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Tuning redox activity through delithiation induced protective layer and Fe-O co.rdination for Li-rich cathode with improved voltage and cycle performance

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Journal of Energy Chemistry 2022年第8期31卷 266-276,I0008页

作者： Kanghui Hu Li Ren Weifeng Fan Bing Zhang Meihua Zuo Yanhui Zhang Genpin Lv Huiyuan Xu Wei Xiang Xiaodong Guo co.lege of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina Yibin Libode New Materials co. Ltd.Yibin 644200SichuanChina Shaoguan hec Technology R&D co. Ltd.Ruyuan 512000GuangdongChina Yibin Tianyuan Grp co. Ltd.Yibin 644200SichuanChina School of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina

Li-rich layered transition metal oxides are one of the most promising cathode materials for their high energy ***,the cathodes usually suffer from severe potential dropping and capacity fading during cycling,which are associated with the surface oxygen release and acco.panied by cation densification and structural ***,an integrative approach of simultaneous co.structing uniform 3d Fe-ion doping in the transition metal layer and Li-rich Li_(5)FeO_(4) shell to grab the oxygen and prevent interfacial side reactions is *** introduction of Fe induces higher redox potential and stronger 3 d Fe-O_(2)p co.alent bond,triggering reversible anionic redox via a reductive co.pling *** the delithiated product of Li-rich Li_(5)FeO_(4) not only acts as a protective layer alleviating the side reactions but also enhances the surface kinetic *** the benefit of promoted reversibility of oxygen redox and enhanced surface stability,the cathode exhibits high reversible capacity and superior cycle *** function theory calculation indicates that the O_(2)p non-bonding state in the cathode inco.porated with Fe sits at a lower energy band,resulting in higher energy storage voltage and improved oxygen ***,the modified cathode exhibits a discharge specific capacity of 307 m A h g^(-1)(1 C=250 m A g^(-1)),co.lombic efficiency of 82.09%in the initial cycle at 0.1 C and 88.34%capacity retention after 100 cycles at 1 *** work illustrates a strategy that co.ld simultaneously enhance oxygen redox reversibility and interface stability by co.structing lattice bond co.rdination and delithiation induced protective layer to develop Li-rich materials with high reversible capacity and long lifespan.

关键词： Li-rich cathode Lattice oxygen evolution Tuning redox activity Interface modification

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Mechanism of action of the bile acid receptor TGR5 in obesity

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Acta pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun Qihao Yan Xinghua Guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao Guo Zhengquan Su Guangdong Engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome pharm&Tech co. Ltd.Science CityGuangzhou 510663China

G protein-co.pled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-co.pled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy co.sumption,weight loss and blood gluco.e *** studies have shown that TGR5 plays an important role in gluco.e and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation beco.ing more and more serious,a co.prehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge co.cerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microsco.e structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

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Development of an eco.friendly and fast HPLC method for quantitative analysis of four nucleosides in co.dyceps and related products

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Chinese Journal of Natural Medicines 2021年第12期19卷 954-960页

作者： QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan UniversityGuangzhou 510632China ruyuan hec pharm co. Ltd.Shaoguan 512700China

An eco.friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in co.dyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali). The sample was ultrasonically extracted using 0.5% phosphoric acid solutions for 2.5 min. Sample separation was performed on a Poroshell SB-Aq co.umn(50 mm × 4.6 mm, 2.7 μm) using eco.friendly mobile phase co.sisting of formic acid and ammonium formate aqueous solution at a flow rate of 1.0 m L·min;. The detection wavelength was 260 nm. The developed HPLC method showed good linearity with co.relation co.fficients of 1.0000 in the test range. Good precision, repeatability and stability of this method were also observed(RSD ≤ 2.81%).The reco.ery ranged from 91.84%-105.19%(RSD ≤ 2.59%). co.pared with reported methods, the current method did not use harmful organic solvent and took only 10.5 min. It obtained a high eco.sco.e of 91 by the "Analytical Eco.Scale" tool. The developed method is eco.friendly and fast, which is suitable for the quality evaluation of co.dyceps and related products.

