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New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: synthesis, Cytotoxic Effects on Tumoral Cell Lines and in silico ADMET Properties

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： Marwa Dhiabi sirine Karoui Mehdi Fakhfakh souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Department of Chemistry (science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia s2wave platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in silico ADMET

A decomposition of light’s spin angular momentum density

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Light(science & Applications) 2024年第8期13卷 1578-1589页

作者： Alex J.Vernon sebastian Golat Claire Rigouzzo Eugene A.Lim Francisco J.Rodríguez-Fortuño Department of Physics King’s College LondonStrandLondon WC2R 2LSUK London Centre for Nanotechnology LondonUK

Light carries intrinsic spin angular momentum(sAM)when the electric or magnetic field vector rotates over time.A familiar vector equation calculates the direction of light’s sAM density using the right-hand rule with reference to the electric and magnetic polarisation *** Maxwell’s equations,this vector equation can be decomposed into a sum of two distinct terms,akin to the well-known Poynting vector decomposition into orbital and spin *** present the first general study of this spin decomposition,showing that the two terms,which we call canonical and Poynting spin,are chiral analogies to the canonical and spin momenta of light in its interaction with *** canonical momentum,canonical spin is directly *** canonical and Poynting spin incorporate spatial variation of the electric and magnetic fields and are influenced by optical *** decomposition allows us to show that a linearly polarised vortex beam,which has no total sAM,can nevertheless exert longitudinal chiral pressure due to equal and opposite canonical and Poynting spins.

关键词： canonical momentum angular

Temporal and environmental factors drive community structure and function of methanotrophs in volcanic forest soils

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Journal of Forestry Research 2024年第2期35卷 1-13页

作者： Rusong Chai Hongjie Cao Qingyang Huang Lihong Xie Fan Yang Hongbin Yin Heilongjiang Forest Botanical Garden Harbin 150040People’s Republic of China 2 Institute of Natural Resources and Ecology Science Academy of Heilongjiang ProvinceHarbin 150040People’s Republic of China

Methanotrophs,organisms that obtain oxygen by oxidizing methane,are recognized as the only known biological sink for atmospheric CH_4,and forest soil methanotrophs play crucial roles in mitigating global *** succession patterns of methanotrophic communities and functions in Wudalianchi volcano forest soils could provide a basis for the study of evolutionary mechanisms between soil microorganisms,the environment,and carbon cycling of temperate forest ecosystems under climate *** this study,the characteristics and drivers of methanotrophic community structure and function of two volcanic soils at different stages of development are analyzed,including an old volcano and a new volcano,which most recently erupted 300 years and 17-19×10^(5)years ago,respectively,and a non-volcano hills as control,based on space for time substitution and Miseq sequencing and bioinformation *** results showed that CH_(4) fluxes were significantly higher in old-stage volcano forest soils than new-stage forest soils and non-volcano forest *** were significant differences in the community composition and diversity of soil methanotrophs from different volcano forest *** was the dominant genus in all soil ***,the relative abundance of Methylococcus,along with Clonothrix,Methyloglobulus,Methylomagum,Methylomonas and Methylosarcina,were the important genera responsible for the differences in methanotrophic community structure in different volcano forest *** relative abundance of methanotroph belonging toγ-proteobacteria was significantly higher than that belonging toα-proteobacteria(Pshannon and simpson indices of soil methanotrophic community were significantly lower in new-stage volcanos and were significantly affected by bulk density,total porosity,p H,nitrate,dissolved organic carbon and dissolved organic *** were significant differences in community structure between new-stage and old-stage volcano

关键词： Methanotrophs pmo A soil development stage Volcanoes Forest soils

Two-dimensional precise figuring of 500 mm-long X-ray mirror using one-dimensional ion beam system

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Advances in Manufacturing 2024年第1期12卷 177-184页

