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World Journal of Clinical Cases 2022年第23期10卷 8422-8424页

作者： Jucier Gonçalves Júnior Percival Degrava Sampaio-Barros Samuel Katsuyuki Shinjo Division of rheumatology São Paulo UniversitySão Paulo 01246-903São PauloBrazil

We performed a literature mini-review of the clinical profile of patients with spondylarthritis who are also human leukocyte antigen(HLA)-*** seems to us that patients with HLA-B27 and HLA-B51 are more common in men,Asians and between the third and ninth decades of *** are more likely to develop peripheral joint conditions,with cutaneous manifestations(e.g.,oral ulcers)and ***,more robust epidemiological studies with more accurate methodology and multicenter locations are needed to better map the role of the interaction between HLA-B51 in patients with spondylarthritis.

关键词： HLA-B27 HLA-B51 Ankylosing spondylitis Spondylarthritis Human leukocyte antigen

Xenobiotics and loss of tolerance in primary biliary cholangitis

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World Journal of Gastroenterology 2016年第1期22卷 338-348页

作者： Jinjun Wang Guoxiang Yang Alana Mari Dubrovsky Jinjung Choi Patrick SC Leung Division of rheumatology Allergy and Clinical ImmunologyUniversity of California at DavisSchool of Medicine College of Environmental Science and Engineering Yangzhou University

Data from genome wide association studies and geoepidemiological studies established that a com-bination of genetic predisposition and environmental stimulation is required for the loss of tolerance in primary biliary cholangitis(PBC).The serologic hallmark of PBC are the presence of high titer anti-mitochondrial autoantibodies(AMA)that recognize the lipoyl domain of the mitochondrial pyruvate dehydrogenase E2(PDC--E2)*** efforts have been directed to investigate the molecular basis of ***,experimental data has pointed to the thesis that the breaking of tolerance to PDC--E2 is a pivotal event in the initial etiology of PBC,including environmental xenobiotics including those commonly found in cos-metics and food additives,suggesting that chemical modification of the PDC--E2 epitope may render its vulnerable to become a neo-antigen and trigger an immune response in genetically susceptible ***,we will discuss the natural history,genetics and immunobiology of PBC and structural constraints of PDC--E2 in AMA recognition which makes it vulnerable to chemical modification.

关键词： Antimitochondrial autoantibodies Primarybiliary cholangitis Pyruvate dehydrogenase E2 Breakingof tolerance Xenobiotics

A simple method for removing low-density granulocytes to purify T lymphocytes from peripheral blood mononuclear cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第7期18卷 605-614页

作者： Si-gong ZHANG Yu-xin SONG Xiao-ming SHU Hai-li SHEN Han-bo YANG Rui-xue DUO Guo-chun WANG Department of rheumatology Lanzhou University Second Hospital Department of Orthopaedics Gansu Provincial Hospital Department of rheumatology China-Japan Friendship Hospital

Objective： Low-density granulocytes （LDGs） can form neutrophil extracellular traps （NETs） spontaneously and excessively. When peripheral blood mononuclear calls （PBMCs） are used for studying T lymphocytes, LDGs contained in the PBMCs may decrease the threshold of activating T lymphocytes by forming NETs. This study focused on the profiles of LDGs in common autoimmune diseases and methods for removing LDGs from PBMCs. Methods： The percentages of LDGs in PBMCs from 55 patients with dermatomyositis （DM）, 15 with polymyositis （PM）, 42 with rheumatoid arthritis （RA）, 25 with systemic lupus erythematosus （SLE）, and 19 healthy controls were determined by flow cytometry. Three methods of removing LDGs were explored and compared. After removal, PBMCs from six patients with positive *** were tested again to find out if LDGs contained in the PBMCs could influence T lymphocyte reactions. Results： Significantly higher LDG percentages were found in PBMCs from patients with DM （（8.41±10.87）%, P〈0.0001 ）, PM （（8.41±10.39）%, P〈0.0001 ）, RA （（4.05±6.97）%, P=0.0249）, and SLE （（7.53±11.52）%, P=0.0006）, compared with the controls （（1.28±0.73）%）. The *** values significantly decreased after LDGs were removed. Increasing relative centrifugal force （RCF） within a limited range can decrease the LDG percentage from an initial high level, but not markedly increase the LDG clearance rate. Compared with the whole blood sediment method, the PBMC adherence method can significantly remove LDGs yet scarcely influence the T lymphocyte percentage in PBMCs. Conclusions： The LDG percentage in PBMCs is significantly increased in patients with S/E, DM, PM, and RA. The influence of LDGs on T lymphocytes cannot be ignored in PBMC cultures. The adherence method is a simple and easy-to-use method for removing LDGs and purifying T lymphocytes from PBMCs.

