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Impact of sleep on gastrointestinal cancer

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World Journal of Clinical Oncology 2024年第6期15卷 677-683页

作者： Joshua Lo Pahnwat T Taweesedt Makoto Kawai Department of Internal Medicine Santa Clara Valley Medical CenterSan JoseCA 95128United States Department of Psychiatry and Behavioral Sciences Stanford UniversityStanfordCA 94305United States Sierra Pacific Mental Illness Research Educationand Clinical Center(MIRECC)VA Palo Alto Health Care SystemPalo AltoCA 94304United States Department of Psychiatry and Behavioral Sciences School of MedicineStanford UniversityRedwood CityCA 94063United States

Sleep problems have become a significant public health concern,affecting a large portion of the global population and have been linked to increased morbidity and *** incidence of gastrointestinal(GI)cancers continues to rise,posing a substantial burden on healthcare systems *** editorial aims to delve into the impact of sleep on GI cancers,including esophageal,gastric,colorectal,hepatobiliary,and pancreatic *** literature investigating the potential connections between GI cancers and sleep was *** considered aspects such as sleep duration,sleep disorders,and circadian rhythmicity,in order to explore the underlying mechanisms that can contribute to the development of GI cancers and propose avenues for future research.

关键词： Sleep Cancer Gastrointestinal cancer Esophagus Stomach Colon Liver

Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

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Military medical Research 2022年第2期9卷 205-214页

作者： Beatrice Alexandra Golomb Sridevi Devaraj Alexis K.Messner Hayley Jean Koslik Jun Hee Han Barnabas Yik Department of Medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Swedish medical center SeattleWA 98109USA Henry M.Jackson Foundation for the Advancement of Military Medicine San DiegoCA 92134USA santa clara valley medical center San JoseCA 95128USA

Background: Malondialdehyde(MDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of MDA to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower MDA level in veterans with ***: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.

关键词： Malondialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide

Internal mammary artery harvesting with its distal end occluded

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Chinese medical Journal 2019年第11期132卷 1385-1386页

作者： Yoandy Lopez-de la Cruz Yolepsis Quintero-Fleites Department of Cardiovascular Surgery Santa Clara Cardiac Center Santa Clara Villa Clara 50200 Cuba

To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose in relation to the internal mammary artery (IMA) harvesting is very useful because they are based on a 20-year experience in more than 10,000 patients.

关键词： coronary artery mammary Lesion of internal mammary artery

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第47期23卷 8263-8276页

作者： Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed Department of Medicine College of MedicineDrexel University Division of Gastroenterology and Hepatology Health Science CenterUniversity of Tennessee Department of Medicine Santa Clara Valley Medical Center Division of Gastroenterology and Hepatology Stanford University School of Medicine

Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis.

关键词： Nonalcoholic fatty liver disease Hepatic steatosis Fatty liver Prevalence Incidence Fibrosis Risk factor Epidemiology Outcomes Nonalcoholic steatohepatitis

Economic burden and healthcare utilization in nonalcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 181-183页

作者： Eric RYoo Aijaz Ahmed Donghee Kim Department of Internal Medicine Santa Clara Valley Medical CenterSan JoseCAUSA Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA

In the United States(US),the shift in the treatment paradigm following the introduction of second generation direct-acting antiviral(DAA)agents for hepatitis C virus(HCV)infection has favorably transformed the landscape of end-stage liver disease(ESLD)with a rapid decline in HCV-related liver transplantation;HCV had been the leading indication for liver transplantation for the last two decades(1).While the rate of liver transplantation in patients with HCV infection has plummeted in the US following the widespread application of DAA-based regimens in the pre-transplant setting,the rise in alcohol use disorder and obesity has catapulted alcoholic liver disease(ALD)to become the leading indication for liver transplantation in the US in 2016 followed closely by nonalcoholic steatohepatitis(NASH),a progressive subset of nonalcoholic liver disease(NAFLD)(1).Despite the decline in HCV-related liver transplantation in the US,the total number of liver transplants per year are on an upward trajectory as a result of marked increase in ESLD associated with ALD and NASH—an ominous trend.

