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Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

Regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu Christina Janko Christoph Alexiou Ana M.Beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stomatological Translational Medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of oto-rhino-laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

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Recent advances in the application of MXenes for neural tissue engineering and regeneration

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Neural Regeneration Research 2024年第2期19卷 258-263页

作者： Menghui Liao Qingyue Cui Yangnan Hu Jiayue Xing Danqi Wu Shasha Zheng Yu Zhao Yafeng Yu Jingwu Sun Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjingJiangsu ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of oto-rhino-laryngology West China HospitalSichuan UniversityChengduSichuan ProvinceChina First Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina Department of otolaryngology-Head and Neck Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijingChina

Transition metal carbides and nitrides(MXenes)are crystal nanomaterials with a number of surface functional groups such as fluorine,hydroxyl,and oxygen,which can be used as carriers for proteins and *** have excellent biocompatibility,electrical conductivity,surface hydrophilicity,mechanical properties and easy surface ***,at present,the stability of most MXenes needs to be improved,and more synthesis methods need to be *** are good substrates for nerve cell regeneration and nerve reconstruction,which have broad application prospects in the repair of nervous system *** the application of MXenes in neuroscience,mainly at the cellular level,the long-term in vivo biosafety and effects also need to be further *** review focuses on the progress of using MXenes in nerve regeneration over the last few years;discussing preparation of MXenes and their biocompatibility with different cells as well as the regulation by MXenes of nerve cell regeneration in two-dimensional and three-dimensional environments in *** have great potential in regulating the proliferation,differentiation,and maturation of nerve cells and in promoting regeneration and recovery after nerve *** addition,this review also presents the main challenges during optimization processes,such as the preparation of stable MXenes and long-term in vivo biosafety,and further discusses future directions in neural tissue engineering.

关键词： hydrogels MXenes nerve regeneration neural cells neural stem cells organoids spiral ganglion neurons

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Nodular fasciitis of the external auditory canal: Clinical case report and review of the literature

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中华耳科学杂志:英文版 2023年第4期18卷 240-245页

作者： Adrien Philippart Jean-Christophe Degols Jacques Vilain Department of oto-rhino-laryngology-Head and Neck Surgery Saint-Luc University HospitalCatholic University of LouvainAvenue Hippocrate 101200BrusselsBelgium Chief of Department of oto-rhino-laryngology-Head and Neck Surgery Saint-Pierre Clinic OttigniesAvenue Reine Fabiola 91340Ottignies-Louvain-la-NeuveBelgium Department of oto-rhino-laryngology-Head and Neck Surgery Saint-Pierre Clinic Ottignies Avenue Reine Fabiola 91340Ottignies-Louvain-la-NeuveBelgium

Nodular fasciitis is a benign reactive soft tissue tumor arising from fibroblasts and *** incidence is low and misdiagnosis is frequent especially for malignant *** can lead to inappropriate and unnecessary invasive *** fasciitis of the external auditory canal is extremely *** far,around fifteen cases have been *** present here the case of a 90-year-old patient with nodular fasciitis of the right external auditory *** lesion extends anteriorly for 6.5 cm and reaches the posterior wall of the maxillary *** our knowledge,this is the first case in the literature of an external auditory canal nodular fasciitis presenting as an inflammatory ear polyp with such a wide extension.

关键词： Nodular fasciitis External ear canal Polyp

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Cosmetic evaluation of surgical scars after external dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1745-1750页

作者： Syed Ali Raza Rtzvi Mohammad Saquib Rakesh Maheshwari Yogesh Gupta Zafr Igbal Purleet Maheshwari Institute of Ophthalmology Jawaharlal Nehru Medical College AMU Aligarh.UP 202002 India Department of oto-rhino-laryngology Jawaharlal Nehru Medical College AMU Aligarh.UP 202002 India Department of oto-rhino-laryngology Era's Lucknow Medical College and Hospital Lucknow.UP 226003 India

AIM： To evaluate the surgical scars of external dacryocystorhinostomy （DCR） cosmetically. METHODS： Totally 50 consecutive cases of primary acquired nasolacrimal duct obstruction （PANDO） were included in the study. Surgical scars were assessed by the patients and two independent observers at 2, 6 and 12wk postoperatively on the basis of visibility of the scars and still photographs respectively and were graded from 0-3. Kappa test was utilised to check the agreement of scar grading between the two observers. Wilcoxan signed ranks test was used to analyse the improvement of scar ***： Thirty-four （68%） patients graded their incision site as very visible （grade 3） at 2wk. At 6 and 12wk, incision site was observed as grade 3 by 7 （14%） and 1 （2%） patients respectively. Photographic evaluation of patients by 2 observers showed an average score of 2.75, 1.94 and 0.94 at 2, 6 and 12wk respectively. Change in scar grading from grade 3 to grade 0 in consecutive follow-up （2, 6 and 12wk） was found to be highly significant both for the patient as well for the observers （P〈0.0001）.CONCLUSION： The external DCR is a highly effective and safe procedure and in view of low percentage of cases who complained of marked scarring in the present study, thus scarring should not be the main ground for deciding the approach to DCR surgery, even in young cosmetically conscious patients.

