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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin Thomas Nystrom institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Spectrum of L-fuzzy Prime Ideals of a Distributive Lattice

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模糊系统与数学 2013年第1期27卷 12-19页

作者： Y. S. Pawar S. S. Khopade rukhmai institute of technology Solapur India Department of Mathematics K. H. College Gargoti India)

A topological space denoted by Fspec(D),called L-fuzzy prime spectrum of a bounded distributive lattice D is *** space Fspec(D) is compact and it contains a subspace homeomorphic with the prime spectrum of D which is dense in *** correspondence associating D to the topological space Fspec(D) is shown to define a contravarient functor from the category of bounded distributive lattices into the category of compact topological spaces.

关键词： L-fuzzy Sublattice L-fuzzy Ideal L-fuzzy Prime Ideal Compact Space Contravarient Functor

INTEGRATED ARCHITECTURAL AND ENGINEERING DESIGN STRATEGIES FOR A ZERO-ENERGY BUILDING:Illinois institute of technology’s Design Entry for the 2018 *** of Energy Race to Zero(Solar Decathlon Design Challenge)

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Journal of Green Building 2021年第2期16卷 251-270页

作者： Edoarda Corradi Dell’Acqua Jaime Marin Eric Wright Department of Civil Architectural and Environmental EngineeringArmour College of EngineeringIllinois Institute of Technology CEM ME Mechanical&Aerospace EngineeringIllinois Institute of Technology LEED Green Associate ME Architectural EngineeringIllinois Institute of Technology

This paper describes the design of InterTech,a zero-energy mixed-use student residence hall,developed in 2018 by an interdisciplinary team of Illinois institute of technology(Illinois Tech)students for the *** of Energy Solar Decathlon Design Challenge,formerly known as Race to *** main focus is the team’s integrated and iterative approach,which blended architectural design and engineering concepts and led to achieving the high-performance *** aims to provide an innovative housing solution to Illinois institute of technology’s graduate students and their *** along State Street in between Illinois Tech’s main campus and downtown Chicago,it offers a mix of living options providing both independence and access to the campus and to the *** addition to the residential program,the project includes a small grocery/cafe con-nected to an outdoor public plaza,and an underground *** modeling was introduced in the early design *** potential of on-site renewable energy generation defined the project’s target Energy Use Intensity(EUI)of 37 kBtu/*** passive and active strategies were implemented to reduce the building’s total energy needs and meet the target *** implementation of energy conservation measures led to a 25%reduction of the building’s cooling load and a 33%reduction of the heating load.A design EUI of 28 kBtu/sqft was calculated,validating that this design met and exceeded the zero-energy goal.

关键词： zero-energy buildings integrated design high-performance buildings renewable energy systems energy analysis mixed-use buildings student housing

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang Liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

Output Consensus of Heterogeneous Linear MASs via Adaptive Event-Triggered Feedback Combination Control

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 285-287页

作者： Shuo Yuan Chengpu Yu Jian Sun the School of Automation Beijing Institute of Technology the Beijing institute of technology Chongqing Innovation Center

Dear Editor,This letter studies output consensus problem of heterogeneous linear multiagent systems over directed graphs. A novel adaptive dynamic event-triggered controller is presented based only on the feedback combination of the agent's own state and neighbors' output,which can achieve exponential output consensus through intermittent communication. The controller is obtained by solving two linear matrix equations, and Zeno behavior is excluded.

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research institute of China Electronics technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Buried interface bridging for inverted cesium-formamidinium triiodide perovskite solar cells with long operational stability

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Science China Chemistry 2025年第01期 163-173页

作者： Chenhui Zhang Chunjun Liang Fulin Sun Ting Zhu Xinghai Huang Yuzhu Guo Xinyu Guo Kunyang Ge Dan Li Fangtian You Zhiqun He Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic TechnologyBeijing Jiaotong University Department of Physics School of Physical Science and Engineering Beijing Jiaotong University

In the field of perovskite solar cells(PSCs), the research on defects in the buried interface has been relatively limited due to its non-exposure; however, this interface significantly impacts the performance enhancement of inverted PSCs. This study employs phenylethylammonium chloride(PEACl) molecules as a buffer layer to modify the buried interface of p-i-n structured PSCs,aiming to enhance the uniformity of self-assembled monolayers(SAMs) and facilitate the uniform nucleation and growth of perovskite films on the substrate. Furthermore, the introduction of the PEACl buffer layer effectively passivates defects at the bottom of the perovskite layer and notably enhances the crystal quality of the perovskite film by mitigating residual stress,thereby reducing nonradiative recombination loss. Following these optimizations, the MA-free PSCs treated with PEACl achieve a power conversion efficiency(PCE) of 24.11%, with significant improvements in storage, thermal stability, and operational stability. Particularly noteworthy is the device's performance in an unencapsulated state, whereas after 1,500 hours of continuous light operation stability testing, it retains 97% of its original efficiency. This study not only enriches the systematic understanding of the characteristics of the buried interface in PSCs but also contributes significantly to advancing the commercial production of perovskite photovoltaic technology.

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the Shandong Electric Power Engineering Consulting institute science and technology project(Grant No.37-K2014-33).

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Fluid Dynamics & Materials Processing 2021年第1期17卷 123-139页

作者： Mengyuan Cao Yi Xu Yilin Dong institute of Biothermal Science&technology University of Shanghai for Science and TechnologyShanghai200093China

The damage caused by thermal stress during rewarming vitrified biosamples is one of the major obstacles for clinical *** warming is a highly effective approach to overcome this hurdle and can achieve rapid and spatially homogeneous *** current research investigates the effects of magnetic warming on the histological and biomechanical properties of the vitrified umbilical arteries(UAs)through experiments and *** results of experiments show that,for the case of magnetic warming comparing with the conventional water bath,magnetic warming presents better preservation of extracellular matrix(ECM),collagen fibers,elastic fibers,and muscle fibers of the umbilical *** is no significant difference between magnetothermal and fresh UAs(p>0.05)in the elastic modulus and the ultimate *** theoretical results reveal that the maximum temperature difference Tmax inside the biosample is 1.117±0.649℃,and the maximum thermal stressmax is 0.026±0.016 ***,for the case of conventional water bath,Tmax is 32.342±0.967℃andmax is 1.453±0.047 ***,we have arrived at the same conclusion by simulation as theoretical calculation ***,magnetic warming can effectively reduce the thermal stress damage of biological samples during the warming period due to more uniform and rapid *** results confirm that magnetothermal can significantly improve the mechanical properties of large size cryopreserved tissues or organs such as UAs.

关键词： Umbilical artery vitrified magnetic warming mechanical properties thermal stress

Nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期 283-302页

作者： Veeranna MODI Prasad B.RAMPURE Sunil Kumar SHETTY Madeva NAGARAL Channa Keshava NAIK N Johar MGM Muhammad Irsyad ABDULLAH Abdullah I.AL-MANSOUR Shamshad ALAM KLE College of Engineering and technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+Neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

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