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The Effects of Simulated Microgravity on Immune Function of Macrophages

医用生物力学 2019年第A1期34卷 129-130页

作者： Guolin Shi Sufang Wang Wenjuan Zhao Hui Yang School of Life Sciences Northwestern Polytechnical UniversityXi’an710072China research center of specialenvironmental biomechanics&medical engineering Northwestern Polytechnical UniversityXi’an710072China medical research Institute Northwestern Polytechnical UniversityXi’an710072China

Since the 1 960 s,many successful space missions have highlighted the advantages and necessity of humans in the exploration of space,but scientists have long worried about the adverse effects of spaceflight on *** flight and models that create conditions similar to those that occur during space flight have been shown to deleteriously affect a variety of immunological *** mechanisms and biomedical consequences of these changes remain to be *** experiments in an environment of true microgravity requires a roundtrip ticket into space,a feat that is both expensive and *** microgravity(SMG)models allow scientists to gather preliminary data without the cost and logistical challenges of *** objective of the present study was to evaluate the effects of SMG on immunity function of macrophages that exposed to RPM and RCCS *** many studies have demonstrated that alterations occur in the immune system as a result of space travel,the level at which these mechanisms exert their effect,at the level of the mature immune cell or earlier at the progenitor or stem cell stage is not *** particular,macrophages,as one of the most important immune cells and play a key role in both specific and non-specific immunity,did not have received much ***,in our study,we mainly study the influence of microgravity on the immune function of *** this study,we evaluated the immune dysfunction of macrophages under ***,we found that the morphology and structure of the macrophages were changed,specifically,we observed that there were more protrusions on cell surface and the cells were shrinking significantly after exposure to ***,we demonstrated that under simulated microgravity(SMG)conditions,the phagocytic and proliferative functions of macrophages were significantly ***,several processes,including surface receptor expression,cytoskeleton,and cytokines secreted

关键词： simulated microgravity effect RAW 264.7 phagocytosis cytoskeleton antigen processing and presentation

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Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer

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Chinese Journal of Polymer Science 2014年第1期32卷 43-50页

作者：牛旭锋 Feng Tian Li-zhen Wang Xiao-ming Li Gang Zhou 樊瑜波 Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University BUAA research Institute

Chitosan-graft-poly（lactic acid）（CS-g-PLA） copolymer was synthesized through emulsion self-assembly in a water-in-oil （W/O） microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-（3-dimethylaminopropyl）-N＇ethylcarbodiimide hydrochloride （EDC＇HCI）. FTIR and IH-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125-375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.

关键词： Poly(lactic acid) Chitosan Copolymer Self-assembling Grafting.

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Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

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Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials:Based on the mechanisms of occurrence and development of adhesions

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Bioactive Materials 2023年第8期26卷 387-412页

作者： Jie Liao Xiaoming Li Yubo Fan Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Postoperative adhesion(POA)widely occurs in soft tissues and usually leads to chronic pain,dysfunction of adjacent organs and some acute complications,seriously reducing patients’quality of life and even being *** for adhesiolysis,there are few effective methods to release existing ***,it requires a second operation and inpatient care and usually triggers recurrent adhesion in a great ***,preventing POA formation has been regarded as the most effective clinical *** have attracted great attention in preventing POA because they can act as both barriers and drug ***,even though much reported research has been demonstrated their efficacy on POA inhibition to a certain extent,thoroughly preventing POA formation is still ***,most biomaterials for POA prevention were designed based on limited experiences,not a solid theoretical basis,showing ***,we aimed to provide guidance for designing anti-adhesion materials applied in different soft tissues based on the mechanisms of POA occurrence and *** first classified the postoperative adhesions into four categories according to the different components of diverse adhesion tissues,and named them as“membranous adhesion”,“vascular adhesion”,“adhesive adhesion”and“scarred adhesion”,***,the process of the occurrence and development of POA were analyzed,and the main influencing factors in different stages were ***,we proposed seven strategies for POA prevention by using biomaterials according to these influencing ***,the relevant practices were summarized according to the corresponding strategies and the future perspectives were analyzed.

