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A novel small-animal locomotor activity recording device for biological clock research

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Animal Models and Experimental Medicine 2024年第1期7卷 71-76页

作者： Yi-Long Wu Ming Zhong Jun Yin Wei-Jie Ou Yu-Bin Zhuang Nan-Wen Zhang su Lin Yue-Yong Zhu Endoscopy Center The First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Endocrinology The First Affiliated HospitalFujian Medical UniversityFuzhouChina Chuangke Workshop Technology Co. LtdShenzhenChina Department of Digestive Nutrition Fujian Children's HospitalFuzhouChina Experimental Animal Center Fujian Medical UniversityFuzhouChina Department of Pharmacology Fujian Medical UniversityFuzhouChina Department of Hepatology Hepatology Research InstituteClinical Research Center for Liver and Intestinal Diseases of Fujian ProvinceThe First Affiliated HospitalFujian Medical UniversityFuzhouChina

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian *** study demonstrated how to construct a simple and intelligent running-wheel recording *** running wheel was attached to the cage's base,whereas the hall sensor was attached to the cage's ***,the RJ25 adaptor relayed the running signal to the main control ***,the main control board was connected to the UsB port of the computer with the UsB *** were collected using the online-accessible,self-created software *** Magturning,generated data were saved and exported in real ***,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light *** conclusion,this new device can record circadian activity of *** device is appropriate for interdisciplinary investigations related to biological clock research.

关键词： biological clock circadian rhythm intelligent equipment locomotor activity running wheel

Xuefuzhuyu decoction and astragalus prevent hypoxic-ischemic brain injury

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Neural Regeneration Research 2011年第21期6卷 1635-1639页

作者： Ning Wang Dongpi Wang Zhong LV Xuan Chen Long Lin Zhiyong Hu Children's hospital of Zhejiang University school of Medicine Hangzhou 310003 Zhejiang Province China Huqingyu hall Traditional Chinese Medicine Museum Hangzhou 310000 Zhejiang Province China Red Cross hospital Hangzhou 310000 Zhejiang Province China

Hypoxic-ischemic brain injury models were generated by bilateral carotid artery ligation in sprague-Dawley rats. successful models were treated with a combination of Xuefuzhuyu decoction and 10g of astragalus. The experimental results showed that neuronal morphology and structure recovered, nerve growth factor mRNA expression increased in brain tissues, and neurological function signifi-cantly improved. There was no significant difference in these measures compared with rats treated with Xuefuzhuyu decoction alone or a combined treatment of Xuefuzhuyu decoction with 40 g as-tragalus. These experimental findings revealed that, Xuefuzhuyu decoction combined with astra-galus may up-regulate the expression of nerve growth factor mRNA and accordingly exert a neu-roprotective effect; however, this protection is not dependent on astragalus dosage.

关键词： Xuefuzhuyu decoction astragalus hypoxic ischemic encephalopathy cerebral protection nerve growth factor neural regeneration

Overview of juvenile localized scleroderma and its management

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World Journal of Pediatrics 2020年第1期16卷 5-18页

作者： suzanne C.Li Rong-Jun Zheng Department of Pediatrics Division of Pediatric RheumatologyJoseph M.Sanzari Children's HospitalHackensack University Medical Center30 Prospect AvenueImus 337Hackensack 07601NJUSA Department of Pediatrics Hackensack Meridian School of Medicine at Seton Hall UniversityClifton 07110NJUSA Department of Rheumatology Immunologyand AllergyChildren's HospitalZhejiang University School of MedicineHangzhou 310003China

Background Juvenile localized scleroderma(JLs)is a rare pediatric disease characterized by inflammation and skin thick *** is associated with deep tissue and extracutaneous involvement that often results in functional impairment and growth *** article provides an overview of the disease with a focus on active features and *** sources We searched databases including PubMed,Elsevier and MedLine and Wanfang,reviewing publications from 2013 to *** earlier publications were also *** Linear scleroderma is the most common JLs *** lines of evidence suggest that JLs is an autoimmune *** involvement is common and can present before the onset of skin *** skin features are associated with disease activity,and activity can also manifest as arthritis,myositis,uveitis,seizures,and growth *** immunosuppressive treatment,commonly methotrexate with or without glucocorticoids,greatly improves outcome and is recommended for treating JLs patients with active disease and moderate or higher *** term monitoring is needed because of the disease's chronicity and the high frequency of relapses off of *** JLs is associated with a risk for disabling and disfiguring morbidity for the growing *** active disease is important for guiding treatment,but often difficult because of the paucity of markers and lack of a universal skin activity *** studies of JLs pathophysiology are needed to allow the identification of biomarkers and therapeutic *** effectiveness treatment studies are also needed to work towards optimizing care and outcome.

