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Creeping fat and gut microbiota in Crohn’s disease

World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla o Magro Marcello Imbrizi Ellen Cs De oliveira Luiz C Di stasi Ligia Y sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

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Long-term Regional Dynamic sea Level Changes from CMIP6 Projections

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Advances in Atmospheric sciences 2021年第2期38卷 157-167页

作者： Bruno FERRERo Marcos ToNELLI Fernanda MARCELLo Ilana WAINER university of são paulo São Paulo 05508120Brazil

Anthropogenic climate forcing will cause the global mean sea level to rise over the 21st ***,regional sea level is expected to vary across ocean basins,superimposed by the influence of natural internal climate ***,we address the detection of dynamic sea level(DsL)changes by combining the perspectives of a single and a multimodel ensemble approach(the 50-member CanEsM5 and a 27-model ensemble,respectively,all retrieved from the CMIP6 archive),under three CMIP6 projected scenarios:ssP1-2.6,ssP3-7.0 and *** ensemble analysis takes into account four key metrics:signal(s),noise(N),s/N ratio,and time of emergence(ToE).The results from both sets of ensembles agree in the fact that regions with higher s/N(associated with smaller uncertainties)also reflect earlier *** DsL signal is projected to emerge in the southern ocean,southeast Pacific,Northwest Atlantic,and the *** common for both sets of ensemble simulations show that while s progressively increases with increased projected emissions,N,in turn,does not vary substantially among the ssPs,suggesting that uncertainty arising from internal climate variability has little dependence on changes in the magnitude of external *** changes are greater and quite similar for the scenarios ssP3-7.0 and ssP5-8.5 and considerably smaller for the ssP1-2.6,highlighting the importance of public policies towards lower emission scenarios and of keeping emissions below a certain threshold.

关键词： dynamic sea level CMIP6 sea level rise signal-to-noise time of emergence

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Equity issues and the PeCUs index:an indirect analysis of community severance

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Geo-spatial Information science 2020年第4期23卷 293-304页

作者： Daniela Vanessa Rodriguez Lara Antonio Nelson Rodrigues da silva Department of Transportation Engineering São Carlos School of EngineeringUniversity of São PauloSão PauloBrazil

Urban barriers are often a consequence of the unplanned expansion of transport infrastructures,housing growth nearby existing transport infrastructures,and the vehicular traffic *** process,also known as“community severance”,is a problem that affects the travel patterns of the population and causes negative impacts to adjacent communities,but it is not easy to *** an alternative to the costly technologies and restricted-access data sometimes used to analyze urban barriers,we propose an analytical approach that assesses community severance levels by classifying the quality of Pedestrian Crossings on Urban streets(the PeCUs index).Additionally,the approach is used to identify possible inequities nearby the different classification groups regarding demographic *** used the chi-square(χ^(2))test of independence and the standardized Pearson residuals to indicate deficits and excesses of residents regarding the demographic characteristics studied surrounding the urban *** found the following evidences of associations:residents with low-income or those aged up to 19 tend to live close to the worst crossings,whereas residents with permanent mobility constraints or the elderly tend to live near the crossings with the best ***,the study shows that the assessment of community severance by the analysis of the PeCUs index is ***,it reveals that the distribution of residents surrounding the distinct classes of quality of crossings is equitable for vulnerable social groups,except for low-income or young residents.