关键词： Low-density granulocyte Neutrophil extracellular trap Peripheral blood mononuclear cells Autoimmune disease T-SPOT. TB

Effectiveness of Huai Qi Huang Granules on Juvenile Collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

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Current Medical Science 2019年第5期39卷 784-793页

作者： Ting HE Xie XU Xin-yan ZHANG Pan SHEN Jia-yun LING Yan-xin-li HAN Yu WEN Xiu-fen HU Hui-ling LU Division of Pediatric rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Summary:Huai Qi Huang(HQH)exerts great effects in clinic,such as anti-inflammation,immune-regulation,anti-cancer,and so ***,the mechanism by which HQH protects juvenile idiopathic arthritis(JIA)is ***,we explored deeply the protective mechanisms in juvenile collagen-induced arthritis(CIA)rat *** is Gasdermin D(GSDMD)-dependent programmed cell death,involved in many diseases,such as *** investigated whether GSDMD-induced pyroptosis take part in mechanisms of juvenile CIA *** Wistar rats(3-4 weeks)were injected intradermally with fully emulsified bovine typeⅡcollagen and complete Freund's adjuvant to establish CIA rat ***,the CIA rats received oral administration of HQH(4.16 g/kg)once a day from the day 21 of modeling,with the treatment lasting for 28 *** of indicators were measured for evaluation of anti-inflammation effect of HQH,including hind paw swelling,arthritis scores,micro CT,and histopathological changes and the level of pro-inflammatory cytokines in the serum,including tumor necrosis factor alpha(TNF-α)and interleukin-18(IL-18).The expression of GSDMD and caspasein the joint synovial tissues was *** results demonstrated that the expression of the pyroptotic protein GSDMD and its upstream caspase-1 was significantly increased in the synovial tissues of CIA *** treatment of HQH ameliorated the symptoms in CIA rats,reduced levels of pro-inflammatory cytokines and hind paw swelling,down-regulated the expression of GDSMD and *** pyroptosis participated in the pathogenesis of CIA *** study supported that HQH can effectively improve joints inflammation of juvenile collagen-induced arthritis rats by inhibiting pyroptosis pathway in the joint synovial tissues.

关键词： Huai Qi Huang juvenile collagen-induced arthritis Gasdermin D pyroptosis

Perioperative management of the patient with rheumatoid arthritis

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World Journal of Orthopedics 2014年第3期5卷 283-291页

作者： Megan L Krause Eric L Matteson Division of rheumatology Department of MedicineMayo ClinicRochesterMN 55905United States

A multidisciplinary approach is required to care for patients with rheumatoid arthritis(RA)in the perioperative *** preparation for surgery,patients must have a cardiovascular risk assessment performed due to the high risk of heart disease in patients with *** of RA is with immunomodulatory medications,which present unique challenges for the perioperative ***,there is no consensus on how to manage disease modifying antirheumatic drug(DMARD)therapy in the perioperative *** of the data to guide therapy is based on retrospective cohort *** regarding DMARDs require an individualized approach with collaboration between surgeons and *** regarding biologic therapy is to hold the therapy in the perioperative period with the length of time dictated by the half-life of the *** attention is required at the time of surgery for potential need for stress dose ***,there must be close communication with anesthesiologists in terms of airway management particularly in light of the risk for cervical spine *** are no consensus guidelines regarding the requirement for cervical spine radiographs prior to ***,history and exam alone cannot be relied upon toidentify cervical spine *** with RA who undergo joint replacement arthroplasty are at higher risk for infection and dislocation compared to patients with osteoarthritis,necessitating particular vigilance in postoperative follow *** review summarizes available evidence regarding perioperative management of patients with RA.

关键词： Rheumatoid arthritis Perioperative management Disease modifying antirheumatic drugs Tumor necrosis factor inhibitors Postsurgical complications

The expanding functional diversity of plasma cells in immunity and inflammation

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Cellular & Molecular Immunology 2020年第4期17卷 421-422页

作者： Kongyang Ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin Ma Dongzhou Liu Liwei Lu Department of rheumatology and Immunology Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhenChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Department of rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina

The generation and function of plasma cells have been well recognized as the central events in humoral *** particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune *** the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely ***,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity.

关键词： immunity inflammation autoimmune

Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin Lim Eul Noh Ro-Woon Lee Kyong-Hee Jung Won Park rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

Effects of TRPA1 activation and inhibition on TRPA1 and CGRP expression in dorsal root ganglion neurons

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Neural Regeneration Research 2019年第1期14卷 140-148页

作者： Xiao-Lei Wang Li-Wei Cui Zhen Liu Yue-Ming Gao Sheng Wang Hao Li Hu-Xiang Liu Ling-Jia Yu Department of rheumatology Qilu Hospital of Shandong University Department of Respiratory Medicine Qilu Hospital of Shandong University Department of Orthopedics Qilu Hospital of Shandong University

