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Effects of pneumoperitoneum of laparoscopic cholecystectomy on the coagulation system of patients： a prospective observational study

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Chinese medical Journal 2014年第14期127卷 2599-2604页

作者： Amin Buhe Zhang Chengcai Yan Wei Sun Zhipeng Zhang Yankai Du Dexiao Gong Ke Capital med univ Dept Gen Surg Beijing Shijitan Hosp Beijing 100038 Peoples R China Zibo Cent Hosp Dept Laparoscopy Surg Zibo 255036 Shandong Peoples R China

BacKground Laparoscopic cholecystectomy has been widely used in clinical practice during the recent decades; however, the effects of pneumoperitoneum and the surgery on the coagulation system are largely unknown. This clinical study aimed to observe any possible effects of pneumoperitoneum and the surgery on the coagulation system of patients. Methods This was a prospective observational study. The inclusion criteria included （1） patients with chronic cholecystitis and/or cholecystic polyps and （2） patients in the relief stage of acute cholecystitis. The exclusion criteria included （1） patients in the episodic stage of acute cholecystitis and those complicated with cholangiolithiasis; （2） patients with concomitant hematologic diseases, damages to the liver function, malignant tumors or immune system diseases, or patients complicated with thrombotic or hemorrhagic disorders; and （3） patients who had taken anticoagulant medication within a week before surgery. Fifty patients who were hospitalized into our department for elective laparoscopic cholecystectomy between November 2011 and February 2013 were eligible and enrolled into this study. Of the 50 patients, 22 were male and 28 female. The age of the patients ranged from 29 to 78 （mean 56.7±11.5） years. The surgery for each of the 50 patients was performed with the same equipment and conditions. The surgeries for all the patients were performed under general anesthesia with the patients in a 30-degree head-up tilted posture, and the pressure of pneumoperitoneum was maintained at 13 mmHg. Venous blood specimens were taken from each patient before and at the end of pneumoperitoneum （i.e., 0 hour after surgery） and at 8 hours after surgery for determination of prothrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen （Fib）, thrombin time （TT）, and D-dimer （DD）. The results of the determinations of these parameters were compared. Results （1） All the patients recovered well without any complications.

关键词： pneumoperitoneum cholecystectomy laparoscopic coagulation system

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Application of third-party mediation for medical disputes： an introduction of Chinese experience

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Chinese medical Journal 2014年第14期127卷 2707-2710页

作者： Cao Yanlin Wang Jiangjun Zheng Xueqian Jin Qinghan Tian Yongquan Wen Xuebin Wei Zhanying Li Wu Cent S univ Sch Publ Hlth Changsha 410013 Hunan Peoples R China Chinese Acad med Sci Inst Med Informat Beijing 100020 Peoples R China China Japan Friendship Hosp Beijing 100029 Peoples R China Chinese Hosp Assoc Med Legal Syst Comm Beijing 100081 Peoples R China shandong Jining First Peoples Hosp Jining 272002 Shandong Peoples R China

to disputes that occur when milies are unsatisfied with medical services offered by medical workers.1 China stands at the point of social transformation2 with various social contradictions, one of which is the increasing medical disputes. According to the statistics from the Minister of Health, there are more than one million medical disputes in China per year, with an average of 40 per medical institution.3 The China Hospital Management Association＇s survey that was completed in 2013 showed that medical workers were attacked with injures by patients in 63.7% of hospitals in 2012, rising from 47.7% in 2008. The percentage of hospitals with more than six such incidences was 8.3% in 2012, which was twice more than that in 2008 （4.5%）. It is increasingly common to see medical workers abused and threatened. The average number of such occurrences for each hospital was 20.6 in 2008, but 27.3 in 2012. The study also shows that there were 40 serious violence incidences against medical workers causing severe injuries, disabilities, and even death between 2003 and 2012, which had affected the normal diagnoses and treatments in hospitals and undermined social harmony and stability.4

关键词：暴力创伤和损伤统计学亚洲大陆世系人群胰岛素异议和争论中国

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Cardinium infection alters cotton defense and detoxification metabolism of its whitefly host

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Insect Science 2023年第2期30卷 473-485页

作者： Ying Liu Kun Yang Jicheng Wang Dong Chu shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdaoShangdong ProvinceChina

Field monitoring revealed that the infection ratio of the bacterial symbiont Cardinium in the whitefly(Bemisia tabaci med)was relatively low in northern ***,the role of this symbiont and the symbiont-whitefly-host plant interaction mechanism are poorly *** investigated the influence of Cardinium on the competitiveness of the host whitefly and the physiological interaction between the host plants and host ***-infected whiteflies were displaced by uninfected whiteflies after 5 generations,which showed that Cardinium infection reduced whitefly *** defense response genes of cotton significantly decreased under infestation by infected whiteflies compared to uninfected *** expression of detoxification metabolism genes,especially the uridine 5ʹ-diphospho-glucuronyltransferase and P450 genes,in infected whiteflies significantly *** results demonstrated that Cardinium could inhibit the defense response of the host plant and decrease the detoxification metabolism ability of the host *** reduced competitiveness of infected whiteflies may be associated with the inhibition of the whitefly detoxification metabolism by Cardinium,resulting in the reduced performance of infected ***,Cardinium infection can suppress plant defenses,which may benefit both infected and uninfected whiteflies when they *** research illustrates the symbiont–whitefly–host plant interaction mechanism and the population dynamics of the whitefly.

