Xuefuzhuyu decoction and astragalus prevent hypoxic-ischemic brain injury

作     者：Ning Wang Dongpi Wang Zhong LV Xuan Chen Long Lin Zhiyong Hu 

作者机构：Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China Huqingyu Hall Traditional Chinese Medicine Museum Hangzhou 310000 Zhejiang Province China Red Cross Hospital Hangzhou 310000 Zhejiang Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第21期

页      面：1635-1639页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 

基　　金：a grant by Bureau of Traditional Chinese Medicine of Zhejiang Province  No.491040-W50434 

主　　题：Xuefuzhuyu decoction astragalus hypoxic ischemic encephalopathy cerebral protection nerve growth factor neural regeneration 

摘      要：Hypoxic-ischemic brain injury models were generated by bilateral carotid artery ligation in Sprague-Dawley rats. Successful models were treated with a combination of Xuefuzhuyu decoction and 10g of astragalus. The experimental results showed that neuronal morphology and structure recovered, nerve growth factor mRNA expression increased in brain tissues, and neurological function signifi-cantly improved. There was no significant difference in these measures compared with rats treated with Xuefuzhuyu decoction alone or a combined treatment of Xuefuzhuyu decoction with 40 g as-tragalus. These experimental findings revealed that, Xuefuzhuyu decoction combined with astra-galus may up-regulate the expression of nerve growth factor mRNA and accordingly exert a neu-roprotective effect; however, this protection is not dependent on astragalus dosage.