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Potential therapeutic options for coronavirus disease 2019:using knowledge of past outbreaks to guide future treatment

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Chinese Medical Journal 2020年第11期133卷 1350-1352页

作者： John Lin Jing Ouyang Xiao-Rong Peng Stephane Isnard Brandon Fombuena Jean-pierre Routy Yao-Kai Chen infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontrealQC H4A 3J1Canada Chronic Viral Illness Service McGill University Health CentreMontrealQC H4A 3J1Canada Division of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310000China Department of Microbiology and Immunology McGill UniversityMontrealQC H3A 0G4Canada Division of Hematology McGill University Health CentreMontrealQC H4A 3J1Canada

In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract ***,other variants have rapid transmission rates and can cause severe respiratory syndrome and *** variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV.

关键词： respiratory acute China.

Prevalence and Determinants of Kidney Markers among Subjects with Hepatitis C Virus Infection

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Open Journal of Nephrology 2020年第2期10卷 85-101页

作者： Mathurin pierre Kowo Sylvain Raoul Simeni Njonnou Murielle Sonia Mehly Ngninzeko Firmin Ankouane Andoulo Antonin Ndjitoyap Ndam Michelle Tagny Sartre Vicky Ama Moor Jeanne Ngongang François Folefack Kaze Department of Internal Medicine and Specialty Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaounde University Teaching hospital Yaoundé Cameroon Department of Internal Medicine and Specialty Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Higher Institute of Health Sciences Université des Montagnes Bangangté Cameroon Medical Centre “La Cathédrale” Yaoundé Cameroon Department of Physiological Sciences and Biochemistry Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction: Hepatitis C virus (HCV) infection is a worldwide public health problem with multisystemic involvements including kidneys. We assessed the prevalence and determinants of kidney markers among HCV infected subjects. Methods: A cross-sectional study was conducted from March to July 2017 in two referral centers in Yaoundé. Sociodemographic, clinical and paraclinical data were collected from patient’s records. Renal involvement was evaluated using estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease’s (MDRD) equation, urine dipstick and albumin/creatinine ratio (ACR). An eGFR 2 was defined as low and reduced respectively. Albuminuria was defined by an ACR > 30 mg/g and divided into A1 (300 mg/g). Results: We included 65 (41.5% males) HCV infected patients with a mean age of 56.8 ± 10.5 years. HCV infection was diagnosed for more than 5 years in 54 (83.1%) patients. HCV viral load and genotype were available in 40 (61.5%) patients;viral load was high (>5.9 logs/mL) in 20 (50%) of them and genotypes 4 (40%), 1 (32.5%) and 2 (27.5%) were found in this population. The mean eGFR was 112.9 ± 31.9 mL/min/1.73 m2 with 14 (21.5%) and 4 (6.2%) patients having reduced and low eGFR respectively. Albuminuria (80%), leukocyturia (24.6%) and hematuria (4.6%) were the observed dipstick abnormalities. Median albuminuria (IQR) was 542.4 (238.7 - 961.5) mg/g, with 7 (11%), 12 (18%) and 46 (71%) patients in A1, A2 and A3 respectively. Reduced/low eGFR and albuminuria were observed in 58 (89.2%) patients while low eGFR and albuminuria were found in 55 (84.6%) patients. Advanced age, female gender, HCV genotype 1 and 4, and albuminuria (all p Conclusion: Renal abnormalities are common in HCV infected patients leading by proteinuria and decr

关键词： Hepatitis C Virus Chronic Kidney Disease Prevalence Sub-Saharan Africa

Attitudes and Practices of Health Care Providers Regarding the Management of Uncomplicated Malaria in Abidjan, Cote d＇lvoire

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Journal of Life Sciences 2012年第7期6卷 747-753页