关键词： Bemisia tabaci med Cardinium defense response detoxification metabolism

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Bibliometrics and visual analysis for clinical research on intervention of traditional Chinese medicine nursing technology on rheumatoid arthritis

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Journal of Integrative Nursing 2022年第1期4卷 20-25页

作者： Ling TANG Jianni QU Hong GUO Mei WANG Nini XU Xiaoyan BAI Xueyan FAN Zhixuan XU Yihui TIAN Fen ZHOU Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina School of Nursing Beijing University of Chinese MedicineBeijingChina School of Nursing and Rehabilitation Shandong UniversityShandongChina#contributed equally to this work.

Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth *** and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-med),Pubmed,Embase,and the Cochrane Library were *** bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included ***:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by *** were only 30(3.73%)pieces of literature published in nursing *** hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by *** included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal *** beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and ***:The related studies are on the *** has entered the field of international readers with clear research hot ***,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and *** current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion *** is suggested that further research can focus on ev

关键词： Literature metrology rheumatoid arthritis traditional Chinese medicine nursing technology visual analysis Wangbi

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Clinical curative effect analysis and predictors of prognosis in patients with temporal lobe epilepsy after anterior temporal lobectomy： results after five years

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Chinese medical Journal 2014年第14期127卷 2588-2593页

作者： Sun Zhenxing Yuan Dan Sun Yaxing Zhang Jianguo Zuo Huancong Zhang Kai Tsinghua univ Dept Neurosurg Yuquan Hosp Med Ctr Beijing 100049 Peoples R China Capital med univ Dept Nephrol Luhe Teaching Hosp Beijing 101149 Peoples R China Second Municipal Hosp Zaozhuang City Dept Psychiat Zaozhuang 277103 Shandong Peoples R China Capital med univ Dept Neurosurg Beijing Tiantan Hosp Beijing 100050 Peoples R China

Background Anterior temporal Iobectomy （ATL） is the most common surgical treatment for temporal lobe epilepsy （TLE）although long-term prognosis is often less favorable than short-term outcomes. This study aimed to examine the outcomes of patients with TLE 5 years after undergoing ATL, and to seek possible predictors of prognosis. Methods We examined the clinical records of 121 patients with TLE who underwent ATL in our institution between January 2005 and December 2008. The Engel seizure classification was used to divide patients into ＂seizure free＂ and ＂non-seizure free＂ groups. univariate and multivariate Logistic regression analyses were used to identify potential prognostic indicators, including history, clinical features of seizures, and magnetic resonance imaging （MRI） and video- electroencephalography （EEG） findings. Results The majority of patients were seizure free during the follow-up period： 71.9% 1 year after surgery; 71.6% after 2 years; 75.8% after 3 years; 78.8% after 4 years after surgery and 68.8% after 5 years. There were significant differences between seizure-free and non-seizure-free groups in terms of preoperative seizure duration, history of febrile seizures, type of seizure, and MRI and video-EEG findings （P 〈0.05）, but not in terms of sex, age at seizure onset, age at surgery, side of surgery, auras, family history of seizure, or history of traumatic brain injury, perinatal anoxia or intracranial infection history （P 〉0.05）. Multivariate Logistic regression analysis showed that a preoperative seizure duration 〈10 years, a history of febrile seizures, simple complex partial seizures, positive MRI findings, hippocampal sclerosis and unilateral localized video-EEG spikes predicted better outcome （P 〈0.05）. Conclusions ATL appears to be an effective means of treating TLE. Patients undergoing ATL for TLE require careful and comprehensive assessment to ensure optimal outcomes and to allow patients to make informed decisions about their treatment.

