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Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks

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Chinese Journal of Natural Medicines 2016年第4期14卷 241-254页

作者： LIU Hai-Xin WANG Yu LU Qing YANG Ming-Zhu FAN Guan-Wei KARAS richard H GAO Xiu-Mei ZHU Yan Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine research and Development center of Traditional Chinese Medicine Tianjin International Joint Academy of Biotechnology & Medicine Molecular cardiology research Institute Tufts Medical Center

Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERa and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERa and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERa, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERa and ERβ may be critical in the balance of pro- or anti-angiogenesis process.

关键词： Phytoestrogen Selective estrogen receptor modifies (SERMs) ERa ERβ Bidirectional regulation of angiogenesis IPA

Method to assess component contribution to toxicity of complex mixtures： Assessment of puberty acquisition in rats exposed to disinfection byproducts

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Journal of Environmental Sciences 2017年第8期29卷 311-321页

作者： Shahid Parvez Glenn E.Rice Linda K.Teuschler Jane Ellen Simmons Thomas F.Speth susan D.richardson richard J.Miltner E.Sidney Hunter Ⅲ Jonathan G.Pressman Lillian F.Strader Gary R.Klinefelter Jerome M.Goldman Michael G.Narotsky Indiana University richard M. Fairbanks School of Public Health Department of Environmental Health Sciences IUPUI Campus Indianapolis IN 46202 USA National center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Lincla Teuschler and Associates St. Petersburg FL 33707 USA National Health and Environmental Effects research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park NC 27711 USA National Risk Management research Laboratory Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts（DBPs）. Chemical disinfection of drinking water forms DBP *** of concerns about possible reproductive and developmental toxicity, a whole mixture（WM） of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley（S–D） rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation（PPS） and vaginal opening（VO）, was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture（DM） of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or VO from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints.

关键词： Drinking water disinfection byproducts DBP Puberty delay Four Lab Study Mixtures risk assessment

Challenges in managing ST elevation myocardial infarction during the COVID-19 pandemic

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World Journal of cardiology 2021年第4期13卷 76-81页

作者： Megan smith Aniruddha Singh Douglas McElroy Shilpi Mittal richard Pham Department ofcardiology University of Kentucky College of MedicineBowling GreenKY 42101United States Department of cardiology Western Kentucky Heart and Lung Research FoundationBowling GreenKY 42101United States Department of cardiology The Medical CenterBowling GreenKY 42101United States Department of Biology Western Kentucky UniversityBowling GreenKY 42101United States Department of Neurology Vanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Coronavirus disease 2019(COVID-19)may contribute to delayed presentations of acute myocardial *** presentation with late reperfusion is often associated with an increased risk of mechanical complications and adverse *** delays are possible as every patient who is acutely sick is being considered a potential case or a career of ***,standardized personal protective equipment precautions are established for all members of the team,regardless of pending COVID-19 testing which might further add to *** To compare performance measures and clinical outcomes of all patients who presented to our facility with ST elevation myocardial infarction(STEMI)during the COVID-19 pandemic to same time cohort from *** All patients who presented to our facility with STEMI during the pandemic were compared to a matched cohort during the same time period in *** with unknown time of symptom onset and inpatient STEMI patients were *** outcome was major adverse cardiac events(MACE)in-hospital and up to 14 d after STEMI,including death,myocardial infarction,cardiac arrest,or *** differences among groups for continuous variables were tested through ANOVA,using SYSTAT,version ***-square tests of association were used to compare patient characteristics among groups using *** risk scores and associated tests for significance were calculated for discrete variables using MedCalc(MedCalc Software,Ostend,Belgium).RESULTS There was a significantly longer time interval from symptom onset to first medical contact(FMC)in the COVID-19 group(P50%)lesion(s)remote from the culprit ***-hospital and 14 d MACE were more prevalent in the COVID-19 group

关键词： COVID-19 ST elevation myocardial infarction First medical contact to balloon Major adverse cardiac events Cardiac arrest Death

RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition

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分子细胞生物学报:英文版 2015年第1期7卷 88-90页

作者： Chaoqun Zhu Zhiyong Yin Jun Ren richard J.McCormick Stephen P.Ford Wei Guo Department of Animal Science College of Agriculture and Natural ResourcesUniversity of WyomingLaramieWY 82071USA Department of cardiology XiJing HospitalFourth Military Medical UniversityXi’an 710032China center for Cardiovascular research and Alternative Medicine College of Health ScienceUniversityof WyomingLaramieWY 82071USA

Dear Editor,Diastolic heart failure(DHF)and systolic heart failure(SHF)are two main subsets of chronic heart failure that are commonly encountered in clinical practice(Chatterjee and Massie,2007).