作者： Frederic Nogbou Ello Thomas Yapo Aba Ismael Ouattara Didier Koumavi Ekouvi Offoue Kra pierre Aime Assemian Amath Wade Serge-Paul Eholie Emmanuel Bissagnene Department of lnfectious and Tropical Diseases in Abidjan University Hospital of Treichville 01 BP V3 Abidjan 01 Cote d 'lvoire PAC-CI Program Abidjan University Hospital ofTreichville USAC Extension 18 BP 1954 Abidjan 18 Cote d'Ivoire Laboratoire Sanofi Aventis Sanofi-Aventis Dakar BP 3529 Senegal

Acute myocarditis triggering coronary spasm and mimicking acute myocardial infarction

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World Journal of Cardiology 2014年第9期6卷 1045-1048页

作者： Andreas Kumar Rodrigo Bagur Patrick Béliveau Jean-Michel Potvin pierre Levesque Nancy Fillion Benoit Tremblay éric Larose Valérie Gaudreault Division of Cardiology Department of MedicineQuebec University Hospital Centre Department of Medicine Laval UniversityQuebec City Quebec Heart and Lung Institute Laval University

A 24-year-old healthy man consulted to our center because of typical on-and-off chest-pain and an electrocardiogram showing ST-segment elevation in inferior leads. An urgent coronary angiography showed angiographically normal coronary arteries. Cardiovascular magnetic resonance imaging confirmed acute myocarditis. Although acute myocarditis triggering coronary spasm is an uncommon association, it is important to recognize it, particularly for the management for those patients presenting with ST-segment elevation and suspect myocardial infarction and angiographically normal coronary arteries. The present report highlights the role of cardiovascular magnetic resonance imaging to identify acute myocarditis as the underlying cause.

关键词： myocarditis triggering spasm urgent elevation inferior recognize highlights chest arteries

A body-packer with a cocaine bag stuck in the stomach

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World Journal of Radiology 2011年第6期3卷 155-158页

作者： Yan Beauverd pierre-Alexandre Poletti Hans Wolff Frédéric Ris Jean-Marc Dumonceau Bernice S Elger Department of General Internal Medicine University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Radiology University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Community Medicine Primary Care and Emergency medicineUniversity Hospitals of Geneva and Faculty of Medicine University of GenevaRue Michel-Servet 11211 Geneva 4Switzerland Department of visceral surgery University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Gastroenterology University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland University of Geneva Center for legal medicineCMURue Michel-Servet 11211 Geneva 4Switzerland

Management of patients carrying packets of drugs in the digestive tract is a frequent medical *** on a patient who was referred by the police after ingestion of packets of *** spontaneous elimination of 81 drug packets,the patient had three unremarkable stools.A plain abdominal X-ray disclosed no residual packet but computed tomography(CT) scan showed one in the *** this was not eliminated during the 10 d following ingestion,it was removed through *** case stresses the usefulness of the CT scan to ensure that no residual packet is present before hospital discharge.

关键词： Body-packing Cocaine Management Surgery Gastroscopy

Yunpi Qushi Jiangzhuo Recipe Alleviates Lipid Deposition and Reduces Liver Damage in Mice with Non-alcoholic Fatty Liver Disease

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Clinical Complementary Medicine and Pharmacology 2023年第1期3卷 1-7页

作者： Xiangyao Wu Linwensi Zhu Mengmeng You Yanli Chen Hui Chai Lin Chen Qianyu Qian Zuifei Shangguan Fusheng Jiang Songtao Li Xiaobing Dou School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Zhejiang Provincial hospital of Traditional Chinese Medicine Hangzhou 310006ZhejiangChina School of Public Health Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Molecular Medicine Institute Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina

