检索结果-南通市图书馆

A case of advanced intrahepatic cholangiocarcinoma successfully treated with chemosensitivity test-guided systemic chemotherapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第41期15卷 5228-5231页

作者： Kazumichi Abe Takeru Wakatsuki Fumiko Katsushima Kyoko Monoe Yukiko Kanno Atsushi Takahashi Junko Yokokawa Hiromasa Ohira Department of Gastroenterology and rheumatology Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan

Intrahepatic cholangiocarcinoma （ICC） is a relatively rare and highly fatal neoplasm that arises from the biliary epithelium. Prognosis is generally poor and survival is limited to a few months. Here we present a case of advanced ICC successfully treated by chemosensitivity test-guided systemic chemotherapy combining S-1 and cisplatin （CDDP）. A 65-year-old woman with a liver tumor was referred to our hospital on November 21, 2007. Abdominal ultrasonography and computed tomography （CT） showed low-density masses of 50 and 15 mm in diameter, respectively in segment w of the liver and in the enlarged lymph node in the para-aorta. Ultrasonography-guided fine needle biopsy diagnosed the tumors as ICC. Since the patient was inoperable for lymph node metastasis, she underwent systemic chemotherapy with gemcitabine. Six months afcer initiation of chemotherapy, CT revealed ICC progression in the liver and pleural dissemination with pleural effusion. The patient was admitted to our hospital for anticancer drug sensitivity testing on June 9, 2008. Based on the sensitivity test results, we elected to administer systemic chemotherapy combining S-1 and CDDP. Two months into the second chemotherapy treatment, CT revealed a reduction of the tumors in the liver and lymph node and a decrease in pleural *** eight cycles of the second chemotherapy, 17 mo after ICC diagnosis, she is alive and well with no sign of recurrence. We conclude that chemosensitivity testing may effectively determine the appropriate chemotherapy regimen for advanced ICC.

关键词： Chemosensitivity testing Cholangiocarcinoma, Cisplatin Liver neoplasms Gemcitabine S-1 Systemic chemotherapy

EVALUATION OF EFFICACY AND SAFETY OF DIACEREIN IN KNEE OSTEOARTHRITIS IN CHINESE PATIENTS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2006年第2期21卷 75-80页

作者： Wen-jie Zheng Fu-lin Tang Jun Li Feng-chun Zhang Zhan-guo Li Yin Su Dong-hai Wu Li Ma Hui-qiong Zhou Feng Huang Jiang-lin Zhang Dong-feng Liang Yi-xiong Zhou Hui Xu Department of rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of rheumatology People＇s Hospital Medical School of Peking University Beijing 100044 Department of rheumatology China-Japan Friendship Hospital Beijing 100029 Department of rheumatology General Hospital of People＇s Liberation Army Beijing 100853 Department of Orthopedic Surgery Jishuitan Hospital Medical School of Peking University Beijing 100035

Objective To evaluate the efficacy and safety of diacerein in patients with knee osteoarthritis (OA). Methods A total of 223 patients satisfying the American College of rheumatology criteria for knee OA were chosen for this 17-week, randomized, double-dummy, diclofenac sodium-controlled trial, with diacerein dosage of 100 mg/d and diclofenac sodium of 75mg/d. Efficacy and safety of both drugs were evaluated. Results Totally 106 patients in the diacerein group and 107 patients in the diclofenac group were considered qualified for the evaluation. After 12 weeks of treatment, the total effective rates of patients/physicians’ overall assessment in diacerein and diclofenac groups were 65.4%/61.6% and 61.2%/61.2%, respectively (P>0.05). The primary efficacy parameter [visual analog scale (VAS) assessment of pain on 20 metres walking] and the secondary efficacy parameters [tenderness on palpation, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and 36-item Short-Form (SF-36) Health Survey] significantly improved compared with baseline in both groups (P<0.05). In the follow-up period, there were no obvious changes in above parameters in diacerein group. However, in diclofenac group, pain on 20 metres walking, tenderness on palpation, and WOMAC became aggravated after withdrawing the drug for 4 weeks (P<0.05). Moreover, the consumption of paracetamol was significantly lower in diacerein group than in diclofenac group during follow-up (P<0.001). The incidences of related adverse events were 35.7% in diacerein and 45.1% in diclofenac group, respectively. Mild-to-moderate gastrointestinal disorders were the most frequent adverse events. Conclusions Diacerein is as effective as diclofenac sodium in treating patients with knee OA. Furthermore, it has better extended effect and a good safety profile. It is generally well tolerated and has no severe adverse effect.