关键词： Community severance transport barriers pedestrian crossings equity open data geographic information systems(GIs)

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Prognostic factors for progression of liver structural lesions in chronic hepatitis C patients

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World Journal of Gastroenterology 2008年第16期14卷 2522-2528页

作者： Liliana sC Mendes Marcelo E Nita suzane K ono-Nita Evandro s Mello Luiz Caetano da silva Venancio AF Alves Flair J Carrilho Department of Gastroenterology-Hepatology Branch University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil Department of Pathology University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil

AIM: To evaluate the epidemiological, clinical, laboratory and histological variables capable of predicting the progression of hepatic structural disturbances in chronic hepatitis C patients during the time interval between two liver biopsies. METHoDs: Clinical charts of 112 chronic hepatitis C patients were retrospectively analyzed, whereas liver biopsies were revised. Immunohistochemical detection of interferon receptor was based on the Envision-Peroxidase system. REsULTs: In the multivariate analysis, the variables in the age at first biopsy, ALT levels, presence of lymphoid aggregates and siderosis were the determinants of the best model for predicting the severity of the disease. The direct progression rate of hepatic structural lesions was significantly higher in untreated patients, intermediate in treated non-responders and lower in treated responders to antiviral therapy (non-treated vs responders, 0.22 ± 0.50 vs -0.15 ± 0.46, P = 0.0053). Immuno-expression of interferon receptor is not a relevant factor. CoNCLUsIoN: The best predictors of the progression of fibrosis are age at the first liver biopsy, extent of ALT elevation, inflammation at liver histology and hepatic siderosis. Antiviral treatment is effective in preventing the progression of liver structural lesions in chronic hepatitis C patients.

关键词： Hepatitis C Histology Fibrosis Interfemns Disease progression

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Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress

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World Journal of Gastroenterology 2003年第3期9卷 446-448页

作者： Claudia P.M.s.oliveira paulo Kassab Fabio P.Lopasso Heraldo P.souza Mariano Janiszewski Francisco R.M.Laurindo Kioshi Iriya Antonio A.Laudanna Department of Gastroenterology of Medical school of university of so paulo (UsP) So PauloBrazil Department of Emergency Medicine of Mcdical school of university of so paulo (UsP) So PauloBrazil Heart Institute of Medical school of university of so paulo (UsP) So PauloBrazil Depatment of Pathology of Medical school of university of so paulo (UsP) So PauloBrazil

AIM;oxidative stress participates in the cell carcinogenesis by inducing DNA *** aim was to assess whether ascorbic acid,an antioxidant,could have a role in preventing Ros(Reactive oxygen species)generation in experimental gastric carcinoma in a rat model. METHoDs:Experimental gastric cancer was induced in twelve Wistar male rats(weighting 250-350 g)by profound duodeno-gastric reflux throught split *** rats were allocated to the following groups:Group Ⅰ(n=6) was the control;Group Ⅱ(n=6)which was mantained with daily intake of tape water with Vitamin C(30 mg/Kg).After 6 or 12 months,samples of gastric tumor or non tumor mucosa were taken from the anastomosis of both groups. oxidative stress was measured by superoxide quantification through lucigenin-amplified chemiluminescence base and by staining with *** histopathologic confirmation of adenocarcinoma was made by eosin- hemathoxilin method. REsULTs:The intestinal type of gastric adenocarcinoma was microscopically identified in all animals of group Ⅰ whereas only 3 rats of group Ⅱ showed an adenocarcinoma without macroscopic evidence of *** cancers were located in the anastomosis in all *** luminescence from tumor gastric tissue generated 38.4±6.8 count per minute/mg/×10~6(mean±sD)and 14.9±4.0 count per minute/mg/×10~6,respectively,in group Ⅰ and Ⅱ animals(P obluetetrazolium method showed intense staining in tumor tissues but not in non neoplasic mucosa. CoNCLUsIoN:Experimental gastric tumors seem to produce more reactive oxygen species than non neoplasic gastric *** reduction of oxidative stress and gastric tumor incidence in rats were induced by the intake of ascorbic ***,it may have a role in the prevention of gastric carcinoma. oliveira CPMs Kassab P Lopasso FP souza HP Janiszewski M Laurindo FRM Iriya K Laudanna *** effect of ascorbic acid in experimental gastric cancer:reduction of oxidative *** J G

关键词： Animals Antioxidants Ascorbic Acid Male oxidative stress Rats Rats, Wistar stomach Neoplasms control

