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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering research center of Precision Diagnostics and Therapeutics development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Significant changes in the physicochemical properties of BC-containing particles during the cold season in Beijing

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Journal of Environmental Sciences 2025年第5期151卷 667-676页

作者： Shuya Hu Linghan Zeng Gang Zhao Shiyi Chen Chunsheng Zhao Weilun Zhao Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Research Center for Atmospheric Research(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation center of Atmospheric Environment and Equipment technology Nanjing University of Information Science and TechnologyNanjing 210044China

The ambient air quality has improved significantly under strict emission controls in Beijing,China over the last *** carbon(BC),as a short-lived climate forcer in ambient aerosols,profoundly impacts the air quality and *** studies have demonstrated a decline in the mass concentration of *** this study,we characterized the chemical compositions and size distributions of BC-containing particles during the cold season of 2022 in Beijing using state-of-the-art instruments capable of exclusively measuring BCcontaining *** optical properties of BC-containing particles were further calculated based on the Mie ***,we compared the properties of BC-containing particles in 2022 with the results of previous *** results showed that the diameters of BC cores became larger while the coating thickness of BC-containing particles became thinner in *** the coating materials,the mass fraction of nitrate increased obviously,and even replaced organic matter as the dominant component during the peak of the pollution *** in chemical compositions and size distributions resulted in lower mass absorption cross-sections(MAC)of BC-containing particles from 10.5±1.1 m^(2)/g in 2016 to 7.3±0.8 m^(2)/g in 2022,reduced by 30.5%.Our results demonstrate the synergistic benefits of air pollution control in improving air quality and mitigating climate ***,the MAC of BC adopted in climate models should vary with the changing air pollution *** study emphasizes that it is imperative to conduct long-term observations of BC-containing particles to better estimate BC’s climate effects.

关键词： Black carbon Chemical composition Size distribution Light absorption ability

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationHubei Key Laboratory of Novel Reactor and Green Chemical TechnologySchool of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan 430205HubeiChina Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079HubeiChina College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianChina

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER ***,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic ***,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during *** hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)*** obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER *** work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin Lu National Engineering research center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China(Life Sciences) 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level,limiting their applications in biological ***,we introduce ImSpiRE,an image feature-aided spatial resolution enhancement method for in situ capturing spatial *** the information stored in histological images,ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution,together with extending the gene expression profiles into unmeasured *** to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains,signaling communication patterns,and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing Li Yan-Dong Wu Kai-Lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of research and development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor

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Chinese Chemical Letters 2025年第2期36卷 262-269页

作者： Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu Department of radiation Oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University Department of radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer Hospital Chongqing Key Laboratory of translational research for Cancer Metastasis and individualized Treatment Chongqing University Cancer Hospital Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Pharmacy The First Affiliated Hospital of Wannan Medical CollegeYijishan Hospital of Wannan Medical College Institute of Surgery research Daping HospitalThird Military Medical University

It is of great significance to find safe and effective radiosensitizers. A primary investigation has been made on fisetin's modification of radiation effect, but its radiosensitization and related mechanisms still need to be deeply clarified. Furthermore, fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application. In this study, we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2) signaling pathway in the tumor. Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo. On the cellular level, fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells) to radiation. In the mouse models of colon and breast cancers, fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity. Additionally, we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity. In general, this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo, but also profoundly explored its mechanisms underlying, to provide a theoretical and experimental basis for the clinical application of fisetin micelles.

关键词： Fisetin Platelet-derived growth factor receptor-β Polymetric micelles Radiosensitizer Radiotherapy

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and technology Renewable Energy Conversion and Storage CenterState Key Laboratory of Photovoltaic Materials and CellsNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and technology of Tianjin Tianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Engineering research center of Thin Film Photoelectronic technology of Ministry of Education Tianjin 300350China Collaborative Innovation center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells(IPSCs),which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid(5-MVA)was introduced as a strain buffer to release the residual strain of CsPbI_(2.85)Br_(0.15)*** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb^(2+)through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI_(2.85)Br_(0.15)perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI_(2.85)Br_(0.15),resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency(PCE)of NiOxbased inverted IPSCs increased from 19.25%to 20.82%with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI_(2.85)Br_(0.15)perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

Facile fabrication of NiCo-hydroxysulfide nanosheets array for electrocatalytic urea oxidation

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Science China(Technological Sciences) 2025年第1期68卷 218-228页

作者： Jing ZOU Chang LIU Kun XIANG Qiong LI Shihao DAI Jizhou JIANG School of Chemistry and Environmental Engineering School of Environmental Ecology and Biological EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationNovel Catalytic Materials of Hubei Engineering Research CenterWuhan Institute of TechnologyWuhan 430205China

Urea oxidation reaction(UOR)instead of anodic oxygen evolution reaction(OER)is considered an effective way to reduce energy consumption in electrocatalytic water splitting for hydrogen ***,the slow rate of reaction of UOR,which entails a procedure of transferring six electrons,has hindered its widespread ***,it is crucial to design highly effective electrocatalysts for the implementation of ***,a novel NiCo-hydroxysulfide(NiCo-HOS)electrocatalyst has been reported for UOR,which is obtained by the exchange of sulfur ions in NiCo layered double hydroxide(NiCo-LDH)nanosheets at room *** from the sulfurization process,the composition,electronic structure,and surface properties of electrocatalysts have undergone significant changes and *** sulfurization treatment,the resulting NiCo-HOS showed enhanced chemical resistance to alkaline electrolytes and improved electrical *** a 40 h operation test,it maintained high stability and provided a stable current density of 100 mA cm^(-2)at a relatively low potential of 1.33 V(***)in a solution of 1 mol L^(-1)KOH+0.5 mol L^(-1)***,the anode electrolytic product is analyzed through gas chromatography(GC),and N_2 is detected as the product without the presence of CO,indicating that the urea has undergone complete oxidation.

关键词： urea oxidation reaction NiCo-hydroxysulfide electrocatalyst hydrogen

Dynamic damage characteristics and control mechanism of rocks anchored by constant resistance and energy absorption material

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International Journal of Mining Science and technology 2025年第1期35卷 57-67页

作者： Bei Jiang Kunbo Wu Qi Wang Yetai Wang Wenrui Wu Yaoxia Feng Yanbo Zhang State Key Laboratory for Tunnel Engineering China University of Mining&Technology-BeijingBeijing 100083China State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing 100081China Collaborative Innovation center of Green development and Ecological Restoration of Mineral Resources North China University of Science and TechnologyTangshan 063210China

With resource exploitation and engineering construction gradually going deeper,the surrounding rock dynamic disaster becomes frequent and *** anchorage support is a common control method of surrounding rock in underground *** study the dynamic damage characteristics of anchored rock and the energy absorption control mechanism of dynamic disasters,a new type of constant resistance and energy absorption(CREA)material with high strength,high elongation and high energy absorption characteristics is developed.A contrast test of rockbursts in anchored rock with different support materials is *** test results show that the surface damage rates and energy release degree of anchored rock with common bolt(CB)and CREA are lower than those of unanchored rock,*** total energy,average energy and maximum energy released by CREA anchored rock are 30.9%,94.3%and 84.4%lower than those of CB anchored *** with unanchored rock,the rockburst peak stress in the CREA anchored rock is increased by 39.9%,and the rockburst time is delayed by 53.2%.Based on the rockburst energy calculation model,the evolution law of rockburst peak stress and energy release is *** control mechanism of CREA support units on rock dynamic failure is clarified.

关键词： Constant resistance and energy absorption Anchored rock Rockburst Peak stress Control mechanism