关键词： osteoarthritis drug evaluation diacerein diclofenac sodium

Clinical heterogeneity and five phenotypes identified in pediatric Behçet’s syndrome: a cohort study from Shanghai Behçet’s syndrome database

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第8期20卷 801-808页

作者： Dan Hu Chun-Hui She Hua-Fang Bao Jun Zou Jian-Fei Cai Jing‑Fen Ye Yan Shen Hai‑Fen Ma Dan Luo Jian-Long Guan Department of rheumatology and Immunology Huadong Hospital Affiliated to Fudan University221 Yan’an West Road200040ShanghaiChina

Objectives Behçet’s syndrome(BS)is a rare disease of unknown etiology,with limited reports especially in pediatric *** clinical characteristics and phenotypes of pediatric BS as a highly heterogeneous variable vessel vasculitis were investigated in this *** A cross-sectional study was conducted to compare clinical variables and descriptive characteristics of BS by age of onset and *** analysis was then performed to identify the phenotypes of pediatric *** A total of 2082 BS patients were included in this study,1834 adults and 248 *** with adult-onset BS,pediatric BS had a higher incidence of folliculitis[relative risks(RR)and 95%confidence interval(CI)1.3(1.0–1.5)],uveitis of the left eye[RR and 95%CI 2.3(1.0–5.0)],intestinal ulcer complications[RR and 95%CI 2.1(1.1–4.2)],pericarditis[RR and 95%CI 2.5(1.0–6.2)],and psychiatric disorders[RR and 95%CI 2.8(1.0–7.9)],while the incidence of thrombocytopenia was lower[RR 0.2(0.1–1.0)].Among pediatric BS,females had more genital ulcers,while males were more likely to have skin lesions,panuveitis,vascular involvement,venous lesions,cardiac involvement,and aortic *** analysis classified pediatric BS into five clusters(C1–C5):C1(n=61,24.6%)showed gastrointestinal(GI)involvement;C2(n=44,17.7%)was the central nervous system(CNS)type where 23 cases overlapped joint involvement;in C3(n=35,14.1%),all patients presented with arthritis or arthralgia;all patients in C4(n=29,11.7%)manifested ocular involvement,with a few patients overlapping with GI involvement or joint damage;C5(n=79,31.9%)was the mucocutaneous type,presenting both oral ulcers,genital ulcers,and skin *** The clinical features of pediatric and adult BS differ *** and female pediatric BS also have a distinct *** phenotypes including GI,CNS,joint,ocular,and mucocutaneous types were identified for pediatric BS.

关键词： Behçet's syndrome Clinical manifestation Cluster analysis Pediatric Phenotype

Glucocorticoids combined with tofacitinib in the treatment of Castleman’s disease:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第29期10卷 10794-10802页

作者： Xiao-Rui Liu Mei Tian Department of rheumatology and Immunology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Castleman’s disease(CD),also known as vascular follicular lymphadenopathy is a rare proliferative disease of lymphoid tissue of unknown etiology that is clinically classified as unicentric CD(UCD) or multicentric CD(MCD) depending on lymph node *** present,idiopathic MCD(iMCD) is treated with interleukin-6 inhibitors,but some patients have poor clinical *** paper reports on a case of iMCD that achieved a good therapeutic effect after treatment with glucocorticoids combined with *** relevant data are summarized and reported *** SUMMARY This paper reports on a case of MCD in a 49-year-old female with persistent peritoneal effusion as the first manifestation and combined with multiple *** node biopsy showed Castleman’s disease-like *** ascites subsided after treatment with glucocorticoids and tofacitinib,indicating that the treatment was *** The combination of glucocorticoids with tofacitinib is an effective regimen for the treatment of CD.

关键词： Castleman’s disease Multicentric Castleman’s disease Idiopathic multicentric Castleman’s disease Abdominal dropsy Tofacitinib Glucocorticoids Case report

Effect of family caregiver nursing education on patients with rheumatoid arthritis and its impact factors:A randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第28期9卷 8413-8424页

作者： Jing Li Ying Zhang Ya-Juan Kang Nan Ma Department of Immunology and rheumatology The Third Hospital of Hebei Medical UniversityShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Rheumatoid arthritis(RA)is a common autoimmune *** education for family caregivers is considered a workable and effective intervention,but the validity of this intervention in RA has not been *** To explore whether family caregiver nursing education(FCNE)works on patients with RA and the factors that influence *** In this randomized controlled study,a sample of 158 pairs was included in the study with 80 in the intervention group and 78 in the control *** data of patients and caregivers was *** FCNE intervention was admi-nistered to caregivers,and inflammation level indicators,disease activity indicators and mood disorder indicators of patients were followed up and *** Baseline characteristics of the intervention and the control groups had no significant *** were significantly reduced in the intervention group compared to the control *** intervention group showed significant differences in stratification of relationship,education duration and *** The effect of FCNE on RA is multifaceted,weakening inflammation level,alleviating disease activity and relieving mood *** between caregiver and patient,caregiver’s education level and patient’s age may act as impact factors of FCNE.

关键词： Nursing education Family nursing Rheumatoid arthritis Family caregivers Depression Anxiety

The role of CD6 in autoimmune diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第11期15卷 1001-1002页

作者： David A.Fox Division of rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA

In a recent publication in the Cellular and Molecular Immunology,Consuega-Fernandez and colleagues present new data from patients with psoriasis,linking the CD6 lymphocyte surface structure to the pathogenesis of this disease.1 In this commentary,I will discuss these new findings in the context of accumulating evidence for important roles of CD6 in a variety of autoimmune *** CD6 was one of the earliest“CD antigens”to be described,it is only recently that attention has refocused on the potential for CD6 as a treatment target in immune-mediated diseases.

