检索结果-南通市图书馆

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

引用

Neural Regeneration research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu shenzhen Key Laboratory of Bone Tissue Repair and Translational research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Janus MXene film with gradient structure for highly efficient terahertz and infrared electromagnetic absorption

引用

Nano research 2025年第1期18卷 434-442页

作者： Shaodian Yang Weiqiang Huang Zhiqiang Lin Zibo Chen Rongliang Yang Yi Jia Xuebin Liu Rui Wang Zhiping Zeng Yougen Hu Huanjun Chen Xuchun Gui11 State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China China Academy of Aerospace Science and Innovation Beijing 100176China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

Electromagnetic interference (EMI) shielding inhigh-frequency range, especially the rapidly growing terahertz(THz) frequency range, attracts increasing attention due tothe potential application of terahertz in 6G wirelesscommunication, and security inspection. However, traditionalconductive EMI films typically achieve high shieldingeffectiveness through strong reflection, which may causesecondary pollution to other devices. Here, a gradientstructure strategy was proposed to constructTi_(3)C_(2)Tx/hydroxypropyl methyl cellulose (HPMC) film, in whichthe content of Ti_(3)C_(2)Tx gradually increases along the thicknessdirection, resulting in different conductivity of the two surfaces(surface-M and surface-H) for the film. The obtained gradientfilmexhibits an EMI shielding efficiency of over 48.5 dB in theTHz range (0.2-1.6 THz) at a thickness of 40 μm. Especially,as the THz waves incident from the surface-H to the film, the absorption effectiveness reaches 48.2 dB (average absorbedpower loss up to 91.4%), and the reflection effectiveness is only 0.3 dB. In additions, the gradient-film also demonstrates ahigh absorption rate of 95.5% in the infrared band (2.5-16.7 μm). Moreover, the gradient-film exhibits an excellent tensilestress and Young’s modulus value of 173.1 MPa and 2.8 GPa, respectively. Therefore, the gradient-film proposed in thiswork, with excellent electromagnetic absorption in both THz and infrared band, provides a promising candidate for the nextgenerationEMI shielding applications.

关键词： electromagnetic interference shielding Janus film terahertz MXene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

引用

Neural Regeneration research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Simple BCH Decoder for NoC Interconnects and SoC Buses

引用

Chinese Journal of Electronics 2021年第3期30卷 444-450页

作者： WU Tao YANG Ailin School of Data and Computer Science Sun Yat-sen University shenzhen research institute of sun yat-sen university

Network on a chip(No C) uses packetswitched network to implement interconnections in System on chip(So C). In So C design, performance and energy efficiency are respectively the first and second priorities,and optimal on-chip communication should decrease the power consumption and area overhead. In this work, a simplified BCH codec is proposed for reliable communication in No C and So C. It performs BCH error corrections without Berlekamp’s algorithm, only using reduced syndrome bits to determine error patterns. The error locations can be found by looking up tables, by which the possible errors are directly corrected. Only one matrix product and one ROM access are required in the BCH decoder. The proposed(20, 8, 2) and(31, 16, 3) decoders in the paper can be easily applied for error corrections of interconnects and buses for No C and So C. It is also beneficial to correct data lines without length definition and control lines without storage.

关键词： packet-switched network energy efficiency error locations simplified BCH codec NoC interconnects packet switching reliable communication BCH codes decoding error patterns simple BCH decoder error correction codes SoC buses reduced syndrome bits power consumption on-chip communication Berlekamp's algorithm BCH error corrections possible errors system buses network-on-chip

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Topology optimization design of micro-mass sensors for maximizing detection sensitivity

引用

Acta Mechanica Sinica 2015年第4期31卷 536-544页

作者： Zheqi Lin Xuansheng Wang Yiru Ren School of Information Science and Technology Sun Yat-sen University shenzhen research institute of sun yat-sen university Sun Yat-sen University College of Mechanical and Vehicle Engineering Hunan University