关键词： Prevention of postoperative adhesions(POA) Soft tissues Mechanisms of occurrence and development Biomaterials

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Controllable Nanostructural Transitions in Grafted Nanoparticle-Block Copolymer Composites

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Nano research 2010年第5期3卷 356-362页

作者： Guang-Kui Xu Xi-Qiao Feng Shou-Wen Yu Institute of biomechanics and medical engineering Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

We report a theoretical investigation of self-assembled nanostructures of polymer-grafted nanoparticles in a block copolymer and explore underlying physical mechanisms by employing the self-consistent field method. By varying the particle concentration or the chain length and density of the grafted polymer, one can not only create various ordered morphologies (e.g., lamellar or hexagonally packed patterns) but also control the positions of nanoparticles either at the copolymer interfaces or in the center of one-block domains. The nanostructural transitions we here report are mainly attributed to the competition between entropy and enthalpy.

关键词： Block copolymer nanocomposite pattern formation self-assembly self-consistent field theory

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In vitro and in vivo evaluation of micro-alloyed magnesium for potential application in alveolar bone fixation screws

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Journal of Materials Science & Technology 2023年第13期144卷 62-69页

作者： Hongyan Tang Qing Li Min Li Xuenan Gu Chengkung Cheng Yubo Fan Key Laboratory of biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China center of Digital Dentistry Peking University School and Hospital of StomatologyBeijing 100081China National engineering research center of Oral Biomaterials and Digital medical Devices Beijing 100081China School of Biomedical engineering Shanghai Jiao Tong UniversityShanghai 200030China

Alveolar bone augmentation with fixation screws has difficulties such as non-degradable materials that could lead to secondary surgery and insufficient osseointegration due to the subgingival environment in dental *** degradability and a high degree of osteogenesis,Mg alloy is a successful biodegrad-able material for orthopedic applications,and its application in dentistry has made certain ***-ever,considering the unique subgingival healing properties of oral implants,there is still a gap between the desired material properties for clinical applications and available ***,studies on the use of Mg-based fixation screws for dentistry applications are still *** this study,we reported a magnesium alloy with low combined addition of strontium and *** mechanical properties,degradation behavior,osteogenesis,and gingival compatibility were systematically investigated for assess-ing its potential application in alveolar bone fixation *** the alloying element content restricted to 0.3 wt.%,Mg-Sr-La alloy still exhibited good mechanical properties,with yield tensile and compressive strength twice higher than those of pure *** in vitro degradation rate of this alloy was 0.10 mm y-1,which was slightly slower than high-purity *** indirect and direct cell assay confirmed the elevated osteoblastic differentiation of MC3T3-E1 and migration of HGF-1 ***,Mg-Sr-La alloy demon-strated a relatively slow degradation in the maxillary bone of Beagles.A remarkable promotion of the bone-implant contacts and significantly decreased fibrous encapsulation was observed in the subgingival environment,implying superior osseointegration of the experimental alloy than the titanium *** empirical findings here reveal the great potential of Mg-Sr-La alloy for the application in alveolar bone fixation devices.

关键词： Magnesium alloys Alveolar ridge augmentation Fixation screws Osseointegration

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Comparative assessment of liver tissue:from microstructural and mesoscale vascular architecture to macroscopic mechanics

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Acta Mechanica Sinica 2024年第7期40卷 195-205页

作者： Wei Kang Kaixin Sun Lizhen Wang Yubo Fan Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of engineering Medicine Beihang UniversityBeijing 100083China

Accurately characterizing the liver's mechanical properties is of paramount importance for disease diagnosis,treatment,surgical prosthetic modeling,and impact injury ***,due to its inherent biological soft tissue nature,the characterization of mechanical behavior varies across testing methods and sample *** this study,we employed transmission electron microscope and Micro CT to observe the morphology of the marginal and center of rat livers and conducted macroscopic mechanical tests to characterize their elasticity and *** results revealed that the central region displayed higher metabolic levels,elongated mitochondria,and an abundance of rough endoplasmic reticulum at the *** the mesoscale,larger diameter portal veins were mainly distributed in the central region,while smaller diameter arteries were predominantly located at the *** the macroscale,under a strain rate of 0.0167 s^(-1),no significant differences were observed in the elastic properties between the two ***,as the strain rate increased up to 0.167 s^(-1),the central region displayed higher porosity,resulting in reduced liquid loss,increased hardness,and higher viscosity compared to the ***,the liver demonstrated overall heterogeneity,with isotropic models suitable for the peripheral region,while more intricate models may be required to capture the complexity of the central region with its intricate vasculature.

