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Two-photon imaging of lymphoma cells targeted by gold nanoparticles

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Chinese Optics Letters 2008年第12期6卷 879-881页

作者：屈晓超王晶姚翠萍张镇西 Life science Research Centerschool of Electronic Engineering Xidian University Key Laboratory of biomedical Information Engineering of Ministry of Education Institute of Biomedical Analytical Technology and InstrumentationSchool of Life Science and TechnologyXi'an Jiaotong University

Gold nanoparticles （NPs） have highly efficient multi-photon-induced luminescence. In this paper, we record the two-photon images of gold NPs, lymphoma cell line Karpas 299, and Karpas 299 incubated with 30-nm-diameter gold NPs and ACT-1 antibody conjugates （Au30-ACT-1 conjugates） by using a multi-photon microscopy system. Due to the specific conjugation of ACT-1 antibody and cell membrane receptor CD25, gold NPs are only bound to the surface of cell membrane of Karpas 299. The luminescence intensity of gold NPs is higher than that of cells at 750-nm laser excitation. By comparing the images of Karpas 299 cells incubated with and without gold NPs, it is found that by means of gold NPs, we can get clear cell images with lower excitation power. Their excellent optical and chemical properties make gold NPs an attractive contrast agent for cellular imaging.

关键词： Animal cell culture Cell culture Cell membranes Chemical properties Cytology Image enhancement Laser excitation Light emission Light sources Luminescence Nanoparticles Photons Scanning

FeCo alloy/N,S co-doped carbon aerogel derived from directionalcasting cellulose nanofibers for rechargeable liquid flow and flexible Zn–air batteries

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Nano Research 2023年第5期16卷 6870-6880页

作者： Yiwen Zhang Xifeng Zhang Yuting Li Juan Wang Sibudjing Kawi Qin Zhong school of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Department of Chemical and biomolecular Engineering National University of SingaporeSingapore 117582Singapore

Bifunctional oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)electrocatalysts with the advantages of excellent activity and stability are the vital components of air cathodes for rechargeable Zn–air batteries(ZABs).Herein,the carbon aerogel with honeycomb-like structure,N and S double doping and loaded with FeCo alloy nanoparticles(NSCA/FeCo)was prepared successfully as cathodes for rechargeable liquid flow and two-dimensional flexible ZABs by clever directional *** interaction between the bimetallic alloy and the double-doped carbon with specifical structure,large surface,great conductivity endows NSCA/FeCo with effective ORR/OER active sites and small charge/mass transport barrier,thus achieving outstanding bifunctional catalytic *** NSCA/FeCo displays a half-wave potential of+0.85 V(*** hydrogen electrode(RHE))for ORR and an overpotential of 335 mV at a current density of 10 mA·cm^(−2)for OER,which is even comparable to the performance of noble-metal catalysts in relevant fields(Pt/C for ORR and RuO_(2)for OER).Consequently,the rechargeable liquid flow ZABs assembled with NSCA/FeCo showed excellent performance(maximum power density:132.0 mW·cm^(−2),specific capacity:804.5 Wh·kg^(−1)at 10 mA·cm^(−2),charge and discharge cycle stability of more than 250 cycles).Furthermore,the flexible NSCA/FeCo-based ZABs have a maximum power density of 43.0 mW·cm^(−2),outstanding charging–discharge stability of more than 450 cycles,exhibit good flexibility under different bending ***,this work has provided an efficient bifunctional electrocatalyst for OER/ORR and a promising strategy of air cathodes for rechargeable and wearable ZABs.

关键词： carbon aerogel bifunctional electrocatalyst FeCo alloy directional freeze-casting rechargeable zinc–air batteries flexible batteries

Gold nanocages as multifunctional materials for nanomedicine

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Frontiers of physics 2014年第3期9卷 378-384页

作者： Xiaohu Xia The Wallace H. Coulter Department of biomedical Engineering Georgia Institute of Technology and Emory University Medical School Atlanta GA 30332 USA school of Chemistry and Biochemistry School of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332 USA

Featured by tunable localized surface plasmon resonance peaks in the near-infrared region and hollow interiors, Au nanocages represent a novel class of multifunctional nanomat, erials that have gained considerable attention in recent vears. This short review summarizes our recent work on the capabilities of An nanocages in nanomedicine. We start with a brief description of the synthesis of Au nanocages and highlight our recent protocols for the scaled-up production of An ***. We then use a numer of examples to illustrate how Au nanocages can contribute to nanomedicine with respect to both diagnosis and therapy.