Transient receptor potential ankyrin 1 （TRPA1） is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion （DRG） neurons. TRPA1 plays a major role in the transmission of nociceptive sensory signals. The generation of neurogenic inflammation appears to involve TRPAl-evoked release of calcitonin gene-related peptide （CGRP）. However, it remains unknown whether TRPA1 or CGRP expression is affected by TRPA 1 activation. Thus, in this study, we examined TRPA 1 and CGRP expression in DRG neurons in vitro after treatment with the TRPA1 activator tbrmaldehyde or the TRPA1 blocker menthol. In addition, we examined the role of extracellular signal-regulated protein kinase 1/2 （ERK1/2） in this process. DRG neurons in culture were exposed to formaldehyde, menthol, the ERK1/2 inhibitor PD98059 ＋ formaldehyde, or PD98059 ＋ menthol. After treatment, real-time polymerase chain reaction, western blot assay and double immunofluorescence labeling were performed to evaluate TRPA1 and CGRP expression in DRG neurons. Formaldehyde elevated mRNA and protein levels of TRPA 1 and CGRP, as well as the proportion of TRPA1- and CGRP-positive neurons. In contrast, menthol reduced TRPA1 and CGRP expression. Furthermore, the effects of lbrmaldehyde, but not menthol, on CGRP expression were blocked by pretreatment with PD98059. PD98059 pretreatment did not affect TRPA1 expression in the presence of formaldehyde or menthol.

关键词： nerve regeneration TRPA1 TRPV1 formaldehyde menthol CGRP dorsal root ganglion neuron neurogenic inflammation nociceptive signal ERK1/2 neural regeneration

Effects of serum inflammatory factors,health index and disease activity scores on ankylosing spondylitis patients with sleep disorder

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World Journal of Psychiatry 2024年第6期14卷 866-875页

作者： Hui Wang Jia-Ying Sun Yue Zhang Department of rheumatology and Immunology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Patients with ankylosing spondylitis(AS)frequently suffer from comorbid sleep disorders,exacerbating the burden of the disease and affecting their quality of *** To investigate the clinical significance of serum inflammatory factors,health index and disease activity scores in patients with AS complicated by sleep *** A total of 106 AS patients with comorbid sleep disorders were included in the *** patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical *** serum levels of inflammatory factors,including C-reactive protein,erythrocyte sedimentation rate,interleukin(IL)-6,tumour necrosis factor-αand IL-1β,were *** activity scores,such as the Bath AS functional index,Bath AS disease activity index,Bath AS metrology index and AS disease activity score,were *** health index was obtained through the Short Form-36 *** The study found significant associations amongst serum inflammatory factors,health index and disease activity scores in AS patients with comorbid sleep *** correlations were found between serum inflammatory factors and disease activity scores,indicating the influence of heightened systemic inflammation on disease severity and functional ***,negative correlations were found between disease activity scores and health index parameters,highlighting the effect of disease activity on various aspects of healthrelated quality of *** regression analysis further confirmed the predictive value of these factors on patient outcomes,underscoring their potential utility in risk assessment and *** The findings demonstrate the intricate interplay amongst disease activity,systemic inflammation and patientreported health outcomes in AS patients complicated by sleep *** results emphasise the need for comprehensive care strategies that address the diverse needs and challe

关键词： Inflammatory factors Disease activity scores Health index Ankylosing spondylitis Sleep disorders

Serum Renalase Inversely Related to Heart Rate Variability in Dialysis Patients

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Journal of Shanghai Jiaotong university(Science) 2014年第4期19卷 508-512页

作者：黄宝瑞王锋李军辉汪年松 Medical College of Soochow University Department of Nephrology and rheumatology Shanghai Jiaotong University Affiliated Sixth People’s Hospital

Heart rate variability(HRV) is a noninvasive technique for autonomic nerve activity assessment and an indirect index of adrenergic cardiovascular drive. Renalase is the only known enzyme degrading circulatory catecholamines, participating in regulations of the cardiovascular and sympathetic nervous systems. This study aims at the relation between serum renalase and HRV indexes in dialysis patients. There were 14 hemodialysis(HD)cases, 16 continuous ambulatory peritoneal dialysis(PD) cases, and 16 healthy volunteers enrolled in this *** the subjects underwent 24 h Holter testing by using a dynamic electocardiogram monitor system to determine HRV parameters, and serum renalase levels were measured. The standard deviation of normal to normal R-R intervals(SDNN, a measure of beat-to-beat variability), root mean square successive difference(RMSSD), and the proportion derived by dividing NN50(the number of interval differences of successive normal to normal intervals greater than 50 ms) by the total number of NN intervals(pNN50) were determined to assess HRV. Both HD and PD patients presented increased maximum heart rate(Max-HR), minimum heart rate(Min-HR) and average heart rate(Ave-HR), and presented decreased SDNN, RMSSD and pNN50 relative to healthy controls. Serum levels of renalase were highly negatively correlated with Ave-HR(correlation coefficient r =-0.68, probability P < 0.01), while positively correlated with SDNN(r = 0.64, P < 0.01) in both the HD and PD groups. Serum level of renalase was positively correlated with 24 h urine volume(r = 0.73, P < 0.01) in PD patients. Renalase might be reciprocally related to HRV and inversely related to Ave-HR in dialysis patients, which will help to probe into renalase's physiology and may pave the way to explore renalase replacement therapy in patients with end stage renal disease(ESRD).

关键词： heart rate variability(HRV) renalase correlation heart rate(HR)