关键词： autoimmune Immunology diseases

Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第1期10卷 35-42页

作者： Yi-Min Huang Yu Zhuang Zhi-Ming Tan Department of rheumatology and Immunology Huizhou Central People’s HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Rheumatoid arthritis(RA)is a prevalent clinical autoimmune disease that is commonly treated with diclofenac and *** recent years,the application of traditional Chinese medicine in RA has received widespread attention;it promotes blood circulation,strengthens the immune system,and eliminates *** sinomenine preparation of Zhingqeng Fengtongning is studied as a possible treatment for patients with *** To explore the value of sinomenine injection into the articular cavity for the treatment of *** A total of 94 patients with RA treated from January 2019 to January 2021 were selected and divided into the study and control groups with 47 patients each using a simple random number table *** groups received conventional treatment with diclofenac sodium and methotrexate *** control group received diproxone and lidocaine by intra-articular administration while the study group received an intra-articular administration of the sinomenine preparation of Zhengqing Fengning and lidocaine.χ^(2) test was used to evaluate the therapeutic effect and synovial thickness,degree of pain through the visual analog scale(VAS),blood flow grade,arthroinflammatory indexes[rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR)]before and after treatment in the two *** The total effective rate of the study group(93.62%)was higher than that of the control group(78.72%)(P0.05).After treatment,the synovial thickness and VAS score were significantly lower(P<0.05)in the study group than in the control group(2.05±0.59 mm vs 2.87±0.64 mm and 2.11±0.62 vs 2.90±0.79 scores,respectively).The rate of blood flow at grade 0 in the study group(76.60%)was higher than that in the control group(57.45%),and the rate of blood flow at grade I(10.64%)was lowe

关键词： Rheumatoid arthritis Articular injection Sinomenine Ultrasonic changes Inflammatory factors Zhengqing Fengtongning

Effects of Simvastatin on the Function of Dendritic Cells in Patients with Rheumatic Arthritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第6期30卷 741-745页

作者：刘宇宏王莎莎沈凌汛徐玉兰 Department of Immunology and rheumatology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

The present study examined the functional profile of dendritic cells (DCs) in patients with rheumatoid arthritis (RA) and the effects of simvastatin on the function of DCs.A total of 40 patients who was recently diagnosed as having RA were equally assigned to two groups:the routine treatment group (group R) and the routine treatment plus simvastatin group (group R+S).Twenty healthy individuals served as *** peripheral blood mononuclear cells (PBMCs) were isolated before and 4 weeks after the treatment and then cultured with interleukin-4 (IL-4) and granulocyte-macrophage colony stimulatory factor (GM-CSF) to prepare mature *** expression of co-stimulating factor CD86 on the surface of DCs was assessed by flow *** the stimulating capacity of DCs was measured by mixed lymphocyte reaction (MLR).The contents of cytokines in culture supernatants of DCs in MLR were detected by *** lipids and high-sensitivity C-reactive protein (hs-CRP) were *** relationship between the expression of CD86 and the blood CRP level was also *** results showed that,as compared with the control group,the CD86 expression and the level of cytokines secreted by DCs were significantly increased in RA patients and greater stimulating capacity of DCs in MLR was demonstrated in RA patients.T lymphocytes in MLR secreted higher levels of proinflammatory cytokines (IL-2,IL-17,TNF-α and INF-γ) and lower level of anti-inflammation cytokine (IL-10).The function of DCs was markedly weakened and the level of hs-CRP and low-density lipoprotein was substantially lowered in group R+S in comparison to group *** CD86 expression was positively correlated with *** was concluded that DCs in RA are highly activated and DC-initiated immune reaction may play an important role in the pathogenesis of *** administration can significantly inhibit the DCs function and reduce the level of hs-CRP,indicating the suppression on inflammatory reaction may be on

关键词： rheumatoid arthritis dendritic cell simvastatin cytokines

Glucocorticoid reduction induced chorea in pediatric-onset systemic lupus erythematosus:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第32期11卷 7872-7875页

作者： Yan-Qiu Xu Miao Wang Ying Zhang Department of rheumatology Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

BACKGROUND Pediatric-onset systemic lupus erythematosus(SLE)is typically more severe than adult-onset SLE,with a higher incidence of nervous system *** is a relatively rare neurological complication reported in 2.4%-7%of SLE *** particular,chorea induced by glucocorticoid dose reduction is even ***,we report the case of a girl with SLE,who developed chorea during the process of glucocorticoid therapy *** SUMMARY We describe a 14-year-old girl who was diagnosed with *** was treated with methylprednisolone and rituximab,and her symptoms *** the second day after the methylprednisolone dose was reduced according to the treatment guidelines,the patient developed *** condition improved after adjusting her glucocorticoid *** This case is a reminder that extra attention to chorea is required in SLE patients during glucocorticoid dose reduction.

关键词： Glucocorticoid Chorea Pediatric systemic lupus erythematosus Case report