Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion
作者机构：Department of UrologySapporo Medical UniversitySchool of MedicineSapporoJapan Sapporo Kidney Disease Treatment ForumSapporoJapan Department of UrologySunagawa City Medical CenterSunagawaJapan Department of UrologyTakikawa Municipal HospitalTakikawaJapan Department of UrologySaiseikaiOtaru HospitalOtaruJapan
出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)
年 卷 期：2015年第2卷第3期
页 面：167-169页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Renal function Cystatin C Urinary diversion
摘 要：Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal ***,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in such ***:We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and *** creatinine(sCr)and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and ***:The median CysC and sCr concentrations were 1.12 mg/L(range 0.75-2.47 mg/L)and 0.99 mg/dL(range 0.61-2.22 mg/dL),*** median estimated concentrations of glomerular filtration rate(GFR)based on CysC(eGFRcys)and GFR based on creatinine(eGFRcreat)were 61.08 mL/min/1.73 m^2(range 22.64e99.89 mL/min/1.73 m^2)and 58.01 mL/min/1.73 m^2(range 23.48e91.82 mL/min/1.73 m2),*** had a significant correlation with sCr(r=0.8607,p0.0001)and eGFRcreat(r=-0.8993,p0.0001).eGFRcys also had a significant correlation with eGFRcreat(r=0.8104,p0.0001).Conclusion:The correlation between CysC and sCr was strong and the correlation coefficient was equivalent to that in patients without *** results suggest that CysC is not affected by UD and can be used as a marker of renal function similarly to sCr in patients with UD.
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