关键词： temporal lobe epilepsy anterior temporal lobectomy prognosis predictor

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Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 267-272页

作者： Lu, Yun Wu, Li-Qun Dong, Qian Li, Chang-Sheng Qingdao univ Dept Hepatobiliary Surg Affiliated Hosp Coll Med Qingdao 266003 Peoples R China Qingdao univ Dept Pediat Surg Affiliated Hosp Coll Med Qingdao 266003 Peoples R China Qingdao univ Ctr Cell & Mol Pathol Affiliated Hosp Coll Med Qingdao 266003 Peoples R China

BACKGROUND: Kang-Lai-Te (KLT) is extracted from the traditional Chinese herbal medicine Semen Coicis, which has been used in China as an effective clinical drug for over a thousand years. It contains numerous ingredients with anti-tumor effects. In our previous studies on transplanted hepatomas in rats, KLT could stop the cells in the G2+M stage of cell cycle and then reduce the number of cells entering the stage G0 and G1, but the mechanism of the anti-proliferative effect was unknown. In this experiment, we examined whether KLT inhibits HepG2 cell growth, if so, tried to explore its mechanism. METHODS: KLT at different concentrations was used for the treatment of hepatocellular carcinoma cells in vitro, respectively. The proliferation inhibitory rate was evaluated by MTT assay, induction of cell apoptosis rate and the protein levels of Fas and Fas ligand (FasL) were determined by flow cytometry (FCM), and the expression of Fas and FasL mRNA was detected by real-time fluorescent quantitative RT-PCR. RESULTS: KLT produced an obvious time and dose-dependent inhibitory effect on HepG2 cells, and marked apoptosis was detected by FCM The protein of Fas increased by 11.01%, 18.71%, 28.71% and 37.15%; the protein of FasL increased by 1.49%, 1.91%, 3.27% and 3.38% in comparison with the control (Pmediated through activation of the Fas/FasL pathway. (Hepatobiliary Pancreat Dis Int 2009; 8: 267-272)

关键词： Kang-Lai-Te drugs, Chinese herbal hepatocellular carcinoma HepG2 Fas/FasL

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Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous VX2 cancer

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Chinese medical Journal 2014年第14期127卷 2605-2611页

作者： Li Peijing Zhu Mei Xu Yali Zhao Yang Gao Shunji Liu Zheng Gao Yun-hua Third Mil med univ Dept Ultrasound Xinqiao Hosp Chongqing 400037 Peoples R China Gen Hosp Jinan Mil Area Dept Ultrasound Jinan 250000 Shandong Peoples R China Kunming med Coll Dept Ultrasound Affiliated Hosp 1 Kunming 650032 Yunnan Peoples R China

Background Intravascular microbubble-enhanced acoustic cavitation is capable of disrupting the vascular walls of capillaries and small vessels. This study was designed to investigate the impact of microbubble-enhanced, pulsed and focused ultrasound （MEUS） on the blood perfusion of subcutaneous VX2 tumors in rabbits. Methods Subcutaneous VX2 cancers in twenty New Zealand rabbits were treated by combining high-pressure amplitude, pulsed and focused therapeutic ultrasound （TUS） and intravenous microbubble injections. The TUS transducer was operated with a peak negative pressure of 4.6 MPa and a duty cycle of 0.41%. Controls were subcutaneous VX2 cancers treated with TUS or microbubbles only. Contrast-enhanced ultrasound （CEUS） and intravenous Evans Blue （EB） perfusion were performed to assess the tumor circulation. The tumor microvascular disruption was assessed by histological examination. Results CEUS showed that the tumor circulation almost vanished after MEUS treatment. The average peak grayscale value （GSV） of tumor CEUS dropped significantly from 84.1±22.4 to 15.8±10.8 in the MEUS-treated tumors but no significant GSV changes were found in tumors in the two control groups. The mean tumor EB content of the MEUS-treated tumors was significantly lower than that of the controls. Histological examination found scattered tumor microvascular disruption with intercellular edema after MEUS treatment. Conclusion The tumor circulation of VX2 cancers can be arrested or significantly reduced by MEUS due to microvascular disruption. Chin M~.cl ,I 2014：127 （14）： 2605-2611

关键词： VX2 tumor circulation therapeutic ultrasound microbubble contrast-enhanced ultrasound

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Small bowel diseases discovered by computed tomography enterography but omitted by small bowel endoscopy

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Chinese medical Journal 2013年第4期126卷 800-800页

作者： Gong Pei-you Li Jun-xia Wang Bin Wang Xi-ming shandong univ Dept Radiol Shandong Med Imaging Res Inst Jinan 250021 Shandong Peoples R China Yantai Yuhuangding Hosp Dept Radiol Yantai 264000 Shandong Peoples R China Yantai Yuhuangding Hosp Dept Oncol Yantai 264000 Shandong Peoples R China Binzhou med univ Affiliated Hosp Dept Radiol Med Imaging Ctr Yantai 264003 Shandong Peoples R China

To the editor： We found two small bowel diseases discovered by computed tomography enterography （CTE） and omitted by small bowel endoscopy. The two patients were both found obscure gastrointestinal bleeding in our hospital. One was found a small bowel stromal tumor, CTE findings mainly characterized by congested tumor without obstruction, with calcification spots in the tumor, and with obvious thickening of the feeding artery and draining vein and obvious edema of the intestinal wall （Figure I A）.