关键词： Liver Mechanical properties Micro and macro tests

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Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization

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Bioactive Materials 2022年第8期7卷 416-429页

作者： Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen Guangdong Provincial Biomedical engineering Technology research center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart CenterSino-Japanese Cooperation Platform for Translational Research in Heart FailureZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Biomaterials research center School of Biomedical EngineeringSouthern Medical UniversityGuangzhou510515China Guangdong engineering research center for Translation of medical 3D Printing Application Guangdong Provincial Key Laboratory of Medical BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell *** direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical *** reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial *** this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics *** results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the *** addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1α*** brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization.

关键词： Artificial stem cells Exosomes Myocardial infarction Coronary collateralization

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Responses of osteoblasts under varied tensile stress types induced by stretching basement materials

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International Journal of Smart and Nano Materials 2024年第2期15卷 279-295页

作者： Xuezheng Geng Qiao Li Yan Yao Lizhen Wang Yubo Fan Beijing Advanced Innovation center for Biomedical engineering School of Biological Science and Medical EngineeringKey Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijingChina School of engineering Medicine Beihang UniversityBeijingChina

Osteoblasts are mechanosensitive *** stress with different conditions,including loading time,frequency,magnitude,*** cause varied responses in ***,it was not clarified that the effect of the loading types on the *** this study,we focused on the effect of varied tensile stress types on osteoblasts,including isotropic stretch,biaxial stretch,and uniaxial stretch with the negative ratio of transverse strain to axial strain(NR)-1,0,and 0.2 *** proliferation was determined to be most efficient when stimulated by 6%strain at a frequency of 1 Hz and a negative value of 0 for 1 h/*** varied strain resulted in a thickening of the F-actin cytoskeleton and a thinning of the *** flattening caused Yes-associated protein(YAP)to be transported to the *** was suggested that the influence of loading types on the mechanobiology responses must be *** mechanism of cell mechanical sensitivity under varied loading types was explored,which would provide good sugges-tions for designing microstructures to control deformation patterns in bone tissue engineering.

关键词： MC3T3-E1 tensile stress negative poisson’s ratio cell proliferation YAP

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Effects of Geometrical Characteristics of Suture on Fracture Resistance of Walnut Shell

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Journal of Bionic engineering 2023年第6期20卷 2732-2741页

作者： Peng Xu Lizhen Wang Jinglong Liu Yanxian Yue Yubo Fan Key Laboratory of biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of engineering Medicine Beihang UniversityBeijing100083China

Nut shells have good impact and fracture resistance,but many kinds of nut shells have suture structures with low bonding ***,the mechanism of impact and fracture resistance of nut shells as a whole is important to study,particularly given that sutures maintain low bonding *** this study,we investigated the effect of the geometrical characteristics of sutures(morphology,thickness,and number)on the overall fracture resistance of walnuts,based on mechanical tests of C-ring samples,microstructure analysis after cracking,quantitative analysis of suture geometric model,and numerical *** found that the cracking of walnuts was mainly caused by tensile stress,and the bonding strength was approximately 2.48±0.64 *** discovered that the thickness of the suture was 1.55±0.32 times thicker than the shell,which improved the fracture resistance ability by more than 28.4%.The undulating and inclined morphology of the walnut suture also increased the fracture ***,an appropriate suture number reduced the cracking of *** conclusion,our study sheds light on the physiological function of walnut sutures from a biomechanical perspective and provides useful references for designing fracture resistance measures in thin shell structures.

关键词： Fracture resistance Walnut Suture Bonding strength Numerical simulations biomechanics

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