关键词： Disease activity Extracutaneous involvement Juvenile localized scleroderma Morphea Pediatric scleroderma Treatment

Non-pharmacological management of abdominal pain-related functional gastrointestinal disorders in children

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世界儿科杂志:英文版 2016年第4期12卷 389-398页

作者： siba Prosad Paul Dharamveer Basude Torbay hospital Vowden HallLowes BridgeTorquayTQ27AAUK Bristol Royal hospital for Children Upper Maudlin StreetBristolBS28BJUK

Background:Abdominal pain-related functional gastrointestinal disorder(AP-FGID)comprises of 4 main conditions:functional dyspepsia,irritable bowel syndrome,abdominal migraine and functional abdominal ***-FGIDs are diagnosed clinically based on the Rome IV criteria for FGIDs of *** is limited evidence for pharmacological *** sources:This review article discusses non-pharmacological management of AP-FGID based on the current literature including systematic reviews,randomized controlled trials,cohort and case control *** aim to provide a comprehensive overview on the available evidence for the pediatricians and pediatric gastroenterologists involved in managing children with ***:Managing AP-FGIDs can be *** should follow a stepwise approach with focused history,identification of“red flag”signs and symptoms,physical examination and investigations done following initial *** needs explaining that there is nothing seriously wrong with the child’s *** explanation and reassurance can achieve symptom control in large number of ***-pharmacological interventions are delivered through lifestyle and dietary changes and bio-psychosocial *** interventions vary depending on the type of ***-psychosocial therapies such as hypnotherapy,cognitive behavioral therapy and yoga aim at stress ***:There is increasing evidence for use of non-pharmacological interventions in children with AP-FGID.

关键词： abdominal pain behavioral intervention diet gastrointestinal diseases hypnosis RomeⅣcriteria

Deposition of stain resistance coating by non-thermal plasma brush application to dental whitening

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Plasma science and Technology 2019年第6期21卷 115-121页

作者： Yu XU Xiaoqing DONG Xueyan LI Jing ZHANG state Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Materials science and Engineering Donghua University Shanghai 201620 People's Republic of China Department of Mechanical and Aerospace Engineering Missouri University E3411 Lafferre HallColumbia MO 65211 United States of America stomatology department Eye and Eat Hospital of Fudan University Shanghai 200031 People's Republic of China

A non-thermal plasma brush is employed to deposit stain-resistant siO2-like coatings on resin composite fillings and bovine *** post-treating by plasma,the hardness of the coating increases from H to 8H and the water contact angle decreases from 98.8° to 61.7°.The Fourier transform infrared spectroscopy (FTIR) results show that,after plasma post-treating,the si-O-si and si-OH bonds of the coating *** electron microscope (sEM) images show the coatings to be uniform,without *** coatings present outstanding performance in a stain resistance test both on resin composite and bovine *** easy to handle and less time consuming than traditional methods,with a body-friendly temperature and material,this plasma brush provides a promising in-situ coating method on patient teeth in dental clinics.

关键词： non-thermal plasma brush stain-resistant coating dental plasma post-treatment

Newly developed self-expandable Niti-s MD colonic metal stent for malignant colonic obstruction

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World Journal of Gastrointestinal surgery 2020年第4期12卷 138-148页

作者： Yuki Miyasako Toshio Kuwai sauid Ishaq Kanae Tao Hirona Konishi Ryoichi Miura Yuki sumida Kazutaka Kuroki Yuzuru Tamaru Ryusaku Kusunoki Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Department of Gastroenterology National Hospital OrganizationKure Medical Center and Chugoku Cancer CenterKure 737-0023Japan Gastroenterology Department Russells Hall HospitalBirmingham City UniversityBirmingham B179BEUnited Kingdom st George’s University University Centre GrenadaWest IndiesGrenada

BACKGROUND Colonic stents are increasingly used to treat acute malignant colonic *** Wall Flex and Niti-s D type stents are the commonly used self-expandable metallic stents available in Japan since *** Flex stent has a risk of stentrelated perforation because of its axial force,while the Niti-s D type stent has a risk of obstructive colitis because of its weaker radial ***-s MD type stents not only overcome these limitations but also permit delivery through highly flexible-tipped smaller-caliber *** To compare the efficacy and safety of the newly developed Niti-s MD type colonic *** This single-center retrospective observational study included 110 patients with endoscopic self-expandable metallic stents placed between November 2011 and December 2018:Wall Flex(Group W,n=37),Niti-s D type(Group N,n=53),and Niti-s MD type(Group MD,n=20).The primary outcome was clinical success,defined as a resolution of obstructive colonic symptoms,confirmed by clinical and radiological assessment within 48 *** secondary outcome was technical success,defined as accurate stent placement with adequate stricture coverage on the first attempt without *** The technical success rate was 100%in Groups W,N,and MD,and the overall clinical success rate was 89.2%(33/37),96.2%(51/53),and 100%(20/20)in Groups W,N,and MD,*** adverse events included pain(3/37,8.1%),poor expansion(1/37,2.7%),and fever(1/37,2.6%)in Group W and perforation due to obstructive colitis(2/53,3.8%)in Group N(likely due to poor expansion).Late adverse events(after 7 d)included stent-related perforations(4/36,11.1%)and stent occlusion(1/36,2.8%)in Group W and stent occlusion(2/51,3.9%)in Group *** stent-related perforation rate in Group W was significantly higher than that in Group N(Pse event was observed in Group *** In our early and limited experience,the newly developed Niti-s MD type colonic stent was effective

