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Roadmap to quality and innovation

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中华医学杂志(英文版) 2014年第6期127卷 1197-1198页

作者： James Nguyen Faisal Latif Thach Nguyen Theodore A.Bass Department of Cardiology University of Texas Health Science CenterSan Antonio7703 Floyd Curl DrTX 76229USA Department of Medicine Cardiovascular SectionVA Medical Center and University of Oklahoma Health Sciences CenterOklahoma CityOklahomaUSA St. mary medical center MerrillvilleIN 46410USA Division of Cardiology University of FloridaUSA

In the first decade of the 21st century,the activities in theAmerican cardiac catheterization laboratories underwentsignificant *** mostly cardiac diagnosticcatheterization and basic angioplasty and stenting the

关键词： quality initiatives quality assurance cardiac catheterization laboratories

Fly boyz,hybrid artists or cool guys:testing the boundaries of imagination

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Journal of Geriatric Cardiology 2005年第3期2卷 191-192页

作者： Thach Nguyen Hoang Pham James Nguyen Bikash Agarwal St mary medical center Hobart IN Long Island College Hospital Brooklyn NY St Anthony Memorial Health center Michigan City IN

In the early years of coronary interventions,when a single lesion was found,the question then was asked whether it was feasible and safe to dilate right away the lesion with plain old balloon angioplasty (ad hoc POBA) or to call in a senior interventional cardiologist to do POBA on a later *** lesions were found in more than one coronary artery territories,then the interventional cardiologists had to pull his or her hair and asked whether it was feasible and safe to dilate right away the other lesion(s) at the same *** than 20 years later,at this present time,with nearly perfect outcomes due to stent availability and high level of experiences from operators,the question of multiple coronary stenting in one session is neither problematic nor ***,if not all lesions are taken care immediately or in near future sessions,the question would be whether the patient receives standard of care as there is no complete revascularization.

关键词： PCI than

Appropriate use criteria for cardiac catheterization and coronaryrevascularization

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Chinese medical Journal 2014年第6期127卷 1161-1165页

作者： Jack P.Chen Thach Nguyen Faisal Latif Theodore A.Bass Department of Medicine Northside Hospital Atlanta Georgia USA Indiana University School of Medicine Community Healthcare System St Mary Medical Center Hobart Indiana USA Department of Medicine Cardiovascular Section VA Medical Center and University of Oklahoma Health Sciences Center Oklahoma CityOklahoma USA Division of Cardiology University of Florida USA

Challenges Since its inception,the field of invasive and interventionalcardiology has witnessed tremendous procedural andtechnological advancements,thereby offering quantumexpansion in clinical *** the complexity ofth... 详细信息

关键词： appropriate use criteria cardiac catheterization percutaneous coronary intervention treadmill risk factors

Quality assurance for cardiovascular catheterization and intervention

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Chinese medical Journal 2014年第6期127卷 1191-1193页

作者： Faisal Latif Thach Nguyen Aravinda Nanjundappa Bonnie H.Weiner Department of Medicine Cardiovascular Section VA Medical Center and University of Oklahoma Health Sciences Center Oklahoma CityOklahoma USA Indiana University School of Medicine Community Healthcare System St Mary Medical Center Hobart Indiana USA West Virginia University Charleston West Virginia USA St.Vincent Hospital at Worcestermedical center HarvardMassachusetts USA

Challenges There are more than 2 000 cardiac catheterizationlaboratories(CCL)in the *** could be a full serviceCCL or they only perform emergency primary coronaryinterventions(PCI).They could also perform elective PCI

关键词： quality assurance cardiovascular catheterization standard of excellence accreditation

Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

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World Journal of Gastroenterology 2009年第10期15卷 1209-1218页

作者： Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney mary M Huerter Lynell W Klassen Geoffrey M Thiele Department of Internal Medicine University of Nebraska Medical Center 986350 Nebraska Medical Center Omaha NE 68198-6350 United States Veterans Administration Alcohol Research center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Department of Pathology and Microbiology University of Nebraska Medical Center 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.

关键词： Alcoholic liver disease Inflammation Fibrosis Sinusoidal liver endothelial cells Kupffer cells Hepatocyte Stellate cells Precision cut liver slices

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

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Cellular & Molecular Immunology 2021年第5期18卷 1161-1171页

作者： Chang H.Kim Department of Pathology and mary H.Weiser Food Allergy center University of Michigan School of MedicineAnn ArborMIUSA

A mounting body of evidence indicates that dietary fiber(DF)metabolites produced by commensal bacteria play essential roles in balancing the immune ***,considered nonessential nutrients in the past,is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory and allergic ***-chain fatty acids(SCFAs),such as acetate,propionate,and butyrate,are the major DF metabolites and mostly produced by specialized commensal bacteria that are capable of breaking down DF into simpler saccharides and further metabolizing the saccharides into *** act on many cell types to regulate a number of important biological processes,including host metabolism,intestinal functions,and immunity *** review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major innate and adaptive *** information regarding how SCFAs regulate innate lymphoid cells,T helper cells,cytotoxic T cells,and B cells and how these functions impact immunity,inflammation,and allergic responses are discussed.

关键词： Microbiota Dietary fiber Short-chain fatty acids Innate lymphoid cells B cells Th1 Th17 Tregs CD8 Microbial metabolites

Clinical significance of isolated biliary candidiasis in patients with unresectable cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 533-539页

作者： In-Ho Kim Jae-Ki Choi Dong-Gun Lee In Seok Lee Tae Ho Hong Young Kyoung You Ho Jong Chun Myung Ah Lee Departments of Internal Medicine Division of Medical 0ncologySeoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Departments of Internal Medicine Division of Infectious Diseases Bucheon St. Mary’s Hospital The Catholic University of Korea Seoul Korea Division of Infectious Diseases Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Division of Gastroenterology Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Surgery Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Radiology Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Hepato-Biliary-Pancreatic Cancer center Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea

BACKGROUND: The frequency of isolated biliary candidiasis is increasing in cancer patients. The clinical signiifcance of isolated biliary candidiasis remains unclear. We analyzed the risk factors of biliary candidiasis and outcomes of the patients with unresectable cholangiocarcinoma after percutaneous transhepatic biliary drainage (PTBD). METHODS: Among 430 patients who underwent PTBD between January 2012 and March 2015, 121 patients had unresectable cholangiocarcinoma. Bile and blood samples were collected for consecutive fungal culture. RESULTS: The study cohort included 49 women and 72 men with a median age of 71 years. Multivariate analysis showed that cancer progression (P=0.013), concurrent presence of another microorganism (P=0.010), and previous long-term (>7 days) antibiotic use (P=0.011) were potential risk factors of biliary candidiasis. Chemotherapy was not associated with overall biliary candidiasis (P=0.196), but was signiifcantly related to repeated biliary candidiasis (P=0.011). Patients with isolated biliary candidiasis showed remarkably reduced survival compared with those without (median overall sur-vival (OS): 32 vs 62 days,P=0.011)Subgroup analysis was also performed. Patients with repeated candidiasis had markedly decreased survival compared with those with transient candi-diasis (median OS: 30 vs 49 days,P=0.046). Biliary candidiasis was identiifed as a poor prognostic factor by univariate and multivariate analyses (P=0.033). Four cases of repeated can-didiasis (4/19, 21%) showedCandida species in consecutive blood culture until the end of the study, but others showed no candidemia. CONCLUSIONS: Isolated biliary candidiasis may be associ-ated with poor prognosis in patients with unresectable chol-angiocarcinoma. Especially, repeated biliary candidiasis may have the possibility of progression to candidemia. We suggest that biliary dilatation treatment or antifungal agents might be helpful for patients with biliary candidiasis.

关键词： biliary candidiasis biliary obstruction cholangiocarcinoma percutaneous transhepatic biliary drainage

Compartmentalization of local cAMP signaling in neuronal growth and survival

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Neural Regeneration Research 2020年第3期15卷 453-454页

作者： Tomasz Boczek Michael S.Kapiloff Department of Ophthalmology Byers Eye InstituteMary M.and Sash A.Spencer Center for Vision ResearchStanford University School of MedicinePalo AltoCAUSA Department of Molecular Neurochemistry Medical University of LodzPoland

Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and *** highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite *** these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream *** the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in *** complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.

关键词： metabolism specificity integrate

In vivo and ex vivo confocal endomicroscopy of pancreatic cystic lesions: A prospective study

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World Journal of Gastroenterology 2017年第18期23卷 3338-3348页

作者： Somashekar G Krishna Rohan M Modi Amrit K Kamboj Benjamin J Swanson Phil A Hart mary E Dillhoff Andrei Manilchuk Carl R Schmidt Darwin L Conwell Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical Center Department of Internal Medicine The Ohio State University Wexner Medical Center College of Medicine The Ohio State University Wexner Medical Center Department of Pathology The Ohio State University Wexner Medical Center Division of Surgical Oncology The Ohio State University Wexner Medical Center Deparment of General Surgery The Ohio State University Wexner Medical Center

To investigate the reproducibility of the in vivo endoscopic ultrasound (EUS) - guided needle based confocal endomicroscopy (nCLE) image patterns in an ex vivo setting and compare these to surgical histopathology for characterizing pancreatic cystic lesions (PCLs).METHODSIn a prospective study evaluating EUS-nCLE for evaluation of PCLs, 10 subjects underwent an in vivo nCLE (AQ-Flex nCLE miniprobe; Cellvizio, MaunaKea, Paris, France) during EUS and ex vivo probe based CLE (pCLE) of the PCL (Gastroflex ultrahigh definition probe, Cellvizio) after surgical resection. Biopsies were obtained from ex vivo CLE-imaged areas for comparative histopathology. All subjects received intravenous fluorescein prior to EUS and pancreatic surgery for in vivo and ex vivo CLE imaging *** total of 10 subjects (mean age 53 ± 12 years; 5 female) with a mean PCL size of 34.8 ± 14.3 mm were enrolled. Surgical histopathology confirmed 2 intraductal papillary mucinous neoplasms (IPMNs), 3 mucinous cystic neoplasms (MCNs), 2 cystic neuroendocrine tumors (cystic-NETs), 1 serous cystadenoma (SCA), and 2 squamous lined PCLs. Characteristic in vivo nCLE image patterns included papillary projections for IPMNs, horizon-type epithelial bands for MCNs, nests and trabeculae of cells for cystic-NETs, and a “fern pattern” of vascularity for SCA. Identical image patterns were observed during ex vivo pCLE imaging of the surgically resected PCLs. Both in vivo and ex vivo CLE imaging findings correlated with surgical *** vivo nCLE patterns are reproducible in ex vivo pCLE for all major neoplastic PCLs. These findings add further support the application of EUS-nCLE as an imaging biomarker in the diagnosis of PCLs.

关键词： Confocal laser endomicroscopy Serous cystadenoma Pancreatic neuroendocrine tumor Intraductal papillary mucinous neoplasm Pancreatic cystic neoplasm