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Estimation of transit trip production using Factorial Kriging with External Drift:an aggregated data case study

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Geo-spatial Information science 2016年第4期19卷 245-254页

作者： Anabele Lindner Cira souza Pitombo samille santos Rocha JoséAlberto Quintanilha Department of Transportation Engineering São Carlos School of EngineeringUniversity of São PauloSão CarlosBrazil Department of Transportation Engineering Polytechnic SchoolUniversity of São PauloSão PauloBrazil

studies in transportation planning routinely use data in which location attributes are an important source of ***,using spatial attributes in urban travel forecasting models seems *** main objective of this paper is to estimate transit trip production using Factorial Kriging with External Drift(FKED)through an aggregated data case study of Traffic Analysis Zones in são paulo city,*** method consists of a sequential application of Principal Components Analysis(PCA)and Kriging with External Drift(KED).The traditional Linear Regression(LR)model was adopted with the aim of validating the proposed *** results show that PCA summarizes and combines 23 socioeconomic variables using 4 *** first component is introduced in KED,as secondary information,to estimate transit trip production by public transport in geographic coordinates where there is no prior knowledge of the ***-validation for the FKED model presented high values of the correlation coefficient between estimated and observed ***,low error values were *** accuracy of the LR model was similar to ***,the proposed method is able to map the transit trip production in several geographical coordinates of non-sampled values.

关键词： Travel demand forecasting Geostatistics Kriging spatial statistics

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Hydrocarbon indication in Rio Bonito Formation sandstone:Implication for Co_(2)storage in são paulo,Brazil

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Energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson M.Abraham-A Haline V.Rocha saulo B.de oliveira Colombo C.G.Tassinarri orlando C.da silva Institute of Energy and Environment University of São PauloSão PauloBrazil Research Centre for Greenhouse Gas Innovation University of São PauloSão PauloBrazil

são paulo state has witnessed Co_(2)storage-based investigations considering the availability of suitable geologic structures and proximity to primary Co_(2)source sinks related to bioenergy and carbon capture and storage(BECCs)*** current study presents the hydrocarbon viability evaluations and Co_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objective is to apply petrophysical evaluations with geochemical inputs in predicting future hydrocarbon(gas)production to boost Co_(2)storage within the study *** study used data from eleven wells with associated wireline logs(gamma ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accumulation and fluid mobility in the investigated *** samples(shale and carbonate)obtained from depths>200 m within the study location have shown bitumen *** geochemistry data of the Rio Bonito Formation shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accumulations within the sandstone *** drilled well data,e.g.,CB-1-sP and TI-1-sP,show hydrocarbon(gas)presence based on the typical resistivity and the combined neutron-density responses at depths up to 3400 m,indicating the possibility of other hydrocarbon members apart from the heavy oil(bitumen)observed from the near-surface rocks *** the three-dimensional(3-D)model,the free fluid indicator(FFI)is more significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for Co_(2)injection,circulation and permanent ***,future studies based on contemporary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance Co_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication sandstone reservoirs Rio Bonito Formation Co_(2)storage Hydrocarbon recovery factor Fluid injection rate

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Hydrometallurgical processing of chalcopyrite:A review of leaching techniques

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International Journal of Minerals,Metallurgy and Materials 2024年第12期31卷 2537-2555页

作者： Darwin Michell Cheje Machaca Amilton Barbosa Botelho Junior Thamyres Cardoso de Carvalho Jorge Alberto soares Tenório Denise Crocce Romano Espinosa Department of Chemical Engineering University of Sao PauloSão PauloBrazil

Copper,an essential metal for the energy transition,is primarily obtained from chalcopyrite through hydrometallurgical and pyrometallurgical *** risks and harmful impacts of these processes pose significant concerns for environmental and human safety,highlighting the need for more efficient and eco-friendly hydrometallurgical *** review article emphasizes current pro-cesses such as oxidative leaching,bioleaching,and pressure leaching that have demonstrated efficiency in overcoming the complicated chalcopyrite *** leaching operates under benign conditions within the leaching media;nevertheless,the introduction of oxidizing agents provides benefits and ***,a non-aggressive method,has shown a gradual increase in copper extrac-tion efficiency and has been explored using both primary and secondary *** leaching,known for its effectiveness and se-lectivity in copper extraction,is becoming commercially more viable with increased research *** research also provides im-portant data for advancing future research in the field.