作者： Qiu-shi Huang Han-Dan Huang Qiao-Yu Wu Jun Yu Zhong Zhang Zhan-shan Wang MOE Key Laboratory of Advanced Micro-structured Materials Institute of Precision Optical Engineering(IPOE)School of Physics Science and EngineeringTongji UniversityShanghai200092People’s Republic of China shanghai Professional Technical service platform for Full-spectrum and High-Performance Optical Thin Film Devices and Applications Tongji UniversityShanghai200092People’s Republic of China shanghai Frontiers science Center of Digital Optics Tongji UniversityShanghai200092People’s Republic of China

In this study,a new method was developed to realize two-dimensional(2D)figure correction of grazing-incidence X-ray mirrors using a one-dimensional(1D)ion-beam figuring system.A mask of holes was specifically designed to generate removal functions at different widths and extend the figuring capability over a wide ***,a long mirror could be *** this method,the surface height root-mean-square(RMs)error of the center area of 484 mm×16 mm was reduced from 11.49 nm to 2.01 nm,and the 1D meridional RMs error reached 1.0 *** proposed method exhibits high precision and cost effectiveness for production of long X-ray mirrors.

关键词： Long-size mirrors Ion beam figuring Two-dimensional figure correction Mask

The nature of electron density enhancement over a wide altitude range during ionosphere heating experiments at EIsCAT

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Earth and Planetary Physics 2024年第2期8卷 408-414页

作者： Jun Wu Jian Wu Jie Feng QingLiang Li shuJi Hao ZhengWen Xu Haisheng Zhao YaBin Zhang National Key Laboratory of Electromagnetic Environment China Research Institute of Radio Wave PropagationBeijing 102206China school of Physics Xidian UniversityXi’an 710071China

During the course of ionospheric heating experiments, researchers at the European Incoherent scatter scientific Association (EIsCAT) observed an apparent electron density enhancement. The enhancement extended over a wide range of altitudes, above the reflection altitude of the high-frequency pump wave. However, whether this enhancement actually corresponds to a true enhancement in electron density remains an open question. When the dispersion relation of ion acoustic waves is followed, the frequency ratio of the enhanced ion line to the background ion line suggests that the profile of the effective ion mass may have remained unchanged. Furthermore, the solar radio flux and ion drift velocity indicate no significant changes in the ion species and their densities. In conclusion, the electron density enhancement observed at EIsCAT should not, in fact, be considered a true enhancement.

关键词： incoherent scatter radar(IsR) ionospheric heating electron density ion acoustic wave

Electrodynamics with violations of Lorentz and U(1)gauge symmetries and their Hamiltonian structures

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Chinese Physics C 2024年第6期48卷 45-57页

作者：杨秀鹏李瀑飞朱涛 Institute for Theoretical Physics and Cosmology Zhejiang University of TechnologyHangzhou 310032China United Center for Gravitational wave Physics(UCGWP) Zhejiang University of TechnologyHangzhou 310032China

This study aims to investigate Lorentz/U(1)gauge symmetry-breaking electrodynamics in the framework of the standard-model extension and analyze the Hamiltonian structure for the theory with a specific dimension of Lorentz breaking *** this purpose,we consider a general quadratic action of the modified electrodynamics with Lorentz/gauge-breaking operators and calculate the number of independent components of the operators at different dimensions in gauge invariance and *** this general action,we then analyze how Lorentz/gauge symmetry-breaking can change the Hamiltonian structure of the theories by considering Lorentz/gauge-breaking operators with dimension as *** show that the Lorentz-breaking operators with gauge invariance do not change the classes of the theory constrains and the number of physical degrees of freedom of the standard Maxwell *** U(1)gauge symmetry-breaking operators are present,the theories generally lack a first-class constraint and have one additional physical degree of freedom compared to the standard Maxwell electrodynamics.

