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Efficacy of third-line pemetrexed monotherapy versus pemetrexed combination with bevacizumab in patients with advanced EGFR mutation-positive lung adenocarcinoma

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Chinese Journal of Cancer research 2014年第6期26卷 705-710页

作者： Cheng-Zhi Zhou Yin-Yin Qin Zhan-Hong Xie Jie-Xia Zhang Ming Ou-Yang Shi-Yue Li Rong-Chang Chen National Clinical research Center for respiratory disease State Key Laboratory of Respiratory Disease Department of Medicine Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University

Objective： The purposes of this study were to observe the effects of different treatment strategies, including third-line pemetrexed alone versus its combination with bevacizumab, in patients with advanced epidermal growth factor receptor（EGFR） mutation-positive lung adenocarcinoma, and to analyze the effects of the different medication orders of first- and second-line drugs on third-line *** and methods： One hundred and sixteen cases of patients with EGFR-positive lung adenocarcinoma who had received third-line pemetrexed alone or in combination with bevacizumab between March 2010 and March 2014 at Guangzhou Institute of respiratory diseases, the First Affiliated Hospital of Guangzhou Medical University were analyzed retrospectively. Additionally, all the patients were treated with first-line gemcitabine and cisplatin（GP） chemotherapy and second-line EGFR tyrosine kinase inhibitor（TKI） or with first-line EGFR-TKI and second-line GP ***： The median survival of 61 cases with third-line pemetrexed monotherapy was 36.22 months, the median survival time of 55 cases with third-line pemetrexed plus bevacizumab was 38.76 months, and there was a significant difference in survival time between the two groups（P=0.04）. Subgroup analysis revealed that among the 55 cases with third-line bevacizumab plus pemetrexed treatment, the median survival of 29 patients with first-line GP and second-line EGFR-TKI was 42.80 months, while the median survival of 26 patients with first-line EGFR-TKI and second-line GP was only 34.46 months; additionally, there was a significant difference in the survival time between the two subgroups（P=0.001）. Among 61 cases with thirdline pemetrexed treatment, the median survival of 34 patients with first-line GP and second-line EGFR-TKI was 38.72 months, while the median survival of 27 patients with first-line EGFR-TKI and second-line GP was only 32.94 months; the survival time of the two subgroups was significantly different（

关键词： Epidermal growth factor receptor(EGFR) mutation lung adenocarcinoma pemetrexed bevacizumab

Evolution of the newest diagnostic methods for COVID-19:a Chinese perspective

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 463-484页

作者： Mingtao LIU Jiali LYU Xianhui ZHENG Zhiman LIANG Baoying LEI Huihuang CHEN Yiyin MAI Huimin HUANG Baoqing SUN Department of Clinical laboratory National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseaseState Key Laboratory of Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510140China National Center for respiratory Medicine National Clinical Research Center of Respiratory DiseaseState Key Laboratory of Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510140China Guangzhou Medical University Guangzhou 511495China

Coronavirus disease 2019(COVID-19)has continued to spread globally since late 2019,representing a formidable challenge to the world's healthcare systems,wreaking havoc,and spreading rapidly through human *** fever,fatigue,and a persistent dry cough being the hallmark symptoms,this disease threatened to destabilize the delicate balance of our global *** and accurate diagnosis of COVID-19 is a prerequisite for understanding the number of confirmed cases in the world or a region,and an important factor in epidemic assessment and the development of control *** also plays a crucial role in ensuring that patients receive the appropriate medical treatment,leading to optimal patient *** transcription-polymerase chain reaction(RT-PCR)technology is currently the most mature method for detecting viral nucleic acids,but it has many ***,a variety of COVID-19 detection methods,including molecular biological diagnostic,immunodiagnostic,imaging,and artificial intelligence methods have been developed and applied in clinical practice to meet diverse scenarios and *** methods can help clinicians diagnose and treat COVID-19 *** review describes the variety of such methods used in China,providing an important reference in the field of the clinical diagnosis of COVID-19.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Diagnosis Polymerase chain reaction(PCR) Immunoassay Radiography

UniBind:a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution

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Signal Transduction and Targeted Therapy 2024年第1期9卷 14-15页

作者： Qihong Yan Jincun Zhao State Key laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

In a recent study published in Nature Medicine,Wang et *** an excellent framework called UniBind based on artificial intelligence(AI),which enables accurately predicting infectivity of SARS-CoV-2 variants and evolutionary trends of future viral variants.1 This computational method holds the possibility to not only serve as a valuable early-warning tool for monitoring potential pathogenic SARS-CoV-2 variants but also facilitate fundamental research on protein-protein interactions(PPIs).

关键词： artificial Bind prediction

Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses

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Chinese Journal of Cancer research 2013年第1期25卷 124-127页

作者： Wenlong Shao Wei Wang Weiqiang Yin Zhihua Guo Guilin Peng Ying Chen Jianxing He Department of Thoracic Surgery the First Affiliated Hospital of Guangzhou Medical College Guangzhou research Institute of respiratory disease China State Key laboratory of respiratory disease

Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,

关键词： node VATS Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses lung

A Sensitive and High-Throughput Flow Cytometry-Based Assay for Measuring Antibody Neutralization of Human Adenovirus Type 3

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Virologica Sinica 2021年第3期36卷 537-544页

作者： Zhenwei Liu Xingui Tian Wenkuan Liu Yuting Xian Weilue Chen Rong Zhou State Key laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510000China

