,vector mediated and *** tight junction disruptor cytochalasin D significantly increased the level of transepithelial KRQKYD transport(P<0.05),suggesting that intact KRQKYD was absorbed by paracellular transport.

关键词： Jinhua ham KRQKYD(Lys-Arg-Gln-Lys-Tyr-Asp) Environmental stability Gastrointestinal digestive Transport mechanism

Additives strategies to improving cycling stability of Li metal batteries by modifying electrode electrolyte interphases

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan Li Pengfei Huang Chunyu Cui Xiaoyuan Ma Li Chen Zekun Li Linhai Li Yuhong Tian school of biological and Chemical engineering Guangxi University of Science and Technology school of College of Chemistry and Chemical engineering Hunan University Isky Future Energy Institute

Li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the Li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of Li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a LiF and Li3N-rich solid electrolyte interphase（SEI）.The LiF component increases the robustness of SEI and suppresses the formation of Li dendrites,while the Li3N component facilitates the transportation and reaction kinetics of Li *** a result,the Li‖Li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with LiFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： Electrolyte additive Li dendrites Li metal batteries LiF and Li3N-Rich electrode-electrolyte interphase LiFePO4 cathode

In situ high-quality LiF/Li_(3)N inorganic and phenyl-based organic solid electrolyte interphases for advanced lithium–oxygen batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Carbon Energy 2024年第9期6卷 29-38页

作者： Qianyan Wang Minsheng Wu Yunkai Xu Chuyue Li Yuanjia Rong Yaling Liao Menglin Gao Xiaoping Zhang Weirong Chen Jun Lu school of Electrical engineering Southwest Jiaotong UniversityChengduChina College of Chemical and biological engineering Zhejiang UniversityHangzhouChina

Lithium metal shows a great advantage as the most promising anode for its unparalleled theoretical specific capacity and extremely low electrochemical ***,uncontrolled lithium dendrite growth and severe side reactions of the reactive intermediates and organic electrolytes still limit the broad application of lithium metal ***,we propose 4-nitrobenzenesulfonyl fluoride(NBSF)as an electrolyte additive for forming a stable organic-inorganic hybrid solid electrolyte interphase(SEI)layer on the lithium *** abundance of lithium fluoride and lithium nitride can guarantee the SEI layer's toughness and high ionic conductivity,achieving dendrite-free lithium ***,the phenyl group of NBSF significantly contributes to both the chemical stability of the SEI layer and the good adaptation to volume changes of the lithium *** lithium-oxygen batteries with NBSF exhibit prolonged cycle lives and excellent cycling *** simple approach is hoped to improve the development of the organic-inorganic SEI layer to stabilize the lithium anodes for lithium-oxygen batteries.

关键词： lithium anode lithium-oxygen batteries reactive oxygen species solid electrolyte interphase

Proteomics Study of Benzene Metabolite Hydroquinone Induced Hematotoxicity in K562 Cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 341-353页

作者： JIN Yi Shan YI Zong Chun ZHANG Yu Jing RONG Long YU Chun Hong school of biological Science and Medical engineering Beihang UniversityBeijing 100191China school of engineering Medicine Beihang UniversityBeijing 100191China

Objective Hydroquinone(HQ),one of the phenolic metabolites of benzene,is widely recognized as an important participant in benzene-induced ***,there are few relevant proteomics in HQ-induced hematotoxicity and the mechanism hasn’t been fully understood *** In this study,we treated K562 cells with 40μmol/L HQ for 72 h,examined and validated protein expression changes by Label-free proteomic analysis and Parallel reaction monitoring(PRM),and performed bioinformatics analysis to identify interaction *** One hundred and eighty-seven upregulated differentially expressed proteins(DEPs)and 279 downregulated DEPs were identified in HQ-exposed K562 cells,which were involved in neutrophilmediated immunity,blood microparticle,and other GO terms,as well as the lysosome,metabolic,cell cycle,and cellular senescence-related *** on the 23 DEGs and 5 DEPs in erythroid differentiation-related pathways,we constructed the network of protein interactions and determined 6 DEPs(STAT1,STAT3,CASP3,KIT,STAT5B,and VEGFA)as main hub proteins with the most interactions,among which STATs made a central impact and may be potential biomarkers of HQ-induced *** Our work reinforced the use of proteomics and bioinformatic approaches to advance knowledge on molecular mechanisms of HQ-induced hematotoxicity at the protein level and provide a valuable basis for further clarification.

