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Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy

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Biomedical Engineering Frontiers 2023年第1期4卷 52-65页

作者： Johannes Karges Faculty of Chemistry and Biochemistry Ruhr-University BochumUniversitasstrasse 15044780 BochumGermany.

Ru(II)polypyridine complexes have attracted much attention as anticancer agents because of their unique photophysical,photochemical,and biological *** their promising therapeutic profile,the vast majority of compounds are associated with poor water solubility and poor cancer *** the different strategies employed to overcome these pharmacological limitations,many research efforts have been devoted to the physical or covalent encapsulation of the Ru(II)polypyridine complexes into *** article highlights recent developments in the design,preparation,and physicochemical properties of Ru(II)polypyridine complex-loaded nanoparticles for their potential application in anticancer therapy.

关键词： properties. pyridine complexes

Microstructure analyses and phase-field simulation of partially divorced eutectic solidification in hypoeutectic Mg-Al Alloys

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Journal of Magnesium and Alloys 2022年第6期10卷 1672-1679页

作者： Joo-Hee Kang Jiwon Park Kyung Song Chang-Seok Oh Oleg Shchyglo Ingo Steinbach Korea Institute of Materials Science Changwon 51508Republic of Korea Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University Bochum44801 BochumGermany

In this study the partially divorced eutectic microstructure ofα-Mg andβ-Mg17Al12was investigated by electron backscatter diffraction,transmission electron microscopy,and phase-field modeling in hypoeutectic Mg-Al *** orientation relationships between the individual eutecticαgrains,eutecticβphase,and primaryαgrains were *** the amount of eutectic morphology is primarily determined by the Al content,the in-depth microstructure analyses and the phase-field simulation suggest non-interactive nucleation and growth of eutecticαphase in theβphase grown on the interdendritic primaryα***,phase-field simulations showed a preferred nucleation sequence where theβphase nucleates first and subsequently triggers the nucleation of eutecticαphase at the movingβphase solidification front,which supports the microstructural analysis results.

关键词： Mg-Al alloy Partially divorced eutectic Solidification Electron backscatter diffraction Phase-Field modeling

Liquid-phase epitaxy of metal organic framework thin films

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Science China Chemistry 2011年第12期54卷 1851-1866页

作者： FISCHER Roland A. Organometallics and Materials Chemistry Ruhr-Universitt Bochum

Metal-organic framework(MOF) thin films are multilayer materials ranging from nanometers to micrometers in thickness,physically or chemically adhesive to a(functionalized) substrate and,in an ideal case,exhibiting low roughness and high *** innovative approaches have been developed for MOF thin film *** these advanced materials,surface-attached metal-organic frameworks(SURMOFs) are an important class of MOF ***,fabricated in a step-by-step liquid phase epitaxial(LPE) fashion by alternating deposition of metal and organic linker precursors on a functionalized substrate,for example,thiolate-based self-assembled monolayers(SAMs),have already exhibited their utility in both research and potential *** combine surface science and the chemistry of MOFs,possessing the following unique advantages that cannot be accessed through other methods:(i) precisely controlling thickness,roughness and homogeneity as well as growth orientation,(ii) studying of MOF growth mechanism,(iii) modifying/tailoring MOFs' structures during the SURMOF growth and thus creating customizable properties,and(iv) existing in the form of thin film/membrane for direct applications,for example,as *** review discusses the oriented and crystalline SURMOFs fabricated by LPE approach,covering their preparation,growth mechanism,and characterization methodology as well as applications based upon the most newly updated knowledge.

关键词： coordination chemistry metal-organic frameworks (MOFs) liquid phase epitaxy step-by-step approach surface science thin film

DNA methylation in hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第11期14卷 1741-1748页

作者： Iris Tischoff Andrea Tannapfel Institute of Pathology Ruhr-University of BochumBürkle-de-la-Camp-Platz 1Bochum44789Germany

As for many other tumors,development of hepatocellular carcinoma(HCC)must be understood as a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes,leading to activation of oncogenes and inactivation or loss of tumor suppressor genes(TSG).In the last decades,in addition to genetic alterations,epigenetic inactivation of(tumor suppressor) genes by promoter hypermet hylation has been recognized as an important and alternative mechanism in *** HCC,aberrant methylation of promoter sequences occurs not only in advanced tumors, it has been also observed in premalignant conditions just as chronic viral hepatitis B or C and cirrhotic liver. This review discusses the epigenetic alterations in hepatocellular carcinoma focusing DNA methylation.

关键词： Hepatocellular carcinoma DNA methylation Histone modification Tumor suppressor genes

Determination of Elastic and Creep Properties of Thin-film Systems from indentation Experiments

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Journal of Materials Science & Technology 2000年第6期16卷 559-567页

作者： Z.F.Yue and G.Eggeler (Institut fur Werkstoffe, ruhr-Universitat bochum, 44 801 bochum, Germany) [Manuscript received February 16, 2000, in revised form April 12, 2000] ruhr Univ bochum Inst Werkstoffe D-44801 Bochum Germany

Based on the detailed computer simulation of the indentation testing on the thin-film systems, the present paper explores the detailed procedure of determining elastic properties (elastic modulusE^(f) and Poisson ratio v(f)) and creep parameters (CCREEP^(f) and nCREEP^(f)) for a simple Norton law (ε=CCREEP^(f)σ^n CREE^(f), where e is creep strain rate, and a is the stress) material for a thin film coated on a creep substrate, whose elastic properties(E^(s) and v^(s)) and creep properties (CCREEP^(s) and nCREEP^(s)) of the substrate are known, from indentation elastic and creep testing,respectively. The influences of the thickness of the thin-film and the size of the indenter on the indentation behavior have been discussed. It is shown that the boundary between the thin film and the substrate has great influence on the indentation creep behavior. The relative sizes of indentation systems are chosen so that the behavior of the indentation on the film is influenced by the substrate. The two elastic parameters E^(f) and v^(f) of the film are coupled on the influence of the elastic behavior of indentation. With the two different size indenters, the two elastic parameters E^(f) and v^(f) of the film can be uniquely determined by the indentation experimental slopes of depth to applied net section stress results. The procedure of determining of the two Norton law parameters CCREEP^(f) and nCREEP^(f) includes the following steps by the steady indentation rate d. The first step to calculate the creep indentation rate on certain loads of the two different sizes of indenters on a set of assumed values of CCREEP^(f) and nCREEP^(f)Then to build relationship between the creep indentation rate and the assumed CCREEP^(f) and nCREEP^(f) With the experimental creep indentation rate to intersect two sets of which have the same values of d. The last step is to build the CCREEP^(f) and nCREEP^(f)curves from the intersection points for the two indenters. These two curves CCREEP^(f) a

关键词： Thin Determination of Elastic and Creep Properties of Thin-film Systems from indentation Experiments

Long-term survival after pancreaticoduodenectomy in patients with ductal adenocarcinoma of the pancreatic head

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 271-278页

作者： Andreas Minh Luu Chris Braumann Orlin Belyaev Monika Janot-Matuschek Henrik Rudolf Michael Praktiknjo Waldemar Uhl Department of General and Visceral Surgery St.Josef HospitalRuhr University BochumGudrunstrasse 56Bochum 44791Germany Department of Medical Informatics Biometry and EpidemiologyRuhr University BochumUniversitaetsstrasse 105Bochum 44789Germany Department of Internal Medicine University of BonnVenusberg-Campus 1Bonn 53127Germany

Background: Pancreatic ductal adenocarcinoma(PDAC) has the worst prognosis of all malignant tumors due to unavailable screening methods, late diagnosis with a low proportion of resectable tumors and resistance to systemic treatment. Complete tumor resection remains the cornerstone of modern multimodal strategies aiming at long-term survival. This study was performed to investigate the overall rate of long-term survival(LTS) and its contributing factors. Methods: This was a retrospective single-center analysis of consecutive patients undergoing pancreaticoduodenectomy(PD) for PDAC between 2007 and 2014 at the St. Josef Hospital, ruhr university bochum, Germany. Clinical and laboratory parameters were assessed and evaluated for prediction of LTS with Cox regression analysis. Results: The overall rate of LTS after PD for PDAC was 20.4%(34/167). Median survival was 24 months regardless of adjuvant treatment. Carbohydrate antigen 19-9 levels, tumor grade, lymph vessel invasion, perineural invasion and reduced general condition were significantly associated with LTS in univariate analysis( P<0.05). Serum levels of carbohydrate antigen 19-9, American Joint Committee on Cancer stage, tumor grade, abdominal pain, male, exocrine pancreatic insufficiency and duration of postoperative hospital stay were independent predictors of cancer survival in multivariable analysis. Conclusions: Cancer related characteristics are associated with LTS in multimodally treated patients after curative PDAC surgery.