关键词： clinical heart systolic

Impact of lunar phase on the incidence of cardiac events

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World Journal of Cardiovascular Diseases 2012年第3期2卷 124-128页

作者： Rajan Kanth richard L. Berg Shereif H. Rezkalla Biomedical Informatics research center Marshfield Clinic Research Foundation Marshfield USA Department of cardiology Marshfield Clinic Marshfield USA Department of Internal Medicine Marshfield Clinic Marshfield USA

Objectives: Popular opinion holds that the phase of the moon influences human behavior, and several reports substantiate this claim;however, reports of correlation between the lunar cycle and cardiac events remain controversial. The purpose of the present study was to determine whether a relationship exists between lunar cycle and the occurrence of acute cardiac events. Methods: A retrospective review of cardiac events, including ST-elevated myocardial in-farction (STEMI), non-ST elevated myocardial infarction (NSTEMI), and unstable angina, over a 5- year period was performed. The dates of cardiac events were recorded and merged with the four phases of the lunar cycle (new moon, first quarter, full moon, and last quarter). Results: A total of 4751 cardiac events (578 STEMI, 1446 NSTEMI, 2727 unstable angina) occurred during the 5-year study period in 3935 unique patients. Cardiac events occurred equivalently during various phases of the lunar cycle. Conclusions: Despite popular opinion, our evidence suggests that the lunar cycle has no effect on the occurrence of acute coronary syndromes.

关键词： Emergency Service/Hospital Moon Lunar Cycle Myocardial Infarction Acute Coronary Syndromes

Coronary Flow Reserve Assessment of Orbital Atherectomy: An Observational Pilot Study

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Journal of Biomedical Science and Engineering 2019年第4期12卷 269-275页

作者： Nabil Dib Brad J. Martinsen Bynthia M. Anose John McB. Hodgson Robert Kohler Georges Nseir Nathalie R. Antonios richard Shlofmitz Jeffrey W. Chambers Cardiovascular research and New Devices Mercy Gilbert Medical Center Gilbert USA International Society for Cardiovascular Translational research Phoenix USA Scientific Affairs Cardiovascular Systems Inc. St. Paul USA Technology Solutions Group Moreland Hills USA Premier Cardiovascular center Dignity Health Chandler Hospital Chandler USA Chicago Medical School North Chicago USA Department of cardiology St. Francis Hospital Heart Center Roslyn USA Metropolitan Heart and Vascular Institute Mercy Hospital Minneapolis USA

The aim of this prospective observational pilot study was to observe the impact of orbital atherectomy (OA) on the coronary microcirculation via coronary flow reserve (CFR) measurements. Fifteen subjects who had successful OA and stent placement with no procedural complication were enrolled at 3 hospitals in the U.S. Baseline and hyperemic velocities were 16 ± 5.2 and 36 ± 14 cm/sec, respectively. The average CFR post-procedure was within the normal range at 2.23 ± 0.33. The observation of normal CFR following OA may be attributed to the orbital action of the device that allows for continuous flow during treatment, minimizing a bolus embolization effect which can impact microvascular function.

关键词： Percutaneous Coronary Intervention Microvascular Function Orbital Atherectomy Calcified Lesions Coronary Flow Reserve

Cardiac rehabilitation and exercise therapy in the elderly： Should we invest in the aged？

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Journal of Geriatric cardiology 2012年第1期9卷 68-75页

作者： Arthur R Menezes Carl J Lavie richard V Milani Ross A Arena Timothy S Church Department of Cardiovascular Diseases John Ochsner Heart and Vascular Institute Ochsner Clinical School The University of Queensland School ofMedicine 1514 Jefferson Highway New Orleans LA 70121 USA Department of Orthopaedics Physical Therapy Program and Division of Cardiology Department of Internal Medicine University of New MexicoAlbuquerque NM87131 USA Department of Preventive Medicine Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA 70808 USA