关键词： Hydroquinone Proteomics Hematotoxicity K562 cells

Spectroscopic and temperature sensing properties of Sm3+ in self-activated CsLu（WO4）2 phosphors

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第11期42卷 2033-2042页

作者： Mingjun Song Jing Wang Zhi Xie Li Liu Wang Zhao Weiwei Zhou school of Chemistry Chemical and Environmental EngineeringWeifang University College of Mechanical and Electrical engineering Fujian Agriculture and Forestry University school of Chemistry and Materials engineering Huainan Normal University

In this research,a series of Sm3+doped CsLu（WO4）2phosphors was prepared via high temperature solid phase technique to design new red phosphors and optical thermometric *** structures,morphology,band gap and luminescence properties were characterized by X-ray diffraction,scanning electron microscopy,diffuse reflection and luminescence spectra,*** UV excitation,CsLu（WO4）2gives rise to a blue broad emission band between 350 and 700 nm,which stems from the3T1u→1A1gtransition of *** Sm3+is introduced into CsLu（WO4）2,energy transfer between WO66-groups and Sm3+ions takes place in CsLu（WO4）2:Sm3+phosphors,and color-tunable luminescence from blue to red is realized by controlling the Sm3+doping *** energy transfer efficiency between WO66-groups and Sm3+ons was analyzed,and the energy transfer mechanism was determined to be dipole-dipole *** to the temperature-dependent luminescence spectra,WO66-groups and Sm3+ions exhibit large discrepancy in thermal quenching rates,and thus the temperature sensing properties of CsLu（WO4）2:Sm3+in the temperature range of 283-403 K were *** on the framework of fluorescence intensity ratio theory,the basic optical thermometry parameters including absolute and relative sensitivity of CsLu（WO4）2:Sm3+we re calculated and the results show that it has great potential for application in optical thermometry.

关键词： Phosphors Energy transfer Fluorescence intensity ratio Optical thermometry Rare earths

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Study on the green extraction of corncob xylan by deep eutectic solvent

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Grain & Oil Science and Technology 2024年第1期7卷 50-59页

作者： Bingyu Jiao Le Wang Haitao Gui Zifu Ni Rong Du Yuansen Hu school of biological engineering National Engineering Research Center of Wheat and Corn Further ProcessingZhengzhou 450001China

Corn as one of the world's major food crops,its by-product corn cob is also rich in ***,the unreasonable utilization of corn cob often causes the environmental pollution,waste of resources and other *** one of the most abundant polymers in nature,xylan is widely used in food,medicine,materials and other *** cob is rich in xylan,which is an ideal raw material for extracting ***,the intractable lignin is covalently linked to xylan,which increases the difficulty of xylan *** has been reported that the deep eutectic solvent(DES)could preferentially dissolve lignin in biomass,thereby dissolving the ***,the xylan in the extract was separated by ethanol precipitation *** xylan precipitate was obtained after centrifugation,while the supernatant was *** components of the supernatant after ethanol precipitation were separated by the rotary *** ethanol,water and DES were collected for the subsequent extraction of corn cob *** this study,a novel way was provided for the green production of corn cob *** DES was used to extract xylan from corn cob which was used as the raw *** effects of solid-liquid ratio,reaction time,reaction temperature and water content of DES on the extraction rate of corn cob xylan were investigated by the single factor ***,the orthogonal test was designed to optimize the xylan extraction *** structure of corn cob xylan was analyzed and *** results showed that the optimum extraction conditions of corn cob xylan were as follows:the ratio of corn cob to DES was 1:15(g:mL),the extraction time was 3 h,the extraction temperature was 60℃,and the water content of DES was 70%.Under these conditions,the extraction rate of xylan was 16.46%.The extracted corn cob xylan was distinctive triple helix of polysaccharide,which was similar to the structure of commercially available *** was effectively and workably extracted from corn

关键词： Corncob Deep eutectic solvent Xylan Process optimization Extraction

Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 420-425页

作者： Hao Cai Xiaoyan Wu Lei Jiang Feng Yu Yuxiang Yang Yan Li Xian Zhang Jian Liu Zijian Li Hong Bi school of Materials Science and engineering Anhui UniversityHefei 230601China school of Chemistry and Chemical engineering Anhui UniversityHefei 230601China school of Food and biological engineering Hefei University of TechnologyHefei 230009China

The reactive oxygen species(ROS) generation efficiency is always limited by the extreme tumor microenvironment(TME), leading to unsatisfactory antitumor effects in photodynamic therapy(PDT). As a promising gas therapy molecule, nitric oxide(NO) is independent of oxygen and could even synergize ROS to enhance the therapeutic effect. However, the short half-life, instability, and uncontrollable release of exogenous NO limited the application of tumor synergistic therapy. Herein, we reported a novel kind of red-emissive carbon dots(CDs) that was capable of lysosome-targeted and light-controlled NO delivery. The CDs were synthesized by using metformin and methylene blue(MB) via a hydrothermal *** obtained metformin-MB CDs(MMCDs) exhibited a higher1O2quantum yield and NO generation efficiency under light emitting diode(LED) light irradiation. Noteworthily, the1O2could further in situ oxidize NO into peroxynitrite anions(ONOO-), which own the higher cytotoxicity against cancer *** experiments indicate that MMCDs could destruct lysosome membrane integrity and kill almost 80%of Hep G2 cells under light irradiation while very low cytotoxicity in the dark. Moreover, MMCDs significantly decreased tumor volume and weight after phototherapy in hepatoma Hep G2-bearing mice. Our study provides a new strategy for light-controlled NO generation as well as precise lysosome-targeting for enhancement of PDT efficiency.

关键词： Carbon dots Nitric oxide Lysosome-targeting Photodynamic therapy Cancer