关键词： gold nanocage nanomedicine diagnosis therapy

Imaging the structure and organization of mouse cerebellum and brain stem with second harmonic generation microscopy

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Chinese Optics Letters 2017年第9期15卷 7-11页

作者： Xiuli Liu Daozhu Hua Ling Fu Shaoqun Zeng Britton Chance Center for biomedical Photonics School of Engineering Sciences Wuhan National Laboratory for Optoelectronics--Huazhong University of Science and Technology Wuhan 430074 China MoE Key Laboratory for biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan 430074. China

To visualize the structure and organization of the brain is a fundamental requirement in the research of neuroscience. Here, combining with two-photon excitation fluorescence microscopy and transgenetic mouse GAD67,we demonstrate a custom-built second harmonic generation（SHG） microscope to discriminate brain layers and sub regions in the cerebellum and brain stem slices with cellular resolution. In particular, the cell densities of neurons in different brain layers are extracted due to the cell soma appearing as dark shadow on an SHG ***, the axon initial segments of the Purkinje cell are easily recognized without labeling, which would be useful for guiding micropipettes for electrophysiology.

关键词： SHG Imaging the structure and organization of mouse cerebellum and brain stem with second harmonic generation microscopy

Strategies for engineering advanced nanomedicines for gas therapy of cancer

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National science Review 2020年第9期7卷 1485-1512页

作者： Yingshuai Wang Tian Yang Qianjun He Guangdong Provincial Key Laboratory of biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical Engineering Health Science CenterShenzhen University

As an emerging and promising treatment method, gas therapy has attracted more and more attention for treatment of inflammation-related diseases, especially cancer. However, therapeutic/therapy-assisted gases（NO, CO, H2S, H2, O2, SO2and CO2） and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release, resulting in limited cancer therapy efficacy and potential side effects. Therefore, development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired, and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also reduce their side effects. The design of nanomedicines with these functions is vitally important, but challenging. In this review, we summarize a series of engineering strategies for construction of advanced gas-releasing nanomedicines from four aspects:（1） stimuli-responsive strategies for controlled gas release;（2） catalytic strategies for controlled gas release;（3） tumor-targeted gas delivery strategies;（4）multi-model combination strategies based on gas therapy. Moreover, we highlight current issues and gaps in knowledge, and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer. This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.

关键词： nanomedicine gas therapy drug delivery controlled release cancer treatment

Effects of smoking on cerebral and ventricular volumes in healthy males

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Neural Regeneration Research 2011年第1期6卷 72-75页

作者： Hyun-Jun Kim Mi-Hyun Choi Beob-Yi Lee Su-Jeong Lee Jae-Woong Yang Ji-Hye Kim Jin-Seung Choi Dong-Won Kang Jang-Yeon Park Jae-Hoon Jun Gye-Rae Tack Soon-Cheol Chung Department of Obstetrics & Gynecology Konkuk University Department of biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University Department of Anatomy School of MedicineKonkuk University

Previous studies have reported decreased cerebral volume as a result of smoking. However, little is known about accompanying changes in ventricular volume for healthy subjects who smoke, although ventricular volume is increased in patients with multiple sclerosis who smoke. The present study analyzed whether cerebral volume decreased with smoking through the use of magnetic resonance imaging. In addition, accompanying changes in ventricular volume that resulted from decreased cerebral volume and smoking were analyzed in healthy subjects. When multivariate analysis of covariance was performed by integrating the 2 age groups, aged 20-28 years and 40-49 years, with statistical significance, results showed that cerebral volume of smokers was smaller and ventricular volume was greater compared with the non-smokers. These findings suggest that ventricular volume changes could be utilized to characterize the effects of smoking.