Coronary heart disease （CHD） is the leading cause of death worldwide and becomes increasingly prevalent among patients aged 65 years and *** patients are at a higher risk for complications and accelerated physical deconditioning after a cardiovascular event,especially compared to their younger *** last few decades were privy to multiple studies that demonstrated the beneficial effects of cardiac rehabilitation （CR） and exercise therapy on mortality,exercise capacity,psychological risk factors,inflammation,and obesity among patients with ***,a significant portion of the available data in this field pertains to younger patients.A viable explanation is that older patients are grossly underrepresented in these programs for multiple reasons starting with the patient and extending to the *** this article,we will review the benefits of CR programs among the elderly,as well as some of the barriers that hinder their participation.

关键词： Cardiac rehabilitation Exercise therapy Elderly patients Exercise capacity

抗高血压治疗期间心电图左心室肥厚消退及其对主要心血管事件的预测作用

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美国医学会杂志（中文版） 2005年第6期24卷 323-329页

作者： Peter M. Okin, MD richard B. Devereux, MD Sverker Jern, MD Sverre E. Kjedsen, MD,PhD Stevo Julius, MD, ScD Markkus S. Nieminen, MD, PhD Steven Snapinn, PhD Katherine E. Harris, DrPH Peter Aurup, MD Jonathan M. Edelman, MD Hans Wedel, PhD Lars H. Lindholm, MD, PhD Bjorn Dahlof MD, PhD 倪靖炜（译）沈卫峰（校） Department of Medicine Division of Cardiology Cornell University Medical Center New York NY Sahlgrenska University Hospital/OEstra Goeteborg Sweden Ulleval University Hospital Oslo Norway University of Michigan Medical center Ann Arbor Division of cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland Amgen Inc Thousand Oaks Calif Merck research Laboratories West Point Pa Merck ＆ Co Inc Whitehouse Station NJ Nordic School of Public Health Gbteborg Sweden Umea. University Umea Sweden 不详

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡... 详细信息

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡率越低，并与血压水平及其降低和治疗方式无关的假说。设计、设置及参试者：1995～2001年于9193例55至80岁（均值，67岁）男性和女性高血压患者进行的双盲、随机、平行组研究。心电图LVH用康奈尔电压一时间乘积或Sokolow—Lyon电压表示，患者均入选氯沙坦降低高血压终点事件干预研究（Losartan Intervention For Endpoint，LIFE）。干预：以氯沙坦或阿替洛尔为基础的治疗方案，随访评估至少4年（均值，4．8年[SD，0．9]）。主要结果测定：心血管死亡、心肌梗死或卒中复合终点与基线及随后1年或每年心电图LVH严重程度的关系。结果：1096例（11．9％）发生心血管死亡、非致死性心肌梗死或卒中。在控制治疗方式、基线Framingham危险记分、基线和治疗期间血压以及基线心电图LVH严重程度（康奈尔乘积或Sokolow—Lyon电压）的Cox回归模型中，康奈尔乘积和Sokolow—Lyon电压所示治疗中LVH严重程度较低者，复合心血管终点事件的发生率分别降低14％和17％（康奈尔乘积每降低1050mm×ms,[1-SD]：校正风险比[hazard ratio，HR]，0．86；95％可信区间[confidence interval，CI]，0．82～0．92；P〈0．001；Sokolow—Lyon电压每降低10．5mm[1-SD]：HR，0．83；95％CI，0．78～0．88；P〈0．01）。在平行分析中，较低的康奈尔乘积和Sokolow—Lyon电压均与较低的心血管死亡（分别为HR，0．78；95％CI，0．73～0．83；P〈0．001和HR，0．80；95％CI，0．73～0．87；P〈0．001）、心肌梗死（HR，0．90；95％CI，0．82～0．98；P=0．01和HR，0．90；95％CI，0．81～1．00；P=0．04））和卒中（HR，0．90；95％CI，0．84～0．96；P=0．002；HR，0．81；95％CI，0．75～0．89；P〈0．001）独立相关。结论：抗高血压治疗期间，根据康奈尔乘积和Sokolow—Lyon电压判定的心电图LVH程度较轻与心血管并发症和死亡可能性较低相关，而且独立于原发性高血压患者的血压降低及治疗方式。旨在改善或预防心电图LVH的抗高血压治疗可以改善患者的预后。

关键词：抗高血压治疗心血管事件治疗期间左心室肥厚心电图原发性高血压患者预测作用致死性心肌梗死心血管并发症 interval

高血压患者心电图左心室肥厚消退与新发房颤发生率下降

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美国医学会杂志（中文版） 2007年第5期26卷 265-270页

作者： Peter M. Okin Kristian Wachtell richard B. Devereux Katherine E. Harris Sverker Jern Sverre E. Kjeldsen Stevo Julius Lars H. Lindholm Markku S. Nieminen Jonathan M. Edelman t Darcy A. Hille Bjoern Dahloef 阮雯（译）沈卫峰（校） Greenberg Division of cardiology Weill Medical College of Comell University New York NY Departrnent of Medicine Glostrup University Hospital Glostrup Denmark Merck research Laboratories West Point Pa Sahlgrenska University Hospital/Oestra GoeteborgSweden University of Oslo Uileval Hospital OsloNorway University of Michigan Medical center Ann Arbor Umea University Umea Sweden Division of cardiology Department of MedicineHelsinki University Central HospitalHelsinkiFinland Umea university and merck＆co Inc Whitehouse Station.Nu 不详

背景：心房纤颤（简称房颤）与死亡和心血管事件（特别是卒中）危险性增加相关，因此，预防新发房颤是一个重要的临床问题。虽然心电图左心室肥厚（electrocardiographic left ventricular hypertrophy，LVH）的存在及其严重程度可以预... 详细信息

背景：心房纤颤（简称房颤）与死亡和心血管事件（特别是卒中）危险性增加相关，因此，预防新发房颤是一个重要的临床问题。虽然心电图左心室肥厚（electrocardiographic left ventricular hypertrophy，LVH）的存在及其严重程度可以预测房颤的发生，但是心电图LVH消退是否与房颤发生率下降相关尚不清楚。目的：验证降压治疗期间心电图LVH消退或持续消失与房颤发生率下降相关且独立于血压水平及治疗模式的假设。设计、方法及参试者：1995～2001年于8831例男性和女性高血压患者中进行双盲、随机、平行分组研究。患者年龄55～80岁（中位数，67岁），均根据心电图Comell电压-间期乘积或Sokolow—Lyon电压标准诊断LVH。患者无房颤史，基线心电图无房颤，已入选氯沙坦干预降低终点事件高血压研究。干预：氯沙坦或阿替洛尔治疗方案，6个月时进行随访评估，之后每年随访，直至患者死亡或试验终止。主要观测指标：基线及随访各时点心电图LVH与新发房颤的相关性。心电图LVH的测量使用性别校正的Comell乘积标准（{RavL＋Sv3[女性＋6mm]}×QRS间期）。结果：经过平均（SD）4．7（1．1）年的随访，治疗期间心电图Comell乘积标准LVH消退或持续消失的患者有290例新发房颤（发生率为14．9／1000病人-年）；而心电图LVH持续或进展的患者则有411例新发房颤（19．0／1000病人-年）。时间依赖Cox分析显示，在校正治疗效果、基线房颤危险因素差异、基线及治疗期间血压以及基线LVH严重程度后，治疗期间Comell乘积标准LVH降低作为一种时间变异协变量与新发房颤下降相关。Comell乘积每下降1050mm×msec（每个SD），新发房颤就下降12．4％（校正风险比[hazard ratio，HR]，0．88；95％可信区间[confidence interval，CI]0．80～0．97；P=0．007）；氯沙坦减少高血压患者发生房颤的益处优于阿替洛尔（HR，0．83；95％CI，0．71～0．97；P=0．01）。结论：原发性高血压患者在降压治疗期间，心电图Comell乘积标准LVH消退与新发房颤下降相关，而且独立于血压和治疗方案。这些发现提示，以降低或预防心电图LVH为目标的降压治疗可以降低新发房颤的发生率。

关键词：原发性高血压患者左心室肥厚心电图发生率房颤消退标准诊断降压治疗