Micro-mass sensors have attracted increasing attention in the field of biomolecular and chemical detec- tion. It has been found that the size, shape, and geometry of the structure may affect the performance of the sensor. As a result, a topology optimization methodology is proposed in this paper for the design of micro-mass sensors. A phase- field function controlled by nodal variables and finite element shape functions is used to describe the configuration of a sen- sor in the constructed optimization problem. The design goal is to maximize the mass detection sensitivity. On the basis of these formulations, an optimization algorithm is constructed using the finite element method and the method of moving asymptotes. Numerical examples are presented to demon- strate the validity of the proposed problem formulation. The results suggest that the performance of the micro-mass sensor can be improved by using the proposed approach.

关键词： Topology optimization Mass detectionsensitivity Finite element method Phase-field functionMicro-mass sensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Automatic Cage Building with Quadric Error Metrics

引用

Journal of Computer Science & Technology 2011年第3期26卷 538-547页

作者：邓正杰罗笑南苗晓萍 School of Information Science and Technology Sun Yat-Sen University National Engineering research Center of Digital Life research institute of sun yat-sen university in shenzhen School of Software Sun Yat-Sen University

Modern computer graphics applications usually require high resolution object models for realistic rendering. However, it is expensive and difficult to deform such models in real time. In order to reduce the computational cost during deformations, a dense model is often manipulated through a simplified structure, called cage, which envelops the model. However, cages are usually built interactively by users, which is tedious and time-consuming. In this paper, we introduce a novel method that can build cages automatically for both 2D polygons and 3D triangular meshes. The method consists of two steps： 1） simplifying the input model with quadric error metrics and quadratic programming to build a coarse cage; 2） removing the self-intersections of the coarse cage with Delaunay partitions. With this new method, a user can build a cage to envelop an input model either entirely or partially with the approximate vertex number the user specifies. Experimental results show that, compared to other cage building methods with the same number of vertex, cages built by our method are more similar to the input models. Thus, the dense models can be manipulated with higher accuracy through our cages.

关键词： cage quadric error metrics mesh simplification self-intersection deformation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breakthrough in construction of oxygen-independent photosensitizer for type Ⅲ photodynamic therapy

引用

Science China Chemistry 2022年第5期65卷 834-835页

作者： Zhishang Zhang Huaiyi Huang School of Pharmaceutical Sciences(shenzhen) Shenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107China

Cancer remains one of the leading causes of mortality *** enormous research efforts over the last several decades,death caused by cancer is predicted to rise by ca.70%within 2030 [1].Traditional treatment modalities i... 详细信息

关键词： mortality Cancer surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Whole wheat flour coating with antioxidant property accelerates tissue remodeling for enhanced wound healing

引用

Chinese Chemical Letters 2020年第6期31卷 1612-1615页

作者： Caihong Xian Zhipeng Gu Guiting Liu Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China research institute of sun yat-sen university in shenzhen Shenzhen 518057.China

As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural ***,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been *** results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound *** kind of whole wheat flour solution has great potential application for cutaneous wound repair.

关键词： Whole wheat flour Coating Antioxidant Tissue remodeling Wound healing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early identification of stroke through deep learning with multi-modal human speech and movement data

引用

Neural Regeneration research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NP-Logic Systems and Model-Equivalence Reductions

引用

Journal of Computer Science & Technology 2010年第6期25卷 1321-1326页

作者：沈榆平赵希顺 institute of Logic and Cognition Sun Yat-Sen University Department of Philosophy Sun Yat-Sen University

In this paper we investigate the existence of model-equivalence reduction between NP-logic systems which are logic systems with model existence in *** is shown that among all NP-systems with model checking problem in NP,the existentially quantified propositional logic（PF） is maximal with respect to poly-time model-equivalent ***,PF seems not a maximal NP-system in general because there exits an NP-system with model checking problem DP-complete.

关键词： logic system model-equivalent reduction expressive power computational complexity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：