Background:Non-alcoholic fatty liver disease(NAFLD)is a multifactorial liver metabolic disease,which af-fects nearly a quarter of the world’s *** Qushi Jiangzhuo Recipe(QSJZR)is a traditional Chi-nese medicine compound,which is composed of Amomum kravanh pierre ex Gagnep,Coix lacryma-jobi ***-yuen(Roman.)Stapf,Prunus armeniac a *** Maxim,Salvia miltiorrhiza Bge,Nelumbo nucifera Gaertn,Alisma plantago-aquatica Linn,Polyporus umbellatus(Pers.)Fries,Poria cocos(Schw.)Wolf,and Artemisia capillaris *** has a certain therapeutic effect on NAFLD patients,but its specific mechanism is not ***:To investigate the effect of QSJZR on high-fat diet(HFD)-fed NAFLD mice and its ***:Twenty-four SPF female C57BL/6 J mice(21.0±0.5 g)were randomly divided into normal diet(ND)group,HFD group and QSJZR *** group was given basal diet,while the other two groups were given ***,each mouse in QSJZR group was given 0.2 mL/day(containing 2.27 g crude drug per mL)QSJZR,ND group and HFD group were given the same amount of normal saline for 13 consecutive ***,the serum was collected for biochemical assay,and the liver was removed for pathological examination and biochemical ***:Body weight and white fat weight of the HFD-induced NAFLD mice significantly decreased after min-istration with QSJZR,while liver weight had no significant *** also significantly reduced liver and serum triglyceride levels,and alleviated hepatocyte lipid deposition by regulating genes and proteins expression related to lipid metabolism,including AMPK,SREBP1C,CPT1A and *** addition,compared with HFD group,liver malondialdehyde(MDA)content was lower in QSJZR group,while glutathione peroxidase(GPx)content was *** alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels were lower in QSJZR group than those in HFD *** with QSJZR significantly alleviated liver injury by increasing BCL2/BAX

关键词： Non-alcoholic fatty liver disease Chinese medicine compound High-fat diet Liver damage Lipid metabolism

不同文化传统的国家中饮酒模式与缺血性心脏病的关系：心肌梗死前瞻性流行病学研究（PRIME研究）

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英国医学杂志中文版 2011年第2期14卷 114-115页

作者： Jean-Bernard Ruidavets pierre Ducimetiere Alun Evans Michele Montaye Bernadette Haas Annie Bingham John Yamell Philippe Amouyel Dominique Arveiler Frank Kee Vanina Bongard Jean Ferrieres 齐文安(译) Department of Epidemiology INSERM U558 Toulouse University School of Medicine Toulouse France INSERM-Paris XI University Villejuif France UK Clinical Research Collaboration Centre of Excellence for Public Health Queen's University Belfast Belfast UK Department of Epidemiology and Public Health INSERM U744 Pasteur Institute of Lille Lille France Department of Epidemiology and Public Health EA 3430 Medical Faculty University of Stmsbourg Strasbourg France INSERM U970 Paul Brousse Hospital Villejuif France Department of Cardiology B and Depamnent of Epldemiology INSERM U558 Toulouse University Hospital Toulouse France 《中华病理学杂志》编辑部

目的探讨在两个生活方式不同的国家（北爱尔兰和法国）中，饮酒方式对缺血性心脏病发生的影响。

关键词：缺血性心脏病心肌梗死前流行病学饮酒模式文化传统北爱尔兰生活方式饮酒方式

AB046. The retinoblastoma model for translational research

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Annals of Eye Science 2018年第1期 452-452页

作者： pierre Hardy Chung Yang Rosanne Superstein Mike P.Sapieha Patrick Hamel Departments of Pediatrics and Pharmacology University of MontrealMontrealQuébecCanada Department of Ophthalmology CHU Ste-JustineMontréalCanada Department of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealQuebecCanada

Background:Our national collaborative research initiative is proposing to develop a common infrastructure for Rb *** are proposing a novel in vivo Rb model using human Rb cells ***:The rabbit model has advantages over the mouse models:(I)the larger eye size of rabbits,similar to the human infant eye,permits a more accurate injection of the drugs and evaluation of methods of targeted intraocular drug delivery;(II)the rabbit model demonstrated similar fundus appearance and pathologic features to human Rb,including vitreous seeds of viable tumor when the retinal tumor is mid-sized,which are usually found in the late stage in mouse *** lack of ability to eliminate vitreous seeds is a major reason of current treatment failures in Group C and D tumors;therefore,the rabbit model of Rb may be used as a model to evaluate the effectiveness and various routes of drug ***:This is an implementation of an infrastructure for evaluating therapeutic *** addition,this finding enables a variety of pharmacokinetic studies,pharmacodynamic and toxicology studies for new therapeutic ***:This infrastructure meets the growing concern of practitioners and researchers in the *** common facility is easily accessible to all VHRN members on request,including requests from other sectors.

关键词： Retinoblastoma animal model rabbit rat

Multidrug-Resistant Tuberculosis in the Democratic Republic of Congo: Analysis of Continuous Surveillance Data from 2007 to 2016

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Journal of Tuberculosis Research 2019年第1期7卷 25-44页

作者： Serge Bisuta-Fueza Jean Marie Kayembe-Ntumba Marie-Jose Kabedi-Bajani Pascale Mulomba Sabwe Hippolyte Situakibanza-Nani Tuma Jean-pierre Simelo Ernest Sumaili-Kiswaya John Ditekemena-Dinanga Patrick Kayembe-Kalambayi Pneumology Unit University Hospital of Kinshasa University of Kinshasa Kinshasa Democratic Republic of Congo Department of Microbiology Medical Biology Department University of Kinshasa Kinshasa Democratic Republic of Congo National Tuberculosis Program Ministry of Public Health Kinshasa Democratic Republic of Congo Infectious Diseases Unit Department of Internal Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Physiology Unit Department of Internal Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Community Health Kinshasa School of Public Health University of Kinshasa Kinshasa Democratic Republic of Congo Department of Epidemiology & Biostatistics Kinshasa School of Public Health University of Kinshasa Kinshasa Democratic Republic of Congo

Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done primarily among at-risk groups. The knowledge of the true extent of the MDR-TB remains a major challenge. This study tries to determine the proportion of MDR-TB in each group of presumptive MDR-TB patients and to identify some associated factors. Methods: This is an analysis of the DRC surveillance between 2007 and 2016. The proportions were expressed in Percentage. The logistic regression permits to identify the associated factors with the RR-/MDR-TB with adjusted Odds-ratio and 95% CI. Significance defined as p ≤ 0.05. Results: Overall, 83% (5407/6512) of the MDR-TB presumptive cases had each a TB test. 86.5% (4676/5407) had each a culture and drug sensitive testing (DST) on solid medium, and 24.3% (1312/5407) had performed an Xpert MTB/RIF test. The proportion of those with at least one first-line drug resistance was 59.3% [95% CI 57.2 - 61.4] among which 50.1%, [95% CI 47.9 - 52.3] for the isoniazid, 45.6% [95% CI 43.4 - 47.8] for the rifampicin, 49.9% [95% CI 47.8 - 52.1] for ethambutol and 35.8% [95% CI 33.7 - 37.9] for streptomycin. The confirmation of MDR-TB was 42.8% [95% CI 38.4 - 47.8]. Combining both tests, the proportion of RR-/MDR-TB was 49.6% [95% CI 47.9 - 51.4] for all presumptives. This proportion was 60.0% for failures, 40.7% for relapses and 34.7% for defaulters. Associated factors with the diagnosis of MDR-TB were: aged less than 35 years;prior treatment failure;defaulters;the delay between the collection of sputum and the test completion. Conclusion: The proportion of RR-/MDR-TB among the presumptives has been higher than those estimated generally. The National tuberculosis programme (NTP) should improve patient follow-up to reduce TB treatment failures and defaulting. Moreover, while increasing the use of molecular tests, they sho

关键词： Multidrug-Resistant Tuberculosis Resistance to Rifampicin Factors Associated DR Congo