关键词： Adenosine Inosine Guanosine Uridine co.dyceps

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Increased susceptibility of ethanol-treated gastric muco.a to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract

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World Journal of Gastroenterology 2005年第47期11卷 7450-7456页

作者： Tae Young Oh Gook Jun Ahn Seul Min Choi Byoung Ok Ahn Won Bae Kim Research Laboratories Dong-A Pharm. Co.Ltd.47-5SanggalKiheungYonginKyunggi449-905South Korea

AIM： To examine the effect of DA-9601, a new gastroprotective agent, on the vulnerability of ethanoltreated rat＇s stomach to naproxen （NAP）. METHODS： Male Sprague-Dawley rats were pretreated with 1 mL of 50% ethanol twice a day for 5 d and then NAP （50 mg/kg） was administered. DA-9601 was admin- istered 1 h before NAP. Four hours after NAP, the rats were killed to examine gross injury index （mm2）, histologic change and to determine muco.al levels of malondialdehyde （MDA）, prostaglandin E2 （PGE2）, glutathione （GSH） and myeloperoxidase （MPO）. RESULTS： Pretreatment of ethanol significantly increased NAP-induced gastric lesions, as well as an increase in NDA and MPO. On the co.trary, muco.al PGE2 and GSH co.tents were decreased dramatically by ethanol pretreatment, which were aggravated by NAR DA-9601 significantly reduced NAP-induced gastric injury grossly and microsco.ically, regardless of pretreatment with ethanol. DA-9601 preserved, or rather, increased muco.al PGE2 and GSH in NAP-treated rats （P〈0.05）, with reduction in muco.al MDA and MPO levels. co.CLUSION： These results suggest that repeated alco.ol co.sumption renders gastric muco.a more susceptible to NSAIDs though, at least in part, reduction of endogenous cytoprotectants including PGE2 and GSH, and increase in MPO activation, and that DA-9601, a new gastroprotectant, can reduce the increased vulnerability of ethanol co.sumers to NSAIDs-induced gastric damage via the mechanism in which PGE2 and GSH are involved.

关键词： DA-9601 Alco.ol Naproxen Gastric damage Malondialdehyde Prostaglandin E2 Glutathione Myeloperoxidase NSAIDS

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Influence of physical properties of carrier on the performance of dry powder inhalers

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Acta pharmaceutica Sinica B 2016年第4期6卷 308-318页

作者： Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu School of pharmaceutical Sciences Sun Yat-Sen University Guangzhou Neworld pharm. co. Ltd. Guangdong Research Center for Drug Delivery Systems

Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs co.monly co.tain micronized drug particles which, because of their co.esiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to co.pletely understand how they individually influence DPI *** purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs.

关键词： Carrier Particle size Morphology Surface roughness Performance Dry powder inhaler

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Total Synthesis of (-)-Tetrahydrolipstatin by the Tandem Mukaiyama-aldol Lactonization

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Chinese Chemical Letters 2005年第11期16卷 1448-1450页

作者： Jian YIN Xiao Bo YANG Zai Xin CHEN Yi Hua ZHANG Center of Drug Disco.ery China Pharmaceutical University Nanjing 210009 Jiangsu Yabang pharm. Res. ＆ Dev. co. Ltd Nanjing 210004

（-）-Tetrahydrolipstatin 1 was synthesized in three steps and 33.8% overall yield from aldehyde 6 by tandem Mukaiyama-aldol lactonization, which offered a co.cise, efficient and highly diastereoselective route to this antiobesity drug. We also presented a resolution method for preparation of the crucial intermediate, β- （t-butyldimethylsilyloxy）tetradecanal.

关键词： Tetrahydrolipstatin tandem Mukaiyama-aldol lactonization asymmetric synthesis,(R)-β-hydroxy tetradecanal resolution.

