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46 XX karyotype during male fertility evaluation; case series and literature review

Asian Journal of Andrology 2017年第2期19卷 168-172页

作者： Ahmad Majzoub Mohamed Arafa Christopher Starks Haitham Elbardisi Sami A1 Said Edmund Sabanegh Jr Cleveland Clinic Foundation Department of Urology Cleveland Ohio USA Hamad Medical Corporation Department of Urology Qatar Cairo University Department of Andrology Giza Egypt reston hospital Department of Urology Virginia USA

Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man＇s fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients＇ clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using ＂46 XX man＂ as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients＇ mean age _＋ s.d. was 34 ＋ 10 years and their mean height ＋ s.d. was 166 ＋ 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% （4120）, 25.8% （8/31）, and 42% （13131） of the patients, respectively. The SRYgene was detected in 36 （83.7%） and was absent in the remaining seven （16.3%） patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption.

关键词： hypogonadism infertility male sex-determining region XX disorders of sex development

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In memoriam： Wissam S. Al-Hashimi

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Episodes 2005年第4期28卷 300-300页

作者： John M. Aaron IUGS Web Manager 2504 Charlestown Lane reston VA USA 20191

Dr. Wissam S. Al-Hashimi has died. His daughter, Tara, reports that he was kidnapped early in the morning of August 24 while on his way to work. The ransom demanded by his abductors was paid by his family, but to no avail. He died of two bullet wounds to his head. Because his identification was taken from him, it took his family two weeks to find his body in a Baghdad hospital. Tragic indeed, and senseless.

关键词： WissamS.A1-Hashimi 地质学家学术成就地质工作

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Potential clinical treatment for Ebola pandemic

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Science China(Life Sciences) 2014年第10期57卷 982-984页

作者： ZHONG Ying XU Jun LI TaiSheng YU XueZhong SHENG MiaoMiao State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Biochemistry and Molecular Biology Peking Union Medical College Tsinghua University Department of Emergency Medicine Peking Union Medical Collage Hospital Peking Union Medical College Chinese Academy of Medical Sciences Department of Infectious Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Laboratory of Molecular Genetics of Aging & Tumor Medical Faculty Kunming University of Science and Technology Chenggong Campus

West African countries are currently suffering the most severe pandemic of Ebola virus disease ever recorded, with 4269 human cases and 2288 deaths （through 6 September 2014）, and the number of cases in the current outbreak exceeds the number from all previous outbreaks combined. Ebola virus disease was first described in 1976 originating from the Ebola River in the Democratic Republic of the Congo. Five Ebola viruses have been reported to cause Ebola virus pandemics, including Zaire Ebola virus, Sudan Ebola virus, Ivory Coast Ebola virus, reston Ebola virus and Bundibugyo Ebola virus. The Zaire Ebola virus is the most deadly with a fatality rate up to 90%. Unfortunately, the current outbreak in the West African countries is caused by the Zaire Ebola virus, and no specific treatment for the disease is yet available.

关键词：埃博拉病毒临床治疗刚果民主共和国扎伊尔死亡人数感染病例象牙海岸传染病

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在结直肠癌中商业软件升级能显著改变灌注CT参数值

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国际医学放射学杂志 2011年第3期 301-302页

作者： V.Goh M.Shastry A.Engledow J.reston D.M.Wellsted J.Peck 焦慧 Paul Strickland Scanner Centre Mount Vernon Hospital

目的确定商业软件平台升级如何影响结肠直肠癌相关参数。材料和方法获伦理委员会批准,30例疑为结肠直肠癌的病人在术前进行64排PET/CT灌注成像。应用升

关键词：灌注CT 结肠直肠癌 CT对比

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