关键词： chalcopyrite leaching bioleaching ionic liquids chloride hydrogen peroxide

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Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release

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Journal of Integrative Medicine 2022年第2期20卷 153-162页

作者： Célia Cristina Malaguti Figueiredo Amanda da Costa Gomes Filipe oliveira Granero Joao Luiz Bronzel Junior Luciana Pereira silva Valdecir Farias Ximenes Regildo Márcio Goncalves da silva Institute of Chemistry São Paulo State UniversityAraraquaraSão Paulo 14800-060Brazil Educational Foundation of the City of Assis AssisSão Paulo 19807-130Brazil Department of Chemistry School of SciencesSão Paulo State UniversityBauruSão Paulo 17033-360Brazil Department of Biotechnology School of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão Paulo 19806-900Brazil

objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus *** also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule ***:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)*** activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(No)and thiobarbituric acid reactive species(TBARs)*** were prepared using maltodextrin as wall material and freeze-drying as encapsulation *** characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins *** and antioxidant assays were performed using crude dry extract and saponin fraction of *** before and after ***:saponin fraction showed an increase of 32.8%total ***-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained *** evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with ***,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the *** dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARs(32.49%)*** fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and No test(15.13μmol nitrite formed per gram of extract)presented the highest ***:This study presen

关键词： Glycation Microencapsulation oxidative stress saponins Tribulus terrestris

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Implementation of a High-Risk outpatient Clinic for Children with Complex Congenital Heart Disease in a Reference service in Brazil

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Congenital Heart Disease 2023年第6期18卷 649-656页

作者： Gustavo Foronda Vanessa Ferreira Amorim de Melo Claudia Regina Pinheiro de Castro Grau Ingrid Magatti Piva Glaucia Maria Penha Tavares Ana Cristina sayuri Tanaka Nana Miura Department of Pediatric Cardiology and Adult Congenital Heart Diseases Heart Institute of the University of São PauloSão PauloBrazil Foronda Clinic São PauloBrazil Institute of orthopedics and Traumatology University of São PauloSão PauloBrazil Department of Echocardiography Heart Institute of the University of São PauloSão PauloBrazil

Background:Children with congenital heart disease(CHD),even after surgical approaches,and especially those who undergo staged procedures in theﬁrst months of life,remain vulnerable to readmissions and complications,requiring very close monitoring and differentiated intervention ***:Descriptive and exploratory study,of the experience report type,which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases(AAR)at the Instituto do Coração(InCor).Results:Report of the path taken to structure the AAR,demonstrating the organization,interface with the multidisciplinary team,admission and discharge criteria,training,and patient proﬁ*** theseﬁve years of care,275 patients were treated,59.65%with biventricular interstage physiology,followed by univentricular interstage physiology(34.55%),residual defects after surgical procedures(3.63%),tumors with risk of mechanical obstruction(1.45%)and patients with an intrauterine approach(0.72%).The signiﬁcant number of critical patients who were successfully discharged from hospital(44.72%),the low mortality rate due to sudden deaths at home and the high adherence to follow-up cor-roborate the impact of this specialized ***:Despite the limitations of the study,this experi-ence report showed that with few resources,there is the possibility of organizing an AAR with differentiated care,with the objective of early detection and treatment of residual injuries,identiﬁcation of early interventions,edu-cation of parents for follow-up of their children,resulting in individualized treatment,promoting a better quality of life for this population.

关键词： Congenital heart defects ambulatory care heart defects

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