关键词： cosmetic surgical scar external dacryocystorhinostomy primary acquired nasolacrimal duct obstruction

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Tracheotomy in ENT at CNHU HKM of Cotonou

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International Journal of otolaryngology and Head & Neck Surgery 2021年第6期10卷 526-535页

作者： Warou Dolou Stephen LA Lawson Sonia Lawson Afouda Franç ois Avakoudjo Wassi Adjibabi Berndadette Vignikin-Yehouessi Department of oto-rhino-laryngology University Teaching Hospital of Kara Kara Togo Department of oto-rhino-laryngology University Teaching Hospital Hubert Koutoukou MAGA (HKM) Cotonou Benin

Background: known since more than 5000 years, tracheotomy is indicated in severe obstructions of the upper airways or in improvement of ventilation in cases of problematic tracheal intubation. Its usefulness and efficiency are certain, but it needs regular assessments. Aim: to determine the frequency of tracheotomies in ENT at CNHU of Cotonou, identify the indications, surgical technics and the postoperative course. Materials and methods: the study was retrospective, based on files of patients who have had tracheotomies for ten years since 2010. Results: in 10 years, 105 tracheotomies were performed for 99 patients, average 10 to 11 per year. Patients were male in 61.9%. Extreme of age where 09 months and 80 years old. Children under15 were concerned in 41.9%, while patients from 45 to 64 years old in 33.3%. Emergency tracheotomy represented 76%. Causes were tumors in 62.8%. Laryngeal papillomatosis was the predominant tumor in children;28 cases or 26.67%. In adults, larynx cancer represented 20%. Skin incisions were horizontal in 94.3%. Tracheal opening was “H-shaped” in 92.4%. Complications occurred in 28.6%. They included granuloma (13.3%) and oeso-tracheal fistula (1.9%). Decanulation was possible in 87.6%, but it was more difficult in children. Conclusion: tracheotomy was an act of rescue in our practice.

关键词： Tracheotomy ENT Tumors Emergency

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Trans-nasosphenoid pituitary adenoma microsurgery in 100 cases

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Journal of Medical Colleges of PLA(China) 1991年第2期6卷 192-196页

作者：陆书昌吕光宇 Department of oto-rhino-laryngology Changzheng HospitalSecond Military Medical UniversityShanghai 200003

The rhinologist participating in microsurgery of the pituitary adenomaplays an important role in relieving the patients from suffering and indecreasing the incidence of *** paper summarily reportsrhinological aspects in 100 cases undergoing trans-nasosphenoid intrasellarmicrosurgery,including operative routes and incisions,methods for opening andreconstructing the sellar floor and nasal *** authors suggest aseptavestibular incision to modify Hirsch’s septal incision,and outline our fivemethods to open and reconstruct the sellar *** operator should select themost proper method according to different situations,in *** most dan-gerous complications are CSF rhinorrhea with supurative meningitis and *** our experience five such cases were cured by medical and surgicaltreatments.

关键词： pituitary adenoma transsphenoid microsurgery CSF rhinorrhea fatal hemorrhage

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A dosimetric comparative study between conformal and intensity modulated radiation therapy in the treatment of primary nasopharyngeal carcinomas: the Egyptian experience

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The Chinese-German Journal of Clinical Oncology 2012年第11期11卷 626-631页

作者： Ehsan G. El-Ghoneimy Mohamed A. Hassan Mahmoud F. El-Bestar Omar M. Othman Karim N. Mashhour Department of Clinical Oncology Kasr Al-Einy School of Medicine Cairo University Department of oto-rhino-laryngology Kasr Al-Einy School of Medicine Cairo University Department of Radiology Kasr Al-Einy School of Medicine Cairo University