关键词： Pancreaticoduodenectomy Whipple’s procedure Pancreatic cancer survival Ductal adenocarcinoma Pancreas Pancreatic surgery

Antibody-based immunotherapies for Parkinsonian syndromes

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Neural Regeneration Research 2019年第11期14卷 1903-1904页

作者： Lars Tonges Maria Angela Samis Zella Department of Neurology St. Josef-HospitalRuhr-University BochumBochumGermany Neurodegeneration Research Protein Research Unit Ruhr (PURE)Ruhr University BochumBochumGermany Department of Neurology St. Josef-HospitalKatholische Kliniken RuhrhalbinselContilia GruppeEssenGermany

What is the rationale for immunotherapies in Parkinsonian syndromes (PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic phenotype in combination with additional motor and non-motor symptoms. One major pathological hallmark of all PS consists of a non-physiological detrimental accumulation of protein aggregates which appear intracellularly in neurons and glial cells but also in the extracellular space (Wong and Krainc, 2017). Depending on the pathogenic protein, PS can be divided into synucleinopathies, characterized by aggregation of the protein alpha-Synuclein (aSyn), and tauopathies, characterized by aggregation of the protein Tau (Levin et al., 2016;Poewe et al., 2017). Clinical syndromes of synucleinopathies include Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies, and tauopathies include progressive supranuclear palsy (PSP) and corticobasal degeneration.

关键词： Parkinsonian syndromes Parkinson’s disease(PD) multiple system atrophy(MSA)

Enhancement of THz generation in LiNbO_(3) waveguides via multi-bounce velocity matching

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Light(Science & Applications) 2022年第12期11卷 2994-3001页

作者： Blake S.Dastrup Eric R.Sung Frank Wulf Clara Saraceno Keith A.Nelson Department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Faculty of Electrical Engineering and Information Technology Ruhr University BochumBochum 44801Germany

To realize the full promise of terahertz polaritonics(waveguide-based terahertz field generation,interaction,and readout)as a viable spectroscopy platform,much stronger terahertz fields are needed to enable nonlinear and even robust linear terahertz *** use a novel geometric approach in which the optical pump is totally internally reflected to increase the distance over which optical rectification *** matching is achieved by tuning the angle of internal *** doing this,we are able to enhance terahertz spectral amplitude by over 10x compared to conventional single-pass terahertz *** analysis of the depletion mechanisms reveals that 3-photon absorption and divergence of the pump beam are the primary limiters of further *** level of enhancement is promising for enabling routine spectroscopic measurements in an integrated fashion and is made more encouraging by the prospect of further enhancement by using longer pump wavelengths.

关键词： pump waveguide tuning

Fracture propagation in sandstone and slateeLaboratory experiments, acoustic emissions and fracture mechanics

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第3期7卷 237-249页

作者： Ferdinand Stoeckhert Michael Molenda Sebastian Brenne Michael Alber ruhr-Universitt bochum

Fracturing of highly anisotropic rocks is a problem often encountered in the stimulation of unconventional hydrocarbon or geothermal reservoirs by hydraulic fracturing. Fracture propagation in isotropic material is well understood but strictly isotropic rocks are rarely found in nature. This study aims at the examination of fracture initiation and propagation processes in a highly anisotropic rock, specifically slate. We performed a series of tensile fracturing laboratory experiments under uniaxial as well as triaxial loading. Cubic specimens with edge lengths of 150 mm and a central borehole with a diameter of13 mm were prepared from Fredeburg slate. An experiment using the rather isotropic Bebertal sandstone as a rather isotropic rock was also performed for comparison. Tensile fractures were generated using the sleeve fracturing technique, in which a polymer tube placed inside the borehole is pressurized to generate tensile fractures emanating from the borehole. In the uniaxial test series, the loading was varied in order to observe the transition from strength-dominated fracture propagation at low loading magnitudes to stress-dominated fracture propagation at high loading magnitudes.

关键词： Sleeve fracturing Acoustic emission(AE) Fracture mechanics Sandstone Slate