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COVID-19-associated disseminated mucormycosis:An autopsy case report

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World Journal of Clinical Cases 2022年第28期10卷 10358-10365页

作者： Daisuke Kyuno Terufumi Kubo Mitsuhiro Tsujiwaki Shintaro Sugita Michiko Hosaka Hazuki Ito Keisuke Harada Akira Takasawa Yusaku Kubota Kumi Takasawa Yusuke Ono Kazufumi Magara Eichi Narimatsu Tadashi Hasegawa Makoto Osanai Department of Pathology Sapporo Medical UniversitySapporo 0608556HokkaidoJapan Department of Surgical Pathology Sapporo Medical UniversitySapporo 0608556Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608556Japan

BACKGROUND Reports of mucormycosis,an infectious disease that commonly affects immunocompromised individuals,have increased during the ongoing coronavirus disease 2019(COVID-19) *** mucormycosis associated with COVID-19 is rare but fatal and is characterized by an aggressive clinical course and delayed *** report documents a case of disseminated mucormycosis after COVID-19 *** is a rare pathological autopsy report on COVID-19-associated *** SUMMARY A 58-year-old man was transferred to our hospital with severe COVID-19 *** treatment for acute respiratory distress syndrome,he developed intra-abdominal bleeding that required a right hemicolectomy and ileostomy for *** ileostoma and surgical wound developed necrosis followed by sepsis and multi-organ failure,which led to *** autopsy revealed multiple thrombi associated with Rhizopus oryzae infection,which led to the necrosis of multiple infected *** Early suspicion and diagnosis followed by treatment are keys to better outcomes of mucormycosis in patients with severe COVID-19.

关键词： COVID-19 Mucormycosis Mucorales infection Rhizopus oryzae SARS-Co V-2 Case report

Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice

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World Journal of Stem Cells 2023年第4期15卷 268-280页

作者： Takayasu Ohtake Shoichi Itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai Makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo Kobayashi Regenerative Medicine The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan kidney disease and Transplant center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Regenerative Medicine Shonan Research Institute of Innovative MedicineKamakura 247-8533KanagawaJapan Kamakura Techno-science Inc. Kamakura 248-0036Japan Advanced Medicine Science Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Sapporo Tokushukai HospitalSapporo 004-0041Japan Department of Pathology Sapporo Medical CenterSapporo 004-0041Japan Human Life CORD Japan Inc Chuo-ku 103-0012TokyoJapan Cell Processing and Cell/Genome Analysis Center The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan kidney disease and Transplant Center Shonan Kamakura General HospitalKamakura 247-8533KanazawaJapan

BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in *** Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning *** culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming *** tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine *** Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control *** interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(Pkidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(Pkidney *** administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.

关键词： Chronic kidney disease CD34+cell Adenine Tubulointerstitial injury Quality and quantity control culture Umbilical cord blood

Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients:A pilot study

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World Journal of Gastroenterology 2014年第30期20卷 10512-10517页

作者： Hirotoshi Ishiwatari Tsuyoshi Hayashi Makoto Yoshida Michihiro Ono Hiroyuki Masuko Tsutomu Sato Koji Miyanishi Yasushi Sato Rishu Takimoto Masayoshi Kobune Atsushi Miyamoto Tomoko Sonoda Junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Hospital Pharmacy Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Public Health Sapporo Medical University School of MedicineSapporo 0600061Japan

AIM: To investigate the effectiveness of phenol for the relief of cancer pain by endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN).

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Phenol Pain management Upper gastrointestinal cancer

Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder

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Current Urology 2022年第3期16卷 136-141页

作者： Takashi Muranaka Kohei Hashimoto Tetsuya Shindo Kosuke Shibamori Yuki Kyoda Ko Kobayashi Toshiaki Tanaka Naoya Masumori Department of Urology Sapporo Medical University School of MedicineSapporo060-8543Japan

Background:Small cell carcinoma of the urinary bladder(SCUB)is *** optimal treatment for SCUB remains *** address the problem of appropriate treatment for each case,we assessed single-modality and surgery-based multimodality treatments in patients with *** and methods:We retrospectively reviewed the medical records of 12 patients with SCUB between 1990 and *** pa-tients underwent transurethral resection of the bladder tumor and were diagnosed with *** clinicopathological characteristics were assessed,and the outcomes were compared according to the treatment ***:The median(range)age at diagnosis was 66 years(range,53-85 years).T1-4N0M0 was observed in 8 patients(66%),N1-3M0 in 2(17%),and NanyM1 in 2(17%).After transurethral resection of the bladder tumor,6 patients(50%)underwent cystectomy alone,and 4(33%)underwent cystectomy and presurgical or adjuvant chemotherapy with etoposide and *** the median follow-up period of 20.7 months,6 patients(50%)died of cancer,and 2 patients(17%)died of other *** median overall survival period was 1.9 *** 5-year overall survival rate in patients who underwent cystectomy and chemotherapy was 75%,whereas that in those who underwent cystectomy alone and transurethral resection alone were 22%and 0%,respectively(p=0.012).Recurrence-free survival was significantly correlated with cause-specific survival(r=0.95;95%confidence interval,0.81-0.99;ptreatment strategy is crucial.