Objective: The study is a comparative study, the aim of which is to compare 3D conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) in treating nasopharyngeal carcinomas; dosimetrically evaluating and comparing both techniques as regard target coverage and doses to organs at risk (OAR). Methods: Twenty patients with nasopharyngeal carcinoma were treated by 3D-CRT technique and another 20 patients were treated by IMRT. A dosimetric comparison was done by performing two plans for the same patient using Eclipse planning system (version 8.6). Results: IMRT had a better tumor coverage and conformity index compared to 3D-CRT plans (P value of 0.001 and 0.004), respectively. As for the dose homogeneity it was also better in the IMRT plans and the reason for this was attributed to the dose inhomogeneity at the photon/electron junction in the 3D-CRT plans (P value 0.032). Also, doses received by the risk structures, particularly parotids, was significantly less in the IMRT plans than those of 3D-CRT (P value 0.001). Conclusion: IMRT technique was clearly able to increase the dose delivery to the target volume, improve conformity and homogeneity index and spare the parotid glands in comparison to 3D-CRT technique.

关键词： 3D conformal radiation therapy (3D-CRT) intensity-modulated radiotherapy (IMRT) nasopharyngeal carcinoma Xerostomia

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Brown Tumor of the Maxilla Revealing Primary Hyperparathyroidism

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International Journal of Clinical Medicine 2015年第4期6卷 252-256页

作者： Madiha Mahfoudhi Khaled Khamassi Amel Gaieb Battikh Rym Lahiani Turki Sami Mamia Ben Salah Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia Department of oto-rhino-laryngology Charles Nicolle Hospital Tunis Tunisia

Brown tumor or localized form of osteitis fibrosa cystic is a focal lesion complicating hyperpara-thyroidism. It’s rarely revelatory of the clinical feature and corresponds to a mass with partly cystic and partly solid areas. A 65-year-old man, followed up for hypertension, complained of a progressive swelling in the left paranasal part of the face lasting for 3 months. Physical examination revealed a left paranasal swelling of 4 cm diameter, with a healthy looking skin. CT facial bones found a round formation of 2 cm involving the left maxilla. He received tumor resection by vestibular pathway. Histological examination showed many giant cells. We then discussed the brown tumor diagnosis. The PTH dosage was high: 645 pg/mL (normal: 15 - 68 pg/mL). The serum calcium was in the superior normal limit (100 mg/dL). Cervical ultrasound revealed a bottom left parathyroid nodule. A lower left parathyroidectomy was performed. Histological results confirmed parathyroid adenoma. Monitoring was marked by a marked decrease of the PTH serum level then a return to normal values, a normocalcemia and no recurrence of the maxillary tumor with Recoil of 14 months. Brown tumor of the maxilla is rare and should be considered even in absence of hypercalcemia.

关键词： Hyperparathyroidism Brown Tumor Maxilla

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Primary Thyroid Non-Hodgkin’s Lymphoma

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Open Journal of Pathology 2015年第4期5卷 114-116页

作者： Madiha Mahfoudhi Khaled Khammassi Imen Gorsane Mounira El Euch Sami Turki Mamia Ben Salah Taieb Ben Abdallah Department of Internal Medicine Charles Nicolle Hospital Tunis Tunisia Department of oto-rhino-laryngology Charles Nicolle Hospital Tunis Tunisia

Primary non-Hodgkin’s lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin’s lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.

关键词： Thyroid Gland Lymphoma Immunohistochemistry

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Systemic Sarcoidosis Revealed by a Nasal Lesion: A Case Report

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International Journal of Clinical Medicine 2015年第4期6卷 257-261页

作者： Madiha Mahfoudhi Khaled Khammassi Sami Turki Mamia Ben Salah Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia Department of oto-rhino-laryngology Charles Nicolle Hospital Tunis Tunisia

A 62-year-old man presented with bilateral nasal obstruction and recurrent epistaxis episodes. Physical examination revealed normal body temperature and free cervical lymph nodes areas. Nasal endoscopy found a congestive nasal mucosa associated to bilateral inferior turbinate hypertrophy with a granular aspect of the right inferior turbinate. The biological examination showed lymphopenia, inflammatory syndrome, high serum level of angiotensin-converting enzyme and β2 microglobulin. Tuberculin skin test and Quantiferon gold were negative. The nasal and accessory salivary gland biopsies revealed granulomatous giant cell lesions non-caseating evoking systemic sarcoidosis. Ziehl-Neelsen staining and Lowenstein culture were negative. The diagnosis was systemic sarcoidosis revealed by nasal localization. The systemic extension research was negative. The treatment was based on corticosteroids (1 mg/kg/day) and gradual degression doses associated to a local nasal corticosteroid. The outcome was favorable with improvement of nasal obstruction and disappearance of initial lesions. The follow-up was 2 years.

关键词： Sarcoidosis Nose Granuloma Corticosteroids

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