关键词： Small bowel diseases computed tomography enterography

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Comparison of Charlson＇s weighted index of comorbidities with the chronic health score for the prediction of mortality in septic patients

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Chinese medical Journal 2014年第14期127卷 2623-2627页

作者： Cui Yunliang Wang Tao Bao Jun Tian Zhaotao Lin Zhaofen Chen Dechang Jinan Mil Gen Hosp Dept Crit Care Med Jinan 250031 Shandong Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Emergency & Intens Care Unit Hainan Branch Sanya 572013 Hainan Peoples R China Second Mil med univ Dept Emergency Med Changzheng Hosp Shanghai 200003 Peoples R China

Background Comorbidity is one of the most important determinants ot short-term and long-term outcomes in septic patients. Charlson＇s weighted index of comorbidities （WIC） and the chronic health score （CHS）, which is a component of the acute physiology and chronic health evaluation （APACHE） II, are two frequently-used measures of comorbidity. In this study, we assess the performance of WIC and CHS in predicting the hospital mortality of intensive care unit （ICU） patients with sepsis. Methods A total of 338 adult patients with sepsis were admitted to a multisystem ICU between October 2010 and August 2012. Clinical data were collected, including age, gender, underlying diseases, key predisposing causes, severity-of- sepsis, and hospital mortality. The APACHE II, CHS, acute physiology score （APS）, sequential organ failure assessment （SOFA） and WIC scores were assessed within the first 24 hours of admission. univariate and multiple Logistic regression analyses were used to compare the performance of WlC and CHS. The area under the receiver operating characteristic curve （AUC） was used to predict hospital mortality over classes of risk. Results Of all the enrolled patients, 224 patients survived and 114 patients died. The surviving patients had significantly lower WlC, CHS, APACHE II, and SOFA scores than the non-surviving patients （P 〈0.05）. Combining WIC or CHS with other administrative data showed that the hospital mortality was significantly associated with age, severe sepsis, key predisposing causes such as pneumonia, a history of underlying diseases such as hypertension and congestive cardiac failure, and WlC, CHS and APS scores （P 〈0.05）. The AUC for the hospital mortality were 0.564 （95% confidence interval （CO 0.496-0.631） of CHS, 0.663 （95% CI 0.599-0.727） of WIC, 0.770 （95% CI 0.718-0.822） of APACHE II, 0.856 （95% Cl 0.815-0.897） of the CHS combined with other administrative data, and 0.857 （95% CI 0.817-0.897） of the WlC combined with other administrative data

关键词： Charlson's weighted index of comorbidities acute physiology and chronic health evaluation II sequential organ failure assessment sepsis outcome

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Meta-analysis of gemcitabine plus nab-paclitaxel combined with targeted agents in the treatment of metastatic pancreatic cancer

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World Journal of Clinical Cases 2022年第27期10卷 9703-9713页

作者： Zhong-Hui Li Yin-Jie Ma Zong-Hang Jia Yue-Yan Weng Ping Zhang Shi-Jie Zhu Fang Wang Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Oncology Shandong University of Traditional Chinese MedicineJinan 250022Shandong ProvinceChina Department of Acupuncture and Moxibustion Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Pathology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

BACKGROUND Gemcitabine plus nab-paclitaxel(GA) is a commonly used first-line treatment regimen for metastatic pancreatic cancer,and many studies will add a novel targeted agent to this regimen for improving patient survival ***,the clinical effectiveness of GA is the most controversial *** To compare the efficacy and safety of GA regimen with a targeted agent and GA *** Up to 1 December 2021,the eligible randomized controlled trials(RCTs) relating to GA and GA with a targeted agent were searched on Pub med,EMBASE and Cochrane Library for eligible *** screened out appropriate studies for overall survival(OS),progression-free survival(PFS),objective response rate(ORR),and toxicity,which had been pooled and finally analyzed by using Stata version *** addition,we use Reference Citation Analysis(https://***/) to collect the latest related literature to improve the latest cutting-edge research *** Seven RCTs involving 1544 patients(848 men and 696 women) were *** were no significant differences between GA with a targeted agent and GA in PFS [hazard ratio(HR):1.18 95% confidence interval(CI):0.91-1.53],OS(HR:1.12 95%CI:0.99-1.27),and ORR(HR:0.96 95%CI:0.71-1.29).There was no notable difference in the two groups in grade 3/4 toxicity(fatigue,anemia,vomiting and neutropenia),whereas the incidence of grade 3/4 diarrhea considerably increased in GA with a targeted *** Adding a novel targeted agent to the GA regimen did not improve survival rate of patients with metastatic pancreatic cancer.

关键词： Metastatic pancreatic cancer Gemcitabine Nab-paclitaxel Novel targeted agent Survival

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