Influence of physical properties of carrier on the performance of dry powder inhalers

作     者：Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu 

作者机构：School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou Neworld Pharm. Co. Ltd. Guangdong Research Center for Drug Delivery Systems 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2016年第6卷第4期

页      面：308-318页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Pearl River S&T Nova Program of Guangzhou(2014J2200082) 

主　　题：Carrier Particle size Morphology Surface roughness Performance Dry powder inhaler 

摘      要：Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI *** purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs.