Coronary Flow Reserve Assessment of Orbital Atherectomy: An Observational Pilot Study

作     者：Nabil Dib Brad J. Martinsen Bynthia M. Anose John McB. Hodgson Robert Kohler Georges Nseir Nathalie R. Antonios Richard Shlofmitz Jeffrey W. Chambers 

作者机构：Cardiovascular Research and New Devices Mercy Gilbert Medical Center Gilbert USA International Society for Cardiovascular Translational Research Phoenix USA Scientific Affairs Cardiovascular Systems Inc. St. Paul USA Technology Solutions Group Moreland Hills USA Premier Cardiovascular Center Dignity Health Chandler Hospital Chandler USA Chicago Medical School North Chicago USA Department of Cardiology St. Francis Hospital Heart Center Roslyn USA Metropolitan Heart and Vascular Institute Mercy Hospital Minneapolis USA 

出 版 物：《Journal of Biomedical Science and Engineering》 (生物医学工程（英文）)

年 卷 期：2019年第12卷第4期

页      面：269-275页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Percutaneous Coronary Intervention Microvascular Function Orbital Atherectomy Calcified Lesions Coronary Flow Reserve 

摘      要：The aim of this prospective observational pilot study was to observe the impact of orbital atherectomy (OA) on the coronary microcirculation via coronary flow reserve (CFR) measurements. Fifteen subjects who had successful OA and stent placement with no procedural complication were enrolled at 3 hospitals in the U.S. Baseline and hyperemic velocities were 16 ± 5.2 and 36 ± 14 cm/sec, respectively. The average CFR post-procedure was within the normal range at 2.23 ± 0.33. The observation of normal CFR following OA may be attributed to the orbital action of the device that allows for continuous flow during treatment, minimizing a bolus embolization effect which can impact microvascular function.