关键词： nonalcoholic landscape spite

Burns resulting from spontaneous combustion of electronic cigarettes: a case series

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Burns & Trauma 2016年第4期4卷 323-326页

作者： Clifford Sheckter Arhana Chattopadhyay John Paro Yvonne Karanas Division of Plastic Surgery Stanford UniversityPalo AltoCAUSA Division of Plastic Surgery Stanford UniversityPalo AltoCAUSA santa clara valley medical center Regional Burn center 751 South Bascom AvenueSan JoseCA 95128USA

Background:Electronic cigarette(e-cigarette)sales have grown rapidly in recent years,coinciding with a public perception that they are a safer alternative to traditional ***,there have been numerous media reports of fires associated with e-cigarette spontaneous *** Presentation:Three severe burns caused by spontaneous combustion of e-cigarettes within a 6-month period were treated at the santa clara valley medical center Burn *** sustained partial and full-thickness *** required hospitalization and surgical ***:E-cigarettes are dangerous devices and have the potential to cause significant *** and the general public should be made aware of these life-threatening devices.

关键词： Electronic cigarettes E-cigarette E-cig Burn

Use of direct-acting antiviral agents in hepatitis C virusinfected liver transplant candidates

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World Journal of Gastroenterology 2018年第3期24卷 315-322页

作者： Chiranjeevi Gadiparthi George Cholankeril Brandon J Perumpail Eric R Yoo Sanjaya K Satapathy Satheesh Nair Aijaz Ahmed Division of Gastroenterology and Hepatology University of Tennessee Health Sciences CenterMemphisTN 38104United States Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCA 94304United States Drexel University College of Medicine PhiladelphiaPA 19129United States Department of Medicine Santa Clara Valley Medical CenterSan JoseCA 95128United States

Since the advent of direct acting antiviral(DAA) agents, chronic hepatitis C virus(HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant(LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation. Sustained virological response(SVR) rates following HCV treatment may improve hepatic function sufficiently enough to negate the need for LT in certain patients. On the other hand, the decrease in MELD without improvement in quality of life in certain patients may lead to delay or dropout from potentially curative LT surgery list. In this context, our review focuses on the approach to and optimal timing of DAA-based treatment of HCV infection in LT candidates in the peri-transplant period.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation Purgatory Model for End-stage liver disease Sustained virological response

Timing of Hepatitis C Virus Treatment in Liver Transplant Candidates in the Era of Direct-acting Antiviral Agents

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Journal of Clinical and Translational Hepatology 2017年第4期5卷 363-367页

作者： George Cholankeril Mairin Joseph-Talreja Brandon J.Perumpail Andy Liu Eric R.Yoo Aijaz Ahmed Aparna Goel Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine California Pacific Medical CenterSan FranciscoCAUSA Department of Medicine Santa Clara Valley Medical CenterSan JoseCAUSA

Chronic hepatitis C virus(HCV)infection remains the leading indication for liver transplantation(LT)in the United *** most patients with chronic HCV infection remain asymptomatic,up to one-third develop progressive liver disease resulting in *** is often the only curative treatment once significant hepatic decompensation ***,antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral *** new regimens are well tolerated,of short duration and highly effective,unlike the traditional treatment with pegylated-interferon and *** achieving sustained virological response becomes increasingly attainable for a majority of HCV-infected patients,concerns have been raised regarding the optimal timing of treatment for HCV infection in the setting of end-stage liver disease and during the peri-transplant *** one hand,HCV treatment may improve hepatic function and negate the need for LT in some,which is crucial given the scarcity of donor organs and mortality on the waiting list in certain *** the other hand,HCV treatment may result in lowering the priority for LT without improving quality of life,thereby delaying potentially curative LT *** review evaluates the evidence supporting the use of direct-acting antiviral agents in the period before and following LT.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation

Recent advances in colorectal cancer screening

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Chronic Diseases and Translational Medicine 2018年第3期4卷 139-147页

作者： Dan Li Department of Gastroenterology Kaiser Permanente Medical CenterSanta ClaraCA 95051USA Division of Research Kaiser Permanente Northern CaliforniaOaklandCA 94612USA

Introduction Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide.1 In the United States, 135,430 new cases of CRC were diagnosed in 2017, with 50,260 CRC-related deaths.2 In the Asia-Pacific region, the incidence varies between regions, with an increasing trend among countries that have undergone rapid development and industrialization. In China, for example, age-standardized incidence of CRC increased from 12.8 in 2003 to 16.8 in 2011 per 100,000 in-dividuals.3 Timely screening for CRC is critical to reducing CRC-related mortality by detecting the tumor at the early, curable stage.

关键词： Colorectal cancer Screening Colonoscopy