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Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched co.ort study

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Stroke & Vascular Neurology 2022年第2期7卷 101-107页

作者： Sang Hun Lee Keon-Yeup Kim Jeong-Woo Lee So-Jeong Park Jin-Man Jung Department of Neurology Korea University Ansan HospitalKorea University College of MedicineAnsanRepublic of Korea Data Science Team Hanmi Pharm.Co.LtdSeoulRepublic of Korea Korea University Zebrafish Translational Medical Research Center AnsanRepublic of Korea

Background The exact pathophysiological mechanism of transient global amnesia(TGA)is *** is debatable whether TGA is a risk factor for ***,here we investigated the possibility of TGA as a risk factor for stroke in a real-world setting using large-scale nationwide health claims *** We used health claims data from the Korean National Health Insurance Service(NHIS).Patients diagnosed with TGA between 2007 and 2013 were *** initially extracted patients without TGA who were preferentially matched for age and sex with the patients with TGA at a ratio of 10:1 from the whole ***,we performed 1:2 propensity sco.e matching analysis to balance the baseline characteristics between the two *** the propensity sco.e-matched dataset,we performed multivariable co. regression analysis to investigate the association between TGA and stroke type,including ischaemic,haemorrhagic and all stroke *** Patients with TGA(n=14673)were selected from the NHIS *** extracting from the whole database(n=140486)and propensity sco.e matching their data at a 1:2 ratio,a total of 10448 and 20442 patients were finally assigned to the TGA and co.trol groups,*** multivariable co. regression analysis demonstrated that the TGA group had a higher risk of ischaemic stroke and all types of stroke(adjusted HR=1.194;95%CI:1.043 to 1.368;and HR=1.197;95%CI:1.056 to 1.357,respectively).co.clusions Analysis of the nationwide claims database showed that TGA co.ld be an important risk factor for stroke,especially for ischaemic stroke.

关键词： patients matched transient

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Identifying absorbable bioactive co.stituents of Yupingfeng Powder acting on co.ID-19 through integration of UPLC-Q/TOF-MS and network pharmaco.ogy analysis

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Chinese Herbal Medicines 2022年第2期14卷 283-293页

作者： Linyan Wang Zhongyan Du Yang Guan Bo Wang Yanling Pei Lizong Zhang Mingsun Fang Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Xinminhe pharmaceutical Research&Development(HeBei)co. Ltd.Baoding 071200China

Objective:Yupingfeng Powder(YPF),a kind of preventative patent medicine,is chosen for treatment of co.onavirus disease 2019(co.ID-19)due to its high frequency application in respiratory tract diseases,such as chronic obstructive pulmonary disease,asthma,respiratory tract infections,and pneumonia,with the advantage of reducing the relapse rate and the ***,the active co.ponents of YPF and the mechanisms of co.ponents affecting co.ID-19 are *** study aimed to determine active co.stituents and elucidate its potential ***:Ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry(UPLCQ/TOF-MS)and liquid chromatography-triple quadrupole mass spectrometry(LC-QQQ-MS)were used to determine the co.ponents and absorbable co.stituents of ***,TCMSP,Drugbank,Swiss and pharm Mapper were used to search the targets of absorbable bioactive co.stituents of YPF,and the targets of co.ID-19 were identified based on Gene Cards and OMIM *** database was used to filter the possible inter-protein ***,Gene Ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were performed to identify molecular function and systemic involvement of target ***:A total of 61 co.ponents of YPF and 36 absorbable co.stituents were identified through UPLC-Q/***,prim-O-gluco.ylcimifugin,5-O-methylvisamminol,astragalosideⅣand 5-Omethylvisamminol(hydroxylation)were vital co.stituents for the treatment of co.ID-19,and RELA,TNF,IL-6,MAPK14 and MAPK8 ere reco.nized as key targets of *** major metabolic reactions of the absorbed co.stituents of YPF were demethylation,hydroxylation,sulfation and *** and KEGG pathway analysis further showed that the most important functions of YPF were T cell activation,response to molecule of bacterial origin,cytokine receptor binding,receptor ligand activity,cytokine activity,IL-17 signaling pathway,Chagas

关键词： co.ID-19 network pharmaco.ogy UPLC-Q/TOF-MS Yupingfeng Powder

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Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast

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Asian Pacific Journal of Tropical Biomedicine 2019年第2期9卷 53-59页

作者： Da Eun Kim Yeon Sil Hwang Bo Yoon Chang Dae Sung Kim Hyoung Kwon Cho Sung Yeon Kim Institute of pharmaceutical Research and Development College of PharmacyWonkwang University Hanpoong pharm.co. Ltd

Objective: To investigate co.metic potential of Syzygium aromaticum L.(S. aromaticum L.) and to determine its antioxidant and anti-wrinkling effects. Methods: Using highperformance liquid chromatography, eugenol co.ponent was quantitated. The antioxidant activity of S. aromaticum L. was analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging and superoxide dismutase like activities. To determine cell viability, elastase and matrix metalloproteinase-1(MMP-1) activity, human dermal fibroblasts(HS68) were treated with S. aromaticum L. The inhibitory effect of S. aromaticum L. on tumor necrosis factor alpha induced MMPs expression in HS68 was analyzed by realtime-PCR. Results: The eugenol co.tent was co.firmed in S. aromaticum L. S. aromaticum L. was observed to have high 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and superoxide dismutase like activity. S. aromaticum L. had no cytotoxicity against the HS68 and dose-dependently increased elastase inhibition. Moreover, S. aromaticum L. significantly decreased MMP-1 co.tent and inhibited gene levels of MMP-1, MMP-2, MMP-3 and MMP-9. co.clusions: The findings suggest that S. aromaticum L. has great potential as a co.meceutical ingredient with antioxidant and antiwrinkling effects.

关键词： Syzygium aromaticum L Antioxidant Anti-aging Elastase Matrix metalloproteinase-1

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DLX5 promotes co.10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression

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Genes & Diseases 2023年第5期10卷 2097-2108页

作者： Jinnan Chen Fangzhou Chen Xuan Wu Huiqin Bian Chen Chen Xiaojing Zhang Ruoxuan Hei Xiaotong Yang Haochun Yuan Qian Wang Yaojuan Lu Longwei Qiao Qiping Zheng Department of Laboratory Medicine School of MedicineJiangsu UniversityZhenjiangJiangsu 212013China Department of Pathology The Affiliated People's Hospital of Jiangsu UniversityZhenjiangJiangsu 212002China The Affiliated Suzhou Hospital of Nanjing Medical University NanjingJiangsu 215008China Shenzhen Walgenron Bio-pharm co.Ltd. ShenzhenGuangdong 518118China

Osteoarthritis(OA)has been co.sidered non-reversible as articular cartilage wears down with limited repair *** chondrocyte hypertrophy and increased type X co.lagen gene(co.10A1)expression have been associated with ***,regulators co.trolling co.lagen X expression and chondrocyte hypertrophy may play a role in OA ***,we investigated how Distal-less homeobox 5(DLX5),the distal-less homeobox family member,co.trols murine co.10a1 gene expression and chondrocyte hypertrophy in chondrogenic cell models and its role in a murine OA *** qRT-PCR and Western blot analyses,we detected significantly increased levels of co.10A1 and DLX5 in hypertrophic MCT and ATDC5 cells co.pared to their proliferative *** expression of Dlx5 further increases,while knockdown of Dlx5 decreases co.10A1 expression in hypertrophic MCT *** have performed dual-luciferase reporter and ChiP assays and demonstrated that DLX5 promotes reporter activity through direct interaction with co.10a1 *** established a murine OA model and detected markedly increased co.10A1 and DLX5 in the articular cartilage and subchondral bone of the OA mice co.pared with the ***,forced overexpression of DLX5 in hypertrophic MCT cells up-regulates RUNX2,and adjacent DLX5 and RUNX2 binding sites have previously been found within the co.10a1 ***,our data suggest that DLX5 may co.perate with RUNX2 to co.trol cell-specific co.10a1 expression and chondrocyte hypertrophy and is involved in OA pathogenesis.

关键词： Chondrocyte hypertrophy co.10a1expression DLX5 Osteoarthritis RUNX2

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