AB046. The retinoblastoma model for translational research
作者机构：Departments of Pediatrics and PharmacologyUniversity of MontrealMontrealQuébecCanada Department of OphthalmologyCHU Ste-JustineMontréalCanada Department of OphthalmologyMaisonneuve-Rosemont Hospital Research CentreUniversity of MontrealQuebecCanada
出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)
年 卷 期：2018年第1期
页 面：452-452页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Retinoblastoma animal model rabbit rat
摘 要：Background:Our national collaborative research initiative is proposing to develop a common infrastructure for Rb *** are proposing a novel in vivo Rb model using human Rb cells ***:The rabbit model has advantages over the mouse models:(I)the larger eye size of rabbits,similar to the human infant eye,permits a more accurate injection of the drugs and evaluation of methods of targeted intraocular drug delivery;(II)the rabbit model demonstrated similar fundus appearance and pathologic features to human Rb,including vitreous seeds of viable tumor when the retinal tumor is mid-sized,which are usually found in the late stage in mouse *** lack of ability to eliminate vitreous seeds is a major reason of current treatment failures in Group C and D tumors;therefore,the rabbit model of Rb may be used as a model to evaluate the effectiveness and various routes of drug ***:This is an implementation of an infrastructure for evaluating therapeutic *** addition,this finding enables a variety of pharmacokinetic studies,pharmacodynamic and toxicology studies for new therapeutic ***:This infrastructure meets the growing concern of practitioners and researchers in the *** common facility is easily accessible to all VHRN members on request,including requests from other sectors.
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