The assessment of neutralization activity is an important step in the evaluation of neutralizing antibodies (NAbs).The traditional methods for measuring the antibody neutralization of human adenovirus type 3 (HAd V-3) are the microneutralization (MN) assay,which has insufficient sensitivity,and the plaque reduction neutralization test (PRNT),which is not suitable for high-throughput ***,we describe the development of a flow cytometry-based neutralization(FCN) assay for measuring the neutralization of sera,cell culture supernatants,and chimeric antibodies against HAd V-3 on the basis of a recombinant HAd V-3 (r HAd V-3) construct expressing the enhanced green fluorescent protein (EGFP).For flow cytometry-based assays,the optimal cell confluence was determined as 90%,and the virus was titrated using the *** established FCN assay follows the percentage law and an optimal MOI of not less than 5 9 10~(-4)was determined by using a purified chimeric *** addition,comparison of the anti-HAd V-3 NAb titers of 72 human serum samples by the MN and FCN assays,showed that both assays correlated strongly with each *** FCN assay was an improvement over the MN assay because the observation period was reduced from 3 to 1 days and data analysis could be performed objectively and ***,the newly established FCN assay allows measurement of the neutralization activity of chimeric antibodies expressed in cell culture ***,this sensitive and highthroughput FCN assay is a useful alternative to the MN assay for measuring the antibody neutralization of HAd V-3 and for screening anti-HAd V-3 NAbs in cell culture supernatants.

关键词： Sensitive High-throughput Flow cytometry Neutralization Adenovirus

Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses:a retrospective study

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Virologica Sinica 2023年第5期38卷 735-740页

作者： Xingui Tian Xiao Li Shuyan Qiu Rong Zhou Wenkuan Liu State Key laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510182China

Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised ***,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent *** this study,the liver function test(LFT)results were retrospectively analyzed among children hospitalized(agerespiratory infection caused by *** transaminase(ALT)and aspartate aminotransferase(AST)levels were elevated in 7.74%and 46.89%of patients,*** patients with>2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or *** higher levels of ALT,AST,γ-glutamyl transpeptidase(γ-GT),and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection ***-55 infection led to significantly higherγ-GT,total bilirubin,and direct bilirubin levels than the other infection *** records of four patients with serial monitoring of the LFT results were further *** indicators remained abnormal during the entire hospitalization in these *** results indicate that HAdV infection is often accompanied by abnormal liver function,and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.

关键词： Acute respiratory disease Adenovirus Hepatitis Liver enzyme Liver function test

Evolution of Influenza A H7N9 Virus with an Emphasis on Gene Constellation

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Journal of Genetics and Genomics 2014年第1期41卷 3-6页

作者： Zifeng Yang Runfeng Li Tianyu Zhang State Key laboratory of respiratory disease The First Affiliated HospitalGuangzhou Medical University Guangzhou Institute of respiratory disease National Clinical research Center for respiratory disease Center for Infection and Immunity Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences

The H7 subtype avian influenza viruses, including H7N2, HTN3 and HTN7, have posed a public health threat worldwide. Except one H7N7 fatal case in the Netherlands in 2003, the other H7 human cases have resulted in self... 详细信息

关键词： In gene Evolution of Influenza A H7N9 Virus with an Emphasis on Gene Constellation

A Potential Chinese Medicine Granule Suppressing ARDS of COVID-19: Keguan-1

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Chinese Journal of Integrative Medicine 2020年第11期26卷 803-804页

作者： ZHONG Nan-shan YANG Zi-feng JIANG Mei LIANG Jing-yi State Key laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou(510120)China

Recently,a well-designed,exploratory clinical trial on the management of patients with coronavirus disease 2019(COVID-19)by a Chinese medicine(CM)Keguan-1 has been conducted by *** Xiao-he and his colleagues.(1)For the emergency of COVID-19 treatment,conventional new vaccine and new drug development is a money consuming and time demanding process.

关键词： vaccine process. clinical

Evaluation of an innovative pediatric isolation(PI)bed using fluid dynamics simulation and aerosol isolation efficacy

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Building Simulation 2021年第5期14卷 1543-1552页

作者： Tiantian Liu Yubing Guo Xiaotang Hao Mei Wang Shicong He Zhengshi Lin Rong Zhou School of Public Health Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510310China State Key laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

Airborne transmission is an important mechanism of spread for both viruses and bacteria in hospitals,with nosocomial infections putting a great burden on public *** this study,we designed and manufactured a bed for pediatric clinic consultation rooms providing air isolation to protect patients and medical personnel from pathogen *** pediatric isolation bed has several primary efficiency filters and a high-efficiency particulate air filter in the bedside *** air circulation between inlet and outlet forms negative pressure to remove the patient's exhaled air timeously and effectively.A computational fluid dynamics model was used to calculate the speed of the airflow and the angle of *** this,we conducted purification experiments using cigarette smoke,Staphylococcus albus(***)and human adenovirus type 5(HAdV-5)to demonstrate the isolation *** results showed that the patient's head should be placed as close to the air inlet hood as possible,and an air intake wind speed of 0.86 m/s was *** isolation efficacy of the pediatric isolation bed was demonstrated by computational fluid dynamics *** isolation efficiency against cigarette smoke exceeded 91.8%,and against *** was greater than 99.8%,while the isolation efficiency against HAdV-5 was 100%.The pediatric isolation bed could be used where isolation wards are unavailable,such as in intensive care units and primary clinical settings,to control hospital acquired infections.

关键词： computational fluid dynamics(CFD) isolation bed particles speed nosocomial infections pediatrics