关键词： Bladder cancer Small cell carcinoma treatment Chemotherapy Radical cystectomy

Non-invasive gene delivery across the blood-brain barrier:present and future perspectives

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Neural Regeneration Research 2022年第4期17卷 785-787页

作者： Seigo Kimura Hideyoshi Harashima Laboratory for Molecular Design of Pharmaceutics Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan Laboratory of Innovative Nanomedicine Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

The aging of society has arrived,and is accompanied by an increase in the absolute numbers of patients with neurological disorders,such as Alzheimer's and Parkinson's diseases(Feigin et al.,2020).Such diseases,particularly Alzheimer's disease and other forms of dementia,affect not only the patients themselves,but also the people around them,including family members and care *** a result,such neurological disorders are thought to carry a larger social burden compared to other *** most critical point in the current situation is that there is no effective treatment despite the fact that the number of patients increase with the aging of the population.

关键词： diseases Alzheimer carry

A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers

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World Journal of Gastroenterology 2010年第46期16卷 5779-5789页

作者： Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University Department of Internal Medicine Sapporo Shirakabadai Hospital Vanderbilt-Ingram Cancer Center and Departments of Medicine and Cell Biology Vanderbilt University

Advances in molecular research in cancer have brought new therapeutic strategies into clinical *** new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) *** concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new *** I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human *** this review,we focus on this promising therapeutic target,*** IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI *** studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer *** results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and *** also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical *** mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single *** summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug ***,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcino

关键词： Dominant negative Gastrointestinal cancer Insulin like growth factor-I receptor Monoclonal anti-body Tyrosine kinase inhibitor

Quality of nursing care,availability and accessibility of treatment and prevention of communicable and chronic diseases

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International Journal of Nursing Sciences 2017年第4期4卷 350-351页

作者： Valentina Sarkisova Russian Nurses Association Russia European forum of National Nursing and Midwifery Associations

*** care·Provision of primary care based on district approach(in resi-dential areas)·Networks of district outpatient clinics specifically working for adults and for children·Network of primary specialized outpatient clinics(women consultancy,cardiology)·Medical stations in rural territories with different staffing depending on population numbers-(doctor and nurse working jointly,or feldshers working alone/independent practice)·Medical rooms at schools and other education settings,large companies·Home visits.

关键词： prevention nurse district

Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1552-1561页

作者： Makoto Saito Akio Mori Shihori Tsukamoto Takashi Ishio Emi Yokoyama Koh Izumiyama Masanobu Morioka Takeshi Kondo Hirokazu Sugino Blood Disorders Center Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 060-8638Japan

BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better ***,the“watch and wait”approach is frequently adopted as the treatment ***,there is an option to actively intervene in ***,the long-term outcomes of such cases are poorly *** To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment *** We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our *** We identified 5 cases of *** patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 *** was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance *** therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 ***,3 patients experienced *** patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous *** remaining patient had systemic widespread recurrence 13 years after the first *** results suggested that the FL lesions were transformed into diffuse large B-cell *** patient died 4 years later despite receiving various *** In this study,the treatment for patients of D-FL in Stage IV was *** the future,criteria for how to treat“advanced”D-FL should be established based on additional *** study of patients with D-FL indicates that whole-body follow-up examinations shou

关键词： Duodenal-type follicular lymphoma treatment Long-term follow-up Radiation Rituximab Chemotherapy

Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6493-6500页

作者： Makoto Saito Masanobu Morioka Koh Izumiyama Akio Mori Reiki Ogasawara Takeshi Kondo Toru Miyajima Emi Yokoyama Satoshi Tanikawa Department of Internal Medicine and Hematology Aiiku HospitalSapporo 0640804HokkaidoJapan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 0608638HokkaidoJapan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo 001-0021HokkaidoJapan

BACKGROUND Phlegmonous gastritis(PG)is a rare bacterial infectious disease characterized by neutrophil-based purulent inflammation of the gastric *** most representative causative bacterium is Streptococcus pyogenes,followed by Staphylococcus,Pneumococcus and *** portal venous gas(HPVG)is considered a potentially fatal condition and is rarely associated with *** SUMMARY The white blood cell count of a 70-year-old woman with acute lymphocytic leukemia in complete remission dropped to 100/μL after consolidation *** vital signs were consistent with septic *** blood culture revealed the presence of Bacillus *** computed tomography(CT)and esophagogastroduodenoscopy(EGD)showed marked thickening of the gastric *** with the other findings,CT was suggestive of HPVG,and EGD showed pseudomembrane-like tissue covering the superficial *** examination of gastric biopsy specimens showed mostly necrotic tissue with lymphocytes rather than *** of gastric specimens revealed the presence of Bacillus *** finally diagnosed this case as PG with Bacillus cereus-induced sepsis and *** patient recovered successfully with conservative treatment,chiefly by using carbapenem *** The histopathological finding of this gastric biopsy specimen should be called"neutropenic necrotizing gastritis".

关键词： Phlegmonous gastritis Chemotherapy neutropenia Bacillus cereus Histopathology Case report