关键词： Colonic stenting New endoscopic colonic stent Malignant colonic obstruction Niti-s WallFlex

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World Journal of Gastroenterology 2007年第38期13卷 5151-5153页

作者： GL Gupte s Mahadevan JR Clarke H Alton sV Beath Liver Unit Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Department of Respiratory Medicine Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Department of Radiology Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Liver Unit Birmingham Children’s Hospital Steelhouse Lane B4 6NH United Kingdom

sirolimus is an immunosuppressant with expanding use in pediatric organ transplantation, dermatology and rheumatology. We report two cases of children who developed asthma like symptoms and were diagnosed with interstitial lung disease, which responded to discontinuation of sirolimus. Pediatricians should be aware about the pulmonary side effects of sirolimus.

关键词： sirolimus Pulmonary toxicity Interstitial lung disease Asthma small bowel transplantation Intestinal transplantation Organ transplantation

Is tailored therapy based on antibiotic susceptibility effective?A multicenter,open-label,randomized trial

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Frontiers of Medicine 2020年第1期14卷 43-50页

作者： Jie Pan Zhengchao shi Dingsai Lin Ningmin Yang Fei Meng Lang Lin Zhencheng Jin Qingjie Zhou Jiansheng Wu Jianzhong Zhang Youming Li Wenzhou Central hospital Wenzhou 325000China The People’s hospital of Ruian Wenzhou 325200China The second People’s hospital of Cangnan Wenzhou 325802China Zhiyuan Inspection Medical Institute Hangzhou 310009China The First People’s hospital of Cangnan Wenzhou 325800China The First People’s hospital of Pingyang Wenzhou 325400China The First Affiliated hospital of Wenzhou Medical University Wenzhou 325000China state Key Laboratory of Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China The First Affiliated hospital College of MedicineZhejiang UniversityHangzhou 310003China

An effective eradication therapy of Helicobacter pylori(***)should be used for the first *** this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional *** also evaluated the factors that cause treatment failure in high-resistance *** this multicenter trial,we recruited 467 ***-positive *** patients were randomly assigned to receive tailored triple therapy(TATT),tailored bismuth-containing quadruple therapy(TABQT),or traditional bismuthcontaining quadruple therapy(TRBQT).For the TATT and TABQT groups,antibiotic selection proceeded via susceptibility testing using an agar-dilution *** patients in the TRBQT group were given amoxicillin,clarithromycin,esomeprazole,and *** eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment *** testing was conducted using an agar-dilution *** eradication rate was examined via intention-to-treat(ITT)and per-protocol(PP)*** clarithromycin,levofloxacin,and metronidazole resistance rates were 26.12%,28.69%,and 96.79%,*** against amoxicillin and furazolidone was *** eradication rates for TATT,TRBQT,and TABQT were 67.32%,63.69%,and 85.99%in the ITT analysis(Psis(Ps affected by clarithromycin resistance,and bismuth exerted a direct influence on TATT *** was the most efficacious regimen for use in high-resistance regions,especially among clarithromycin-susceptible patients.

关键词： tailored triple therapy tailored bismuth-containing quadruple therapy traditional bismuth-containing quadruple therapy antibiotic susceptibility testing eradication rates

single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

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signal Transduction and Targeted Therapy 2021年第10期6卷 3108-3118页

作者： Xiang-Na Zhao Yue You Xiao-Ming Cui Hui-Xia Gao Guo-Lin Wang sheng-Bo Zhang Lin Yao Li-Jun Duan Ka-Li Zhu Yu-Ling Wang Li Li Jian-Hua Lu Hai-Bin Wang Jing-Fang Fan Huan-Wei Zheng Er-Hei Dai Lu-Yi Tian Mai-Juan Ma Center for Disease Control and Prevention of Chinese People's Liberation Army BeijingChina The Walter and Eliza hall Institute of Medical Research ParkvilleVicAustralia Department of Medical Biology The University of MelbourneParkvilleVicAustralia state Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina The Fifth hospital of shijiazhuang Hebei Medical UniversityShijiazhuangChina

While some individuals infected by severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)present mild-to-severe disease,many sARs-CoV-2-infected individuals are *** sought to identify the distinction of immune response between asymptomatic and moderate *** performed single-cell transcriptome and T-cell/B-cell receptor(TCR/BCR)sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic,moderate,and severe patients with healthy *** patients displayed increased CD56^(bri)CD16^(-) natural killer(NK)cells and upregulation of interferon-gamma in effector CD4^(+) and CD8^(+) T cells and NK *** showed more robust TCR clonal expansion,especially in effector CD4^(+) T cells,but lack strong BCR clonal expansion compared to moderate ***,asymptomatic patients have lower interferon-stimulated genes(IsGs)expression in general but large interpatient variability,whereas moderate patients showed various magnitude and temporal dynamics of the IsGs expression across multiple cell populations but lower than a patient with severe *** data provide evidenee of different immune signatures to sARs-CoV-2 in asymptomatic infections.

关键词： patients asymptomatic interferon