关键词： smoking cerebral and ventricular volumes magnetic resonance imaging

Steady state and time-resolved autofluorescence studies of human colonic tissues

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Chinese Optics Letters 2006年第6期4卷 348-350页

作者：李步洪张镇西谢树森 Key Laboratory of biomedical Information Engineering of Ministry of Education and Institute of biomedical Engineering School of Life Science and TechnologyXi'an Jiaotong University Key Laboratory of biomedical Information Engineering of Ministry of Education and Institute of biomedical Engineering School of Life Science and TechnologyXi'an Jiaotong University Key Laboratory of Optoelectronic science and Technology for Medicine of Ministry of Education and Institute of Laser and Optoelectronics Technology Fujian Normal University

Steady state and time-resolved autofluorescence spectroscopies are employed to study the autofluorescence characteristics of human colonic tissues in vitro. The excitation wavelength varies from 260 to 540 nm, and the corresponding fluorescence emission spectra are acquired from 280 to 800 nm. Significant difference in fluorescence intensity of excitation-emission matrices （EEMs） is observed between normal and tumor colonic tissues. Compared with normal colonic tissue, low nicotinamide adenine dinucleotide （phosphate）（NAD（P）H） and flavin adenine dinucleotide （FAD）, and high amino acids and protoporphyrin IX （PpIX） fluorescences characterize high-grade malignant tissue. Moreover, the autofluorescence lifetimes of normal and carcinomatous colonic tissues at 635 nm under 397-nm excitation are about 4.32±0.12 and 18.45±0.05 ns, respectively. The high accumulation of endogenous PpIX in colonic cancers is demonstrated in both steady state and time-resolved autofluorescence spectroscopies.

关键词： Amino acids Fluorescence Matrix algebra Phosphates

A Reliable Neighbor-Based Method for Identifying Essential Proteins by Integrating Gene Expressions, Orthology,and Subcellular Localization Information

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Tsinghua science and Technology 2016年第6期21卷 668-677页

作者： Min Li Zhibei Niu Xiaopei Chen Ping Zhong Fangxiang Wu Yi Pan the school of Information science and Engineering Central South University the Department of Mechanical Engineering and Division of biomedical Engineering University of Saskatchewan the Department of Computer science Georgia State University

Essential proteins are those necessary for the survival or reproduction of species and discovering such essential proteins is fundamental for understanding the minimal requirements for cellular life, which is also meaningful to the disease study and drug design. With the development of high-throughput techniques, a large number of Protein-Protein Interactions（PPIs） can be used to identify essential proteins at the network level. Up to now, though a series of network-based computational methods have been proposed, it is still a challenge to improve the prediction precision as the high false positives in PPI networks. In this paper, we propose a new method GOS to identify essential proteins by integrating the Gene expressions, Orthology, and Subcellular localization *** gene expressions and subcellular localization information are used to determine whether a neighbor in the PPI network is reliable. Only reliable neighbors are considered when we analyze the topological characteristics of a protein in a PPI network. We also analyze the orthologous attributes of each protein to reflect its conservative features, and use a random walk model to integrate a protein＇s topological characteristics and its orthology. The experimental results on the yeast PPI network show that the proposed method GOS outperforms the ten existing methods DC, BC, CC, SC, EC, IC, NC, Pe C, ION, and CSC.

关键词： essential protein reliable neighbors GOS orthology subcellular localization information

Geodesics in the Engel Group with a Sub-Lorentzian Metric——the Space-Like Case

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 147-162页

作者： Qihui CAI Department of Mathematics and Computer science School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China

Let E be the Engel group and D be a bracket generating left invariant distribution with a Lorentzian metric, which is a nondegenerate metric of index 1. In this paper, the author constructs a parametrization of a quasi-pendulum equation by Jacobi functions, and then gets the space-like Hamiltonian geodesics in the Engel group with a sub-Lorentzian metric.

关键词： Sub-Lorentzian metric Engel Group Geodesics