关键词： standard model extension electrodynamics Lorentz violations

“If somebody Needed Help, I Went Over”: social Capital and Therapeutic Communities of Older Adult Farmers in British Columbia Floods

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International Journal of Disaster Risk science 2024年第2期15卷 290-301页

作者： Kyle Breen siyu Ru Luna Vandeweghe Jenna Chiu Lindsay Heyland Haorui Wu school of social Work Dalhousie UniversityHalifaxNS B3H 1S2Canada

Older adults in disaster contexts are often thought of as a passive, vulnerable population that lacks agency and capacities to cope in the aftermath. However, it can be argued that older adults may have underrecognized strengths that can be utilized pre-, peri-, and post-disaster. One of these strengths is older adults' unique social capital that stems from long-standing connections with other members of their respective communities. Using data from in-depth, semistructured interviews with farmers in British Columbia 3–11 months after the 2021 floods, this research explored the experiences of older adult farmers' recovery. The farmers discussed how they leveraged their social capital to aid in their recovery efforts from the flood event. By using their bonding social capital, older adult farmers transformed their existing, deep-rooted connections into post-disaster assistance. This, in turn, generated the idea of the therapeutic community, helping community members cope in the aftermath. This research indicated the need to further examine how older adults in disaster settings can be viewed as assets with community knowledge and skills as opposed to solely as a vulnerable population.

关键词： British Columbia Flood disaster Older adults Qualitative research social capital Therapeutic community

Comparison of Direct Pore-scale and Volume-Averaging Methods for the Performance Evaluation of Porous Volumetric solar Receiver

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Journal of Thermal science 2024年第5期33卷 1607-1617页

作者： DU shen HE Yaling LI Dong LIU Zhanbin LI Mengjie National Innovation platform(Center)for Industry-Education Integration of Energy storage Technology Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of EducationXi’an Jiaotong UniversityXi’an710049China

Direct pore-scale and volume-averaging numerical simulations are two methods for investigating the performance of porous volumetric solar *** clarify the difference in the prediction of heat transfer processes,a direct comparison between these two methods was conducted at both steady state and transient *** numerical models were established based on X-ray computed tomography scans and a local thermal non-equilibrium model,*** empirical parameters,which are indispensable to the volume-averaging simulation,were determined by Monte Carlo ray tracing and direct pore-scale numerical *** predicted outlet air temperature of the receiver by the volume-averaging simulation method corresponded satisfactorily to that in the direct pore-scale *** largest discrepancies were observed when the receiver's working temperature was elevated,with differences of 5.5%and 3.68%for the steady state and transient state simulations,***,the volume-averaging method is incapable of capturing the local temperature information of the air and porous *** underestimates the inlet temperature of the receiver,leading to an overestimation of the receiver's thermal efficiency,with the largest difference being 6.51%.The comparison results show that the volume-averaging model is a good approximation to the pore-scale model when the empirical parameters are carefully selected.

关键词： porous media volumetric solar receiver pore-scale method volume-averaging method thermal performance

Direct visualization of laser-driven dynamic fragmentation in tin by in situ x-ray diffraction

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Matter and Radiation at Extremes 2024年第5期9卷 109-114页

作者： Jing Yang Xinxin Wang Liang Xu Qiannan Wang Yi sun Jiangtao Li Lin Zhang Yinghua Li Yuying Yu Pei Wang Qiang Wu Jianbo Hu Laboratory for shock wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100094China

We present a novel method for investigating laser-driven dynamic fragmentation in tin using in situ X-ray *** experimental results demonstrate the feasibility of the method for simultaneously identifying the phase and temperature of fragments through analysis of the diffraction ***,we observe a deviation from the widely accepted isentropic release assumption,with the temperature of the fragments being found to be more than 100 K higher than expected,owing to the release of plastic work during dynamic *** findings are further verified through extensive large-scale molecular dynamics simulations,in which strain energies are found to be transferred into thermal energies during the nucleation and growth of voids,leading to an increase in *** findings thus provide crucial insights into the impact-driven dynamic fragmentation phenomenon and reveal the significant influence of plastic work on material response during shock release.

关键词： dynamic release diffraction